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New Rental Wheelchair Design in Human Factors and Engineering Analysis

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New Rental Wheelchair Design in Human Factors and Engineerin...

Enabling AIEgens close assembly in tumor-overexpressed protein cluster for boosted image-guided cancer surgery

第十二届人-机-环境系统工程大会

作者： xiaoli wu College of Mechanical and Electrical Engineering Hohai University Changzhou Key Digital Manufacturing Technology Laboratory

As the temporary public conveyance for the particular people, the rental wheelchair has certain market demand and designing prospect. After analyzing the different characters of user group in human factors, four design factors were extracted, folding, general-utility, simplicity and durability. And based on Ergonomic analysis of the sedentary posture size, a new kind of folding rental wheelchair has been designed. Then, establishing structure dimension, material, processing technology and using the engineering software, a small model has been made by rapid prototype manufacturing, which has been identical with the fist design factors. The emergence of the rental wheelchair is a concept of the wheelchair produces change, pregnant with the infinite vitality and unlimited business opportunities.

关键词： Rental wheelchair human factors ergonomics in design engineering design

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Science China Chemistry 2020年第11期63卷 1694-1702页

作者： Junxiao Gao Jun Li Daohe Wei Han Yang Yue Duan Yue Zhang Xiaoqun Gong Hanjie Wang Dan Ding xiaoli wu Jin Chang School of Life Sciences Tianjin UniversityTianjin 300072China Key Laboratory of Bioactive Materials Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China

Development of efficient fluorescent probes that can realize precise fluorescence image-guided cancer surgery(FIGCS)with extremely high tumor-to-normal tissue(T/NT)ratio is urgently ***,we report the design and synthesis of an aggregation-induced emission(AIE)-active,peptide-based fluorescence turn-on probe MPA-Ph-R-FFGYSAYPDSVPMMS(MPA-Ph-R-FFGYSA for short),which consists of a new near-infrared emissive AIE luminogen(AIEgen)MPA-Ph-R,a self-assembling peptide sequence“FFG”,and an“active”targeting peptide YSAYPDSVPMMS that can selectively bind to EphA2 protein cluster overexpressed in many *** compared to the control probe MPA-Ph-R-YSA without“FFG”,MPA-Ph-R-FFGYSA exhibits much higher fluorescent brightness and sensitivity in both cellular and in vivo studies on EphA2 cluster detection/imaging,as“FFG”is beneficial to closer assembly of AIEgens in EphA2 cluster,leading to more effective restriction of the intramolecular motion of *** vivo studies demonstrate that MPA-Ph-R-FFGYSA is a safe bioprobe and gives excellent performance in FIGCS with a rather high T/NT ratio of^13.4 upon intravenous administration into peritoneal carcinomatosis-bearing *** study provides a new strategy of utilizing the close assembly of tumor microenvironment-responsive AIE probes for boost FIGCS.

关键词： aggregation-induced emission luminogen fluorescent probe self-assembling peptide fluorescence image-guided cancer surgery tumor-to-normal tissue ratio

Activity identification of ribozyme and U1 snRNA chimeric ribozyme against TGFβ1 in cell-free system and in hepatic Stellate cells

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Science China(Life Sciences) 2006年第1期49卷 73-81页

作者： SONG Yuhu LIU Fang TIAN Dean XUE Xiulan LIU Nanzhi wu xiaoli LIN Jusheng JIN Youxin Institute of Liver Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hematology Union Hospital Tongji medical CollegeHuazhong University of Science and TechnologyWuhan 430022China State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

Transforming growth factorβ1 (TGFβ1) is known to be intimately involved inmany cellular processes. To explore the mechanism of TGFβ1 in these processes, the non-chimerichammerhead ribozyme and U1 snRNA chimeric ribozyme against TGFβ1 were designed to down-regulateTGFβ1 expression. The activity of non-chimeric ribozyme and U1 snRNA chimeric ribozyme againstTGFβ1 in vitro and in activated hepatic stellate cells (HSCs) was detected. Cleavage reactions ofboth ribozymes in vitro demonstrated that non-chimeric ribozyme possessed better cleavage activityin vitro than U1 snRNA chimeric ribozyme. The further study showed U1 snRNA chimeric ribozymeinhibited TGFβ1 expression more efficiently than non-chimeric ribozyme in transfected HSC cells. Soit indicates that the U1 snRNA chimeric ribozyme provides an alternative approach for the researchon the precise mechanism of TGFβ1 in many cellular processes and a potential therapeutic candidatefor TGFβ1-related diseases.

关键词： RNA catalytic U1 snRNA TGFβ1 HSC

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距离选通条件下的三维建模仿真算法

红外与激光工程 2013年第S2期42卷 298-303页

作者：闫涛吴孝丽河南城建学院

由于实验条件及实验手段的局限性,针对空间目标难以经常进行天基实验,建立了距离选通条件下基于物理模型的三维目标激光主动成像仿真方法。首先将系统各部分分解并逐个分析,分别建立了激光光束传输模型、目标三维模型、非相干成像模型、... 详细信息

由于实验条件及实验手段的局限性,针对空间目标难以经常进行天基实验,建立了距离选通条件下基于物理模型的三维目标激光主动成像仿真方法。首先将系统各部分分解并逐个分析,分别建立了激光光束传输模型、目标三维模型、非相干成像模型、ICCD成像模型,然后根据激光及光学系统参数、ICCD参数仿真了空间目标的二维时间切片图像,最后根据二维切片仿真图像序列实现了距离选通条件下的三维目标成像仿真。仿真结果表明:通过二维仿真图像序列控制不同的距离选通条件,可以完成对目标不同精度的三维重建,能为将来的实验研究提供重要的指导依据。

关键词：距离选通三维仿真空间目标模型

Different burial-cooling history of Triassic strata between the western Weibei Uplift and the northwestern Weihe Basin in northwest China

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Journal of Earth Science 2021年

作者： Qiang Yu Zhanli Ren Rongxi Li Ling Chung Ni Tao Wanshan Lei Baojiang Wang xiaoli wu xiaoli Qin Xianghe Lei The School of Earth Science and Resources， Chang'an University Research Institute on Wisdom Oil & Gas Field， Chang'an University State Key Laboratory of Continental Dynamics， Northwest University School of Earth Sciences， The University of Melbourne School of Information Technology， Xichang University

Analysis of tectonothermal history of the Yanchang Formation in the western Weibei Uplift and in the northwestern Weihe Basin can reconstruct the cooling history of the southwest most remained Upper Triassic source rock of the North China Plate. Apatite fission-track （AFT） and （U-Th-Sm）/He （AHe） analysis were used to recover the cooling and uplift history of the Upper Triassic here. Ten sandstones from the Middle-Upper Triassic strata yield AFT ages between 179.8 Ma±7.4 Ma and 127.6 Ma±8.1 Ma. AHe ages of two sandstones have the value of 37.7 Ma±2.3 Ma ～ 131.1 Ma±8.1 Ma and 45.7 Ma±2.8 Ma ～ 83.5 Ma±5.2 Ma. Time-temperature modeling results showed that tectonothermal history of the Yanchang Formation was initially different in time-space relationships but then became almost identical through time followed by different cooling rate. Modeling results of the Triassic strata in the Qianyang area and the Yaojiagou area revealed three different uplift-cooling stages commencing in the Late Jurassic at ～165 Ma and in Early Cretaceous at ～110 Ma， respectively， both followed by first similar cooling histories to the Early Miocene at ～20-23 Ma and then different since the Late Miocene. Uplift-cooling rate since the Late Miocene at ～8 Ma were different between the Western Weibei Uplift and the Northwestern Weihe Basin. The timing， cooling-uplift rates of the Yaojiagou area， which was mainly controlled by movements related to the Liupanshan Mountains， the Qinling Orogens and the Weibei Uplift， had the earliest onset of uplift-cooling for the Upper Triassic series compared to other regions within the Weibei Uplift. Cooling paths for the Upper Triassic series became uniform regionally in the Early Cretaceous marking a key time for the tectonothermal evolutionary history of Upper Triassic series in the southwestern North China Plate.

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Comprehensive Strategy for Keloid Treatment:Experience at Shanghai Ninth People's Hospital

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Chinese Journal of Plastic and Reconstructive Surgery 2020年第2期2卷 88-92页

作者： xiaoli wu Yating YANG Wei LIU Wenbo WANG Lingling XIA Xiaoqing WANG Qiong ZHAO Zhen GAO Department of Plastic and Reconstructive Surgery Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiP.R.China

Keloids are a notorious fibroproliferative disorder that may cause cosmetic concerns and life *** methods such as surgery,injection,and laser have been used;however,single treatments are at risk of recurrence;therefore,comprehensive therapy is the better ***,we focused on the management of different medical interventions according to subjective and objective conditions of keloid patients and summarized several clinical comprehensive strategies based on our clinical *** original concept of laser combined with radiotherapy was also introduced as a promising method,especially for wide-based pathological scars.

关键词： keloids hypertrophic scar comprehensive treatment laser radiotherapy injection surgery

Direct-to-consumer genetic testing in China and its role in GWAS discovery and replication

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Quantitative Biology 2021年第2期9卷 201-215页

作者： Kang Kang Xue Sun Lizhong Wang Xiaotian Yao Senwei Tang Junjie Deng xiaoli wu WeGene Research Team Can Yang Gang Chen Shenzhen WeGene Clinical Laboratory Shenzhen 518118China WeGene Shenzhen Zaozhidao Technology Co.Ltd.Shenzhen 518042China Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina Hunan Provincial Key Lab on Bioinformatics School of Computer Science and EngineeringCentral South UniversityChangsha 410083China

Background:The direct-to-consumer genetic testing(DTC-GT)industry has exploded in recent years,initiated by market pioneers from the United States and quickly followed by companies from Europe and *** addition to their primary objective of providing ancestry and health information to customers,DTC-GT services have emerged as a valuable data resource for large-scale population and genetics ***:We assessed DTC-GT market leaders in the *** China,user participation in research,and academic reports based on this *** also investigated DTC-GT end-user value by tracing key updates of companies provided via health risk reports and evaluating their predictive *** then assessed the replicability of several genome-wide association studies(GWAS)based on a Chinese DTC-GT ***:As recent entrants to the market,Chinese DTC-GT serv ice providers have published less academic research than their Western counterparts;however,a larger proportion of Chinese users consent to participate in research *** increases in user volume and resultant report updates led to reclassification of some users'polygenic risk levels,but within a reasonable scale and with increased predictive *** among GWAS using the Chinese DTC-GT biobank varied by studied trait,population background,and sample ***:We speculate that the rapid growth in DTC-GT services,particularly in non-Caucasian populations,will yield an important and much-needed resource for biobanking,large-scale genetic studies,clinical trials,and post-clinical applications.

关键词： DTC-GT biobank Chinese population polygenic risk GWAS replication

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张资平小说思想价值与历史影响的再认识

广东社会科学 2006年第6期 150-156页

作者：巫小黎佛山大学中文系

张资平小说以“有意味的形式”生动地呈现出“乡土中国”在资本主义商业化过程中,物质至上的拜金主义思潮对人情感世界销蚀的现代性命题及现代人失去精神家园后的不安与惶惑,艺术地再现了20世纪初期中国社会、历史与人性演进的方方面面... 详细信息

张资平小说以“有意味的形式”生动地呈现出“乡土中国”在资本主义商业化过程中,物质至上的拜金主义思潮对人情感世界销蚀的现代性命题及现代人失去精神家园后的不安与惶惑,艺术地再现了20世纪初期中国社会、历史与人性演进的方方面面,蕴含着反思现代性的意义维度。其具有先锋试验意义的小说文本,为20世纪末的中国文学生产提供了可供借鉴的资源性因素。张氏巨大的文学成就和深远的历史影响与已有的文学史评价极不相称。

关键词：张资平小说叙事结构现代性沉沦救赎自戕

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鲁迅与曾今可及其他

中国现代文学研究丛刊 2007年第3期 283-298页

作者：巫小黎上海师范大学人文与传播学院

1930年代初,曾今可在国难当头之时邀集闲居上海的柳亚子、刘大杰、郁达夫等一群文士,发起了一场“词的解放运动”,宣扬“救国不忘娱乐”的享乐意识,受到鲁迅等人的抨击。本文将这段被湮没在历史烟尘中的文坛往事作了细致的梳理,从文里... 详细信息

1930年代初,曾今可在国难当头之时邀集闲居上海的柳亚子、刘大杰、郁达夫等一群文士,发起了一场“词的解放运动”,宣扬“救国不忘娱乐”的享乐意识,受到鲁迅等人的抨击。本文将这段被湮没在历史烟尘中的文坛往事作了细致的梳理,从文里文外展示出1930年代海上文坛人与文之间错综复杂的关系。

关键词：鲁迅 30年代解放运动享乐意识柳亚子刘大杰郁达夫文坛