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Remediation of preservative ethylparaben in water using natural sphalerite:Kinetics and mechanisms

Journal of Environmental Sciences 2022年第3期34卷 72-80页

作者： Yanpeng Gao Teng Guo xiaolin niu Na Luo Jia Chen Junlang Qiu Yuemeng Ji Guiying Li Taicheng An Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health Guangdong Key Laboratory of Environmental Catalysis and Health Risk ControlInstitute of Environmental Health and Pollution controlGuangdong University of TechnologyGuangzhou 510006China Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Key Laboratory of City Cluster Environmental Safety and Green developmentSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAB T6G 2G3Canada

As a typical class of emerging organic contaminants(EOCs), the environmental transformation and abatement of preservative parabens have raised certain environmental concerns. However, the remediation of parabens-contaminated water using natural matrixes(such as, naturally abundant minerals) is not reported extensively in literature. In this study, the transformation kinetics and the mechanism of ethylparaben using natural sphalerite(NS) were investigated. The results show that around 63% of ethylparaben could be absorbed onto NS within 38 hr, whereas the maximum adsorption capacity was 0.45 mg/g under room temperature. High temperature could improve the adsorption performance of ethylparaben using NS. In particular, for the temperature of 313 K, the adsorption turned spontaneous. The well-fitted adsorption kinetics indicated that both the surface adsorption and intra-particle diffusion contribute to the overall adsorption process. The monolayer adsorption on the surface of NS was primarily responsible for the elimination of ethylparaben. The adsorption mechanism showed that hydrophobic partitioning into organic matter could largely govern the adsorption process, rather than the Zn S that was the main component of NS. Furthermore, the ethylparaben adsorbed on the surface of NS was stable, as only less than 2% was desorbed and photochemically degraded under irradiation of simulated sunlight for 5 days. This study revealed that NS might serve as a potential natural remediation agent for some hydrophobic EOCs including parabens, and emphasized the significant role of naturally abundant minerals on the remediation of EOCs-contaminated water bodies.

关键词： Emerging organic contaminants Paraben Naturally abundant minerals Natural sphalerite Adsorption mechanism

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Bidirectional role of synthetic musk tonalide as photosensitizer and activator on amino acids:Formation of sensitizer imine at aqueous chemistry interface of skin

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Eco-Environment & Health 2023年第1期2卷 32-39页

作者： Na Luo Yanpeng Gao Mei Wang xiaolin niu Guiying Li Taicheng An Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health Guangdong Key Laboratory of Environmental Catalysis and Health Risk ControlInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Key Laboratory of City Cluster Environmental Safety and Green Development of the Ministry of EducationSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China

Personal care products(PCPs)inevitably come into contact with the skin in people’s daily life,potentially causing adverse effects on human *** adverse effects can be exacerbated under UV irradiation but are rarely *** this study,to clearly understand the damage of representative PCPs to human skin and their photochemical transformation behaviors,fragrance tonalide(AHTN)was measured in the presence of amino acids as a basic building block of human *** results showed that amino acids could decelerate the photochemical transformation rate of AHTN,increasing the likelihood of AHNT persisting on the skin surface and the health risk to the human ***,the interaction between amino acids and AHTN was *** could play bidirectional roles in damaging amino acids:the photosensitizer and reactive *** a photosensitizer,the ^(1)O_(2) generated from the AHTN photosensitization was partly employed to oxidative damage amino ***,by combining experiments with quantum chemical computation,the carbonyl group of the activator AHTN was found to be the active site to activate the N-containing group of amino *** activation mechanism was the electron transfer between AHTN and amino *** formed during the photochemical transformation of AHTN with histidine/glycine were the molecular initiating event for potential skin *** study reported for the first time that skin photosensitizer formation threatens human health during the photochemical transformation of AHTN.

关键词： Personal care products Amino acids Photosensitive damage Electron transfer Imines

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microRNAs in heart failure

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Chinese Medical Journal 2014年第18期127卷 3328-3334页

作者： Xing Yujie Gao Dengfeng Liu Zhongwei niu xiaolin Department of Cardiology Second Affiliated Hospital Xi'an JiaotongUniversity School of Medicine Xi'an Shaanxi 710004 China

Heart failure is the leading cause of mortality in the world and represents the fastest growing subclass of cardiovascular diseases. An increasing body of evidence indicates an important role for microRNAs （miRNAs） in the pathogenesis and progression of heart failure. miRNAs are a class of small non-coding RNAs about 20 to 24 nucleotides （nt）（a few less than 20 nt） to regulate target gene expression at the post-transcriptional level. Mature miRNAs are formed after shearing a period of hairpin loop structure, the length of 70-80 nt and single stranded RNA precursors （pre-miRNA） with Dicer or nuclease as similar as Dicer.

关键词： microRNAs heart failure hypertrophy

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The Different Expression of PPARγ in the Artery Tissues of Hypertensive Patients with Different Ages

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Journal of Nanjing Medical University 2005年第4期19卷 191-193页

作者： Yongqin Li xiaolin niu Shijie Wang Shaomin Li Jiancang Ma Department of cardiology the second hospital of xi＇an jiaotong university and Environment and Genes Related to Diseases key Laboratory of Education Ministry Xi＇an 710004P.R. China

Objective： To study the expression of the peroxisome proliferator-activated receptor γ（PPARγ） in the artery tissues of essential hypertensive patients, and the different changes with different ages, especially to the hypertensive patients more than 65 years old. Methods： Collected the mesenteric artery tissues of essential hypertensive patients（〉 65 years old group and 〈 65 years old group）and patients with normal blood pressure, using immunohistochemical analysis and image acquiring and analysis system to detect the expression of PPARγ in the artery tissues. Results： the expression of PPARγ in the artery tissues of essential hypertensive patients is higher than that in the patients with normal blood pressure（ P 〈 0.05）, and to the group of hypertensive patients, the expression of PPARγ in 〉 65 years old group is higher than that in 〈65 years old group （P〈0.05）. Conclusion： the expression of PPARγ in artery tissues is increased in hypertensive patients than in the patients with normal blood pressure, and increased with aging in hypertensive patients, suggesting that PPARγ has great relationship with hypertension.

关键词： essential hypertension PPARγ immunohistochemistry

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Effects of Buchang Wenxin Granule in the treatment of premature beat:a clinical observation

Effects of Buchang Wenxin Granule in the treatment of premat...

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InternationalHeartForum

作者： Dan Su xiaolin niu Anqi Song Second Hospital Affiliated to Xian Jiaotong University

＜正＞Objective To observe the efficacy and tolerability of Buchang WenXin Granule in the treatment of patients with premature beat. Methods 102 patients with frequent premature beats,（34 with supper ventricular premature beats and 68 with ventricular premature beats） were enrolled in the *** Granule 18g（two packs） was taken orally thrice daily for 4 weeks.24 hrs Holter was performed before treatment,1 week and 4 weeks after treatment.

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乳兔房室结细胞原代培养及形态特征

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西安交通大学学报（医学版） 2005年第5期26卷 417-420,434页

作者：张颖牛小麟欧妍凌凤东西安交通大学第二医院心内科陕西西安710004 西安交通大学医学院人体解剖学教研室陕西西安710061

目的观察房室结细胞体外分散培养及形态学特征。方法取新生3 d乳兔房室结组织采用差速贴壁分离技术加机械破坏非心肌细胞法进行原代细胞培养,观察记录各类培养细胞的生长状况,并进行细胞化学染色。结果在培养的房室结细胞中,至少有4种... 详细信息

目的观察房室结细胞体外分散培养及形态学特征。方法取新生3 d乳兔房室结组织采用差速贴壁分离技术加机械破坏非心肌细胞法进行原代细胞培养,观察记录各类培养细胞的生长状况,并进行细胞化学染色。结果在培养的房室结细胞中,至少有4种自发性收缩细胞及少量的不规则细胞和多边形细胞。其中梭形细胞最多,圆形细胞和三角形细胞次之,多角形细胞最少;多角形细胞和圆形细胞收缩频率最高,其次为梭形细胞,三角形细胞收缩频率最低。细胞化学染色显示:三角形细胞肌原纤维最丰富,其次为梭形细胞,多角形细胞和圆形细胞肌原纤维最少。结论兔房室结由多种形态不同的细胞构成,多角形细胞和圆形细胞可能是起搏细胞,梭形细胞可能是过渡细胞,三角形细胞可能是普通心肌细胞。

关键词：房室结细胞培养形态学乳兔

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反刍动物蛋白质代谢及氨基酸营养调控机制

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饲料工业 2023年第19期44卷 67-72页

作者：牛骁麟张千青海农牧科技职业学院青海湟源812100 中国农业科学院草原研究所内蒙古呼和浩特010000

蛋白质是组成机体的重要营养物质,蛋白质营养的核心是氨基酸营养,其吸收与代谢对动物的生长发育起到关键作用。反刍动物拥有独特的微生物发酵系统,影响蛋白质和氨基酸代谢的因素较多,表现出蛋白质利用低、小肠氨基酸营养调控复杂等特点... 详细信息

蛋白质是组成机体的重要营养物质,蛋白质营养的核心是氨基酸营养,其吸收与代谢对动物的生长发育起到关键作用。反刍动物拥有独特的微生物发酵系统,影响蛋白质和氨基酸代谢的因素较多,表现出蛋白质利用低、小肠氨基酸营养调控复杂等特点。文章从反刍动物蛋白质代谢及小肠氨基酸营养两个方面,系统阐述了影响反刍动物蛋白质利用的因素及优化小肠氨基酸组成模式,旨在为相关研究提供科学依据。

关键词：瘤胃蛋白质氨基酸营养代谢微生物

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Construction of a HERG mutant L539fs/47-*558W pEGFP vector and the expression of the fusion protein in HEK293 cells

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Journal of Medical Colleges of PLA(China) 2013年第4期28卷 193-205页

作者： ZHANG Junbo Lü Ying ZHANG Aifeng SUN Chaofeng HAN Wenqi LI Guoliang GAO Jie HUO Jianhua PAN Junqiang ZHOU Xin niu xiaolin Department of Cardiovascular Medicine First Affiliated Hospital Institute of Cardiovascular Channelopathy Ministry of Education Key Laboratory of Environment and Genes Related to Diseases Xi'an Jiaotong University Shaanxi Key Laboratory of Molecular Cardiology Department of Cardiovascular Medicine Second Affiliated Hospital Xi'an Jiaotong University

Objective： To construct a human ether-a-go-go-related gene （HERG） nonsense mutant L539fs/47-558W into the autonomously fluorescent, eukaryotic expression vector pEGFP-C2, and to verify expression of the reconstruct in human embryonic kidney-293 （HEK293） cells. Methods： The mutational fragment was subcloned into pEGFP-C2-HERG by double digestion of Sbf I, Eco91 1 and rejoining of T4 ligase. After verification, the recombinant pEGFP-C2-L539fs/47-558W and pEGFP-C2-HERG were respectively transfected into HEK293 cells for 48 h by the Lipofect method to observe the expression location of the fusion protein by laser confocal imaging scanning in vivo. pcDNA3 -L539fs/47-＊558W and pcDNA3-HERG were transfected to observe the expression location of the HERG protein by immunofluoresceoce. The mutant protein size was determined by Western blotting. Results： The about 1 kb-sized mutation region cDNA fragment from pcDNA3-L539fs/47-＊558Wand the about 7.2 kb-sized target vector fragment from pcDNA3-HERG were ligated after purification and gel recovery pEGFP-C2-L539fs/47＊-558W, approximately 8.2 kb, was demonstrated successfully been constructed under agarose gel electrophoresis and further sequencing. Laser confocal imaging showed that pEGFP-C2-HERG was mainly expressed in the membrane, whereas truncated mutant-type HERG in the pEGFP-C2 vector was partially located in the cytoplasm, the others were transported to the cell membrane in living HEK293 cells. The same as the immunofluoresceoce results after transfection of pcDNA3-HERG and pcDNA3-L539fs/47-558W. Wild-type HERG-GFP fusion protein expressed 160 and 180 kDa bands. The mutant and mutant-GFP fusion proteins were 70 and 100 kDa, respectively. Conclusion： pEGFP-C2-L539fs/47-＊558W was successfully constructed by double digestion method GFP had no effect on its protein expression and trafficking in HEK293 cells, which laid a foundation for the further study on L539fs/47-＊558W

关键词： Human ether-a-go-go-related gene Mutation Eukaryotic expression vector pEGFP-C2

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Effects of different dose endothelin-1 on expession of peroxisome proliferator-γ in cultured vascular smooth muscle cells of adult rats

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Journal of Nanjing Medical University 2005年第6期19卷 332-335页

作者： Zhengli Di xiaolin niu Jin Wei Nanping Wang Department of Cardiology the Second Hospital of Xi＇ an Jiaotong University Xi＇ an 710004 China Research Institute of Cardiology School of Basic Medical Sciences Beijing University Beijing 100089 China

Objective： To investigate the effects of endothlin-1 （ET-1） on vascular smooth muscle cells（VSMCs） proliferation and the expression of Peroxisome proliferator-activated receptorγ （PPAR-γ） in VSMCs. Methods： VSMCs of 16-week-old wistar rats thoracic aorta were cultured. VSMCs were treated by ET-1 for 48 h and observed of the proliferation by MTr. The expression of PPAR-γ mRNA and protein in cultured VSMCs treated by different concentration of ET-1 for 48 h was detected by RT-PCR and Western blot. Results： Compared with control group, VSMCs treated by ET-1 proliferated with the increase concentration of ET-1. There was significant differences among different groups （P 〈 0.01）. Meanwhile,the expression of PPAR-γ both in mRNA and in protein levels deceased. The expression of PPAR-γ in VSMCs was gradually decreased along with the increase concentration of ET-1. There was significant differences among different groups （ P 〈0.01）. Compared with control group, the expression of both PPAR-γ mRNA and PPAR-γ in ET-1 treated groups were lower（ P 〈 0.01 ）. Conclusion： ET-1 could induce VSMCs proliferation and the expression of PPAR-γ in VSMCs, which demonstrates that high dose ET-1 obviously weakens the function of PPAR-γ to increase VSMCs proliferation.

关键词： VSMCs ET-1 PPAR-γ proliferation

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从母女交流障碍看小说《喜福会》中的“失语”现象

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广西教育学院学报 2007年第1期 125-128页

作者：牛晓林福州大学福建福州350002

小说《喜福会》(theJoyLuckClub)描述了美国华裔家庭中的母女关系以及两代人之间由于交流障碍导致的“失语”现象,引起极大反响。本文试从语言和文化关系角度入手,分析两代人之间“失语”现象的成因和“失语”背后的语言文化障碍。作者... 详细信息

小说《喜福会》(theJoyLuckClub)描述了美国华裔家庭中的母女关系以及两代人之间由于交流障碍导致的“失语”现象,引起极大反响。本文试从语言和文化关系角度入手,分析两代人之间“失语”现象的成因和“失语”背后的语言文化障碍。作者谭恩美(AmyTan)站在超越两种文化局限性的高度,看待文化的碰撞与冲突,将华裔家庭中的文化差异与母女情深艺术地展现在读者面前。

关键词：喜福会语言文化交流障碍失语

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