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A dynamic regulation of nitrogen on floret primordia development in wheat

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The Crop Journal 2024年第1期12卷 271-280页

作者： Zhen Zhang Yujing Li Yuxun Wu Xiaoyu Zheng xiaolei guo Wan Sun Zhencai Sun Zhimin Wang Yinghua Zhang College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China College of Biological Sciences China Agricultural UniversityBeijing 100193China Engineering Technology Research Center for Agriculture in Low Plain Areas Cangzhou 061800HebeiChina

Nitrogen(N)fertilization is critical for spike and floret development,which affects the number of fertile florets per spike(NFFs).However,the physiological regulation of the floret development process by N fertilization is largely unknown.A high temporal-resolution investigation of floret primordia number and morphology,dry matter,and N availability was conducted under three N fertilization levels:0(N0),120(N1)and 240(N2)kg ha^(−1).Interestingly,fertile florets at anthesis stage were determined by those floret primordia with meiotic ability at booting stage:meiotic ability was a threshold that predicted whether a floret primordium became fertile or abortive *** the developmental rate of the 4th floret primordium in the central spikelet was accelerated and then they acquired meiotic ability,the NFFs increased gradually as N application increased,but the increase range decreased under *** were no differences in spike N concentration among treatments,but leaf N concentration was increased in the N1 and N2 ***,dry matter accumulation and N content of the leaf and spike in the N1 and N2 treatments was increased as compared to ***,optimal N fertilization increased leaf N availability and transport of assimilates to spikes,and allowed more floret primordia to acquire meiotic ability and become fertile florets,finally increasing *** was no difference in leaf N concentration between N1 and N2 treatment,whereas soil N concentration at 0–60 cm soil layers was higher in N2 than in N1 treatment,implying that there was still some N fertilization that remained ***,improving the leaf’s ability to further use N fertilizer is vital for greater NFFs.

关键词： Fertile florets Floret primordia Grain number Meiotic ability Morphological development

The Relationship Between the Atmospheric Environment and Road Traffic Fatalities — Shandong Province, China, 2012–2021

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China CDC weekly 2024年第13期6卷 267-271页

作者： Tao Wang Jie Chu Zhiying Yao Li Yang Zilong Lu Ge Tian xiaolei guo Cunxian Jia Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department for Chronic and Non-Communicable Disease Control and Prevention Shandong Center for Disease Control and PreventionJinanShandong ProvinceChina

Introduction:This study aims to analyze the potential impact of the meteorological environment and air pollutants on road traffic ***:Road traffic fatality data in Shandong Province from 2012 to 2021 were obtained from the Population Death Information Registration Management *** and air pollutant data for the same period were collected from the *** Oceanic and Atmospheric Administration and the Ecological Environment Monitoring Center of Shandong Province,***’s correlation and ridge regression were used to analyze the impact of the meteorological environment and air pollutants on road traffic ***:From 2012 to 2021,there were 163,863 road traffic fatality *** results of the ridge regression analysis showed that the daily average temperature was negatively correlated with total fatalities and passengers and positively correlated with pedestrians,nonmotorized drivers,and motorized *** daily minimum temperature was negatively correlated with total fatalities and positively correlated with motorized *** daily maximum temperature was positively correlated with both pedestrian and nonmotorized *** daily accumulated precipitation was negatively correlated with *** duration was positively correlated with both nonmotorized and motorized *** particulate matter(PM10)and nitrogen dioxide(NO2)were positively correlated with total fatalities,pedestrians,and nonmotorized *** dioxide(SO2)was positively correlated with total fatalities but negatively correlated with nonmotorized drivers,passengers,and motorized ***:Atmospheric factors associated with the occurrence of road traffic fatalities include air temperature,daily accumulated precipitation,sunshine duration,and air pollutants such as PM10,NO2,and SO2.

关键词： Ecological dioxide sunshine

Status and developmental trends in recombinant collagen preparation technology

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Regenerative Biomaterials 2024年第2期3卷 17-36页

作者： xiaolei guo Yuan Ma Hang Wang Hongping Yin Xinli Shi Yiqin Chen guobiao Gao Lei Sun Jiadao Wang Yunbing Wang Daidi Fan Center for Medical Device Evaluation National Medical Products AdministrationBeijing 100081China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China school of Life Science and Technology China Pharmaceutical UniversityNanjing 210009China National Engineering Research Center for Biomaterials&College of Biomedical Engineering Sichuan UniversityChengdu 610064China Biotech.&Biomed.Research Institute Northwest UniversityXi'an 710127China

Recombinant collagen is a pivotal topic in foundational biological research and epitomizes the application of critical bioengineer-ing *** technological advancements have pro-found implications across diverse areas such as regenerative medicine,organ replacement,tissue engineering,cosmetics and ***,recombinant collagen and its preparation methodologies rooted in genetically engineered celis mark pivotal milestones in medical product *** article pro-vides a comprehensive overview of the current genetic engi-neering technologies and methods used in the production of recombinant collagen,as well as the conventional production process and gquality control detection methods for this ***,the discussion extends to foresee the strides in physical transfection and magnetic control sorting studies,envisioning an enhanced preparation of recombinant collagen-seeded cells to further fuel recombinant collagen production.

关键词： recombinant collagen preparation genetic engineering collagen characterization physical transfection seed cell sorting

一流课程背景下基于OBE的中医药院校数据库课程混合式教学研究

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中国中医药现代远程教育 2024年第15期22卷 206-206,I0001,F0004页

作者：郭小磊李丹山西中医药大学健康服务与管理学院山西太原030024

高校要着力巩固“专业以课程为本、教师以教学为本、学生以学习为本”等3个根本地位,按照“固本培元,守正创新”的工作思路,推进本科教育高质量发展。数据库系统原理是面向信管专业的核心课程,也是中医药院校其他医学类专业的选修课程,... 详细信息

高校要着力巩固“专业以课程为本、教师以教学为本、学生以学习为本”等3个根本地位,按照“固本培元,守正创新”的工作思路,推进本科教育高质量发展。数据库系统原理是面向信管专业的核心课程,也是中医药院校其他医学类专业的选修课程,存在课时不足、成果导向不明显等问题。研究采用OBE理念,从教学目标、教学模式、教学内容和评价手段方面进行改革,做到“思政与专业、线上与线下、理论与实践、过程与效果”4个融合。

关键词：数据库系统原理 OBE理念一流课程产教融合中医药特色数据库

基于短文本扩展和特征融合的市民热线文本分类

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山西大同大学学报（自然科学版） 2024年第1期40卷 42-47,62页

作者：郭小磊张吴波湖北汽车工业学院电气与信息工程学院湖北十堰442002

针对市民热线多为短文本和特征稀疏的特点。提出了一种短文本扩展法和基于双通道特征融合的文本分类(BERT-BiGRU-TextCNN,BGTC)模型,实现了对市民热线文本的自动识别与归类。首先使用TF-IWF模型以及LDA主题模型构建核心词库;然后利用Wor... 详细信息

针对市民热线多为短文本和特征稀疏的特点。提出了一种短文本扩展法和基于双通道特征融合的文本分类(BERT-BiGRU-TextCNN,BGTC)模型,实现了对市民热线文本的自动识别与归类。首先使用TF-IWF模型以及LDA主题模型构建核心词库;然后利用Word2Vec计算词语相似度,完成对短文本内容和词向量特征的扩展;最终通过融合BERT-TextCNN和BERT-BiGRU-Attention两个通道特征信息的BGTC模型实现了对扩展后文本的分类。经过多组对比实验,结果表明该方法在市民热线文本分类任务中具有更好的性能,准确率和F1值分别达到了85.6%和85.8%。

关键词：市民热线短文本扩展文本分类特征融合

右归丸辅助骨髓间充质干细胞对家兔骨质疏松性骨折愈合的影响及机制初探

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国际医药卫生导报 2024年第3期30卷 453-459页

作者：朱俊姚帅辉郭小磊郑州人民医院骨一科郑州450003

目的探讨右归丸辅助骨髓间充质干细胞对家兔骨质疏松性骨折愈合的影响及可能机制。方法研究时间为2023年1月至6月。将50只家兔分为正常对照组、模型对照组、右归丸组、骨髓间充质干细胞组、联合治疗组,各10只。除正常对照组外其余各组... 详细信息

目的探讨右归丸辅助骨髓间充质干细胞对家兔骨质疏松性骨折愈合的影响及可能机制。方法研究时间为2023年1月至6月。将50只家兔分为正常对照组、模型对照组、右归丸组、骨髓间充质干细胞组、联合治疗组,各10只。除正常对照组外其余各组建立骨质疏松性骨折模型,并予以相应药物治疗。治疗结束后,测定家兔股骨骨密度(bone mineral density,BMD)、骨小梁数量、骨小梁厚度、骨小梁分散度以及股骨弹性模量、刚度、最大应力、最大承载力;实时聚合酶链式反应及蛋白印迹法测定股骨Janus蛋白酪氨酸激酶2/信号转导和转录激活子3(Janus kinase 2/signal transducer and activator of transcription 3,JAK2/STAT3)基因与蛋白水平。采用单因素方差分析及LSD-t检验进行数据分析。结果模型对照组家兔股骨BMD、骨小梁数量、骨小梁厚度,股骨弹性模量、刚度、最大应力、最大承载力,股骨JAK2、STAT3 mRNA和蛋白水平均低于正常对照组(均P<0.05),骨小梁分散度高于正常对照组(P<0.05);右归丸组、骨髓间充质干细胞组、联合治疗组家兔股骨BMD、骨小梁数量、骨小梁厚度、股骨弹性模量、刚度、最大应力、最大承载力、股骨JAK2、STAT3 mRNA和蛋白水平均高于模型对照组(均P<0.05),骨小梁分散度低于模型对照组(均P<0.05);联合治疗组股骨BMD[(1.76±0.13)g/cm^(3)]、骨小梁数量[(5.87±0.24)个/mm]、骨小梁厚度[(0.14±0.03)mm],股骨弹性模量[(343.27±21.04)MPa]、刚度[(904.25±73.25)N/mm]、最大应力[(32.63±3.17)N/mm^(2)]、最大承载力[(358.85±13.02)N],股骨JAK2、STAT3 mRNA[(3.45±0.26)、(3.60±0.28)]和蛋白[(0.82±0.05)、(0.84±0.05)]水平高于右归丸组[(1.41±0.15)g/cm^(3)、(3.88±0.28)个/mm、(0.10±0.02)mm、(304.62±20.41)MPa、(698.52±69.55)N/mm、(25.34±3.22)N/mm^(2)、(297.34±13.24)N、(2.58±0.26)、(2.29±0.23)、(0.60±0.05)、(0.53±0.07)]、骨髓间充质干细胞组[(1.47±0.14)g/cm^(3)、(3.89±0.28)个/mm、(0.09±0.03)mm、(299.54±16.94)MPa、(720.33±69.48)N/mm、(23.24±3.13)N/mm^(2)、(289.38±13.13)N、(2.63±0.25)、(2.30±0.24)、(0.59±0.06)、(0.53±0.08)](均P<0.05),骨小梁分散度[(0.34±0.02)mm]低于右归丸组[(0.42±0.03)mm]、骨髓间充质干细胞组[(0.43±0.03)mm](均P<0.05)。结论右归丸辅助骨髓间充质干细胞能明显促进家兔骨质疏松性骨折愈合,其机制可能与右归丸辅助骨髓间充质干细胞治疗能激活骨质疏松性骨折家兔股骨JAK2/STAT3信号通路有关。

关键词：骨质疏松性骨折右归丸骨髓间充质干细胞愈合 JAK2/STAT3信号通路动物实验

Structural relaxation and avalanche dynamics of particle piles under vertical vibration

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Particuology 2022年第9期20卷 65-74页

作者： Lizhuo Zhu Haifeng Lu xiaolei guo Haifeng Liu Shanghai Engineering Research Center of Coal Gasifiication East China University of Science and TechnologyShanghai 200237China

Granular matter can exhibit solid or liquid behavior,which contains complex physical *** this work,we experimentally investigated the structural relaxation and avalanche dynamics of particle piles under vertical *** influence of vibration parameters on the avalanche process was *** morphological features of avalanches were recorded and classified using high-speed *** effects of vibration parameters and particle properties on the relaxation mode are *** is found that the evolution of particle pile height with time can be described by an exponential decay *** relaxation rate and avalanche characteristics of four types of particles with different sizes are *** the same acceleration level,for two larger particles,a smaller amplitude(A=0.025 mm)leads to a faster relaxation rate,while for two smaller particles,a large amplitude(A=0.500 mm)leads to a faster relaxation *** analogy powder surface tension is introduced to address the cohesion and flowability evolution of particles under vibration.

关键词： Particle pile Vertical vibration Avalanche Flowability

2012-2022年山东省肝癌发病与死亡趋势及其年龄-时期-队列分析

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中华肿瘤防治杂志 2024年第5期31卷 280-291页

作者：姜帆付振涛鹿子龙楚洁郭晓雷马吉祥山东省疾病预防控制中心慢性非传染性疾病防治所山东济南250014 山东大学预防医学研究院(山东省预防医学科学院) 山东济南250014

目的分析2012-2022年山东省肝癌发病及死亡变化趋势,并估计其年龄-时期-队列效应。方法基于2012-2022年山东省肿瘤登记地区肝癌新发和死亡病例资料,采用Joinpoint回归分析其发病率及死亡率变化趋势,计算平均年度变化百分比(AAPC)。拟合... 详细信息

目的分析2012-2022年山东省肝癌发病及死亡变化趋势,并估计其年龄-时期-队列效应。方法基于2012-2022年山东省肿瘤登记地区肝癌新发和死亡病例资料,采用Joinpoint回归分析其发病率及死亡率变化趋势,计算平均年度变化百分比(AAPC)。拟合年龄-时期-队列模型分析≥20岁人群肝癌发病、死亡风险的年龄效应、时期效应及队列效应。结果2012-2022年山东省肝癌标化发病率呈显著下降趋势,每年下降6.0%(AAPC=-6.0%,95%CI:-6.9%~-5.1%,P<0.05);男性下降5.9%(AAPC=-5.9%,95%CI:-6.9%~-4.9%,P<0.05),女性下降6.0%(AAPC=-6.0%,95%CI:-6.7%~5.2%,P<0.05);城市下降6.6%(AAPC=-6.6%,95%CI:-8.0%~-5.3%,P<0.05),农村下降4.9%(AAPC=-4.9%,95%CI:-5.9%~-3.9%,P<0.05)。2012-2022年山东省肝癌标化死亡率呈显著下降趋势,每年下降5.1%(AAPC=-5.1%,95%CI:-5.9%~-4.4%,P<0.05);男性下降4.9%(AAPC=-4.9%,95%CI:-5.6%~-4.2%,P<0.05),女性下降5.5%(AAPC=-5.5%,95%CI:-6.6%~4.4%,P<0.05);城市下降4.6%(AAPC=-4.6%,95%CI:-6.0%~3.1%,P<0.05),农村下降4.8%(AAPC=-4.8%,95%CI:-6.1%~3.6%,P<0.05)。肝癌发病和死亡风险均随年龄增加而增大,发病和死亡时期效应和队列效应均随年份推移而减小。结论2012-2022年山东省肝癌发病和死亡均呈下降趋势。年龄是增加肝癌发病和死亡风险重要因素,未来肝癌疾病负担仍然较重。应重视肝癌高危人群早诊早治,同时加强病因学探索性研究,为肝癌防控策略提供参考依据。

关键词：肝癌发病率死亡率 Joinpoint 年龄-时期-队列模型

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生物质气流床气化可行性分析与减碳效应

华东理工大学学报（自然科学版） 2024年第3期50卷 328-334页

作者：陆海峰卞耀郭晓镭代正华刘海峰华东理工大学上海煤气化工程技术研究中心含碳废弃物资源化零碳利用教育部工程研究中心上海200237

气流床气化是生物质大规模高效转化利用的选择之一。本文首先对生物质气流床气化工艺涉及到的制粉、输送、气化等关键单元进行分析,论证了气流床技术应用于生物质气化的可行性;在此基础上,选用6种典型的农林生物质作为原料,借助Aspen P... 详细信息

气流床气化是生物质大规模高效转化利用的选择之一。本文首先对生物质气流床气化工艺涉及到的制粉、输送、气化等关键单元进行分析,论证了气流床技术应用于生物质气化的可行性;在此基础上,选用6种典型的农林生物质作为原料,借助Aspen Plus化工流程模拟软件开展生物质气流床气化模拟,研究了煤和生物质共气化及生物质单独气化特性,并对以生物质为原料的气化过程进行减碳效应分析。结果表明:生物质气流床气化具备操作可行性;在煤中掺混适量的生物质既能维持较好的气化性能,又能显著降低煤耗等指标,减碳效果明显;与传统的固定床和流化床相比,生物质气流床气化获得的合成气热值约为10 MJ/m^(3),优势明显,可用于替代天然气供暖,既有经济价值又能实现碳减排。

关键词：生物质气流床气化 Aspen Plus流程模拟碳减排可行性分析

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