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A drug-loaded flexible substrate improves the performance of conformal cortical electrodes

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Bio-Design and Manufacturing 2024年第4期7卷 399-412页

作者： Rongrong Qin Tian Li Yifu Tan Fanqi Sun Yuhao Zhou Ronghao Lv xiaoli you Bowen Ji Peng Li Wei Huang Frontiers Science Center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering(IBME)Northwestern Polytechnical UniversityXi’an 710072China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China

Cortical electrodes are a powerful tool for the stimulation and/or recording of electrical activity in the nervous ***,the inevitable wound caused by surgical implantation of electrodes presents bacterial infection and inflammatory reaction risks associated with foreign body ***,inflammation of the wound area can dramatically worsen in response to bacterial *** consequences can not only lead to the failure of cortical electrode implantation but also threaten the lives of ***,we prepared a hydrogel made of bacterial cellulose(BC),a flexible substrate for cortical electrodes,and further loaded antibiotic tetracycline(TC)and the anti-inflammatory drug dexamethasone(DEX)onto *** encapsulated drugs can be released from the BC hydrogel and effectively inhibit the growth of Gram-negative and Gram-positive ***,therapeutic cortical electrodes were developed by integrating the drug-loaded BC hydrogel and nine-channel serpentine arrays;these were used to record electrocorticography(ECoG)signals in a rat *** to the controlled release of TC and DEX from the BC hydrogel substrate,therapeutic cortical electrodes can alleviate or prevent symptoms associated with the bacterial infection and inflammation of brain *** approach facilitates the development of drug delivery electrodes for resolving complications caused by implantable electrodes.

关键词： Antibacterial Anti-inflammatory Drug loading Cortical electrodes Bacterial cellulose hydrogel

Smart epidermal electrophysiological electrodes:Materials,structures,and algorithms

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Nanotechnology and Precision Engineering 2023年第4期6卷 75-97页

作者： Yuanming Ye Haochao Wang Yanqiu Tian Kunpeng Gao Minghao Wang Xuanqi Wang Zekai Liang xiaoli you Shan Gao Dian Shao Bowen Ji Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Queen Mary University of London Engineering School Northwestern Polytechnical UniversityXi’an 710072China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China College of Information Science and Technology Donghua UniversityShanghai 201620China College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China

Epidermal electrophysiological monitoring has garnered significant attention for its potential in medical diagnosis and healthcare,particularly in continuous signal ***,simultaneously satisfying skin compliance,mechanical properties,environmental adaptation,and biocompatibility to avoid signal attenuation and motion artifacts is challenging,and accurate physiological feature extraction necessitates effective signal-processing *** review presents the latest advancements in smart electrodes for epidermal electrophysiological monitoring,focusing on materials,structures,and ***,smart materials incorporating self-adhesion,self-healing,and self-sensing functions offer promising solutions for long-term ***,smart meso-structures,together with micro/nanostructures endowed the electrodes with self-adaption and ***,intelligent algorithms give smart electrodes a“soul,”facilitating faster and more-accurate identification of required information via automatic processing of collected electrical ***,the existing challenges and future opportunities for developing smart electrodes are *** as a crucial direction for next-generation epidermal electrodes,intelligence holds the potential for extensive,effective,and transformative applications in the future.

关键词： Epidermal electrodes Electrophysiological signal monitoring Smart materials Smart structures Intelligent algorithms

Brainmask:an ultrasoft and moist microelectrocorticography electrode for accurate positioning and long-lasting recordings

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Microsystems & Nanoengineering 2023年第5期9卷 295-307页

作者： Bowen Ji Fanqi Sun Jiecheng Guo Yuhao Zhou xiaoli you Ye Fan Longchun Wang Mengfei Xu Wen Zeng Jingquan Liu Minghao Wang Huijing Hu Honglong Chang Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Collaborative Innovation Center of Northwestern Polytechnical University Shanghai 201108China Institute of Medical Research Northwestern Polytechnical UniversityXi’an 710072China College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China National Key Laboratory of Science and Technology on Micro/Nano Fabrication Department of Micro/Nano ElectronicsShanghai Jiao Tong UniversityShanghai 200240China

Bacterial cellulose(BC),a natural biomaterial synthesized by bacteria,has a unique structure of a cellulose nanofiberweaved three-dimensional reticulated *** films can be ultrasoft with sufficient mechanical strength,strong water absorption and moisture retention and have been widely used in facial *** films have the potential to be applied to implantable neural interfaces due to their conformality and moisture,which are two critical issues for traditional polymer or silicone *** this work,we propose a micro-electrocorticography(micro-ECoG)electrode named“Brainmask”,which comprises a BC film as the substrate and separated multichannel parylene-C microelectrodes bonded on the top *** can not only guarantee the precise position of microelectrode sites attached to any nonplanar epidural surface but also improve the long-lasting signal quality during acute implantation with an exposed cranial window for at least one hour,as well as the in vivo recording validated for one *** novel ultrasoft and moist device stands as a next-generation neural interface regardless of complex surface or time of duration.

关键词： recording electrode moisture

Progress in Mechanical Modeling of Implantable Flexible Neural Probes

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1205-1231页

作者： xiaoli you Ruiyu Bai Kai Xue Zimo Zhang Minghao Wang Xuanqi Wang Jiahao Wang Jinku Guo Qiang Shen Honglong Chang Xu Long Bowen Ji Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an710072China National Key Laboratory of Unmanned Aerial Vehicle Technology Northwestern Polytechnical UniversityXi’an710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an710072China School of Automobile Chang’an UniversityXi’an710018China MOE Engineering Research Center of Smart Microsensors and Microsystems College of Electronics and InformationHangzhou Dianzi UniversityHangzhou310018China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710129China

Implanted neural probes can detect weak discharges of neurons in the brain by piercing soft brain tissue,thus as important tools for brain science research,as well as diagnosis and treatment of brain ***,the rigid neural probes,such as Utah arrays,Michigan probes,and metal microfilament electrodes,are mechanically unmatched with brain tissue and are prone to rejection and glial scarring after implantation,which leads to a significant degradation in the signal quality with the implantation *** recent years,flexible neural electrodes are rapidly developed with less damage to biological tissues,excellent biocompatibility,and mechanical compliance to alleviate *** them,the mechanical modeling is important for the optimization of the structure and the implantation *** this review,the theoretical calculation of the flexible neural probes is firstly summarized with the processes of buckling,insertion,and relative interaction with soft brain tissue for flexible probes from outside to ***,the corresponding mechanical simulation methods are organized considering multiple impact factors to realize minimally invasive ***,the technical difficulties and future trends of mechanical modeling are discussed for the next-generation flexible neural probes,which is critical to realize low-invasiveness and long-term coexistence in vivo.

关键词： Mechanical modeling flexible neural probes invasive theoretical calculation simulation

《说儒》中“文士”、“法利赛人”之隐喻及多重意涵

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史学理论研究 2019年第3期 56-63,158页

作者：尤小立苏州大学哲学系

胡适《说儒》一文除探寻儒之起源外,亦渗透着强烈的思想性和现实关怀。其参照基督教创教史建构孔子为“儒教教主”时涉及的“文士”、“法利赛人”有隐喻学院派学者之意,并借此揭示出知识人、学者的追求与百姓愿望之间的差距,其目的是... 详细信息

胡适《说儒》一文除探寻儒之起源外,亦渗透着强烈的思想性和现实关怀。其参照基督教创教史建构孔子为“儒教教主”时涉及的“文士”、“法利赛人”有隐喻学院派学者之意,并借此揭示出知识人、学者的追求与百姓愿望之间的差距,其目的是弥合彼此之间的鸿沟,以便在民族危机之时建立起中国社会和文化的重心。从篇尾以理性解构自己建构的“教主”形象可知,胡适在此问题上亦充满困惑。但《说儒》提出的儒家及其思想与民间社会、普通百姓疏离和沟通的问题,仍值得进一步思考。

关键词：胡适说儒文士法利赛人

现代中国科学派科学主义倾向的自我解构——以任鸿隽的科学理念为解读中心

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江苏社会科学 2006年第5期 181-187页

作者：尤小立苏州大学公共管理学院副教授215021

如果说现代中国的科学派确实存在“科学主义”倾向的话,他们的“科学主义”倾向一开始就在自我消解着。对科学精神层面的关注,不仅是为了单纯地启蒙,更重要的是,要在中国建构现代科学体系。此一现实目标影响着他们对科学精神的张扬,求... 详细信息

如果说现代中国的科学派确实存在“科学主义”倾向的话,他们的“科学主义”倾向一开始就在自我消解着。对科学精神层面的关注,不仅是为了单纯地启蒙,更重要的是,要在中国建构现代科学体系。此一现实目标影响着他们对科学精神的张扬,求取科学之本,其话语指向,主要针对的是正在或将要从事科学研究的青年。而从任鸿隽对“科学”的理解看,科学的有限性是其基本理念,之所以倡言“科学方法万能”,既是为了维护科学的合法性,也是一种发展中国科学事业的宣传手段。

关键词：科学派任鸿隽科学理念科学主义倾向

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陈独秀与中国无政府主义者的思想关联和分野

江苏社会科学 2010年第2期 197-205页

作者：尤小立苏州大学政治与公共管理学院副教授 215123

陈独秀和中国无政府主义者之间有着相对密切的交往,彼此的思想既有关联,又有分野,具体表现则因无政府主义的派别不同而有所差异。在进取与对待传统的态度上,陈独秀与天义派产生了思想隔膜;由于共同信奉科学和进化论,他在思想上与新世纪... 详细信息

陈独秀和中国无政府主义者之间有着相对密切的交往,彼此的思想既有关联,又有分野,具体表现则因无政府主义的派别不同而有所差异。在进取与对待传统的态度上,陈独秀与天义派产生了思想隔膜;由于共同信奉科学和进化论,他在思想上与新世纪派较为接近,又因自身的务实与新世纪派的激进姿态拉开了距离。与无政府主义第三代的争论表面上起于现实态度的冲突,其实透露出的是同道者之间深层的经验主义取向与纯粹理想主义取向的差异。从这些属于激进主义内部思想异同的对比中,不难看出陈独秀思想的多重性,特别是过去较少为人所关注,却对其一生颇有影响的务实的一面。

关键词：陈独秀中国无政府主义进取进化务实

语言政治和话语权力:1933—1934年围绕“英语八五运动”的文化论争

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近代史研究 2020年第2期 134-151,M0004页

作者：尤小立苏州大学哲学系

1933年5月,中华书局出于生意考虑,在引进奥格登的“基本英语”后发起“英语八五运动”,却引发了一场文化论争。为了维护世界语,加之对帝国主义文化侵略的戒备以及民族危机下民族主义意识的增强,世界语者难以接受“基本英语”替代世界语... 详细信息

1933年5月,中华书局出于生意考虑,在引进奥格登的“基本英语”后发起“英语八五运动”,却引发了一场文化论争。为了维护世界语,加之对帝国主义文化侵略的戒备以及民族危机下民族主义意识的增强,世界语者难以接受“基本英语”替代世界语成为国际辅助语,更难以接受世界语“没有祖国”的指责,率先批评“基本英语”。林语堂因秉持语言的自然起源论,也反对“基本英语”的人为性和“非自然”。论争涉及诸如谁有资格成为国际辅助语、人造语的合法性、语言的民族性、语言的“祖国”“用武之地”以及语言的代表性、大众性和普及性等问题,呈现话语权力之争的态势。这一论争持续到1934年,虽无明确的结果,却反映了时代的精神和思想状况以及知识人对语言的基本认知。

关键词：基本英语世界语国际辅助语林语堂中华书局英语八五运动

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崇西和用西:陈独秀与杜威实用主义政治哲学

学术研究 2007年第11期 39-44页

作者：尤小立苏州大学公共管理学院

近代中国知识人的"崇西"倾向是不言而喻的,问题是他们如何在"崇西"时"用西"。因为"崇西",陈独秀接受了杜威政治哲学中的民主思想;由于开始倾向于"直接行动"、国民参与、大众民主、社会革命,因此他吸纳杜威思想时又有着明显的选择性。而... 详细信息

近代中国知识人的"崇西"倾向是不言而喻的,问题是他们如何在"崇西"时"用西"。因为"崇西",陈独秀接受了杜威政治哲学中的民主思想;由于开始倾向于"直接行动"、国民参与、大众民主、社会革命,因此他吸纳杜威思想时又有着明显的选择性。而陈独秀并未意识到这一吸纳方式可能产生的根本理念上的内在冲突。晚年陈独秀回归民主立场后,他的思维原则与杜威实用主义有许多暗合之处。

关键词：陈独秀杜威实用主义政治哲学