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Olfactory dysfunction and its related molecular mechanisms in Parkinson’s disease

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Neural Regeneration Research 2024年第3期19卷 583-590页

作者： Yingying Gu Jiaying zhang Xinru Zhao Wenyuan Nie Xiaole Xu Mingxuan Liu xiaoling zhang College of Pharmacy Nantong UniversityNantongJiangsu ProvinceChina

Changes in olfactory function are considered to be early biomarkers of Parkinson’s *** dysfunction is one of the earliest non-motor features of Parkinson’s disease,appearing in about 90%of patients with early-stage Parkinson’s disease,and can often predate the diagnosis by ***,olfactory dysfunction should be considered a reliable marker of the ***,the mechanisms responsible for olfactory dysfunction are currently *** this article,we clearly explain the pathology and medical definition of olfactory function as a biomarker for early-stage Parkinson’s *** the basis of the findings of clinical olfactory function tests and animal model experiments as well as neurotransmitter expression levels,we further characterize the relationship between olfactory dysfunction and neurodegenerative diseases as well as the molecular mechanisms underlying olfactory dysfunction in the pathology of early-stage Parkinson’s *** findings highlighted in this review suggest that olfactory dysfunction is an important biomarker for preclinical-stage Parkinson’s ***,therapeutic drugs targeting non-motor symptoms such as olfactory dysfunction in the early stage of Parkinson’s disease may prevent or delay dopaminergic neurodegeneration and reduce motor symptoms,highlighting the potential of identifying effective targets for treating Parkinson’s disease by inhibiting the deterioration of olfactory dysfunction.

关键词： biomarker early-stage olfactory disorders olfactory dysfunction Parkinson’s disease

Superwetting Ag/α-Fe_(2)O_(3) anchored mesh with enhanced photocatalytic and antibacterial activities for efficient water purification

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Green Energy & Environment 2024年第1期9卷 89-103页

作者： Jiakai Li Changpeng Lv Jiajia Song xiaoling zhang Xizhen Huang Yingzhuo Ma Haijie Cao Na Liu Department of Chemistry Tsinghua UniversityBeijing100084China Anhui Provincial Engineering Laboratory of Silicon-based Materials Engineering Technology Research Center of Silicon-based Materials(Anhui)School of Material and Chemical EngineeringBengbu UniversityBengbu233030China Institute of Materials for Energy and Environment College of Materials Science and EngineeringQingdao UniversityQingdao266071China

Superwetting materials have drawn unprecedented attention in the treatment of oily wastewater due to their preferable anti-fouling property and selective oil/water ***,it is still a challenge to fabricate multifunctional and environmentally friendly materials,which can be stably applied to purify the actual complicated ***,a Ag/Ag/α-Fe_(2)O_(3) heterostructure anchored copper mesh was intentionally synthesized using a facile two-step hydrothermal *** resultant mesh with superhydrophilicity and underwater superoleophobicity was capable of separating various oil/water mixtures with superior separation efﬁciency and high permeationﬂux driven by ***ﬁting from the joint effects of the smaller band gap of Ag/α-Fe_(2)O_(3) heterojunction,inherent antibacterial capacity of Ag/α-Fe_(2)O_(3) and Ag nanoparticles,favorable conductive substrate,as well as the hierarchical structure with superwettability,such mesh presented remarkably enhanced degradation capability toward organic dyes under visible light irradiation and antibacterial activity against both Escherichia coli(***)and Staphylococcus aureus(***)compared with the pure Ag/α-Fe_(2)O_(3) coated ***,the mesh exhibited bifunctional water puriﬁcation performance,in which organic dyes were eliminated simultaneously from water during oil/water separation in oneﬁltration *** importantly,this mesh behaved exceptional chemical resistance,mechanical stability and long-term ***,this material with multifunctional integration may hold promising potential for steady water puriﬁcation in practice.

关键词： Superwetting Ag/α-Fe_(2)O_(3)heterostructure Enhanced photocatalytic and antibacterial activities Water purification Long-term reusability

New dating indicates intermittent human occupation of the Nwya Devu Paleolithic site on the high-altitude central Tibetan Plateau during the past 45,000 years

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Science China Earth Sciences 2024年第2期67卷 531-551页

作者： Junyi GE xiaoling zhang Shejiang WANG Linhui LI Wei HE Yingshuai JIN Peiqi zhang Bing XU Chenglong DENG John WOLSEN Zhengtang GUO Xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academy of Sciences Beijing 100049China Tibetan Cultural Relics Conservation Institute Lhasa 850000China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences.Beijing 100029China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China School of Anthropology University of ArizonaTucson85721USA

The timing and mechanisms of the human occupation of the demanding high-altitude Tibetan Plateau environment are of great ***,we report on our reinvestigations and dating of the Nwya Devu site,located nearly 4600 meters above sea level on the central Tibetan Plateau.A new microblade techno-complex was identified on a lower lake shore at this site,distinct from the previously reported blade tool *** two lithic assemblages were dated to 45.6±2.6 and10.3±0.5 ka using optically stimulated luminescence and accelerator mass spectrometry^(14)C *** represent,respectively,the earliest known Paleolithic and microlithic sites on the interior Tibetan Plateau,indicating multiple occupation episodes of hunter-gatherers during the past 45 *** studies reveal that relatively stable depositional conditions and a paleoenvironment characterized by a comparatively warm climate facilitated these multiple occupations at Nwya *** contemporaneous occurrence of the Upper Paleolithic blade technology on the Tibetan Plateau and most of Eurasia between 50 and 40 ka indicates rapid,large-scale dispersals of humans that profoundly affected human demography on a large *** new archaeological evidence and previously reported genetic data,we conclude that the Tibetan Plateau provided a relatively stable habitat for Upper Paleolithic hunter-gatherers,which may have contributed to the complex and multiple-origin gene pool of present-day Tibetans.

关键词： Tibetan Plateau Paleolithic Nwya Devu High-altitude adaptation Microblade industry Early Upper Paleolithic OSLdating AMS^(14)C dating

The earliest evidence for a microblade adaptation in the remote,high altitude regions of the Tibetan Plateau

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Science China Earth Sciences 2024年第5期67卷 1561-1573页

作者： Yingshuai JIN xiaoling zhang Shejiang WANG Junyi GE Wei HE Wa DA Yunyao TAN Ziyi YANG Christopher MORGAN Xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academy of Sciences Beijing 100049China Cultural Relics Conservation Institute of the Xizang Autonomous Region Lhasa 850000China Nagqu Culture and Tourism Bureau Nagqu 852000China University of Nevada Reno 89557USA

Microblade assemblages are among the most common prehistoric archaeological materials found on the Tibetan Plateau(TP)and are thought to indicate large scale migration to and settlement of the *** microblade sites,however,have been systematically excavated,especially in the remotest,highest-elevation regions of the *** timing of the large-scale arrival,spread,and permanent settlement of people on the TP therefore remains *** this paper,we report on a recently excavated site,Locality 3 of the Nwya Devu Site(ND3),located at 4600 meters above sea level(masl),near the shore of Ngoin Lake,on the interior *** analyses reveal a fairly typical microblade technological orientation and two types of microblade cores:wedge-shaped and semi-conical,which are similar to those found throughout North *** Optically Stimulated Luminescence(OSL)dating and AMS^(14)C dating,the age of ND3 ranges from 11 to 10 *** date range indicates ND3 is the oldest microblade site yet recorded in the remote,high-elevation regions of the TP and thus provides important information about when and how hunter-gatherers using microblades began exploiting the higher altitudes of the *** together,studies at ND3 and throughout the TP suggest that a microblade adaptation is associated with the first prolonged human occupation of the plateau and that microblades played a significant role in mediating the risks and facilitating the mobility necessary to permanently inhabit the TP.

关键词： The interior of Tibetan Plateau Nwya Devu locality 3 Microblade Early Holocene High altitude adaption

Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis

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Bone Research 2024年第1期12卷 215-226页

作者： Yuhang Liu Ruihan Hao Jia Lv Jie Yuan Xuelei Wang Churong Xu Ding Ma Zhouyi Duan Bingjun zhang Liming Dai Yiyun Cheng Wei Lu xiaoling zhang Department of Orthopedic Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(SJTUSM)Shanghai 200092China National Facility for Translational Medicine Shanghai 200240China Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologySchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Orthopaedic Surgery The Second Hospital of Shanxi Medical UniversityTaiyuan 030001China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China School of Medicine Shanghai UniversityShanghai 200444China

Osteoarthritis(OA)is a common degenerative disease worldwide and new therapeutics that target inflammation and the crosstalk between immunocytes and chondrocytes are being developed to prevent and treat *** attempts involve repolarizing pro-inflammatory M1 macrophages into the anti-inflammatory M2 phenotype in *** this study,we found that phosphoglycerate mutase 5(PGAM5)significantly increased in macrophages in OA synovium compared to controls based on histology of human samples and single-cell RNA sequencing results of mice *** address the role of PGAM5 in macrophages in OA,we found conditional knockout of PGAM5 in macrophages greatly alleviated OA symptoms and promoted anabolic metabolism of chondrocytes in vitro and in ***,we found that PGAM5 enhanced M1 polarization via AKT-mTOR/p38/ERK pathways,whereas inhibited M2 polarization via STAT6-PPARγpathway in murine bone marrow-derived ***,we found that PGAM5 directly dephosphorylated Dishevelled Segment Polarity Protein 2(DVL2)which resulted in the inhibition ofβ-catenin and repolarization of M2 macrophages into M1 *** knockout of both PGAM5 andβ-catenin in macrophages significantly exacerbated osteoarthritis compared to PGAM5-deficient *** by these findings,we successfully designed mannose modified fluoropolymers combined with siPGAM5 to inhibit PGAM5 specifically in synovial macrophages via intra-articular injection,which possessed desired targeting abilities of synovial macrophages and greatly attenuated murine ***,these findings defined a key role for PGAM5 in orchestrating macrophage polarization and provides insights into novel macrophage-targeted strategy for treating OA.

关键词： osteoarthritis metabolism inhibited

Recent advances in p-block metal chalcogenide electrocatalysts for high-efficiency CO_(2) reduction

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eScience 2024年第2期4卷 43-56页

作者： Fanrong Chen Ze-Cheng Yao Zhen-Hua Lyu Jiaju Fu xiaoling zhang Jin-Song Hu Beijing National Laboratory for Molecular Sciences(BNLMS) Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China College of Chemistry&Chemical Engineering Yan'an UniversityShaanxi Key Laboratory of Chemical Reaction EngineeringYan'an 716000China School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

Electrocatalytic CO_(2) reduction(ECR)to high-value fuels and chemicals offers a promising conversion technology for achieving sustainable carbon *** recent years,although great efforts have been made to develop highefficiency ECR catalysts,challenges remain in achieving high activity and long durability *** advantage of the adjustable structure,tunable component,and the M–Ch(M¼Sn,In,Bi,etc.,Ch¼S,Se,Te)covalent bonds stabilized metal centers,the p-block metal chalcogenides(PMC)based electrocatalysts have shown great potential in converting CO_(2) into CO or *** addition,the unique p-block electron structure can suppress the competitive hydrogen evolution reaction and enhance the adsorption of ECR *** to systematically understand the structure–activity relationship of PMC-based ECR catalysts,this review summarizes the recent advances in designing PMC electrocatalysts for CO_(2) reduction based on the fundamental aspects of heterogeneous ECR process,including advanced strategies for optimizing the intrinsic activity and improving the loading density of catalytic sites,constructing highly stable catalysts,and tuning product.

关键词： Electrocatalytic CO_(2)reduction P-block metal chalcogenides Catalyst design strategies High-performance electrocatalysts

基于干涉仪阵列的无人机非合作辐射点定位方法

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航空学报 2024年第17期45卷 310-318页

作者：杨顺张帆张伟师君张晓玲电子科技大学信息与通信工程学院成都611731 成都飞机设计研究所成都610041

非合作辐射点定位是电磁测量中的难点和关键问题,对于异常辐射点发现与电磁兼容诊断具有重要意义。本文利用干涉仪阵列技术实现宽带随机非合作辐射点精确定位。该方法通过时域能量积累提升系统对弱小信号的检测能力,通过阵列信号角度估... 详细信息

非合作辐射点定位是电磁测量中的难点和关键问题,对于异常辐射点发现与电磁兼容诊断具有重要意义。本文利用干涉仪阵列技术实现宽带随机非合作辐射点精确定位。该方法通过时域能量积累提升系统对弱小信号的检测能力,通过阵列信号角度估计技术,并优化最小冗余天线阵列设计,实现非合作辐射点定位,最后通过稀疏重建方法对干涉仪角分辨率进行增强,以提升对多非合作辐射点的精确定位。仿真试验表明:干涉仪阵列可实现对多个宽带随机非合作辐射点空间分离与定位,通过最小冗余阵列优化设计并结合稀疏重建方法,其对特高频频段(UHF)多辐射点定位精度优于1 m,可满足电磁兼容诊断问题对辐射点定位精度的要求。进一步分析表明:干涉仪阵列性能受到外部辐射点数目的影响。一般而言,辐射点数目越少,算法稳定性越高,对于8通道最小冗余阵列,应保证外部辐射点数目<7个,以降低辐射点漏检和虚警问题。

关键词：辐射点定位干涉仪最小冗余天线阵列稀疏重建电磁兼容测试

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基于改进YOLOX-s的车辆检测方法研究

系统仿真学报 2024年第2期36卷 487-496页

作者：张稀柳张晓玲何敏军江苏理工学院电气信息工程学院常州213001

为缓解车辆小目标漏检及误检问题,提出一种基于YOLOX网络的多尺度特征融合的改进车辆检测模型。设计基于深度可分离卷积的Ghost-CSP(cross stage partial),替换网络的部分跨阶段局部结构,加快检测速度;将模型的最大池化方式改进为Softp... 详细信息

为缓解车辆小目标漏检及误检问题,提出一种基于YOLOX网络的多尺度特征融合的改进车辆检测模型。设计基于深度可分离卷积的Ghost-CSP(cross stage partial),替换网络的部分跨阶段局部结构,加快检测速度;将模型的最大池化方式改进为Softpool方式,并引入坐标注意力机制,增强待检测目标的特征表达,优化目标漏检问题;选用Focal Loss作为模型置信度损失函数以增加分类不准确样本的权重,提高模型对小目标的预测能力。实验结果表明:改进算法平均准确率提高到74.96%,速度达到73帧/s,在满足实时性要求下可以更好地完成车辆目标检测要求。

关键词： YOLOX 多尺度特征融合车辆检测模型 Softpool 坐标注意力 Focal Loss

RM-CSTV:An effective high-resolution method of non-line-of-sight millimeter-wave radar 3-D imaging

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National Science Open 2024年第5期3卷 36-52页

作者： Xinyuan Liu Shunjun Wei Wei Pu Xiang Cai Yanbo Wen Shisheng Guo Lingjiang Kong xiaoling zhang School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Non-line-of-sight(NLOS)imaging is a novel radar sensing technology that enables the reconstruction of hidden ***,it may suffer from synthetic aperture length reduction caused by ambient *** this study,a complex total variation(CTV)regularization-based sparse reconstruction method for NLOS three-dimensional(3-D)imaging by millimeter-wave(mm W)radar,named RM-CSTV method,is proposed to improve imaging quality and *** this scheme,the NLOS imaging model is first introduced,and associated geometric constraints for NLOS objects are ***,an effective high-resolution NLOS imaging method based on the range migration(RM)kernel and complex sparse joint total variation constraint,dubbed as modified RM-CSTV,is proposed for 3-D high-resolution imaging with edge *** experiments with multi-type NLOS targets show that the proposed RM-CSTV method can provide effective and high-resolution NLOS targets 3-D imaging.

关键词： NLOS imaging 3-D-SAR 3-D imaging sparse reconstruction