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Journal of Traditional Chinese Medicine 2020年第3期40卷 407-413页

作者： Song Yafang Geng Hao Chen Lu Wu xiaoliang yuan Mengqian Xu Wanli Guo Jing Sun Jianhua Pei Lixia Department of acupuncture The Affiliated Hospital of Nanjing University of Chinese MeidicneNanjing 210029China Department of the First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE: To investigate the effect of electroacupuncture(EA) on irritable bowel syndrome(IBS) in mice through regulating nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6(NLRP6).METHODS: Water-avoidance stress(WAS) mice model was used to investigate the effects and the mechanism of EA. Abdominal withdrawal reflex test, open field test, and intestinal motility test were used to evaluate visceral sensitivity, anxiety,and intestinal motility in mice. The expressions of NLRP6, Mucin-2(MUC2) and E-cadherin were determined using immunofluorescence and Western blotting ***: EA significantly upregulated the expression of NLRP6 in the intestine of mice. Moreover, EA increased the expressions of MUC2 and E-cadherin in WAS ***: Our study found that the relief of IBS symptoms by EA may involve the increase in the expression of NLRP6 in WAS mice.

关键词： Electroacupuncture Nod signaling adaptor proteins Irritable bowel syndrome

泌尿系结石成分构成及其临床特征与肾功能分析

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中外医学研究 2022年第22期20卷 68-72页

作者：袁晓亮魏汉平刘晓武焦志敏吴庭纯杨涛史红雷常州市武进人民医院江苏常州213000

目的:分析泌尿系结石成分构成及其临床特征与肾功能。方法:选取2019年1月-2021年10月常州市武进人民医院收治的120例泌尿系结石患者为研究对象。分析泌尿系结石成分构成。通过医院检验科进行血生化检查,测定患者肌酐(Cr)、尿素氮(BUN),... 详细信息

目的:分析泌尿系结石成分构成及其临床特征与肾功能。方法:选取2019年1月-2021年10月常州市武进人民医院收治的120例泌尿系结石患者为研究对象。分析泌尿系结石成分构成。通过医院检验科进行血生化检查,测定患者肌酐(Cr)、尿素氮(BUN),分析不同泌尿系结石成分患者临床特征及肾功能。结果:本研究120例泌尿系结石患者中,以草酸钙结石占比最高,为79.17%,碳酸磷灰石占比(12.50%)低于草酸钙结石,尿酸结石占比为4.17%,胱氨酸结石占比为1.67%,其他成分为主构成占比为2.50%。不同泌尿系结石成分构成性别、BMI、肾脏部位、尿酸升高、尿液结晶对比差异无统计学意义(P>0.05),不同泌尿系结石成分构成年龄、输尿管部位、尿路感染、高血压比较差异有统计学意义(P<0.05)。120例泌尿系结石患者均进行血生化肾功能检测,肾功能正常10例,占比为8.33%,不同结石成分的患者肾功能对比差异有统计学意义(χ^(2)=12.882,P=0.012)。结论:本院患者泌尿系结石成分构成中以草酸钙结石为主;不同结石成分患者的临床特征和肾功能有区别,可为临床病因诊断的参考依据。

关键词：泌尿系结石成分构成临床特征肾功能结石部位

维普期刊数据库博看期刊

新精神活性物质“MAB-CHMINACA”的鉴定研究

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中国司法鉴定 2019年第2期 20-25页

作者：盛振海张玉荣袁晓亮何思阳连茹徐金伦孙文娟上海市公安局物证鉴定中心上海200083

目的采用液相色谱-高分辨质谱(UHPLC-LTQ-Orbitrap MS)和气相色谱-质谱联用(GC-MS)、傅里叶变换红外光谱法(FTIR)、核磁共振波谱(NMR)技术对疑似新精神活性物质样品检测,综合分析鉴定新精神活性物质。方法将可疑粉末样品用甲醇超声溶解... 详细信息

目的采用液相色谱-高分辨质谱(UHPLC-LTQ-Orbitrap MS)和气相色谱-质谱联用(GC-MS)、傅里叶变换红外光谱法(FTIR)、核磁共振波谱(NMR)技术对疑似新精神活性物质样品检测,综合分析鉴定新精神活性物质。方法将可疑粉末样品用甲醇超声溶解,上清液供GC-MS、UHPLC-LTQ-Orbitrap MS检测;粉末样品直接用红外衰减全反射(ATR)装置检测;粉末样品溶解后用核磁氢谱(1H NMR)检测;所获检测结果进行谱库检索。结果粉末样品经综合分析鉴定为一种合成大麻素类新精神活性物质"MAB-CHMINACA",国内未见公开报道。结论建立的多技术联合检测方法可用于新精神活性物质化学结构的确认与鉴定。

关键词：新精神活性物质合成大麻素类 GC-MS UHPLC-LTQ-Orbitrap MS FTIR NMR

GSDME as an executioner of chemotherapy-induced cell death

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Science China(Life Sciences) 2017年第11期60卷 1291-1294页

作者： xiaoliang Yu Sudan He Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology Jiangsu Institute of Hematology Soochow University

Cell death is a crucial process required for development, tissue homeostasis, and pathological cell loss in multicellu- lar organisms. Cell death mainly occurs in two alternative modes： apoptosis or necrosis. Apoptosis is a form of pro- grammed cell death with typical morphological features, including cell shrinkage, chromatin condensation, and DNA fragmentation （Degterev and yuan, 2008）. The dying cell is eventually fragmented into membrane-bound apoptotic bodies that are engulfed by surrounding phagocytes.

关键词： GSDME executioner chemotherapy-induced cell death

Parameters of the AD 849 earthquake east of Baotou City in Inner Mongolia and the adjustion of the potential seismic sources zone spatial distribution functions

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Earthquake Science 2019年第3期32卷 170-178页

作者： Ji Wang Zhanwu Gao Wei Xu Zhaode yuan Zhicheng Liu xiaoliang Zhang China Earthquake Disaster Prevention Center Beijing 100029China Institute of Geology China Earthquake AdministrationBeijing 100029China

According to volume 18(Xuanzong Ji Tang)of the historical book entitled the Old Book of Tang,the Hetao area of Inner Mongolia experienced a large earthquake in AD ***,previous work on that earthquake contains many discrepancies regarding its epicenter location,magnitude,deaths,and *** exploring active faults in Baotou City,the present authors mapped the Daqing Mountain piedmont fault *** on previous work,several seismic deformation traces of more than 1000 years ago were found,and dating tests were *** research showed the Daqing Mountain piedmont fault zone to be the seismogenic structure of the AD 849 *** length of earthquake surface rupture zone was around 80 km,and the macro epicenter was located in the active *** deformation center was located at 40.6°N,110.2°*** collecting and analyzing more historical data about the AD 849 earthquake,reinterpreting some existing historical data,and re-examining the contradictory numbers of deaths in the historical data,the present analysis concludes that around 10,000 people were *** is suggested that this earthquake had a magnitude of 7½.According to the revised seismic parameters and the paleoearthquake recurrence period of the Daqing Mountain piedmont fault,the boundary of some potential seismic sources zone in the Baotou area are adjusted and the recurrence period of M8 and M7.5 are re-calculated.

关键词： earthquake rupture traces parameters AD 849 Daqing Mountain piedmont fault

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前列腺癌进展外源性危险因素的相关分析

泌尿外科杂志（电子版） 2023年第4期15卷 17-20页

作者：吴庭纯蒋鑫滢袁晓亮史红雷吴浩然施云峰吕忠江苏省常州市武进人民医院泌尿外科江苏常州213000

目的探讨前列腺癌进展外源性的相关因素。方法回顾性分析2020年11月至2022年10月江苏省常州市武进人民医院收治的260例前列腺癌患者的临床资料,采用χ^(2)检验与logistic回归方程分析前列腺癌进展与年龄、体质量、身高、体质量指数、前... 详细信息

目的探讨前列腺癌进展外源性的相关因素。方法回顾性分析2020年11月至2022年10月江苏省常州市武进人民医院收治的260例前列腺癌患者的临床资料,采用χ^(2)检验与logistic回归方程分析前列腺癌进展与年龄、体质量、身高、体质量指数、前列腺特异性抗原(prostate specific antigen,PSA)、前列腺体积及血浆血脂水平的相关性。结果选取调查对象共260例,其中局限性前列腺癌74例(28.46%),进展性前列腺癌186例(71.54%)。局限性前列腺癌与进展性前列腺癌患者在体质量、体质量指数、PSA值、前列腺体积、甘油三酯和胆固醇方面,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,上述指标均为影响前列腺癌进展的因素(P<0.05)。结论体质量、体质量指数、PSA值、前列腺体积、甘油三酯和胆固醇均与前列腺癌进展间存在一定关系。

关键词：前列腺癌致病因素回顾性分析

中性粒-淋巴细胞比值预测良性前列腺增生进展价值

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齐鲁医学杂志 2017年第4期32卷 411-413页

作者：綦德柱李方舟官丰菊袁效良孙立江张桂铭青岛市胶州中心医院泌尿外科山东胶州266300 青岛大学附属医院泌尿外科

目的探讨中性粒-淋巴细胞比值(NLR)预测良性前列腺增生(BPH)疾病进展的价值。方法回顾性分析初诊并经术后病理证实的BPH病人908例的临床资料,分析NLR与前列腺特异性抗原(PSA)、前列腺体积和国际前列腺症状评分(IPSS)间的相关性;根据PSA... 详细信息

目的探讨中性粒-淋巴细胞比值(NLR)预测良性前列腺增生(BPH)疾病进展的价值。方法回顾性分析初诊并经术后病理证实的BPH病人908例的临床资料,分析NLR与前列腺特异性抗原(PSA)、前列腺体积和国际前列腺症状评分(IPSS)间的相关性;根据PSA、前列腺体积及IPSS分为高危组和低危组,比较两组NLR的差异;并用ROC曲线分析NLR对高危组的诊断能力。结果 NLR与PSA、前列腺体积和IPSS均呈正相关(r=0.106 9~0.269 5,P0.05)。ROC曲线分析表明,NLR作为BPH进展的预测因子预测IPSS高危的最佳临界点为1.46,其灵敏度为77%,特异度为38%;预测前列腺体积高危的最佳临界点为1.84,灵敏度为62%,特异度为59%。结论 NLR与BPH进展的高危因素有关,可作为病人随访的指标之一。

关键词：中性粒-淋巴细胞比值炎症前列腺增生

First-principles analysis of phonon thermal transport properties of two-dimensional WS2/WSe2 heterostructures

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Chinese Physics B 2021年第3期30卷 25-35页

作者： Zheng Chang Kunpeng yuan Zhehao Sun xiaoliang Zhang Yufei Gao Xiaojing Gong Dawei Tang Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education School of Energy and Power EngineeringDalian University of TechnologyDalian 116024China Institute of Materials Science and Engineering National Experimental Demonstration Center for Materials Science and EngineeringChangzhou UniversityChangzhou 213164China

The van der Waals(vdW)heterostructures of bilayer transition metal dichalcogenide obtained by vertically stacking have drawn increasing attention for their enormous potential applications in semiconductors and ***,by using the first-principles calculations and the phonon Boltzmann transport equation(BTE),we studied the phonon transport properties of WS2/WSe2 bilayer heterostructures(WS2/WSe2-BHs).The lattice thermal conductivity of the ideal WS2/WSe2-BHs crystals at room temperature(RT)was 62.98 W/mK,which was clearly lower than the average lattice thermal conductivity of WS2 and WSe2 single *** interesting finding is that the optical branches below 4.73 THz and acoustic branches have powerful coupling,mainly dominating the lattice thermal ***,we also noticed that the phonon mean free path(MFP)of the WS2/WSe2-BHs(233 nm)was remarkably attenuated by the free-standing monolayer WS2(526 nm)and WSe2(1720 nm),leading to a small significant size effect of the WS2/*** results systematically demonstrate the low optical and acoustic phonon modes-dominated phonon thermal transport in heterostructures and give a few important guidelines for the synthesis of van der Waals heterostructures with excellent phonon transport properties.

关键词： WS2/WSe2 bilayer heterostructures thermal transport first-principles Boltzmann transport equation

中西医结合治疗经尿道前列腺电切术后膀胱痉挛的临床研究

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现代中西医结合杂志 2012年第27期21卷 2975-2976页

作者：甘卫东袁晓亮刘铁石姚林方屈峰燕翔吴隽郭宏骞南京大学医学院附属鼓楼医院江苏南京210008 南京中医药大学中西医结合鼓楼临床医学院江苏南京210029

目的探讨中西医结合治疗经尿道前列腺电切术(TURP)后膀胱痉挛的效果。方法采用随机抽样法将102例TURP术后患者分为对照组47例和治疗组55例,对照组于术后留置硬膜外导管,连接镇痛泵止痛;治疗组在对照组治疗基础上加服改良芍药甘草汤治疗... 详细信息

目的探讨中西医结合治疗经尿道前列腺电切术(TURP)后膀胱痉挛的效果。方法采用随机抽样法将102例TURP术后患者分为对照组47例和治疗组55例,对照组于术后留置硬膜外导管,连接镇痛泵止痛;治疗组在对照组治疗基础上加服改良芍药甘草汤治疗。观察2组患者膀胱痉挛的发生率。结果术后24 h内对照组膀胱痉挛发生率为38%,治疗组为22%,2组比较有显著性差异(P<0.05)。术后24～48 h膀胱痉挛发生率对照组为26%,治疗组为9%,2组比较有极显著性差异(P<0.01)。结论采用改良芍药甘草汤方等治疗能有效缓解TURP术后膀胱痉挛症状。

关键词：前列腺增生经尿道前列腺电切术膀胱痉挛改良芍药甘草汤中西医结合疗法

Research on Ultrafine Tungsten Carbide-Cobalt(WC-Co) Cemented Carbide Rods of Miniature Drills for Highly Integrated Printed Circuit Board(PCB)

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Journal of Materials Science & Technology 2005年第3期21卷 353-356页

作者： xiaoliang SHI, Gangqin SHAO, Xinglong DUAN and Runzhang yuan State Key Laboratory of Advanced Technology for Materials Synthesis & Processing, Wuhan University of Technology, Wuhan 430070, China Lab. of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China

Nanocrystalline tungsten carbide-cobalt (WC-Co) composite powders produced through spray thermal decomposition-continuous reduction and carburization technology were used to prepare φ3.25 mm×38 mm ultrafine tungsten carbide-cobalt (WC-Co) cemented carbide rods through vacuum sintering plus sinterhip technology. The microstructure, Vickers hardness, density and Rockwell A hardness (HRA), transverse rupture strength (TRS), saturated magnetization and coercivity force were tested. The results show that the average grain size of the sintering body prepared through vacuum sintering plus sinterhip technology was 430 nm; transverse rupture strength (TRS) was 3850 MPa; Vickers hardness was 1890 and Rockwell A hardness of sintering body was 93. High strength and high hardness ultrafine WC-Co cemented carbide rods used to manufacture printed circuit board (PCB) drills were obtained.

关键词： Nanocrystalline Composite powder Cemented carbide Rods