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水稻氮素吸收利用与根系特征相互关系的研究进展

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植物生理学报 2024年第3期60卷 441-450页

作者：齐晓丽刘磊崔克辉华中农业大学植物科学技术学院作物遗传改良全国重点实验室农业农村部长江中游作物生理生态与耕作重点实验室武汉430070

水稻(Oryza sativa)根系在氮素吸收和利用过程中起重要作用。本文介绍了水稻氮素吸收和同化过程及根系特征,综述了水稻根系特征对氮素吸收的影响和氮素供应对根系特征的调控,从氮肥吸收利用、根系特征与氮肥互作的角度讨论了今后水稻根... 详细信息

水稻(Oryza sativa)根系在氮素吸收和利用过程中起重要作用。本文介绍了水稻氮素吸收和同化过程及根系特征,综述了水稻根系特征对氮素吸收的影响和氮素供应对根系特征的调控,从氮肥吸收利用、根系特征与氮肥互作的角度讨论了今后水稻根系研究的发展方向,以期为提高水稻氮素吸收利用效率提供理论基础,为氮素高效吸收利用水稻新品种选育工作提供新思路。

关键词：水稻根系形态特征氮素吸收利用氮素同化

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人工智能视域下非遗服饰数字化再现与创新设计研究

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染整技术 2024年第5期46卷 70-75页

作者：亓晓丽东莞职业技术学院创意设计学院广东东莞523808

非遗服饰承载着丰富的历史文化,具有独特的艺术价值,但随着社会的发展逐渐濒临失传,急需借助现代技术手段进行有效保护和创新传承。在信息技术飞速发展的背景下,人工智能已成为推动各领域创新的强大引擎。在非遗服饰的数字化再现与创新... 详细信息

非遗服饰承载着丰富的历史文化,具有独特的艺术价值,但随着社会的发展逐渐濒临失传,急需借助现代技术手段进行有效保护和创新传承。在信息技术飞速发展的背景下,人工智能已成为推动各领域创新的强大引擎。在非遗服饰的数字化再现与创新设计中,人工智能可以辅助建设数字化档案,进行复原和重现,可以利用虚拟现实技术进行互动体验,可以基于机器学习进行设计创新,为非遗服饰的数字化再现与创新设计提供理论指导,切实推动非遗服饰的保护和传承。

关键词：人工智能非遗服饰数字化再现创新设计

基于RegNet-CSAM与ZOA-KELM模型的滚动轴承故障诊断

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振动与冲击 2024年第11期43卷 165-175页

作者：戚晓利王兆俊毛俊懿王志文崔德海赵方祥安徽工业大学机械工程学院安徽马鞍山243032

针对现有深度卷积神经网络对滚动轴承混合故障诊断效果不佳以及模型复杂度过高导致计算成本过大等问题,提出了一种基于RegNet-CSAM与ZOA-KELM模型的滚动轴承故障诊断方法。该模型由RegNet-CSAM网络和ZOA-KELM分类算法组成。首先,将融合... 详细信息

针对现有深度卷积神经网络对滚动轴承混合故障诊断效果不佳以及模型复杂度过高导致计算成本过大等问题,提出了一种基于RegNet-CSAM与ZOA-KELM模型的滚动轴承故障诊断方法。该模型由RegNet-CSAM网络和ZOA-KELM分类算法组成。首先,将融合了通道和空间特征的注意力机制CSAM与组卷积残差模块结合,提升该结构的表征能力,由此构建的RegNet-CSAM网络,模型复杂度为0.48GF;其次,在分类阶段将斑马优化核极限学习机(ZOA-KELM)替代原来网络中使用的Softmax函数完成最后的分类任务。滚动轴承故障诊断试验结果表明,RegNet网络对滚动轴承混合故障样本容易产生误判,CSAM的融入虽将RegNet网络的分类精度进一步提高,但是仍然存在一定程度的滚动轴承混合故障误判问题;而将ZOA-KELM替代Softmax函数后再对RegNet-CSAM网络输出特征进行分类,能够有效识别出滚动轴承的单一和混合故障,准确率达到了99.92%。所提方法对比其他网络,诊断精度最大提升5.02%,模型复杂度最大缩减32倍。

关键词：故障诊断滚动轴承组卷积残差结构注意力机制斑马优化核极限学习机(ZOA-KELM)

连续性静脉-静脉血液滤过联合血液灌流治疗急性重度有机磷中毒的临床观察

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河北医学 2024年第2期30卷 281-286页

作者：漆小莉熊明分陶宁胡建平黄柳四川省遂宁市中心医院急诊科四川遂宁629000

目的:观察连续性静脉-静脉血液滤过(CVVH)联合血液灌流(HP)治疗重度有机磷中毒(ASOPP)的临床疗效。方法:回顾性分析126例ASOPP患者资料,根据治疗方式分为CVVH+HP组(n=60)和HP组(n=66)。观察疗效和治疗情况,记录患者治疗前(T1)及治疗后4h... 详细信息

目的:观察连续性静脉-静脉血液滤过(CVVH)联合血液灌流(HP)治疗重度有机磷中毒(ASOPP)的临床疗效。方法:回顾性分析126例ASOPP患者资料,根据治疗方式分为CVVH+HP组(n=60)和HP组(n=66)。观察疗效和治疗情况,记录患者治疗前(T1)及治疗后4h(T2)、24h(T3)、72h(T4)时血清胆碱酯酶(CHE)水平,比较两组T1、T3时血清炎症因子[白介素-1β(IL-1β)、白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]以及对肝肾损伤相关指标[胱抑素(CysC)、前白蛋白(PA)、高迁移率族蛋白B1(HMGB1)]水平差值,观察并发症发生情况。结果:CVVH+HP组痊愈率为93.33%,高于HP组的78.79%(P0.05)。CVVH+HP组阿托品、氯解磷定用量分别为(143.37±18.72)mg、(10.28±2.62)g,少于HP组的(154.18±21.47)mg、(19.57±4.31)(均P0.05);CVVH+HP组血清IL-1β、IL-6、IL-10、TNF-α、CysC、PA、HMGB1的T1-T3差值大于HP组(均P0.05)。结论:相较于HP单用,CVVH+HP治疗ASOPP可提升治愈率,改善治疗情况,促进血清CHE活性恢复,减轻炎症反应,缓解脏器损伤,且安全性良好,有一定优势。

关键词：有机磷中毒重度血液灌流连续性静脉-静脉血液滤过

Gabapentinoids for the treatment of stroke

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Neural Regeneration Research 2024年第7期19卷 1509-1516页

作者： Ying Zhang Chenyu Zhang xiaoli Yi qi Wang Tiejun Zhang Yuwen Li Department of Pharmacy West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuan ProvinceChina

Gabapentinoid drugs(pregabalin and gabapentin) have been successfully used in the treatment of neuro pathic pain and in focal seizure *** research has demonstrated their potent activities in modulating neurotransmitter release in neuronal tissue,oxidative stress,and inflammation,which matches the mechanism of action via voltage-gated calcium *** this review,we briefly elaborate on the medicinal history and ligand-binding sites of *** systematically summarize the preclinical and clinical research on gabapentinoids in stroke,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,seizures after stro ke,cortical spreading depolarization after stroke,pain after stroke,and nerve regeneration after stro *** review also discusses the potential to rgets of gabapentinoids in stroke;however,the existing results are still unce rtain regarding the effect of gabapentinoids on stroke and related *** preclinical and clinical trials are needed to test the therapeutic potential of gabapentinoids in ***,gabapentinoids have both opportunities and challenges in the treatment of stroke.

关键词： cortical spreading depolarization gabapentinoid intracerebral hemorrhage pain after stroke stroke subarachnoid hemorrhage

Piezoelectric film promotes skin wound healing with enhanced collagen deposition and vessels regeneration via upregulation of PI3K/AKT

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Nano Research 2024年第8期17卷 7461-7478页

作者： qi Xu Wufei Dai Peizhe Li qinglin Li Zhen Gao xiaoli Wu Wei Liu Wenbo Wang Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Research Institute of Plastic Surgery Shandong Second Medical UniversityWeifang 261000China Department of Surgery Air Force Medical CenterPLABeijing 100142China

Skin wounds are common in accidental injuries,and the intricacies of wound repair are closely linked to endogenous electric *** stimulation plays a pivotal role in the restorative processes of skin injuries,encompassing collagen deposition,angiogenesis,inflammation,and *** electrical stimulation therapy replicates and enhances the effects of endogenous wound electric fields by applying an external electric field to the wound site,thereby promoting skin wound *** this study,we developed a self-powered repetitive mechanical impacts-electrical stimulation(RMI-ES)system utilizing a BaTiO3/polydimethylsiloxane(PDMS)piezoelectric composite *** to conventional electrical stimulation devices,the fabricated piezoelectric composite film efficiently harvests energy from the pressure applied by the stimulation device and the tensile force occurring during natural rat *** results demonstrated that piezoelectric stimulation generated by the composite membrane expedited the cell cycle,promoting fibroblast ***,piezoelectric stimulation induced favorable changes in fibroblast gene expression,including increased expression of transforming growth factor-β1(TGF-β1),connective tissue growth factor(CTGF),collagen 1,collagen 3,vascular endothelial growth factor(VEGF),and alpha-smooth muscle actin(α-SMA),while reducing interleukin-6(IL-6)*** analysis revealed that piezoelectric stimulation may induce fibroblast migration,proliferation,and collagen expression by influencing PI3K/AKT serine/threonine kinase(AKT)*** confirmation through the addition of the PI3K inhibitor LY294002 validated that piezoelectric stimulation can regulate the repair process after skin injury through the ***,in vivo results demonstrated that the electric field at the wound site effectively promoted wound healing,reduced inflammation,and stimulated collagen deposition and neova

关键词： BaTiO3/polydimethylsiloxane(PDMS)nano-composite membrane piezoelectrical stimulation skin wound healing collagen deposition PI3K/AKT serine/threonine kinase(AKT)signaling pathway

Optimization of CHARMM force field parameters for the chalcone fragment

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Science China Chemistry 2012年第12期55卷 2580-2586页

作者： ZHANG Hui YAO Yuan qi xiaoli LI ZeSheng College of Chemical and Environmental Engineering Harbin University of Science and TechnologyHarbin 150080China Academy of Fundamental and Interdisciplinary Sciences Department of Chemistry Harbin Institute of Technology Harbin 150080 China Key Laboratory of Cluster Science of Ministry of Education School of Chemistly Beijing Institute of Technology Beijing 100081China

In this work,we developed the CHARMM all-atom force field parameters for the nonstandard biological residue chalcone,followed by the standard protocol for the CHARMM27 force field *** data were generated via ab initio calculations at the MP2/6-31G* and HF/6-31G* *** reference data included interaction energies between water and the model compound F(a fragment of chalcone).Bond,angle,and torsion parameters were derived from the ab initio calculations and renormalized to maintain compatibility with the existing CHARMM27 parameters of standard *** optimized CHARMM parameters perform well in reproducing the target *** expect that the extension of the CHARMM27 force field parameters for chalcone will facilitate the molecular simulation studies of the reaction mechanism of intramolecular cyclization of chalcone catalyzed by chalcone isomerase.

关键词：力场参数参数优化查耳酮从头计算方法相互作用能模型化合物分子内环化查尔酮

Identification of rice cultivars with low brown rice mixed cadmium and lead contents and their interactions with the micronutrients iron,zinc,nickel and manganese

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Journal of Environmental Sciences 2012年第10期24卷 1790-1798页

作者： Bing Li Xun Wang xiaoli qi Lu Huang Zhihong Ye State Key Laboratory for Bio-control and Guangdong Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhou 510006China

Paddy fields in mining areas are usually co-contaminated by a cocktail of mixed toxic heavy metals （e.g., Cd and Pb in Pb/Zn mines）. However, previous studies on rice cultivars screened for effective metal exclusion have mostly focused on individual metals, and have been conducted under pot-trial or hydroponic solution conditions. This study identified rice cultlvars with both low Cd and Pb accumulation under Cd- and Pb-contaminated field conditions, and the interactions of the toxic elements Cd and Pb with the micronutrient elements Fe, Zn, Mn and Ni were also studied. Among 32 rice cultivars tested, there were significant differences in Cd （0.06-0.59 mg/kg） and Pb （0.25-3.15 mg/kg） levels in their brown rice, and similar results were also found for the micronutrient elements. Significant decreases in concentrations of Fe and Mn were detected with increasing Cd concentrations and a significant elevation in Fe, Mn and Ni with increasing Pb concentrations. A similar result was also shown by Cd and Ni. Three cultivars were identified with a combination of low brown rice Cd and Pb, high micronutrient and grain yield （Wufengyou 2168, Tianyou 196 and Guinongzhan）. Present results suggest that it is possible to breed rice eultivars with low mixed toxic element （Cd, Pb） and high micronutrient contents along with high grain yields, thus ensuring food safety and quality.

关键词： rice (Oryza sativa L.) mixed toxic elements micronutrient grain yield

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

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Genes & Diseases 2024年第1期11卷 464-478页

作者： Mengtian Fan Nana Geng Xingyue Li Danyang Yin Yuyou Yang Rong Jiang Cheng Chen Naibo Feng Li Liang xiaoli Li Fengtao Luo Huabing qi qiaoyan Tan Yangli Xie Fengjin Guo Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Laboratory of Stem Cells and Tissue Engineering School of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Department of Orthopedics The 1st Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Wound Repair and Rehabilitation Medicine State Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes,in which the Indian hedgehog(IHH)and parathyroid hormone-related protein-parathyroid hormone-1 receptor(PTHrP-PTH1R)feedback loop is *** inositol-requiring enzyme 1a/X-box-binding protein-1 spliced(IRE1α/XBP1s)branch of the unfolded protein response(UPR)is essential for normal cartilage ***,the precise role of ER stress effector IRE1α,encoded by endoplasmic reticulum to nucleus signaling 1(ERN1),in skeletal development remains ***,we reported that loss of IRE1α accelerates chondrocyte hypertrophy and promotes endochondral bone ***1 acts as a negative regulator of chondrocyte proliferation and differentiation in postnatal growth *** deficiency interrupted PTHrP/PTH1R and IHH homeostasis leading to impaired chondrocyte hypertrophy and ***1s,produced by p-IRE1α-mediated splicing,binds and up-regulates PTH1R and IHH,which coordinate cartilage ***,ER stress cannot be activated normally in ERN1-deficient *** conclusion,ERN1 deficiency accelerates chondrocyte hypertrophy and cartilage mineralization by impairing the homeostasis of the IHH and PTHrP/PTH1R feedback loop and ER ***1 may have a potential role as a new target for cartilage growth and maturation.

关键词： Cartilage development ER stress ERN1 IHH PTHrP/PTH1R