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颈椎病动物模型及其内在分子机制

中国组织工程研究 2025年第17期29卷 3624-3631页

作者：钱嘉铭王小乐方婷周毛生刘福水江西中医药大学江西省南昌市330004 江西中医药大学附属医院江西省南昌市330006

背景:将临床疾病完全转化为动物模型存在许多问题,但理想的动物模型是进行颈椎病机制研究的前提,因此选择合适的颈椎病动物模型至关重要。目的:详细分析颈椎病动物模型的物种、性别、年龄、颈椎病模型类型及其内在分子机制,探讨如何选... 详细信息

背景:将临床疾病完全转化为动物模型存在许多问题,但理想的动物模型是进行颈椎病机制研究的前提,因此选择合适的颈椎病动物模型至关重要。目的:详细分析颈椎病动物模型的物种、性别、年龄、颈椎病模型类型及其内在分子机制,探讨如何选择合适的动物模型应用于颈椎病实验研究。方法:应用计算机检索PubMed、Medline、Embase、Web of science、万方、维普和CNKI等数据库,英文检索词为“cervical spondylosis,cervical spondylotic myelopath,cervical spondylotic radiculopathy,cervical spondylosis of vertebral artery type,neck type cervical spondylosis,unbalanced dynamic and static forces,joint injury,neck pain,animal model”,中文检索词为“颈椎病,神经根型颈椎病,脊髓型颈椎病,椎动脉型颈椎病,颈型颈椎病,动静力失衡,关节损伤,颈痛,动物模型”,按照纳入和排除标准对文献进行筛选,最终纳入61篇文献进行综述。结果与结论:大鼠是最常用的动物,雄性大鼠似乎更受欢迎,推荐使用成年前后的动物。根据造模特点可以将颈椎病模型分为脊髓型、神经根型、颈型和其他型,不同造模方法各有优缺点。从已有动物模型的研究出发,总结了颈椎病的分子机制,治疗信号介导核因子κB、磷脂酰肌醇3-激酶/蛋白激酶B、丝裂原激活蛋白激酶等通路调节脊髓、神经根、椎间盘、肌肉等组织的炎症反应、凋亡、自噬等生物学过程,最终延缓颈椎病的进展。部分研究质量较差,与临床契合度不高,未来需要进一步将颈椎病动物模型标准化,制定相关指南,提高研究结果的可信度,为进一步开展人体临床试验奠定坚实的基础。

关键词：颈椎病动物模型分子机制脊髓神经根颈肌椎间盘

Auto-ignition of biomass synthesis gas in shock tube at elevated temperature and pressure

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Science Bulletin 2015年第22期60卷 1935-1946页

作者： Linqi Ouyang Hua Li Shuzhou Sun xiaole wang Xingcai Lu Laboratory for Power Machinery and Engineering of Ministry of Education Shanghai Jiao Tong University

Ignition delay times of multi-component biomass synthesis gas （bio-syngas） diluted in argon were measured in a shock tube at elevated pressure （5, 10and 15 bar, 1 bar = 105 Pa）, wide temperature ranges （1,100-1,700 K） and various equivalence ratios （0.5, 1.0, 2.0）. Additionally, the effects of the variations of main constituents （H2：CO = 0.125-8） on ignition delays were investigated. The experimental results indicated that the ignition delay decreases as the pressure increases above certain temperature （around 1,200 K） and vice versa. The ignition delays were also found to rise as CO concentration increases, which is in good agreement with the literature. In addition, the ignition delays of bio-syngas were found increasing as the equivalence ratio rises. This behavior was primarily discussed in present work. Experimental results were also compared with numerical predictions of multiple chemical kinetic mechanisms and Li＇s mechanism was found having the best accuracy. The logarithmic ignition delays were found nonlinearly decrease with the H2 concentration under various conditions, and the effects of temperature, equivalence ratio and H2 concentration on the ignition delays are all remarkable. However, the effect of pressure is rela- tively smaller under current conditions. Sensitivity analysis and reaction pathway analysis of methane showed that R1 （H ＋O2= O -9 OH） is the most sensitive reaction promot- ing ignition and R13 （H ＋O2 （＋M） = HO2 （＋M））, R53（CH3＋H （＋M）= CH4 （＋M））, R54 （CH4＋H= CH3 ＋ H2） as well as R56 （CH4 ＋ OH = CH3 ＋ H2O） are key reactions prohibiting ignition under current experimental conditions. Among them, R53 （CH3 ＋ H （＋M） = CH4 （＋M））, R54 （CH4 ＋ H = CH3 ＋ H2） have the largest posi- tive sensitivities and the high contribution rate in rich mixture. The rate of production （ROP） of OH of R1 showed that OH ROP of R1 decreases sharply as the mixture turns rich. Therefore, the ignition delays become longer as the equiva- lence ratio increases.

关键词： Shock tube Biomass synthesis gas Ignition delay time Sensitivity analysis Reactionpathway analysis

针刀干预后颈椎病大鼠头夹肌成纤维细胞生长因子家族及其受体的表达

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中国组织工程研究 2025年第18期29卷 3775-3783页

作者：刘福水钱嘉铭方婷哈留娜赵小兰朱金超王小乐江西中医药大学附属医院江西省南昌市330006 江西中医药大学江西省南昌市330004 蒙古国传统医学技术研究院乌兰巴托17032蒙古国

背景:针刀是治疗颈椎病的有效方法,临床疗效确切,但其关键分子机制尚不明晰。目的:观察针刀干预对颈椎病大鼠头夹肌成纤维细胞生长因子家族及其受体激酶插入域蛋白受体表达的影响,分析针刀治疗颈椎病的作用机制。方法:通过检索GEO数据库... 详细信息

背景:针刀是治疗颈椎病的有效方法,临床疗效确切,但其关键分子机制尚不明晰。目的:观察针刀干预对颈椎病大鼠头夹肌成纤维细胞生长因子家族及其受体激酶插入域蛋白受体表达的影响,分析针刀治疗颈椎病的作用机制。方法:通过检索GEO数据库,获取符合该研究的芯片数据集GSE153761,采用生物信息学方法进行靶标初筛,然后进行动物实验。选取6月龄SPF级SD大鼠24只,随机均分为4组。模型组和针刀组大鼠采用动静力失衡性颈椎病造模方法制备颈椎病大鼠模型;假手术组不切断肌肉及韧带;针刀组造模成功后采用针刀干预,每周1次,共3次;并以正常大鼠作为对照。拍摄颈椎正侧位X射线片进行模型验证;旷场实验观察大鼠行为学变化;苏木精-伊红染色观察头夹肌病理结构;荧光定量PCR法和免疫组化法分别检测头夹肌成纤维细胞生长因子家族及其受体激酶插入域蛋白受体mRNA及蛋白的表达情况。结果与结论:①生物信息学结果表明成纤维细胞生长因子家族/激酶插入域蛋白受体是激活磷脂酰肌醇3-激酶/蛋白激酶B上游的重要信号轴。②造模后大鼠椎间隙变窄,椎体前后缘、关节突骨质增生。③旷场实验中,造模后大鼠总距离、平均速度降低(P<0.05),总休息时间延长(P<0.05);治疗后针刀组大鼠总距离、平均速度大于模型组(P<0.05),总休息时间短于模型组(P<0.05)。④头夹肌病理提示颈肌受损,而针刀可改善颈肌劳损。⑤与正常组比较,模型组大鼠头夹肌成纤维细胞生长因子7、成纤维细胞生长因子9、成纤维细胞生长因子10、成纤维细胞生长因子18和激酶插入域蛋白受体mRNA及蛋白表达均升高(P<0.05);与模型组比较,针刀组以上指标均降低(P<0.05)。⑥结果说明,针刀可能通过调节成纤维细胞生长因子7、成纤维细胞生长因子9、成纤维细胞生长因子10、成纤维细胞生长因子18及其受体激酶插入域蛋白受体的表达,修复劳损颈肌,从而改善椎间盘退变,这可能是针刀治疗颈椎病的关键靶点。

关键词：针刀颈椎病成纤维细胞生长因子激酶插入域蛋白受体工程化细胞因子工程化组织构建

钢丝螺套螺纹连接中螺钉安装不到位、卡死问题分析及控制

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机电元件 2025年第1期45卷 36-39,55页

作者：庞金红王晓乐杨小宁刘善磊曾硕沈阳兴华航空电器有限责任公司辽宁沈阳110021

本文针对矩形连接器产品零件,钢丝螺套螺纹孔存在的螺钉安装不到位、卡死问题,进行原因分析,对钢丝螺套螺纹孔生产加工方法及检测控制要求进行剖析、试验,制定有涂覆层钢丝螺套螺纹孔有效加工工艺控制要求,解决钢丝螺套螺纹存在螺钉安... 详细信息

本文针对矩形连接器产品零件,钢丝螺套螺纹孔存在的螺钉安装不到位、卡死问题,进行原因分析,对钢丝螺套螺纹孔生产加工方法及检测控制要求进行剖析、试验,制定有涂覆层钢丝螺套螺纹孔有效加工工艺控制要求,解决钢丝螺套螺纹存在螺钉安装不到位、卡死问题。

关键词：钢丝螺套镀前丝锥钢丝螺套螺纹孔镀前螺纹规

The Study of Legal Issue of Policy Banks

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International Journal of Technology Management 2013年第10期 80-82页

作者： xiaole wang Civil and Commercial Law School Southwest University of Political Science and Law Chongqing 401120

China has built three policy banks since 1994, which are China Development Bank, China Export-import Bank and China Agricultural Development Bank. Policy banks, as an important financial instrument, have made great contributions to the development of China＇ s economy. But there isn＇ t an official law fbr policy banks for a long time. They just operate based on some relevant documents and regulations of their own. However these documents and regulations are always indistinct in law, which is not good for the further development of policy banks and the accomplishment of our country＇ s financial system. As a result, in order to standardize the operation of China＇ s policy banks, it＇ s essential to position policy banks in law accurately, which is also the only way to legalize policy banks. Aiming at finding out the problems existing in policy banks of China in present, this paper analyzes the general theory of policy banks, some relevant international experience and the current situation of law position of china＇ s policy banks. In addition, through the analyses of possible solutions, this paper wishes to reconstruct the legal location of China ＇ s policy banks.

关键词： Policy Banks Legal Issue Legal Position

The Simulation and Optimization Design of Adams-based Engine Suspension System

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International Journal of Technology Management 2014年第8期 158-161页

作者： Jianxin XlE xiaole wang Chao LIU Qingdao Huanghai University Qingdao Shandong 266427 China

In this study, the engine suspension system was optimized for making the vibration between engine and car body minimized, and also the optimization was simulated using software Adams. The purpose of this study was to research the vibration isolation of the engine mounting system and implement multi-objective optimization for the intrinsic frequency. In this paper, the optimization was implemented in two ways：（1） the intrinsic frequency was optimized by reasonably allocating it：（2） the intrinsic frequency was optimized using energy decoupling. The optimized intrinsic frequencies were simulated using software Adams and then the simulation results were compared. The simulation results showed that the optimized energy distribution was almost up to 90% and the decoupling degree was greatly improved by comparing the initial data, proving the optimized data played a geater effect on engine vibration isolation and further verifying the feasibility of optimization design method.

关键词： Engine Suspension System Optimization Design Simulation ADAMS

Simulation and Optimization Design Based on Adams Engine Mounting System

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International Journal of Technology Management 2014年第7期 152-154页

作者： Xie Jianxin wang xiaole Liu Chao Qingdao Huanghai University Qingdao Shandong 266427 China

The content of this subject research is to conduct optimization for engine mounting system, and through optimization, it can make the vibration between engine and vehicle body achieve a minimum, using Adams software for simulation. It studies the isolation vibration of the engine mounting system and conducts goal optimization for fixed frequency. This paper uses two methods for optimization. One is to use the rational allocation of fixed frequency to optimize the fixed frequency, and the other is to use energy decoupling method to optimize the fixed frequency. It uses Adams software for simulation of the optimized fixed frequency and conducts comparison of simulated results. The simulated results show that the optimized energy distribution situation almost achieves 90%. Compared with original data, decoupling degree also has a very great improvement, illustrating that the optimized data has greater effect for the isolated vibration of engine, in order to further verify the feasibility of optimization design method.

关键词： engine mounting system optimization design simulation Adams

Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling

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The Journal of Biomedical Research 2015年第3期29卷 232-240页

作者： Xiaofan Yang Bin Sun Huijuan wang Cheng Yin xiaole wang Xiaohui Ji Department of Microbiology and Immunology Nanjing Medical University Department of Nephrology the First Affiliated Hospital of Nanjing Medical University

We sought to investigate the expression of Fas and FasL on T cell surface and caspase 8 involvement in T cell apoptosis promoted by serum IL-10 in systemic lupus erythematosus （SLE） patients. Cells and sera were obtained from 35 SLE patients. Apoptosis of T cells in patients with SLE was increased and associated with the SLE disease activity index （SLEDAI）. Elevated expression of Fas and FasL on T cell surface contributed to increased apoptosis of T cells. Increased IL-10 in the sera of SLE patients was capable of inducing Fas and FasL expression on CD4^＋T cell surface, promoting apoptosis of this cell subset. Decreased IL-10 serum levels and low expression of Fas were found in 5 patients of the first follow-up group after 2-month treatment. In another group with one-year treatment, the SLEDAI declined to inactive scores. Serum IL-10 was decreased significantly, and expression of Fas and FasL on T cells was also reduced. Declined apoptosis was predominant only in CD4^＋T cell subset. When sera with high level of IL-10 were used to culture PBMCs from healthy controls, activated caspase 8 was elevated in CD3^＋T, CD4^＋T and CD8^＋T cells. The study showed that serum IL-10 induced apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling. Increased apoptosis of T cells contributes to autoantigen burden, which is pathogenic in the development of SLE.

关键词： apoptosis T cell lupus erythematosus systemic

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全垫升气垫船安全航行控制技术研究综述

哈尔滨工程大学学报 2023年第9期44卷 1475-1486页

作者：王元慧王晓乐王成龙哈尔滨工程大学智能科学与工程学院黑龙江哈尔滨150001

全垫升气垫船是一种具有两栖性的高性能船舶,因其独特的两栖性和高速性被广泛应用于民用和军事领域。由于其特殊的气垫围裙结构,船体可以脱离于航行表面,航行阻力极小,因此会导致其操纵性和安全性比普通水面船差。尤其在垫态高速航行时... 详细信息

全垫升气垫船是一种具有两栖性的高性能船舶,因其独特的两栖性和高速性被广泛应用于民用和军事领域。由于其特殊的气垫围裙结构,船体可以脱离于航行表面,航行阻力极小,因此会导致其操纵性和安全性比普通水面船差。尤其在垫态高速航行时,气垫船缺少足够的向心力和横向力,会涉及失速、低头埋艏、侧漂翻船、高速甩尾等问题。因此针对全垫升气垫船安全航行控制问题,开展其安全航行控制理论与方法研究有着重要的军事意义和民用价值。本文介绍了全垫升气垫船的主要性能和国内外发展概况和全垫升气垫船运动数学模型建立及研究发展;最后归纳总结国内外关于全垫升气垫船安全航行控制技术的研究,分类介绍控制策略发展现状,并讨论全垫升气垫船安全航行技术未来发展方向和趋势。指出未来气垫船安全航行控制将以实现气垫船多功能、智能化、无人化等为目标,在保证气垫船航行安全的前提下实现气垫船自动控制和管理。

关键词：海洋工程全垫升气垫船数学模型航行控制控制系统运动控制技术发展安全航行

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