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Journal of Earth Science 2022年第4期33卷 847-856页

作者： xiaolin huang Yuyang Peng Chuang Cheng Dun Wang Qiang Yao State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan 430074China

The 2021 Madoi M7.4 Earthquake in Qinghai is a major earthquake that occurred in the Bajankara Block of Qinghai-Tibet Plateau in the past 30 years,which spatially filled the seismogenic gap in the eastern section of the northern boundary of the block.Here we determined the values of M_(L),M_(S_BB),m_(B),M_(Wp),M_(WW),M_(dt),and M(GNSS)by abundant regional and global seismic and geodetic observations,which is 6.61,7.43,7.18,7.33,7.43,7.38,and 7.4,respectively.To compare the time efficiency and stability of different magnitude scales,we generated a real-time environment,to iteratively determine the magnitudes over elapsed times.Some methods such as m_(B),M_(S_BB),M_(Wp) gave considerable variations of as large as 0.5 units for the determined magnitudes with elapsed time,as more data were included.Others such as M_(WW) and M_(dt) were very stable with increasing data over time.The systematic calculations of various magnitude scales in this study quantitively evaluated the stability and accuracy of those methods,shading light on the adaptability and applicability of different magnitude scales.

关键词： the 2021 Madoi Earthquake earthquake magnitude magnitude scale earthquakes

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纤维导电性对地聚合物压敏行为的影响

建筑材料学报 2024年第3期27卷 223-229页

作者：马彬张永黄启钦黄小林桂林电子科技大学建筑与交通工程学院广西桂林541004

采用碳纤维和玄武岩纤维改性地聚合物,分析了纤维掺量对其流动性、力学性能、电阻率及压敏行为的影响规律,揭示了纤维导电性能对地聚合物压敏性能的影响机制.结果表明:碳纤维对地聚合物流动性的影响大于玄武岩纤维;当碳纤维掺量升高时,... 详细信息

采用碳纤维和玄武岩纤维改性地聚合物,分析了纤维掺量对其流动性、力学性能、电阻率及压敏行为的影响规律,揭示了纤维导电性能对地聚合物压敏性能的影响机制.结果表明:碳纤维对地聚合物流动性的影响大于玄武岩纤维;当碳纤维掺量升高时,地聚合物电阻率明显下降,且可分为缓降、突降和平缓阶段;随着碳纤维掺量的升高,地聚合物压敏性能先增强后减弱;当碳纤维体积分数为0.4%时,地聚合物压敏性能最优;玄武岩纤维对地聚合物压敏性能具有削弱作用.

关键词：地聚合物物理力学性能压敏性能碳纤维玄武岩纤维

Contrasting patterns of bacterial communities in the rearing water and gut of Penaeus vannamei in response to exogenous glucose addition

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Marine Life Science & Technology 2022年第2期4卷 222-236页

作者： Lei huang Haipeng Guo Zidan Liu Chen Chen Kai Wang xiaolin huang Wei Chen Yueyue Zhu Mengchen Yan Demin Zhang State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Ningbo UniversityNingbo315211China School of Marine Sciences Ningbo UniversityNingbo315211China Zhejiang Institute of Freshwater Fisheries Huzhou313001China Zhejiang Mariculture Research Institute Wenzhou325005China

Supplementing exogenous carbon sources is a practical approach to improving shrimp health by manipulating the microbial communities of aquaculture systems. However, little is known about the microbiological processes and mechanisms of these systems. Here, the effects of glucose addition on shrimp growth performance and bacterial communities of the rearing water and the shrimp gut were investigated to address this knowledge gap. The results showed that glucose addition significantly improved the growth and survival of shrimp. Although the α-diversity indices of both bacterioplankton communities and gut microbiota were significantly decreased by adding glucose, both bacterial communities exhibited divergent response patterns to glucose addition. Glucose addition induced a dispersive bacterioplankton community but a more stable gut bacterial community. Bacterial taxa belonging to Ruegeria were significantly enriched by glucose in the guts, especially the operational taxonomic unit 2575 (OTU2575), which showed the highest relative importance to the survival rate and individual weight of shrimp, with the values of 43.8 and 40.6%, respectively. In addition, glucose addition increased the complexity of interspecies interactions within gut bacterial communities and the network nodes from Rhodobacteraceae accounted for higher proportions and linked more with the nodes from other taxa in the glucose addition group than that in control. These findings suggest that glucose addition may provide a more stable gut microbiota for shrimp by increasing the abundance of certain bacterial taxa, such as Ruegeria.

关键词： Glucose addition C/N ratio Shrimp Gut microbiota Bacterioplankton community

钢渣-偏高岭土基导电地聚合物的压敏性能研究

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材料导报 2024年第6期38卷 147-152页

作者：马彬黄启钦肖薇薇黄小林桂林电子科技大学建筑与交通工程学院广西桂林541004

以钢渣和偏高岭土为主要原材料制备导电地聚合物,分析了钢渣掺量和养护温度对其抗压强度、电阻率、压敏性能以及微观结构的影响规律,并对其压敏性能进行了评估。结果表明:随着养护龄期的延长和养护温度的升高,试样抗压强度均有一定的增... 详细信息

以钢渣和偏高岭土为主要原材料制备导电地聚合物,分析了钢渣掺量和养护温度对其抗压强度、电阻率、压敏性能以及微观结构的影响规律,并对其压敏性能进行了评估。结果表明:随着养护龄期的延长和养护温度的升高,试样抗压强度均有一定的增加,其中钢渣掺量为30%时试样抗压强度最高。在不同养护温度下,钢渣掺量越多,试样电阻率越低。养护温度的升高提升了试样早期物理力学性能,然而随着龄期延长,温度对试样电阻率的影响变弱。此外,在循环压缩荷载作用下,试样的最优应变灵敏度为40.35~50.31,远高于电阻应变片的灵敏度2。其中,当养护温度为40℃、钢渣掺量为30%时,试样电阻变化率(FCR)与循环压缩应力的相关系数R~2高达0.953,试样压敏稳定性最优。由微观分析可知,当养护温度为60℃时,试样微观结构最为致密,稳定性最好,致使其应变灵敏度较低。在相同养护温度下,随着钢渣掺量的增加,试样致密性先增强后减弱,其中SS-30组最优,该结果与强度结果吻合较好。可见,钢渣-偏高岭土基导电地聚合物将是一种理想的压敏基体材料。

关键词：导电地聚合物压敏性能抗压强度钢渣掺量养护温度

Determination and comparison of M， M， m， M， M， M， and M（GNSS） for the 22 May 2021 Mw 7.3 Madoi， Qianghai， China earthquake

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Journal of Earth Science 2022年

作者： xiaolin huang Qiang Yao Yuyang Peng Chuang Cheng Dun Wang State Key Laboratory of Geological Processes and Mineral Resources， School of Earth Sciences， China University of Geosciences

The 2021 Madoi M7.3 earthquake in Qinghai is a major earthquake that occurred in the Bajankara block of Qinghai-Tibet Plateau in the past 30 years， which spatially filled the seismogenic gap in the eastern section of the northern boundary of the block. Here we determined the values of M， M， m， M， M， M， and M （GNSS） by abundant regional and global seismic and geodetic observations， which is 6.61， 7.43， 7.18， 7.33， 7.43， and 7.38， respectively. To compare the time efficiency and stability of different magnitude scales， we generated a real-time environment， to iteratively determine the magnitudes over elapsed times. Some methods such as m， M， Mgave considerable variations of as large as 0.5 units for the determined magnitudes with elapsed time， as more data were included. Others such as Mand Mwere very stable with increasing data over time. The systematic calculations of various magnitude scales in this study quantitively evaluated the stability and accuracy of those methods， shading light on the adaptability and applicability of different magnitude scales.

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Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5873-5886页

作者： Liangjiang huang Song Zhang Jun Wu Baojie Guo Tingting Gao Sayed Zulfiqar Ali Shah Bo huang Yajie Li Bo Zhu Jiaqi Fan Liu Wang Yani Xiao Wenjing Liu Yao Tian Zhengyu Fang Yingying Lv Lingfeng Xie Sheng Yao Gaotan Ke xiaolin huang Ying huang Yujuan Li Yi Jia Zhongwen Li Guihai Feng Yan Huo Wei Li Qi Zhou Jie Hao Baoyang Hu Hong Chen Department of Rehabilitation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina National Stem Cell Resource Center State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyInstitute for Stem Cell and RegenerationChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Stem Cell Research Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina University of Chinese Academy of Sciences BeijingChina Beijing Key Lab for Pre-clinical Safety Evaluation of Drugs National Center for Safety Evaluation of DrugsNational Institutes for Food and Drug ControlBeijingChina Beijing Zephyrm Biotechnologies Co. Ltd.BeijingChina

Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological properties.Despite resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined.Here,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury.Following injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage regeneration.In the dose-escalating phase I clinical trial(NCT03839238)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting.Furthermore,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury treatment.In summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury.Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration.

关键词： meniscus injuries cartilage

乡村教师专业资本积累与专业成长促进机制研究

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教师教育学报 2024年第2期11卷 88-96页

作者：黄晓林西安文理学院信息工程学院陕西西安710065

乡村教师在职学习对打破乡村教师专业成长缓慢的局面、提升教师队伍整体素质具有重要意义。采用情境访谈法收集相关数据、展开案例研究,旨在探讨乡村教师在职学习过程中的专业资本积累问题,探寻促进乡村教师专业成长的有效途径。从积累... 详细信息

乡村教师在职学习对打破乡村教师专业成长缓慢的局面、提升教师队伍整体素质具有重要意义。采用情境访谈法收集相关数据、展开案例研究,旨在探讨乡村教师在职学习过程中的专业资本积累问题,探寻促进乡村教师专业成长的有效途径。从积累专业资本的视角展开研究发现:一方面,乡村教师在职学习过程中面临三重困境,即乡村教师群体社会资本结构性贫乏、个体人力资本和决策资本积累“内外交困”、实践共同体专业资本再生产能力欠缺;另一方面,在乡村教师在职学习过程中,其专业资本实现快速积累的契机在于获得共同体的认可。因此,构建教师专业资本积累与专业成长促进机制,需要激发内部动力,同时还要发挥外部激励作用。从外部系统看,教师队伍培养体系和教师专业成长激励机制是社会资本流动的制度保证,也是人力资本发挥作用的外在动力;从内部系统看,社会资本为人力资本的积累提供机会,为决策资本提供追加与补充,人力资本和决策资本相互制约、相互促进,是社会资本流转的基础,为社会资本“质”的提升提供必要保障。此外,建立以卓越教师、骨干教师和新手教师共同组建的乡村教师学习共同体,引导乡村教师专业资本各要素的流动与增长,是促进乡村教师专业成长的有效途径。

关键词：乡村教师教师专业成长实践共同体专业资本在职学习

喷点雪印小丑鱼的胚胎及仔、稚、幼鱼形态发育观察

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南方水产科学 2024年第2期20卷 73-82页

作者：谭泽宇李涛姜敬哲黄小林杨育凯中国水产科学研究院南海水产研究所深圳试验基地广东深圳518121 大连海洋大学水产与生命学院辽宁大连116023 中国水产科学研究院南海水产研究所/农业农村部南海渔业资源开发利用重点实验室/广东省渔业生态环境重点实验室广东广州510300

为建立喷点雪印小丑鱼(Amphiprion sp.)人工繁育技术,在人工模拟自然条件下对其繁殖习性、胚胎发育及胚后发育进行观察。结果表明:喷点雪印小丑鱼受精卵长径为1.9~2.1 mm,短径为0.93~0.95 mm;胚胎发育主要经历受精卵期→胚盘期→卵裂期... 详细信息

为建立喷点雪印小丑鱼(Amphiprion sp.)人工繁育技术,在人工模拟自然条件下对其繁殖习性、胚胎发育及胚后发育进行观察。结果表明:喷点雪印小丑鱼受精卵长径为1.9~2.1 mm,短径为0.93~0.95 mm;胚胎发育主要经历受精卵期→胚盘期→卵裂期→囊胚期→原肠胚期→神经胚期→器官形成期→孵化期等;在水温为(27±0.5)℃时,受精卵约需197 h孵化出膜。初孵仔鱼全长(4.415±0.412)mm,身体透明,鳍膜明显,卵黄囊仅剩小部分残留,并已开口摄食。9日龄全长(6.813±0.835)mm,鳍膜消失,各鳍基本形成,头部开始出现纹带,进入稚鱼期。21日龄全长(10.581±2.659)mm,身体被鳞,体色、纹路开始分化。35日龄全长(15.512±4.927)mm,形成4种不同体色、纹路的幼鱼。作为人工选育的品系,喷点雪印小丑鱼胚后发育过程中最为明显的变化是幼鱼期体色、纹路等形态特征的形成与分化。

关键词：喷点雪印小丑鱼胚胎发育胚后发育仔、稚鱼纹带

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Multifractal analysis of resting state fMRI series in default mode network: age and gender effects

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Chinese Science Bulletin 2014年第25期59卷 3107-3113页

作者： huangjing Ni xiaolin huang Xinbao Ning Chengyu Huo Tiebing Liu De Ben School of Electronic Science and Engineering Nanjing University School of Physics and Electronic Engineering Changshu Institute of Technology Department of Biomedical Engineering Jinling Hospital

Age-related changes of resting state in default mode network(DMN)may provide new clues to the developing mechanism of normal brain as well as early diagnosis and therapy of some neuropsychiatric disorders.The application of multifractal theory to functional magnetic resonance imaging(fMRI)signals has recently raised increasing attention.We aim to explore the multifractal characteristics underlying the resting state functional magnetic resonance imaging(rs-fMRI)series extracted from DMN,and two issues are mainly discussed:(1)whether there exist multifractals in rs-fMRI series;(2)whether it is possible to distinguish between the different ages or genders by means of multifractal characteristics.Results demonstrated the existence of multifractals in rs-fMRI series in DMN.In addition,slight differences between young subjects and middle-aged or elderly subjects can be successfully detected by Dasa,a modified measure we proposed.Furthermore,it is revealed that the rs-fMRI series from young subjects possess smaller averaged scale index and weaker long range correlation,while those from middle-aged or elderly people present increasing averaged scale index andstronger long range correlation.Whereas no significant statistical differences has been found between male and female group.Our results,therefore,highlight the potential usefulness of multifractal analysis in fMRI series of a certain brain region,and provide important insights into healthy aging in DMN.

关键词：多重分形分析功能磁共振成像年龄相关状态静息性别网络磁共振成像技术

Taming Reactive Oxygen Species:Mitochondria-Targeting Aggregation-Induced Emission Luminogen for Neuron Protection via Photosensitization-Triggered Autophagy

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CCS Chemistry 2022年第7期4卷 2249-2257页

作者： Chao Chen Ruoyao Zhang Jianyu Zhang Yufan Zhang Haoke Zhang Zaiyu Wang xiaolin huang Sijie Chen Ryan T.K.Kwok Jacky W.Y.Lam Dan Ding Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyState Key Laboratory of Molecular NanoscienceDivision of Life ScienceDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 State Key Laboratory ofMedicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin 300071 Ming Wai Lau Centre for Reparative Medicine Karolinska InstitutetHong Kong 999077 Center for Aggregation-Induced Emission SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640 Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172 AIE Institute Guangzhou Development DistrictHuangpuGuangzhou 510530

Oxidative damage to cells leads to accumulated harmful wastes,which in turn aggravate the imbalance of reactive oxygen species(ROS)and related diseases.Therefore,provoking the cellular defense system against severe oxidation and maintaining ROS homeostasis are desired.Herein,we designed and synthesized a powerful mitochondria-targeting aggregation-induced emission photosensitizer(named DTCSPY)by maximal restriction of heat dissipation.It is demonstrated that taming ROS generation within mitochondria through photosensitization-triggered autophagy via DTCSPY achieved a better neuroprotective effect against oxidative damages than Nacety-L-cysteine and vitamin C.This work not only provides a new way to design high-performance photosensitizers by regulating the photophysical property,but also verifies the concept that taming ROS can be used for cell protection against destructive oxidation,thereby displaying broad prospects for alleviating oxidation-related diseases and promoting cell-based therapy.

关键词： aggregation-induced emission mitochondrial targeting photosensitizer reactive oxygen species neuron protection