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Autocatalytic bifunctional supramolecular hydrogels for osteoporotic bone repair

National Science Review 2024年第7期11卷 263-278页

作者： Zhihui Han Xiang Gao Yuanjie Wang Cheng Huang Hao Song Shuning Cheng Xiaoyuan Yang xiaoliang cui Jie Wu Kailu Wei Liang Cheng Institute of Functional Nano&Soft Materials(FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University Department of Orthopedics The Second Affiliated Hospital of Soochow University Macao Institute of Materials Science and Engineering Macau University of Science and Technology

Conventional bone scaffolds, which are mainly ascribed to highly active osteoclasts and an inflammatory microenvironment with high levels of reactive oxygen species and pro-inflammatory factors, barely satisfy osteoporotic defect repair. Herein, multifunctional self-assembled supramolecular fiber hydrogels(Ce–Aln gel) consisting of alendronate(Aln) and cerium(Ce) ions were constructed for osteoporotic bone defect repair. Based on the reversible interaction and polyvalent cerium ions, the Ce–Aln gel, which was mainly composed of ionic coordination and hydrogen bonds, displayed good injectability and autocatalytic amplification of the antioxidant effect. In vitro studies showed that the Ce–Aln gel effectively maintained the biological function of osteoblasts by regulating redox homeostasis and improved the inflammatory microenvironment to enhance the inhibitory effect on osteoclasts. Ribonucleic acid(RNA) sequencing further revealed significant downregulation of various metabolic pathways, including apoptosis signaling,hypoxia metabolism and tumor necrosis factor-alpha(TNF-α) signaling via the nuclear factor kappa-B pathway after treatment with the Ce–Aln gel. In vivo experiments showed that the clinical drug-based Ce–Aln gel effectively promoted the tissue repair of osteoporotic bone defects by improving inflammation and inhibiting osteoclast formation at the defect. Notably, in vivo systemic osteoporosis was significantly ameliorated, highlighting the strong potential of clinical translation for precise therapy of bone defects.

关键词： autocatalysis supramolecular hydrogel anti-inflammation osteoporosis bone defect

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Research on the Online College English Teaching Mode from the Perspective of Autonomous Learning

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Journal of Contemporary Educational Research 2021年第11期5卷 114-117页

作者： xiaoliang cui Xiaoning Wang Linfen College of Shanxi Normal University China

In order to explore the online college English teaching mode from the perspective of autonomous learning and facilitate college students to better learn English independently as well as to master their English application skills,this article expounds the significance of online English teaching through theoretical *** the same time,it expounds how to realize online English teaching in the perspective of autonomous learning,so as to improve the quality of English teaching and students’English skills.

关键词： Autonomous learning College English Online teaching

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3D-printable supramolecular hydrogels with shear-thinning property: fabricating strength tunable bioink via dual crosslinking

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Bioactive Materials 2020年第4期5卷 808-818页

作者： Tian Hu xiaoliang cui Meng Zhu Man Wu Ye Tian Bin Yao Wei Song Zhongwei Niu Sha Huang Xiaobing Fu Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College28 Fu Xing RoadBeijing100853PR China PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury Repair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU05151 Fu Cheng RoadBeijing100048PR China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Chinese Academy of Medical Sciences(CAMS)Oxford Institute Nuffield Department of MedicineUniversity of OxfordOxford OX39DSUK School of Future Technology University of Chinese Academy of SciencesBeijing100049PR China

3-dimensional(3D)bioprinting technology provides promising strategy in the fabrication of artificial tissues and *** the fundamental element in bioprinting process,preparation of bioink with ideal mechanical properties without sacrifice of biocompatibility is a great *** this study,a supramolecular hydrogel-based bioink is prepared by polyethylene glycol(PEG)grafted chitosan,α-cyclodextrin(α-CD)and *** has a primary crosslinking structure through the aggregation of the pseudo-polyrotaxane-like side chains,which are formed from the host-guest interactions betweenα-CD and PEG side *** viscosity measurement shows the shear-shinning property of this bioink,which might be due to the reversibility of the physical ***,withβ-glycerophosphate at different concentrations as the secondary crosslinking agent,the printed constructs demonstrate different Young's modulus(p<0.001).They could also maintain the Young's modulus in cell culture condition for at least 21 days(p<0.05).By co-culturing each component with fibroblasts,CCK-8 assay demonstrate cellular viability is higher than 80%.After bioprinting and culturing,immunofluorescence staining with quantification indicate the expression of Ki-67,Paxillin,and N-cadherin is higher in day 14 than those in day 3(p<0.05).Oil red O and Nissl body specific staining reflect strength tunable bioink may have impact on the cell fate of mesenchymal stem cells(p<0.05).This work might provide new idea for advanced bioink in the application of re-establishing complicated tissues and organs.

关键词： Supramolecular hydrogel Bioink Tunable strength 3D bioprinting

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A Petrological, Geochemical, and Geochronological Study of Shuikou Ultrabasic Rock Mass in Wuding County, Yunnan Province, China

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Open Journal of Geology 2022年第8期12卷 587-612页

作者： Bin Yang Zizheng Wang Qing Zhou xiaoliang cui Shengwei Wang Chengdu Center China Geological Survey Chengdu China

Geotectonically, the Shuikou ultrabasic-basic rock mass is located on the western margin of the Yangtze Platform. As revealed by field geological surveys, the Shuikou rock mass intrudes into the quartz sandstones of the Sinian Chengjiang Formation (Zac). It is dominated by pyroxenites and can be roughly divided into four lithofacies zones, namely gabbros at the outermost periphery and fine-, medium-, and coarse-grained pyroxenites from margin to center. With the transition from pyroxenites to gabbros, the Shuikou rock mass features gradual enrichment in silica and alkali overall, an increase in ΣREE and (La/Yb)N ratio, and a decrease in δEu values and Eu/Sm ratio, indicating that the Shuikou rock mass was formed from the continuous differentiation and crystallization of consanguineous magma and that low-degree partial melting occurred meanwhile. According to the U-Pb baddeleyite geochronology, the crystallization age of the Shuikou rock mass is 210.7 ± 3 Ma (MSWD = 1.01). Based on this, as well as the analysis of geochemical characteristics, the Shuikou rock mass occurred in a continental intraplate tensional environment, this is closely related to the activities of the Emeishan mantle plume during the same period.

关键词： Shuikou Rock Mass Petrological Characteristics Geochemical Characteristics Geochronology Wuding County Yunnan Province

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蚕丝基生物材料精准和功能性组装的3D打印策略

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Engineering 2024年第3期34卷 92-108页

作者： xiaoliang cui Jun Zhang Yan Qian Siqi Chang Benjamin J.Allardyce Rangam Rajkhowa Hui Wang Ke-Qin Zhang National Engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China Institute for Frontier Materials Deakin UniversityGeelongVIC 3216Australia

In recent years,significant progress has been made in both three-dimensional(3D)printing technologies and the exploration of silk as an ink to produce biocompatible *** with the unlimited design potential of 3D printing,silk can be processed into a broad range of functional materials and devices for various biomedical *** ability of silk to be processed into various materials,including solutions,hydrogels,particles,microspheres,and fibers,makes it an excellent candidate for adaptation to different 3D printing *** review presents a didactic overview of the 3D printing of silk-based materials,major categories of printing techniques,and their prototyping mechanisms and structural *** addition,we provide a roadmap for researchers aiming to incorporate silk printing into their own work by summarizing promising strategies from both technical and material aspects,to relate state-of-the-art silk-based material processing with fast-developing 3D printing ***,our focus is on elucidating the techniques and strategies that advance the development of precise assembly strategies for silk-based *** printing(including high printing resolution,complex structure realization,and printing fidelity)is a prerequisite for the digital design capability of 3D printing technology and would definitely broaden the application era of silk,such as complex biomimetic tissue structures,vasculatures,and transdermal microneedles.

关键词： 3D printing Bioink Bioprinting Silk fibroin

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Characteristics of Recent Horizontal Crustal Movement and Tectonic Deformation in the Northwest China Region

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Earthquake Research in China 2006年第3期20卷 271-285页

作者： Zhang Xi Liu Wenyi Wang Shuangxu Wang Wenping Zhang xiaoliang cui Duxin Xue Fuping The Second Monitoring and Application Center CEA Xi＇ an 710054 China

Making use of observation data of GPS in the Northwest China region and infrared distancemeasurements crossing the Qilian-Longshoushan fault zone up to 2004, aided by the least square collocation and inversion of negative dislocation model for the boundaries of elastic blocks and the singular force-source, the dynamic evolution features of deformation and strain fields before and after the Ms = 8. 1 earthquake on the west of Kunlun Mountains Pass, especially the recent tectonic deformation and stress field status three years after this earthquake are studied. The possible regions or segments of active blocks and their boundaries reflecting accumulation background of high strain energy of producing earthquakes over middle magnitude, are obtained, as well as the potential epicenter. The results show that after shortterm relaxation and adjustment in the northern margin of Qinghai-Xizang （Tibet） block after the Ms = 8. 1 earthquake, the main control action of background field of northeastward pushing of Indian plate is now recovering. Moreover, the following regions are found to have the background of high strain energy accumulation. They are the middle segment of the northern Tianshan fault zone and its meeting region with the western segment, the middle and western segments of southern Tianshan fault zone and the meeting region with Western Kunlun fault zone, the middle segment of Altun fault, the middle-eastern segment of Qilianshan fault zone and its meeting region with Haiyuan fault, the meeting region of northern margin fault of west Qinling Range and the southeastward expanding line of Zhuanglanghe fault; The Linze and Haiynan areas also see accumulation of strain energy to some degree.

关键词： Northwest China Region Horizontal deformation Negative dislocation model Seismogenic background Potential epicenter

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河北武安地区斑状角闪二长岩中角闪石矿物学特征及其对矽卡岩铁矿成因的指示

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岩石学报 2020年第7期36卷 2215-2231页

作者：崔晓亮苏尚国孟维一刘璐璐陈晨中国地质大学(北京)地球科学与资源学院北京100083 中国地质科学院矿产资源研究所北京100037

成矿作用需要巨量含矿流体,而矽卡岩铁矿的含矿流体到底是从致矿侵入体中析出还是来自于深部岩浆仍有很大争议。为了研究邯邢地区矽卡岩矿床中成矿岩体演化过程中含矿流体的性质及其对成矿作用的贡献,本文利用电子探针(EMPA)和激光剥蚀... 详细信息

成矿作用需要巨量含矿流体,而矽卡岩铁矿的含矿流体到底是从致矿侵入体中析出还是来自于深部岩浆仍有很大争议。为了研究邯邢地区矽卡岩矿床中成矿岩体演化过程中含矿流体的性质及其对成矿作用的贡献,本文利用电子探针(EMPA)和激光剥蚀等离子质谱仪(LA-ICP-MS)的原位分析,对河北武安地区斑状角闪二长岩中角闪石的主微量元素进行研究。岩相学特征显示角闪石可以根据颜色分为两类:褐色角闪石和绿色角闪石。斑晶主要为褐色角闪石并具有反应边结构,由内而外依次为黑云母带、透辉石和斜长石带、绿色角闪石和磁铁矿带;基质主要为绿色角闪石,少数核部为褐色角闪石。褐色角闪石的成分主要为镁绿钙闪石和韭闪石,绿色角闪石主要成分是镁角闪石、浅闪石和阳起石。化学成分上褐色角闪石低Si,高Ti、Al;绿色角闪石高Si,低Al、Ti。利用角闪石温压计计算褐色斑晶角闪石形成于相对高压(400~560MPa)和高温(950~980℃)的深部岩浆房条件;褐色基质角闪石形成压力比斑晶角闪石降低(200~300MPa)而温度变化不大(870~940℃)的浅部岩浆房;绿色角闪石都形成于相对低压(<100MPa)、低温(700~880℃)的岩浆定位深度条件下。岩浆具有较高的氧逸度,并且从褐色角闪石到绿色角闪石,岩浆的氧逸度升高,高氧逸度条件有利于金属元素进入流体相,阻止其以硫化物的形式在早期沉淀。同时岩浆高含水量促使在低压条件下出溶成矿流体和挥发分,有利于成矿元素的富集和迁移。相对于褐色角闪石,绿色角闪石具有更强的Nb、Sr、Pb、Ti的负异常和极高Nb/Ta值,这代表绿色角闪石是在流体的交代作用下形成的;结合斑晶角闪石反应边产物及其含铁量分析计算,我们得出外来富铁碱性流体的加入是必须的。"邯邢式"铁矿的成因模式不是传统的接触热液交代成因模型,矽卡岩铁矿的铁质来源应该是深部含矿流体。角闪石斑晶在15~20km深部岩浆房结晶,岩浆侵位到7~10km浅部岩浆房时褐色基质角闪石结晶,此时岩浆房接近固结-半固结状态。随后外来碱性富铁流体注入发生岩浆房的活化,岩浆快速侵位并在1~3km处定位,此时压力迅速降低使成矿流体出溶,绿色角闪石也随之形成。外来碱性富铁流体的注入使岩浆快速侵位,高含水量和高氧逸度条件下成矿流体大量出溶,这些因素共同促进矽卡岩铁矿的形成。

关键词：角闪石矿物温压计矽卡岩铁矿成因含矿流体河北武安

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川西南金阳地区麦地坪组沉积特征及成磷沉积环境分析

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矿物岩石 2019年第3期39卷 78-84页

作者：崔晓亮张芹贵曾礼吴科中国地质调查局成都地质调查中心四川成都610081 四川省地质矿产勘查开发局二零七地质队四川乐山614000 四川省地质矿产勘查开发局四零三地质队四川峨眉山614299

寒武系纽芬兰统麦地坪组是海相沉积型磷矿的主要赋存层位。在金阳地区,麦地坪组沿北东-南西向展布,通过由北至南在谷德、西衙门、天地坝等9个地区采集样品27件的手标本及镜下观察,分析这9个地区的的麦地坪组沉积特征,认为金阳地区在早... 详细信息

寒武系纽芬兰统麦地坪组是海相沉积型磷矿的主要赋存层位。在金阳地区,麦地坪组沿北东-南西向展布,通过由北至南在谷德、西衙门、天地坝等9个地区采集样品27件的手标本及镜下观察,分析这9个地区的的麦地坪组沉积特征,认为金阳地区在早寒武世麦地坪期处于潮坪沉积环境。在谷德-西衙门一带为潮下高能环境,形成了内碎屑块状磷块岩;天地坝-桃坪一带亦为潮下高能环境,由于水体更浅,仅形成条纹条带状磷块岩,磷矿层也变薄;往南西,沉积环境变为潮间,由于甲依水下隆起的存在,隔断了磷质向南西运移,因此朗德-对坪一带麦地坪组虽沉积较厚,但难以形成磷矿层。基于麦地坪组沉积特征分析,恢复了成磷期的古地理,认为金阳地区的找矿远景区应位于谷德-西衙门一带。

关键词：麦地坪组磷矿沉积特征成矿环境

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河北武安坦岭多斑斜长斑岩中基质矿物特征及其研究意义

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地学前缘 2019年第1期26卷 286-299页

作者：刘璐璐苏尚国杨睿娜罗照华崔晓亮中国地质大学(北京)地球科学与资源学院北京100083 河南省地质矿产勘查开发局第二地质矿产调查院河南郑州450001

河北武安坦岭斜长斑岩具有多斑斑状结构,基质为显微晶质结构。岩相学观察表明,斜长石斑晶有一个宽广的核部和一个宽度可变的条纹长石反应边,个别核部包含有角闪石、黑云母等矿物。基质矿物主要由蓝透闪石、条纹长石(An0Ab8.4Or91.5～An0... 详细信息

河北武安坦岭斜长斑岩具有多斑斑状结构,基质为显微晶质结构。岩相学观察表明,斜长石斑晶有一个宽广的核部和一个宽度可变的条纹长石反应边,个别核部包含有角闪石、黑云母等矿物。基质矿物主要由蓝透闪石、条纹长石(An0Ab8.4Or91.5～An0.1Ab57.3Or42.6)、石英、钾长石(An0.3Ab5.9Or93.7～An0.3Ab4.7Or95.2)、钠长石(An0.2Ab98.3Or1.5～An0.1Ab99.2Or0.7)、磁铁矿、赤铁矿、钛铁矿、磷灰石、榍石和锆石等11种矿物组成。角闪石温压计计算结果得出,基质角闪石核部的结晶压力高于边部,核部为34.05 MPa,对应的结晶温度为660.35℃,结晶深度为1.29km;边部的结晶压力为24.32MPa,结晶温度为598.32℃,结晶深度为0.92km;而斜长石斑晶中的角闪石形成时压力为159.51～178.19MPa,温度为817.68～819.79℃,对应的形成深度为6.03～6.73km。基质角闪石在Al2O3-TiO2图上落在壳源区,而斑晶中的角闪石和黑云母都落在壳幔混合区。斜长石、条纹长石、磁铁矿和磷灰石的微量和稀土元素测试数据显示,其都具有相对富集LILE、亏损HFSE的特点,暗示了基质矿物的形成有流体参与。ICT三维扫描结果显示,斜长斑岩基质中的孔隙体积含量约为3.428%,铁质体积含量为4.371%,且铁氧化物和孔隙具弱连通性。通过讨论分析,笔者得出:(1)坦岭斜长斑岩中斜长石斑晶具有明显的交代结构,且晶体本身没有明显熔蚀现象,这些特征表明大量的斜长石斑晶快速上升,即"冻结岩浆房"的活化机制与流体密切相关;(2)斜长斑岩中基质矿物有十一种,且矿物类型复杂,不符合平衡系统矿物相律,应属于流体晶矿物组合;(3)坦岭斜长斑岩的基质"岩浆"可能是一种富Fe、K、P、Si、Na等元素的熔体-流体流;(4)多斑斜长斑岩的形成经历了(1)深度6～7km的深部岩浆房形成斜长石堆晶→(2)富Fe、K、P、Si、Na等元素的熔体-流体流加入深部岩浆房,冻结岩浆房活化→(3)由于流体超压,含大量斜长石斑晶的熔体-流体在地壳浅部(0.9～1.2km)呈小岩株状或岩脉状就位。多斑斜长斑岩为深部找矿提供了有力的线索。

关键词：多斑斜长斑岩基质矿物角闪石矿物温压计冻结岩浆活化

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对高血压性脑出血给予经侧裂显微手术对比小骨窗开颅术的疗效分析

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中国社区医师 2016年第16期32卷 18-19页

作者：崔晓亮北华大学附属医院神经外一科 132001

目的:探讨经侧裂显微手术和小骨窗开颅术治疗高血压性脑出血的临床效果。方法:收治高血压性脑出血患者116例,随机分为对照组与试验组各58例,对照组采用小骨窗开颅术,试验组采用经侧裂显微手术,比较两组的治疗效果。结果:在试验组,总有... 详细信息

目的:探讨经侧裂显微手术和小骨窗开颅术治疗高血压性脑出血的临床效果。方法:收治高血压性脑出血患者116例,随机分为对照组与试验组各58例,对照组采用小骨窗开颅术,试验组采用经侧裂显微手术,比较两组的治疗效果。结果:在试验组,总有效率明显高于对照组,残疾率、死亡率、并发症发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:经侧裂显微手术治疗高血压性脑出血的临床效果显著。

关键词：高血压性脑出血经侧裂显微手术小骨窗开颅术

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