检索结果-南通市图书馆

Carvacrol combined with NIR light-responsive nano-drug delivery system with specific anti-bacteria,anti-inflammation,and immunomodulation for periodontitis

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第5期16卷 7199-7215页

作者： Daorun Hu Congkai Zhang Chao Sun Haijing Bai Jialiang xie Yawen Gu Mengyuan Li Junkai Jiang Aiping Le Jiaxuan Qiu xiaolei Wang Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Nanchang UniversityNanchang 330006China The National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational MedicineNanchang UniversityNanchang 330088China Department of Transfusion Medicine The First Affiliated Hospital of Nanchang UniversityKey Laboratory of Jiangxi Province for Transfusion MedicineThe First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330088China

Bacterial infection,biofilm formation,immune dysfunction are common triggers and aggravators in periodontitis,which render periodontal restoration ***,a strategy with antibacterial,anti-inflammatory,immunoregulatory capacities has great promise in the clinical practice of ***,carvacrol(CA)-based near-infrared(NIR)lightresponsive nano-drug delivery system is developed for the first *** system consists of upconversion nanoparticles(UCNPs,which upconvert 808 nm NIR to blue light),mesoporous silica(mSiO_(2),the carrier channel),hydrophobic CA(blue light response properties).Under the irradiation of 808 nm NIR,owing to the synergy of CA and upconverted blue light,the UCNPs@mSiO_(2)-CA(UCMCs)exhibit the properties of specific anti-bacteria(including anaerobic bacteria),anti-inflammation,and ***,high-throughput sequencing results exhibit that many classic inflammatory immune-related signaling pathways,including the MAPK signaling pathway,tumor necrosis factor(TNF)signaling pathway,IL-17 signaling pathway,are enriched to remodel the immune ***,UCMCs with NIR irradiation accelerate periodontal restoration and serve as promising non-invasive management of ***,this study verifies the feasibility of herbal monomer combined with light-responsive in situ nano-drug delivery system and provides a more effective and reliable strategy for various potential applications of deep tissue diseases.

关键词： anti-bacteria near-infrared light upconversion nanoparticle periodontitis drug delivery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

节能减排背景下的机组组合模型和算法研究

水电能源科学 2009年第3期27卷 154-157,167页

作者：何小磊严正谢毓广上海交通大学电子信息与电气工程学院电气工程系上海200240

在节能减排背景下对机组组合目标函数进行了调整,采用排放价格因子将系统总能耗最小和总排放最小的多目标问题转化为单目标问题,利于全网开展机组组合和经济调度。将多时段的机组组合问题在时间上解耦,转化为单小时的子问题,并采用基于... 详细信息

在节能减排背景下对机组组合目标函数进行了调整,采用排放价格因子将系统总能耗最小和总排放最小的多目标问题转化为单目标问题,利于全网开展机组组合和经济调度。将多时段的机组组合问题在时间上解耦,转化为单小时的子问题,并采用基于内点法的混合整数规划法求解子问题。通过两个算例验证了算法和模型的有效性。

关键词：节能减排机组组合罚函数内点法

Neon-concentration dependent retarding effect on the recrystallization of irradiated tungsten:Experimental analysis and molecular dynamics simulation

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2023年第8期139卷 245-259页

作者： Ting Wang Xiaoyang Wang xiaolei Ma Long Cheng Yue Yuan Wangguo Guo Ke Xu Mi Liu Ziyang xie Liping Guo Guang-Hong Lu School of Physics Beihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China Institute of Nuclear Materials University of Science&Technology BeijingBeijing 100083China Institute of High Energy Physics Chinese Academy of ScienceBeijing 100049China School of Physics and Technology Wuhan UniversityWuhan 430072China

Recrystallization is a critical issue in ITER and future fusion devices as it strongly deteriorates the prop-erties and serving life of tungsten divertor *** this work,we investigated the influence of neon on the recrystallization behavior of tungsten and its underlying mechanism by both experimental anal-ysis and molecular dynamics *** tungsten was irradiated by neon ion with energies of 10 and 100 keV and fluences of 1×10^(18)-1×10^(20)m^(−2),followed by isochronal annealing at various temperatures(1473-2073 K)for 1 *** results indicate that 10 keV neon ion irradiation slightly in-hibits tungsten recrystallization due to the shallow depth distribution of neon(35 nm),whereas 100 keV neon ion irradiation exerts a significant retarding effect on tungsten recrystallization when neon con-centration reaches∼102 *** boundaries can hardly move with neon concentration reaching 400 appm,above which the retarding effect is very strong and varies *** retarded recrystallization is mainly attributed to the pinning effect of neon clusters/bubbles on the grain boundary movement dur-ing *** neon clusters are found to play a predominant role in the retarding effect and the un-clustered neon atoms show a very limited effect on the grain boundary *** comparing the neon effects on recrystallization in this work and helium effects reported in the literature,we found that helium exhibits a relatively stronger recrystallization retarding effect than *** is because helium is more easily to diffuse into grain boundaries and form larger clusters due to its high diffusivity and low self-trapping energy in tungsten,which can greatly impede the migration of grain *** work provides a fundamental insight into the neon-concentration dependent recrystallization retarding effect in tungsten and the corresponding underlying atomic-level mechanisms.

关键词： Tungsten Recrystallization Neon clusters Neon nano-bubbles Grain boundary

ISO 105-N01:1993纺织品耐次氯酸盐漂白色牢度测试方法分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

丝绸 2015年第6期52卷 14-17页

作者：杨晓梅潘璐璐谢晓磊王伶何洁董锁拽达利(中国)有限公司杭州311231 浙江出入境检验检疫局丝类检测中心杭州310012 萧山出入境检验检疫局杭州311208

纺织品耐次氯酸盐漂白色牢度是服装洗护的重要指标,现行的ISO 105-N01:1993测试方法能够在一定程度上评价纺织品耐氯漂的性能。文章对实际操作过程中存在的问题及影响因素进行了研究。结果表明,漂白过程具有时温等效性;测试设备密封性... 详细信息

纺织品耐次氯酸盐漂白色牢度是服装洗护的重要指标,现行的ISO 105-N01:1993测试方法能够在一定程度上评价纺织品耐氯漂的性能。文章对实际操作过程中存在的问题及影响因素进行了研究。结果表明,漂白过程具有时温等效性;测试设备密封性对实验结果有较大的影响。文章还提出了不完全符合标准要求的常规次氯酸钠溶液的配制方法。

关键词：纺织品有效氯漂白色牢度测试方法国际标准

CO_(2)环加成的多相催化剂制备及其应用

在线全文

学校读者我要写书评

暂无评论

当代化工 2024年第5期53卷 1158-1161页

作者：谢卓涵王馨瑶张志智王陶孙潇磊中石化(大连)石油化工研究院有限公司辽宁大连116045

CO_(2)环加成反应制备环状碳酸酯是CO_(2)利用的一种有效途径。制备了一种以氯球为载体、固载咪唑基离子液体的新型多相固体催化剂,催化合成碳酸丙烯酯。在固定床上评价,催化剂表现出良好的催化性能。通过考察温度、反应压力、液时空速... 详细信息

CO_(2)环加成反应制备环状碳酸酯是CO_(2)利用的一种有效途径。制备了一种以氯球为载体、固载咪唑基离子液体的新型多相固体催化剂,催化合成碳酸丙烯酯。在固定床上评价,催化剂表现出良好的催化性能。通过考察温度、反应压力、液时空速、原料比对反应的影响,总结出催化反应的最佳条件为130℃、2 MPa、0.6~0.8 h^(-1)、CO_(2)和环氧丙烷进料物质的量比为2.5∶1。在上述条件下,反应转化率大于95%,选择性大于98%。

关键词： CO_(2) 离子液体催化剂固定床

美国在指导和管理染色体微阵列技术临床应用方面的经验和教训

在线全文

学校读者我要写书评

暂无评论

中华医学遗传学杂志 2021年第5期38卷 419-424页

作者：谢小雷虞京威祁仲夏包黎明沈亦平陈天健李培宁广州医科大学附属第六医院-清远市人民医院产前诊断中心 511500 耶鲁大学医学院遗传系美国纽黑文CT 06511 加州大学旧金山分校实验医学系美国旧金山CA94107 科罗拉多大学医学院病理系美国奥罗拉CO 80045 哈佛大学医学院波士顿儿童医院美国波士顿MA 02115 杜兰大学医学院海伍得遗传中心美国新奥尔良LA70112

染色体微阵列分析(chromosome microarray analysis,CMA)是检测染色体异常和拷贝数变异(copy number variation,CNV)的首选方法。本文介绍了CMA转化为临床应用的技术验证过程、技术标准和指南的建立和更新、以及现行规范下的诊断效果,... 详细信息

染色体微阵列分析(chromosome microarray analysis,CMA)是检测染色体异常和拷贝数变异(copy number variation,CNV)的首选方法。本文介绍了CMA转化为临床应用的技术验证过程、技术标准和指南的建立和更新、以及现行规范下的诊断效果,重点阐述通过对病例系列研究中系统证据回顾的总结,提出CMA临床应用的专家共识和实践资源,并建立和更新一系列相应的技术标准和指南。专家共识和临床实践均支持CMA作为发育及智力障碍、多发性先天缺陷和自闭症检测染色体异常和CNV的首选方法并提供了后续检测的建议,相应的技术标准和指南规范完善了产前及产后组成型CNV的检测并扩展到各类肿瘤获得型CNV的检测。CMA检测显著提高了基因组异常的检出率,但仍需克服自身技术的局限并应对其他新型技术的挑战。美国通过对专家共识、实践资源、标准和指南等文献的指导和管理,使CMA检测为患者及亲属提供了合理有效和安全的诊断服务,为相关遗传病的临床诊断和基础研究提供了可靠的依据,同时为新技术的临床转化提供了参考和借鉴。

关键词：染色体微阵列技术专家共识实践资源技术标准和指南

在线全文

学校读者我要写书评

暂无评论

针灸治疗中老年帕金森病睡眠障碍的系统评价

老年医学与保健 2024年第2期30卷 382-389,402页

作者：谢治国叶青顾思纯胡钰卿秦立云袁晓蕾上海中医药大学附属龙华医院脑病科上海200032

目的系统评价针灸治疗帕金森病(Parkinson's disease,PD)伴睡眠障碍的临床疗效。方法检索中国知网期刊全文数据库(CNKI)、万方学术期刊全文数据库(WANGFANG)、维普中文科技期刊数据库(VIP)、中国生物医学网(CBM)、Web of Science、PubMe... 详细信息

目的系统评价针灸治疗帕金森病(Parkinson's disease,PD)伴睡眠障碍的临床疗效。方法检索中国知网期刊全文数据库(CNKI)、万方学术期刊全文数据库(WANGFANG)、维普中文科技期刊数据库(VIP)、中国生物医学网(CBM)、Web of Science、PubMed、Embase各大数据库。检索时间2018年1月1日-2024年3月1日;检索关于针灸治疗PD的随机对照临床试验。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4软件进行临床系统分析。结果共纳入22项临床研究,20篇中文文献,2篇英文文献,纳入研究总受试者1606例。临床系统分析针灸结合其他疗法较对比单纯其他疗法改善情况结果显示:(1)观察组临床总有效率高于对照组,差异有统计学意义[RR=1.29,95%CI(1.09,1.54),P<0.05];(2)观察组降低患者的PSQI评分优于对照组,差异有统计学意义[MD=-2.50,95%CI(-3.49,-1.50),P<0.05];(3)相比于对照组,观察组提高患者的PDSS评分更具优势,差异有统计学意义[MD=11.13,95%CI(7.67,14.58),P<0.05];(4)观察组降低患者的UPDRS评分优于对照组,差异有统计学意义[MD=-4.57,95%CI(-5.89,-3.25),P<0.05];(5)观察组降低患者的PDQ-39评分优于对照组,差异有统计学意义[MD=-7.85,95%CI(-12.78,-2.92),P<0.05];(6)针灸能够降低PD睡眠障碍患者中医症状分级量化积分,差异有统计学意义[MD=-1.94,95%CI(-2.78,-1.10),P<0.05];(7)观察组降低患者的NMSS评分优于对照组,差异有统计学意义[MD=-6.84,95%CI(-10.60,-3.07),P<0.05]。结论针灸对PD患者的睡眠质量具有明显的改善作用,可提高患者的生活质量,且不良反应较少。

关键词：老年 PD 失眠针灸随机对照试验系统综述

在线全文

学校读者我要写书评

暂无评论

基于非线性滑模面的永磁同步电机变结构控制

微电机 2015年第3期48卷 48-52页

作者：曹玲芝谢晓磊任菊萍郑州轻工业学院电气信息工程学院郑州450002 孟州市电力公司河南孟州454750

目前大多采用饱和函数来削弱永磁同步电机滑模变结构控制的抖振,并且饱和函数的边界层厚度越大削弱抖振的能力越强,但这样会降低电机控制的最终精度。为了解决在采用饱和函数时,削弱抖振和提高控制精度之间的矛盾,提出了非线性滑模面。... 详细信息

目前大多采用饱和函数来削弱永磁同步电机滑模变结构控制的抖振,并且饱和函数的边界层厚度越大削弱抖振的能力越强,但这样会降低电机控制的最终精度。为了解决在采用饱和函数时,削弱抖振和提高控制精度之间的矛盾,提出了非线性滑模面。把非线性滑模面和饱和函数结合起来,既能很好地削弱抖振又能提高控制的精度,最后通过分析仿真证明了这点。

关键词：非线性滑模面变结构控制饱和函数

The onset of deep recycling of supracrustal materials at the Paleo-Mesoarchean boundary

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第3期9卷 110-118页

作者： xiaolei Wang Ming Tang Jeff Moyen Di Wang Alfred Kr?ner Chris Hawkesworth Xiaoping Xia Hangqiang xie Carl Anhaeusser Axel Hofmann Junyong Li Linsen Li State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University School of Earth and Space Sciences Peking University Laboratoire Magmas et Volcans UMR6524 Université de LyonUJM-UCA-CNRS-IRD Institut für Geowissenschaften Universit?t Mainz Department of Earth Sciences University of Bristol State Key Laboratory of Isotope Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences SHRIMP Center Institute of Geology Chinese Academy of Geological Sciences Economic Geology Research Unit University of the Witwatersrand Department of Geology University of Johannesburg

The recycling of supracrustal materials, and in particular hydrated rocks, has a profound impact on mantle composition and thus on the formation of continental crust, because water modifies the physical properties of lithological systems and the mechanisms of partial melting and fractional fractionation. On the modern Earth, plate tectonics offers an efficient mechanism for mass transport from the Earth’s surface to its interior, but how far this mechanism dates back in the Earth’s history is still uncertain. Here, we use zircon oxygen(O) isotopes to track recycling of supracrustal materials into the magma sources of early Archean igneous suites from the Kaapvaal Craton, southern Africa. The mean δ18O values of zircon from TTG(tonalite–trondhjemite–granodiorite) rocks abruptly increase at the Paleo-Mesoarchean boundary(ca.3230 million years ago; Ma), from mantle zircon values of 5‰–6‰ to approaching 7.1‰, and this increase occurs in ≤3230 Ma rocks with elevated Dy/Yb ratios. The18O enrichment is a unique signature of low-temperature water–rock interaction on the Earth’s surface. Because the later phase was emplaced into the same crustal level as the older one and TTG magmas would derive from melting processes in the garnet stability field(>40 km depth), we suggest that this evident shift in TTG zircon O isotopic compositions records the onset of recycling of the mafic oceanic crust that underwent seawater hydrothermal alteration at low temperature. The onset of the enhanced recycling of supracrustal materials may also have developed elsewhere in other Archean cratons and reflects a significant change in the tectonic realm during craton formation and stabilization, which may be important processes for the operation of plate tectonics on early Earth.

关键词： zircon oxygen isotopes TTG plate tectonics deep recycling Paleo-Mesoarchean boundary