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A 7-year-old girl with giant congenital biliary dilatation

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 298-299页

作者： xiaolei xu Cancan Gao Lizhen Zhu Xiaobin Feng Haining Fan Department of Hepatobiliary and Pancreatic Surgery Affiliated Hospital of Qinghai UniversityXiningChina School of Clinical Medicine Tsinghua UniversityBeijingChina Qinghai Research Key Laboratory for Echinococcosis XiningChina Center of Hepatobiliary Pancreatic Disease Beijing Tsinghua Changgung HospitalBeijingChina Department of General Medicine PLA Air Force Medical HospitalBeijingChina

A 7-year-old girl presented to our out-patient clinic with complaints of abdominal mass and pain with yellowish skin for over 3 *** patient was also accompanied by clinical manifestations such as nausea and vomiting,skin itching and clay-colored *** denied any past history of gastrointestinal bleeding or *** revealed a non-tender swelling as it moved with breathing(Panel A).

关键词： congenital nausea vomiting

Experimental study on sound preferences for dynamic waterscapes

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Chinese Journal of Acoustics 2019年第4期38卷 403-419页

作者： WANG Yaping LIU Qi xu xiaolei WANG Yu School of Architecture and Urban Planning Shandong Jianzhu University

In this study,the soundscape data on the dynamic waterscapes from different geographical environments were first ***,the Likert 5-point scale and laboratory experiments were adopted to study the relationships between the waterscape sound preferences and physical characteristics,namely the visual preference of waterscape,environment,and *** was found that under single-sound listening,the sound preference had significant negative correlation with A-weighted SPL of waterscape sound(rp=-0.981,p<0.01) and had significant positive correlation with instantaneous variability(rp=0.720,p<0.05).Moreover,the spectral centroid also had significant negative correlation with the sound preference(rp=-0.867,p<0.01),when it had significant correlation with A-weighted SPL and instantaneous *** and environmental videos without sound were projected and their visual preferences were *** sound preferences were evaluated simultaneously with its *** was found that waterscapes and environments with higher visual preference could evidently improve the sound preference for waterscape flowing at high flow velocity,whereas those with lower visual preference could reduce the sound preference for waterscape flowing at low flow *** and female subjects had significant differences in the evaluation,and sound preferences for Heihu Spring made by local students were higher than that made by non-local ***,waterscape sound preference was influenced by physical indices,visual factors,and participants.

关键词： visual sound waters

Comparing Attentional Bias for Money in Different Money Profiles Using a Cueing Paradigm

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Psychology Research 2017年第6期7卷 344-352页

作者： ZHENG Yong xu xiaolei Southwest University Chongqing China University of Electronic Science and Technology of China Chengdu China

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肺嗜酸性粒细胞增多症病因分类及诊断

中华实用儿科临床杂志 2024年第8期39卷 617-621页

作者：徐筱蕾徐保平国家儿童医学中心国家呼吸系统疾病临床医学研究中心首都医科大学附属北京儿童医院呼吸科中国医学科学院儿童危重感染诊治创新单元儿科重大疾病研究教育部重点实验室北京100045

肺嗜酸性粒细胞增多症是一组肺部嗜酸性粒细胞增多的异质性疾病,存在多种病因,可导致单纯肺部受累,也可出现全身多系统病变。目前对肺嗜酸性粒细胞增多症所涵盖的疾病范围、分类存在争议,且不同疾病的诊治、预后存在差异。现就肺嗜酸性... 详细信息

肺嗜酸性粒细胞增多症是一组肺部嗜酸性粒细胞增多的异质性疾病,存在多种病因,可导致单纯肺部受累,也可出现全身多系统病变。目前对肺嗜酸性粒细胞增多症所涵盖的疾病范围、分类存在争议,且不同疾病的诊治、预后存在差异。现就肺嗜酸性粒细胞增多症的病因分类、诊断思路进行综述,旨在提高临床医师对相关疾病的认识。

关键词：肺嗜酸性粒细胞增多症分类临床特点诊断

LysR family factor PltR positively regulates Pyoluteorin production in a pathway-specific manner in Pseudomonas sp. M18

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Science China(Life Sciences) 2007年第4期50卷 518-524页

作者： YAN An, WANG xiaolei, ZHANG xueHong & xu YuQuan Key Laboratory of Microbial Metabolism of Education Ministry, College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China Key Laboratory of Microbial Metabolism of Education Ministry College of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai 200240 China

The pltR gene, coding a putative LysR-type regulator, was identified upstream Plt biosynthetic gene cluster in Pseudomonas sp. M18 using bioinformatics technology. The null mutation of pltR resulted in mutant M18TRG (pltR::Gm) by recombination and its Plt (Pyoluteorin) production declined to 30% while PCA (Phenazine-1-carboxylic acid) production remained unchanged as compared with the wild-type M18 grown in King’s Medium B. After complementation, Plt production of mutant M18TRG was restored to the level in wild-type M18. Overexpression of pltR in M18 led to 13-fold enhancement of Plt produc-tion over the wild-type M18 strain. However, PCA production was unchanged under this condition. These data suggested that PltR was a positive regulator on Plt production. Plt itself, however, could not regulate expression of pltR. Expression of the plt-lacZ transcriptional fusion in mutant M18TRG de-clined obviously as compared with the wild-type M18, which further proved that PltR could regulate expression of Plt biosynthetic genes at the transcriptional level. In addition, the investigation on the pltR expression in gacA mutant M18G and rsmA mutant M18R disclosed that PltR was involved in the positive regulation of gacA on Plt production while being excluded from the negative control caused by rsmA.

关键词： LysR family Pseudomonas sp. M18 Pyoluteorin PltR transcriptional promotion

The Impact of Policy on the Clustering of the Blockchain Industry Evidence from GMM Estimates

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国际计算机前沿大会会议论文集 2022年第2期 465-474页

作者： xiaolei xu Zhen Wu Xiaotuo Qiao Yuxi Zhang Haifeng Guo National Internet Emergency Center CNCERT/CCBeijing 100044China School of Finance Zhongnan University of Economics and LawWuhan 430073China Department of Finance School of ManagementHarbin Institute of TechnologyHarbin 150001China School of Finance Southwestern University of Finance and EconomicsChengdu 610000China

Although local governments in China are encouraging the development of blockchain technology,the regional clustering of the blockchain industry still shows obvious *** use blockchain industry-related data during the period 2012–2019 to calculate the blockchain industrial clustering of each province in *** find that the clustering state of the blockchain industry is quite different from the state of other industries and the situation of economic development in the same *** less-developed regions,the blockchain industry is more prominent,which may benefit from local government *** conduct an empirical analysis on the relationship between blockchain industrial clustering and regional government management using the generalized method of moments(GMM)of a dynamic *** results show that government management has a positive promoting effect on local blockchain industrial clustering as a whole,among which the promotion from economy,technology,infrastructure and policy is more significant.

关键词： Blockchain industrial clustering Government management GMM method

Study on the Diffraction Patterns of α"-Fe_(16)N_2 with Jack-1 and Jack-2 Structural Parameters

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Journal of Materials Science & Technology 2000年第4期16卷 362-366页

作者： Zhiquan LIU and Douxing LI (Laboratory of Atomic Imaging of Solids, Institute of Metal Research, CAS, Shenyang 110015, China) xiaolei xu, Liang WANG and Zukun HEI (Institute of Materials and Technology, Dalian Maritime University, Dalian 116026, China) Laboratory of Atomic Imaging of Solids Institute of Metal Research CAS Shenyang 110015 China Institute of Materials and Technology Dalian Maritime University Dalian 116026 China

Two body centered tetragonal (bet) crystal structures of α'-Fe_(16)N_2 with x=0.25, z=0.3125 (Jack-1) and x=0.222, z=0.306 (Jack-2) respectively, were analyzed theoretically with EMS software package. The simulation of diffraction patterns indicates that both diffraction patterns of the same axis in these two structures obey bcc extinction rule. The conclusion is also obtained from the analyses of the diffracted waves. α'-Fe_(16)N_2 precipitates in the diffusion layer of ion-nitrided α-iron have been studied with transmission electron microscope (TEM). We have distinctly observed the electron diffraction patterns of α'-Fe_(16)N_2 in [100], [111], [110], [011], [210], [021], [311], [113], [331] and [133] zone axes with perfect symmetry, which indicate the parallel orientation relationship with α matrix:α'//α'// {100}.α'// {100}ｔα. The analyses of diffraction patterns, which obey bcc extinction rule, verify the bct structure of α'-Fe_(16)N_2 discovered by X-ray diffraction.

关键词： Study on the Diffraction Patterns of Jack N2 with Jack-1 and Jack-2 Structural Parameters Fe

考虑品牌忠诚度的追随品跨周期质量与定价决策

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西南交通大学学报 2020年第5期55卷 980-987页

作者：徐孝蕾周建亨东华大学旭日工商管理学院上海200051 上海第二工业大学经济与管理学院上海201209

国际知名时尚品牌通常以其较高的质量和独特的文化价值吸引和培育众多忠诚顾客,国内同类本土品牌在追随时面临顾客黏性以及策略性消费行为的影响,如何突破既有的壁垒,吸引策略型顾客购买性价比高的本土品牌产品成为了重要课题.为此,基... 详细信息

国际知名时尚品牌通常以其较高的质量和独特的文化价值吸引和培育众多忠诚顾客,国内同类本土品牌在追随时面临顾客黏性以及策略性消费行为的影响,如何突破既有的壁垒,吸引策略型顾客购买性价比高的本土品牌产品成为了重要课题.为此,基于时尚产品价值衰减的假设,构建了两周期竞争企业的策略性博弈模型,分析了追随企业该如何决策追随品的质量与价格.研究表明:原品顾客忠诚度越高,对其需求越有利,但对其利润却不总是有利;给定原品贬值程度,若消费者策略性较弱,追随品的利润反而可能随原品忠诚度递增,这是因为追随品价格随顾客忠诚度递增的正效应大于市场需求随之递减的负效应,促使追随品利润递增;作为追随品,收益并不是随与原品的相似度单调递增,应当保留一定程度的品牌原创性才能实现利润最大化.

关键词：顾客忠诚度顾客策略行为产品相似度

Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration

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Journal of Molecular Cell Biology 2021年第1期13卷 41-58页

作者： Xiangwen Peng Kaa Seng Lai Peilu She Junsu Kang Tingting Wang Guobao Li Yating Zhou jianjian Sun Daqing Jin xiaolei xu Lujian Liao Jiandong Liu Ethan Lee Kenneth D.Poss Tao P.Zhong State Key Laboratory of Genetic Engineering School of Life SciencesZhong Shan HospitalFudan UniversityShanghai 200438China Shanghai Key Laboratory of Regulatory Biology Institute of Molecular MedicineEast China Normal University School of Life SciencesShanghai 200241China Department of Cell Biology Duke University Medical CenterDurhamNC 27710USA Department of Biochemistry and Molecular Biology Mayo ClinicRochesterMN 55905USA Department of Pathology and Laboratory Medicine McAllister Heart InstituteUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Developmental and Cell Biology Vanderbilt University School of MedicineNashvilleTN 37232USA T These authors share first authorship.

Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes(CMs).However,the signaling mechanisms by which injury induces CM renewal remain incompletely ***,we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors,including Dickkopf 1(Dkkl),Dkk3,secreted Frizzled-related protein 1(sFrpl),and sFrp2,in cardiac tissue adjacent to injury *** blocking of Wnt activity via Dkkl overexpression enhances CM proliferation and heart regeneration,whereas ectopic activation of Wnt8 signaling blunts injury-induced CM dedifferentiation and *** Wnt signaling is dampened upon injury,the cytoplasmic β-catenin is unexpectedly increased at disarrayed CM sarcomeres in myocardial wound *** analyses indicated that p21-activated kinase 2(Pak2)is induced at regenerating CMs,where it phosphorylates cytoplasmic β-catenin at Ser 675 and increases its stability at disassembled ***-specific induction of the phospho-mimeticβ-catenin(S675E)enhances CM dedifferentiation and sarcomere disassembly in response to ***,inactivation of Pak2 kinase activity reduces the Ser 675-phosphorylatedβ-catenin(pS675-β-catenin)and attenuates CM sarcomere disorganization and dedifferentiation・Taken together,these findings demonstrate that coordination of Wnt signaling inhibition and Pak2/pS675-βYatenin signaling enhances zebrafish heart regeneration by supporting CM dedifferentiation and proliferation.

关键词： heart regeneration Wnt signaling PAK2 kinase cardiomyocyte proliferation cardiomyocyte dedifferentiation zebrafish