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Food Science and Human Wellness 2023年第2期12卷 662-668页

作者： Fei Pei Wen Li xiaolei ni Xinyang Sun Yijun Yao Yong Fang Wenjian Yang Qiuhui Hu College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing Nanjing University of Finance and EconomicsNanjing 210023China Department of Food and Human Nutritionl Sciences University of ManitobaWinnipeg MB R3T 2N2Canada

In the present study,the effects of cooked rice(CR)with added fructo-oligosaccharide(FOS)on faecal flora were studied by a simulated in vitro digestion and fermentation method.The total carbohydrate content,p H,and s hort-chain fatty acids(SCFAs)were determined during in vitro digestion and fermentation.The change in the bacterial phase distribution after the fermentation was also analysed.The results showed that t he total carbohydrate content of the CR with added FOS(FCR)significantly decreased during the simulated digestion.Meanwhile,the p H of the FCR decreased and the SCFAs concentration increased significantly compared to those of the CR during the simulated fermentation.In addition,the FCR showed the advantage of promoting beneficial bacteria,such as Bifidobacterium and Lactobacillus,and inhibiting harmful bacteria,such as Bacteroides and Klebsiella compared to the CR.Therefore,the FOS as a prebiotic could be recommended to produce the high-quality healthy rice food.

关键词： Fructo-oligosaccharide In vitro Fermentation Rice Short-chain fatty acids Bacterial phase distribution

Ethanol steam reforming over ni/ZSM-5 nanosheet for hydrogen production

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Chinese Journal of Chemical Engineering 2024年第3期67卷 247-256页

作者： Porapak Suriya Shanshan Xu Shengzhe Ding Sarayute Chansai Yilai Jiao Joseph Hurd Daniel Lee Yuxin Zhang Christopher Hardacre Prasert Reubroycharoen xiaolei Fan Department of Chemical Engineering School of EngineeringThe University of ManchesterManchester M139PLUnited Kingdom Program of Petrochemistry and Polymer Science Faculty of ScienceChulalongkorn UniversityBangkok10330Thailand Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Liaoning Academy of Materials Shenyang 110167China Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals(CBRC) andDepartment of Chemical TechnologyFaculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Nottingham ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo315100China

Compared to reforming reactions using hydrocarbons,ethanol steam reforming(ESR)is a sustainable alternative for hydrogen(H_(2))production since ethanol can be produced sustainably using biomass.This work explores the catalyst design strategies for preparing the ni supported on ZSM-5 zeolite catalysts to promote ESR.Specifically,two-dimensional ZSM-5 nanosheet and conventional ZSM-5 crystal were used as the catalyst carriers and two synthesis strategies,i.e.,in situ encapsulation and wet impregnation method,were employed to prepare the catalysts.Based on the comparative characterization of the catalysts and comparative catalytic assessments,it was found that the combination of the in situ encapsulation synthesis and the ZSM-5 nanosheet carrier was the effective strategy to develop catalysts for promoting H_(2) production via ESR due to the improved mass transfer(through the 2-D structure of ZSM-5 nanosheet)and formation of confined small ni nanoparticles(resulted via the in situ encapsulation synthesis).In addition,the resulting ZSM-5 nanosheet supported ni catalyst also showed high ni dispersion and high accessibility to ni sites by the reactants,being able to improve the activity and stability of catalysts and suppress metal sintering and coking during ESR at high reaction temperatures.Thus,the ni supported on ZSM-5 nanosheet catalyst prepared by encapsulation showed the stable performance with~88% ethanol conversion and~65% H_(2) yield achieved during a 48-h longevity test at 550-C.

关键词： ZSM-5 nanosheet In situ encapsulation ni catalyst Ethanol steam reforming Hydrogen production

左侧乳腺癌保留乳房手术后不同腋窝勾画方法的剂量学特点

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中华肿瘤防治杂志 2024年第9期31卷 563-568页

作者：倪文婕王秀楠葛永青刘骁蕾穆晓峰首都医科大学附属北京世纪坛医院放疗科北京100038

目的评估左侧乳腺癌保留乳房手术后美国肿瘤放射治疗协作组(RTOG)和欧洲放射肿瘤学会(ESTRO)指南腋窝勾画方法的剂量学特点,比较其优缺点,为临床提供参考.方法选取2020-09-01-2021-10-31首都医科大学附属北京世纪坛医院放疗科收治的16... 详细信息

目的评估左侧乳腺癌保留乳房手术后美国肿瘤放射治疗协作组(RTOG)和欧洲放射肿瘤学会(ESTRO)指南腋窝勾画方法的剂量学特点,比较其优缺点,为临床提供参考.方法选取2020-09-01-2021-10-31首都医科大学附属北京世纪坛医院放疗科收治的16例左侧乳腺癌保留乳房手术后患者,根据ESTRO和RTOG指南分别勾画腋窝淋巴引流区和全乳.ESTRO指南腋窝2组和胸肌间淋巴引流区合并勾画,并命名为腋窝Ⅱ组,腋窝3组命名为腋窝Ⅲ组,第4组淋巴结命名为锁骨上区,分别设计PTV-E(ESTRO指南)和PTV-R(RTOG指南)计划,处方剂量为50 Gy/25 f,记录各计划相关剂量学参数.应用SPSS 23.0软件,两组间比较采用配对t检验.结果ESTRO和RTOG指南的腋窝Ⅱ组体积分别为(46.0±11.1)cm^(3)和(16.6±4.7)cm^(3)(t=12.461,P<0.001),左锁骨上体积分别为(11.5±2.6)cm^(3)和(29.1±7.4)cm^(3),t=-9.465,P<0.001.PTV-E计划的患侧肺Dmean、V5、V20和V3.分别为(8.9±0.9)Gy、(40.2±3.2)%、(13.9±2.5)%和(8.7±2.0)%,PTV-R计划分别为(8.2±1.0)Gy、(37.6±4.1)%、(12.1±2.4)%和(7.6±2.0)%,均P<0.05;PTV-E和PTV-R计划甲状腺平均剂量分别为(11.4±7.4)Gy和(27.3±4.2)Gy,t=-7.392,P<0.001;臂丛神经最大剂量分别为(54.4±0.7)Gy和(54.3±1.0)Gy(t=0.122,P=0.904),V30分别为(32.1±11.1)%和(73.5±13.2)%(t=-7.964,P<0.001),V50分别为(20.7±8.9)%和(31.0±17.8)%,t=-2.284,P=0.037.结论两种指南勾画方法危及器官受照剂量均满足临床需要,ESTRO指南勾画的锁骨上淋巴引流区更小,临近的甲状腺及臂丛神经受照剂量更低.

关键词：乳腺肿瘤/放射疗法腋窝淋巴结/放射疗法靶区勾画指南剂量学

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宇航级磁阻尼吸振器试验研究

低温工程 2024年第2期 68-77页

作者：张银倪竹青罗高乔王波吴维薇姚晓蕾刘婷低温技术安徽省重点实验室合肥230088 中国电子科技集团公司第十六研究所合肥230088

为了解决空间站低温存储装置用斯特林制冷机振动难题,设计并开发了一款宇航级磁阻尼吸振器及其保护装置,对吸振器的频率适应性、不同样品质量减振性能及宇航级环境适应性开展了试验研究。试验结果表明:磁阻尼吸振器的吸振频率宽度为0.6 ... 详细信息

为了解决空间站低温存储装置用斯特林制冷机振动难题,设计并开发了一款宇航级磁阻尼吸振器及其保护装置,对吸振器的频率适应性、不同样品质量减振性能及宇航级环境适应性开展了试验研究。试验结果表明:磁阻尼吸振器的吸振频率宽度为0.6 Hz,轴向基频加速度维持在50 mg以内;吸振器在驱动频率0.4 Hz范围内轴向基频加速度维持在30 mg以内;样品质量0—10 kg范围内吸振器对样品质量不敏感,制冷机基频、二阶及时域随样品质量逐渐增加变化较小;制冷机及吸振器通过了宇航级力学环境适应性。力学试验前后,主振方向基频、二阶和时域加速度无明显变化,表明在力学试验前后的吸振器减振性能无变化。

关键词：宇航级斯特林制冷机磁阻尼吸振器频率适应性

Combined control of fluid adsorption capacity and initial permeability on coal permeability

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International Journal of Coal Science & Technology 2022年第6期9卷 127-137页

作者： xiaolei Liu Jianping Wei Guoying Wei Caifang Wu Cao Liu Xiaoming ni State Key Laboratory Cultivation Base for Gas Geology and Gas Control Henan Polytechnic University454000 JiaozuoHenanChina College of Safety Science and Engineering Henan Polytechnic University454000 JiaozuoHenanChina State Collaborative Innovation Center of Coal Work Safety and Clean-efficiency Utilization 454000 JiaozuoHenanChina Key Laboratory of Coalbed Methane Resource and Reservoir Formation Process Ministry of EducationSouth Jiefang Road221008 XuzhouJiangsuChina Collaborative Innovation Center of Coalbed Methane(Shale Gas)in Central Plains Economic Zone 454000 JiaozuoChina

The variations of strain and permeability of coal were systematically studied through the physical simulation of N2 and water injection.The effects of fluid adsorption capacity and initial permeability on strain,permeability and the dominant effect of pore pressure were discussed.The adsorption strain and strain rate of coal during water injection are significantly higher than those during N2 injection.An edge of free adsorption exists in the early phase of N2 and water injection,which is related to fluid saturation.Within this boundary,the strain rate and pore pressure are independent.Moreover,the injec-tion time of initial stage accounts for about 20%of the total injection time,but the strain accounts for 70%of the total strain.For water injection,this boundary is about half of water saturation of coal.Besides,the influence of pore pressure on permeability is complex,which is controlled by adsorption capacity and initial permeability of coal.When the initial permeability is large enough,the effect of adsorption strain on permeability is relatively weak,and the promoting effect of pore pressure on fluid migration is dominant.Therefore,the permeability increases with increasing pore pressure.When the initial permeability is relatively low,the pore pressure may have a dominant role in promoting fluid migration for the fluid with weak adsorption capacity.However,for the fluid with strong adsorption capacity,the adsorption strain caused by pore pressure may play a leading role,and the permeability reduces first and then ascends with increasing pore pressure.

关键词： Initial permeability Adsorption capacity Free adsorption Pore pressure Coal strain

Mother knows best:reproductive regulation of caste ratio in a social hemipteran

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Insect Science 2023年第2期30卷 582-586页

作者： Hui Zhang Qian Liu Kexue Chen Xueqi ni Zhentao Cheng Gexia Qiao xiaolei Huang State Key Laboratory of Ecological Pest Control for Fujan and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhouChina Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijingChina

Dear Editor,The reproductive division of labor between reproductive and non-reproductive castes is regarded as a hallmark of the evolution of eusociality and is vital to the ecological success of social insects(Wilson,1971;Wilson&Holldobler,2005).The social systems of hymenopterans and termites have attracted much attention;however,social organization has also been found in some tiny aphids of the Hemiptera.

关键词： has Mother however

Identification of Bulbocodin D and C as novel STAT3 inhibitors and their anticancer activities in lung cancer cells

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Chinese Journal of Natural Medicines 2023年第11期21卷 842-851页

作者： HE Xinyu FU Jiarui LYU Wenyu HUANG Muyang MO Jianshan CHENG Yaxin XU Yulian ZHENG Lijun ZHANG xiaolei QI Lu ZHANG Lele ZHENG Ying HUANG Mingqing ni Lin LU Jinjian State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Plant Protection Fujian Agriculture and Forestry UniversityFuzhou 350002China National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation Guangdong Key Laboratory of Chiral Molecule and Drug DiscoverySchool of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou 510006China College of Life Sciences China Jiliang UniversityHangzhou 310018China Department of Pharmacy Fujian Medical University Union HospitalFuzhou 350100China Department of Pathology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China School of Basic Medical Sciences Chengdu UniversityChengdu 610106China College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350003China Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoMacao 999078China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research University of MacaoMacao 999078China

Cancer stands as one of the predominant causes of mortality globally, necessitating ongoing efforts to develop innovative therapeutics. Historically, natural products have been foundational in the quest for anticancer agents. Bulbocodin D (BD) and Bulbocodin C (BC), two bibenzyls derived from Pleione bulbocodioides (Franch.) Rolfe, have demonstrated notable in vitro anticancer activity. In human lung cancer A549 cells, the IC50s for BD and BC were 11.63 and 11.71 μmol·L^(−1), respectively. BD triggered apoptosis, as evidenced by an upsurge in Annexin V-positive cells and elevated protein expression of cleaved-PARP in cancer cells. Furthermore, BD and BC markedly inhibited the migratory and invasive potentials of A549 cells. The altered genes identified through RNA-sequencing analysis were integrated into the CMap dataset, suggesting BD’s role as a potential signal transducer and activator of transcription 3 (STAT3) inhibitor. SwissDock and MOE analyses further revealed that both BD and BC exhibited a commendable binding affinity with STAT3. Additionally, a surface plasmon resonance assay confirmed the direct binding affinity between these compounds and STAT3. Notably, treatment with either BD or BC led to a significant reduction in p-STAT3 (Tyr 705) protein levels, regardless of interleukin-6 stimulation in A549 cells. In addition, the extracellular signal-regulated kinase (ERK) was activated after BD or BC treatment. An enhancement in cancer cell mortality was observed upon combined treatment of BD and U0126, the MEK1/2 inhibitor. In conclusion, BD and BC emerge as promising novel STAT3 inhibitors with potential implications in cancer therapy.

关键词： Cancer Natural products Bulbocodin D Bulbocodin C STAT3 ERK

Solid–liquid Interdiffusion Bonding of Cu/Sn/ni Micro-joints with the Assistance of Temperature Gradient

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Acta Metallurgica Sinica(English Letters) 2022年第11期35卷 1912-1924页

作者： Yanqing Lai Shi Chen xiaolei Ren Yuanyuan Qiao ning Zhao School of Materials Science and Engineering Dalian Universityof TechnologyDalian 116024China

A novel solid-liquid interdiffusion(SLID)bonding method with the assistance of temperature gradient(TG)was carried out to bonding Cu and ni substrates with Sn as interlayer.The element distribution and grain morphology of interfacial intermetallic compound(IMC)in Cu/Sn/ni micro-joints during both SLID and TG-SLID bonding and in the final Cu/(Cu,ni)_(6)Sn_(5)/ni full IMC micro-joints were analyzed.Under the effect of Cu-ni cross-interaction,interfacial(Cu,ni)_(6)Sn_(5) dominated the IMC growth at all the interfaces.The morphology of the(Cu,ni)_(6)Sn_(5) grains was closely related to ni content with three levels of low,medium and high.The full IMC micro-joints consisted of L-(Cu,ni)_(6) Sn_(5),M-(Cu,ni)_(6)Sn_(5) and H-(Cu,ni)_(6)Sn_(5) grains after SLID bonding or TG-SLID bonding with ni as hot end,while only L-(Cu,ni)_(6)Sn_(5) grains after TG-SLID bonding with Cu as hot end,showing that the direction of TG had a remarkably effect on the growth and morphology of the interfacial(Cu,ni)_(6)Sn_(5) during TG-SLID bonding.Thermodynamic analysis revealed the key molar latent heat and critical ni content between fine-rounded-like(Cu,ni)_(6)Sn_(5) and block-like(Cu,ni)_(6)Sn_(5) were 17,725.4 J and 11.0 at.%at 260℃,respectively.Moreover,the growth kinetic of the interfacial IMC was analyzed in detail during bonding with and without TG.Under the combination of TG and Cu-ni cross-interaction,void-free full IMC micro-joints were fast formed by TG-SLID bonding with Cu as hot end.This bonding method may present a feasible solution to solve the problems of low formation efficiency and inevitable Cu_(3) Sn growth of full IMC joints for 3 D packaging applications.

关键词： 3D packaging Interfacial reaction Full intermetallic compound(IMC)micro-joints Solid–liquid interdiff usion Temperature gradient Cu-ni cross-interaction

Short Cavity DFB Fiber Laser Based Vector Hydrophone for Low Frequency Signal Detection

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Photonic Sensors 2017年第4期7卷 325-328页

作者： xiaolei ZHANG Faxiang ZHANG Shaodong JIANG Li MIN Ming LI Gangding PENG Jiasheng ni Chang WANG Shandong Key Laboratory of Optical Fiber Sensing & Techonology Laser Institute of Shandong Academy of ScienceChina Jinan 250014 China

一个短洞分布式的反馈(DFB ) 纤维激光被用于低频率声学的信号察觉。有不同中央波长的三 DFB 纤维激光一起被锁住与合适的敏感改进设计做三元素的向量水中听音器，它有广泛、重要的应用到为国家防卫的在水下的声学的监视，油，煤气的探... 详细信息

一个短洞分布式的反馈(DFB ) 纤维激光被用于低频率声学的信号察觉。有不同中央波长的三 DFB 纤维激光一起被锁住与合适的敏感改进设计做三元素的向量水中听音器，它有广泛、重要的应用到为国家防卫的在水下的声学的监视，油，煤气的探索等等。由波长阶段解调，在不同频率信号下面的放射激光的波长变化能被解释，并且敏感被测试大约 33 dB re pm/g。频率反应范围从 5 Hz 是相当扁平的到 300 Hz。

关键词： DFB光纤激光器矢量水听器低频信号灵敏度测试中心波长声信号检测分布反馈相位解调

Mechanical property comparisons between CrConi medium-entropy alloy and 316 stainless steels

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Journal of Materials Science & Technology 2022年第13期108卷 256-269页

作者： Xiaoru Liu Hao Feng Jing Wang Xuefei Chen Ping Jiang Fuping Yuan Huabing Li En Ma xiaolei Wu State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China School of Metallurgy Northeastern UniversityShenyang 110819China Center for Alloy Innovation and Design(CAID) State Key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi’an 710049China

We systematically compared the mechanical properties of CrConi,a recently emerged prototypical medium-entropy alloy(MEA)with face-centered-cubic(FCC)structure,with hallmark FCC alloys,in particular,the well-known austenitic 316 L and 316 LN stainless steels,which are also concentrated singlephase FCC solid solutions and arguably next-of-kin to the MEAs.The tensile and impact properties,across the temperatures range from 373 K to 4.2 K,as well as fracture toughness at 298 K and 77 K,were documented.From room temperature to cryogenic temperature,all three alloys exhibited similarly good mechanical properties;CrConi increased its tensile uniform elongation and fracture toughness,which was different from the decreasing trend of the 316 L and 316 LN.On the other hand,the stainless steels showed higher fracture toughness than CrConi at all temperatures.To explain the differences in macroscopic mechanical properties of the three alloys,microstructural hardening mechanisms were surveyed.CrConi MEA relied on abundant mechanical twinning on the nanoscale,while martensitic transformation was dominant in 316 L at low temperatures.The deformation mechanisms in the plastic zone ahead of the propagating crack in impact and fracture toughness tests were also analyzed and compared for the three alloys.

关键词： Medium-entropy alloy Austenite stainless steel Strain hardening Ductility Fracture toughness Charpy impact toughness