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Advancing electrochemical drilling process via coupling of flow field and electric field in pulsating state generated by a novel tube tool

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Chinese Journal of Aeronautics 2024年第4期37卷 542-555页

作者： Liang chenG xiaolei chen Zhisen YE Yongjun ZHANG State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006China Guangdong Key Laboratory of Advanced Manufacturing Technology of Marine Energy Equipment Guangdong University of TechnologyGuangzhou 510006China Guangzhou Key Laboratory of Nontraditional Machining and Equipment Guangdong University of TechnologyGuangzhou 510006China

This paper introduces an improvement to electrochemical drilling process by coupling flow field and electric field in pulsating state. A novel tube with half-wedged shape at the end(HW-tube) is prepared, with both sidewall and wedged part of the HW-tube insulated. Only the flat part is utilized to provide electric field for electrochemical drilling. By rotating the HW-tube, both flow field and electric field in pulsating state are generated, alternating in different positions within the inter-electrode gap(IEG). The pulsating flow field enhances the mass transfer process, while pulsating electric field disperses material dissolution process and distribution of electrolytic byproducts. Both pulsating fields are coupled at the same frequency, further enhancing the electrochemical drilling process. Simulation results indicate that both flow field and electric field in pulsating state are generated. Compared to the traditional tube, the HW-tube significantly reduces the number of residual particles in IEG, and this number is further reduced by increasing the rotation speed. Experimental results reveal that the surface quality and dimensional uniformity of small hole are improved with HW-tube. With feed rate of 2.22 mm/min, a small hole with diameter of 1.52± 0.017 mm is drilled, resulting in a surface roughness of 0.331 μm.

关键词： Small holes Electrochemical drilling Tools Pulsating flow field Pulsating electric field

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Full-parameter constrained parsimonious subspace identification with steady-state information for DC–DC converters

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Control Theory and Technology 2024年第2期22卷 173-183页

作者： Jie Hou Zhen Yang Taifu Li Huiming Wang Jincheng Jiang xiaolei chen College of Automation Chongqing University of Posts and TelecommunicationsChongqing400065China School of Electrical and Information Engineering Chongqing University of Science and TechnologyChongqing401331China

A full-parameter constrained parsimonious subspace identification method that incorporates the steady-state a priori infor-mation of the system is proposed to model the DC-DC converters.A parsimonious model with fewer parameters is used to represent the system,and then an optimal weighted methods is used to estimate the system parameters matrices by taking into account both dynamical data and steady-state data.Compared with traditional data-driven methods for DC-DC convert-ers,the subspace-based method can simultaneously estimate model structure and parameter with appropriate computational complexity.Moreover,compared with the traditional full-parameter constrained subspace approach,the proposed algorithm can accurately estimate the system parameters with a smaller variance.The experimental results on a DC-DC synchronous buck converter verify the effectiveness and superiority of the proposed method.

关键词： System identification Constrained identification DC-DC converters Subspace identification

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Game-changing insights on vertebral skeletal stem cells in bone metastasis and therapeutic horizons

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Oncology Research 2024年第1期32卷 95-98页

作者： QIUQIANG chen xiaolei ZHAO WENXUE MA Key Laboratory for Translational Medicine The First Affiliated HospitalHuzhou University School of MedicineHuzhou313000China Department of Urology Huaihe Hospital of Henan UniversityKaifeng475004China Department of Medicine Moores Cancer CenterSanford Stem Cell InstituteUniversity of California San DiegoLa Jolla92093USA

Greenblatt and his team have unveiled vertebral skeletal stem cells(vSSCs)as a critical player in the landscape of bone metastasis.This commentary delves into the transformative discoveries surrounding vSSCs,emphasizing their distinct role in bone metastasis compared to other stem cell lineages.We illuminate the unique properties and functions of vSSCs,which may account for the elevated susceptibility of vertebral bones to metastatic invasion.Furthermore,we explore the exciting therapeutic horizons opened by this newfound understanding.These include potential interventions targeting vSSCs,modulation of associated signaling pathways,and broader implications for the treatment and management of bone metastasis.By shedding light on these game-changing insights,we hope to pave the way for novel strategies that could revolutionize the prognosis and treatment landscape for cancer patients with metastatic bone disease.

关键词： Vertebral skeletal stem cells(vSSCs) Stem cell research Metastasis Breast prostate and lung cancers Spinal metastasis Matthew Greenblatt Genetic expressions

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Ultrathin Zincophilic Interphase Regulated Electric Double Layer Enabling Highly Stable Aqueous Zinc‑Ion Batteries

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Nano-Micro Letters 2024年第5期16卷 285-299页

作者： Yimei chen Zhiping Deng Yongxiang Sun Yue Li Hao Zhang Ge Li Hongbo Zeng xiaolei Wang Department of Chemical and Materials Engineering University of Alberta9211‑116 Street NWEdmontonAB T6G 1H9Canada Department of Mechanical Engineering University of Alberta9211‑116 Street NWEdmontonAB T6G 1H9Canada

The practical application of aqueous zinc-ion batteries for large-grid scale systems is still hindered by uncontrolled zinc dendrite and side reactions.Regulating the elec-trical double layer via the electrode/electrolyte interface layer is an effective strategy to improve the stability of Zn anodes.Herein,we report an ultrathin zincophilic ZnS layer as a model regu-lator.At a given cycling current,the cell with Zn@ZnS electrode displays a lower potential drop over the Helmholtz layer(stern layer)and a suppressed diffuse layer,indicating the regulated charge distribution and decreased electric double layer repulsion force.Boosted zinc adsorption sites are also expected as proved by the enhanced electric double-layer capacitance.Consequently,the symmetric cell with the ZnS protection layer can stably cycle for around 3,000 h at 1 mA cm^(-2) with a lower overpotential of 25 mV.When coupled with an I2/AC cathode,the cell demonstrates a high rate performance of 160 mAh g^(-1) at 0.1 A g^(-1) and long cycling stability of over 10,000 cycles at 10 A g^(-1).The Zn||MnO_(2) also sustains both high capacity and long cycling stability of 130 mAh g^(-1) after 1,200 cycles at 0.5 A g^(-1).

关键词： Zinc anode Electric double-layer regulation Multifunction SEI layer Inhibited side reactions and dendrite Rapid kinetics

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Rapid surface texturing to achieve robust superhydrophobicity,controllable droplet impact,and anti-frosting performances

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Friction 2024年第2期12卷 291-304页

作者： Qingwen DAI Lei chen Jiabao PAN Liping SHI Dameng LIU Wei HUANG xiaolei WANG College of Mechanical and Electrical Engineering Nanjing University of Aeronautics&AstronauticsNanjing 210016China State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China School of Mechanical Engineering Anhui Polytechnic UniversityWuhu 241000China School of Mechanical Engineering Anhui University of TechnologyMa’anshan 243032China

Robust superhydrophobic surfaces with excellent capacities of repelling water and anti-frosting are of importance for many mechanical components.In this work,wear-resistant superhydrophobic surfaces were fabricated by curing a mixture of polyurethane acrylate(PUA)coating and 1H,1H,2H,2H-Perfluorodecyltrichlorosilane(HFTCS)on titanium alloy(TC4)surfaces decorated with micropillars pattern,thus,composite functional surfaces with PUA coating in the valleys around the micropillars pattern of TC4 were achieved.Apparent contact angle on fabricated surfaces could reach 167°.Influences of the geometric parameters of micropillars pattern on the apparent contact angle were investigated,and the corresponding wear-resistant property was compared.Droplet impact and anti-frosting performances on the prepared surfaces were highlighted.An optimized design of surface texture with robust superhydrophobicity,controllable droplet impact,and anti-frosting performances was proposed.This design principle is of promising prospects for fabricating superhydrophobic surfaces in traditional mechanical systems.

关键词： surface texture robust superhydrophobic wear-resistant droplet impact anti-frosting

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Status and developmental trends in recombinant collagen preparation technology

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Regenerative Biomaterials 2024年第2期3卷 17-36页

作者： xiaolei Guo Yuan Ma Hang Wang Hongping Yin Xinli Shi Yiqin chen Guobiao Gao Lei Sun Jiadao Wang Yunbing Wang Daidi Fan Center for Medical Device Evaluation National Medical Products AdministrationBeijing 100081China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China school of Life Science and Technology China Pharmaceutical UniversityNanjing 210009China National Engineering Research Center for Biomaterials&College of Biomedical Engineering Sichuan UniversityChengdu 610064China Biotech.&Biomed.Research Institute Northwest UniversityXi'an 710127China

Recombinant collagen is a pivotal topic in foundational biological research and epitomizes the application of critical bioengineer-ing technologies.These technological advancements have pro-found implications across diverse areas such as regenerative medicine,organ replacement,tissue engineering,cosmetics and more.Thus,recombinant collagen and its preparation methodologies rooted in genetically engineered celis mark pivotal milestones in medical product research.This article pro-vides a comprehensive overview of the current genetic engi-neering technologies and methods used in the production of recombinant collagen,as well as the conventional production process and gquality control detection methods for this material.Furthermore,the discussion extends to foresee the strides in physical transfection and magnetic control sorting studies,envisioning an enhanced preparation of recombinant collagen-seeded cells to further fuel recombinant collagen production.

关键词： recombinant collagen preparation genetic engineering collagen characterization physical transfection seed cell sorting

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Peptide or Protein-Protected Metal Nanoclusters for Therapeutic Application

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Chinese Journal of Chemistry 2022年第2期40卷 267-274页

作者： xiaolei chen Xiaojun Ren Xueyun Gao Department of Chemistry and Biology Faculty of Environment and Life ScienceBeijing University of TechnologyBeijing 100124China

What is the most favorite and original chemistry developed in your research group?The most favorite and original work we have done is the development of gold nano clusters for diagnostic and therapeutic application.How do you get into this specific field?Could you please share some experiences with our readers?I have a great passion for research on bioanalytical imaging and the biomedical effects of nanomaterials,which may contribute to early diagnosis and treatment of diseases.My research is focused on exploring the mechanism of protein or peptide-protected metal nanoclusters in disease diagnosis and treatment with the expectation of leading to superior therapeutic outcomes.

关键词： Metal nanoclusters Biocompatibility Peptides Cell apoptosis Therapeutic mechanism

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Seco-cyclic phorbol derivatives and their anti-HIV-1 activities

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Chinese Journal of Natural Medicines 2024年第4期22卷 365-374页

作者： HUANG xiaolei HUANG Xusheng LI Qirun MA Mengdi CUI Yadong YANG Liumeng WANG Haibo LUO Ronghua chen Jinglei YANG Jingxuan LIN Jinrong LI Duxin ZHENG Yongtang ZHANG Jian College of Pharmaceutical Science Soochow UniversitySuzhou 215123China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204China College of Traditional Chinese Medicine Yunnan University of Chinese MedicineKunming 650500China

Phorbol esters are recognized for their dual role as anti-HIV-1 agents and as activators of protein kinase C(PKC).The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20,C3/C4,and C9 of phorbol.Concurrently,the lipids located at positions C12/C13 are essential for both the anti-HIV-1 activity and the formation of the PKC-ligand complex.The influence of the cyclopropane ring at positions C13 and C14 in phorbol derivatives on their anti-HIV-1 activity requires further exploration.This research entailed the hydrolysis of phorbol,producing seco-cyclic phorbol derivatives.The anti-HIV-1 efficacy of these derivatives was assessed,and the affinity constant(Kd)for PKC-δprotein of selected seco-cyclic phorbol derivatives was determined through isothermal titration calorimetry.The findings suggest that the chemical modification of cyclopropanols could affect both the anti-HIV-1 activity and the PKC binding affinity.Remarkably,compound S11,with an EC_(50) of 0.27μmol·L^(−1) and a CC_(50) of 153.92μmol·L^(−1),demonstrated a potent inhibitory effect on the intermediate products of HIV-1 reverse transcription(ssDNA and 2LTR),likely acting at the viral entry stage,yet showed no affinity for the PKC-δprotein.These results position compound S11 as a potential candidate for further preclinical investigation and for studies aimed at elucidating the pharmacological mechanism underlying its anti-HIV-1 activity.

关键词： seco-Cyclic phorbol derivatives Hydrolysis reaction Cyclopropane ring Esterification Anti-HIV-1 agent

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Optimized viewport-adaptive 360-degree video streaming

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CAAI Transactions on Intelligence Technology 2021年第3期6卷 347-359页

作者： xiaolei chen Di Wu Ishfaq Ahmad College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhouChina Department of Computer Science and Engineering University of Texas at ArlingtonArlingtonTexasUSA

Because of the rapid growth of head-mounted displays and 5G networking deployment,360-degree video has become increasingly popular.To generate the real experience of a virtual environment,360-degree videos require an ultrahigh resolution and frame rate to cover an omnidirectional view.These two prerequisites impose challenges for the transmission bandwidth and storage capacity of 360-degree video streaming.To reduce bandwidth and storage waste while providing a good immersive experience,we propose an optimized viewport-adaptive 360-degree video streaming method using high-efficiency video coding tiling,motion-constrained tile sets and MPEG dynamic adaptive streaming over HTTP spatial relationship description.The paper describes the rigorous design of the optimized system,which can assign different bitrates to different tiles in the viewport.The experimental results show that the proposed streaming system compares favourably with existing methods in terms of bitrate savings and storage capacity reduction.

关键词： video streaming system

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美育语境下高校图书馆艺术阅读推广策略探究

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新世纪图书馆 2024年第3期 19-24页

作者：季培培陈亮陈小磊南京艺术学院图书馆江苏南京210013

高校图书馆开展艺术阅读推广,是响应国家对学校美育工作的要求,是提升大学生审美和人文素养的重要举措。论文从艺术阅读推广的内涵开始,结合当前高校图书馆艺术阅读推广的实践情况,探索以资源为基石、以活动为抓手、以空间为依托的艺术... 详细信息

高校图书馆开展艺术阅读推广,是响应国家对学校美育工作的要求,是提升大学生审美和人文素养的重要举措。论文从艺术阅读推广的内涵开始,结合当前高校图书馆艺术阅读推广的实践情况,探索以资源为基石、以活动为抓手、以空间为依托的艺术阅读推广策略,最后提出高校图书馆通过艺术阅读推广促进大学生美育的工作建议。

关键词：美育高校图书馆阅读推广艺术阅读推广

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