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Glibenclamide pretreatment attenuates early hematoma expansion of warfarin-associated intracerebral hemorrhage in rats by alleviating perihematomal blood-brain barrier dysfunction

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Chinese Neurosurgical Journal 2024年第1期10卷 8-19页

作者： Zongwei Zeng Liang Liang Zhou Feng Peiwen Guo xiaoke hao Jishu Xian Hua Feng Yujie Chen Zhi Chen Department of Neurosurgery and State Key Laboratory of Trauma Burn and Combined InjurySouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Neurosurgery The 945Th Hospital of PLAYaanSichuan Province 625099China Department of Rehabilitation Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Chongqing Key Laboratory of Precision Neuromedicine and Neuroregeneration Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Chongqing Clinical Research Center for Neurosurgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China

Background Hematoma expansion is a determinant of poor outcome of intracerebral hemorrhage but occurs frequently,especially in warfarin-associated intracerebral hemorrhage(W-ICH).In the present study,we employ the warfarin-associated intracerebral hemorrhage(W-ICH)rat model,to explore the efficacy and potential mechanism of glibenclamide pretreatment on hematoma expansion after intracerebral hemorrhage,hoping to provide proof of concept that glibenclamide in stroke primary and secondary prevention is also potentially beneficial for intracerebral hemorrhage patients at early stage.Methods In the present study,we tested whether glibenclamide,a common hypoglycemic drug,could attenuate hematoma expansion in a rat model of W-ICH.Hematoma expansion was evaluated using magnetic resonance imaging;brain injury was evaluated by brain edema and neuronal death;and functional outcome was evaluated by neurological scores.Then blood-brain barrier integrity was assessed using Evans blue extravasation and tight junction-related protein.Results The data indicated that glibenclamide pretreatment significantly attenuated hematoma expansion at 24 h after W-ICH,thus mitigating brain edema and neuronal death and promoting neurological function recovery,which may benefit from alleviating blood-brain barrier disruption by suppressing matrix metallopeptidase-9.Conclusions The results indicate that glibenclamide pretreatment in stroke primary and secondary prevention might be a promising therapy for hematoma expansion at the early stage of W-ICH.

关键词： Intracerebral hemorrhage Warfarin Glibenclamide Hematoma expansion Blood-brain barrier Matrix metallopeptidase-9

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Evaluating the performance of genomic selection on purebred population by incorporating crossbred data in pigs

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Journal of Integrative Agriculture 2024年第2期23卷 639-648页

作者： Jun Zhou Qing Lin Xueyan Feng Duanyang Ren Jinyan Teng Xibo Wu Dan Wu xiaoke Zhang Xiaolong Yuan Zanmou Chen Jiaqi Li Zhe Zhang hao Zhang College of Animal Science South China Agricultural University/State Key Laboratory of Swine and Poultry Breeding Industry/National Engineering Research Center for Breeding Swine IndustryGuangzhou 510642China Guangxi State Farms Yongxin Animal Husbandry Group Co. Ltd.Nanning 530022China

Genomic selection(GS)has been widely used in livestock,which greatly accelerated the genetic progress of complex traits.The population size was one of the significant factors affecting the prediction accuracy,while it was limited by the purebred population.Compared to directly combining two uncorrelated purebred populations to extend the reference population size,it might be more meaningful to incorporate the correlated crossbreds into reference population for genomic prediction.In this study,we simulated purebred offspring(PAS and PBS)and crossbred offspring(CAB)base on real genotype data of two base purebred populations(PA and PB),to evaluate the performance of genomic selection on purebred while incorporating crossbred information.The results showed that selecting key crossbred individuals via maximizing the expected genetic relationship(REL)was better than the other methods(individuals closet or farthest to the purebred population,CP/FP)in term of the prediction accuracy.Furthermore,the prediction accuracy of reference populations combining PA and CAB was significantly better only based on PA,which was similar to combine PA and PAS.Moreover,the rank correlation between the multiple of the increased relationship(MIR)and reliability improvement was 0.60-0.70.But for individuals with low correlation(Cor(Pi,PA or B),the reliability improvement was significantly lower than other individuals.Our findings suggested that incorporating crossbred into purebred population could improve the performance of genetic prediction compared with using the purebred population only.The genetic relationship between purebred and crossbred population is a key factor determining the increased reliability while incorporating crossbred population in the genomic prediction on pure bred individuals.

关键词： pigs crossbred population genomic selection reference population construction relationship

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A Biomass-Based Hydrogel Evaporator Modified Through Dynamic Regulation of Water Molecules:Highly Efficient and Cost-Effective

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Energy & Environmental Materials 2023年第3期6卷 20-30页

作者： Boqiu Luo Jin Wen hao Wang Size Zheng Rui Liao Wenjing Chen Omid Mahian xiaoke Li College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu 610059China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China College of Resources and Environment Chengdu University of Information TechnologyChengdu 610225China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710061China Department of Chemical Engineering Imperial College LondonLondon SW72AZUK Renewable Energy and Micro/Nano Sciences Lab Department of Mechanical EngineeringFaculty of EngineeringFerdowsi University of MashhadMashhad 91779-48974Iran

Solar-driven hydrogel evaporator used for water purification demonstrates great potential in seawater desalination and domestic sewage treatment.However,much uncertainty still exists about the most efficient design to obtain cost-effective drinkable water.In this paper,a natural rich biomass Nicandra physalodes(Linn.)Gaertn.polysaccharide was introduced into the polyvinyl alcohol network to control the water distribution during evaporation and build a low-cost hybrid hydrogel solar evaporator with a total material cost of$7.95 m^(−2).The mixed evaporator works stably in a long-span acid–base range(pH 1–14)and salinity range(0–320 g kg^(−1)).Its daily water purification capacity can reach 24.4 kg m^(−2)with a water purification capacity of 3.51 kg m^(−2)h^(−1)under sunlight.This paper provides a new possibility for a highly efficient and cost-effective water desalination system with guaranteed water quality by focusing on the dynamic regulation of water molecules at the evaporation interface.

关键词： desalination hydrogels interfacial evaporation polysaccharide solar energy

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“互联网+”背景下高校公共管理专业信息化改革路径研究

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创新创业理论研究与实践 2024年第5期7卷 100-102,124页

作者：张家旗刘晏男李锐杰关小克郝宏杰郑州轻工业大学政法学院河南郑州450001 郑州轻工业大学计算机与通信工程学院河南郑州450001 郑州轻工业大学国际教育学院河南郑州450001

“互联网+教育”为新文科背景下公共管理专业培养管理型和技术型复合人才提供了新的路径。为了更好地推动公共管理专业信息化改革进程,提升人才培养质量,该文从课程设置、教学方式、教师队伍、创新环境等方面,分析公共管理专业在信息化... 详细信息

“互联网+教育”为新文科背景下公共管理专业培养管理型和技术型复合人才提供了新的路径。为了更好地推动公共管理专业信息化改革进程,提升人才培养质量,该文从课程设置、教学方式、教师队伍、创新环境等方面,分析公共管理专业在信息化时代人才培养过程中存在的主要问题,提出针对性的改进路径,为公共管理专业信息化人才培养模式创新、促进公共管理专业教育信息化改革等提供借鉴。

关键词： “互联网+” 教育信息化人才培养课程改革专业建设公共管理

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基于联邦加权域自适应的多站点自闭症诊断

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河北工业大学学报 2024年第2期53卷 54-63页

作者：郝小可甄时伟周超飞马明明刘时宇曹家辉河北工业大学人工智能与数据科学学院天津300401

为了提高联邦学习(Federated Learning,FL)方法在多站点自闭症诊断中对数据异质性的关注和解决部分站点缺乏标注数据导致的局部阻塞问题,提出了联邦加权域自适应(Federated Weighted Domain Ad⁃aptation,FedWDA)方法。首先,不同于聚合... 详细信息

为了提高联邦学习(Federated Learning,FL)方法在多站点自闭症诊断中对数据异质性的关注和解决部分站点缺乏标注数据导致的局部阻塞问题,提出了联邦加权域自适应(Federated Weighted Domain Ad⁃aptation,FedWDA)方法。首先,不同于聚合一个共享的全局模型的方法,FedWDA在模型聚合的过程中保留了每个本地模型的批量归一化(Batch Normalization,BN)层,使用推土机距离(Earth Mover’s Dis⁃tance,EMD)计算了BN层的统计信息间的相似性,用于指导站点上模型的加权聚合,为每个站点都提供了更加个性化的本地模型,缓解了数据异质性导致的分类准确度不足的问题;其次,对于缺乏数据标注的站点,FedWDA基于样本伪标签的一致性对本地模型进行了无监督聚类调整,充分利用了无标注站点的数据。在公开的数据集ABIDE上的实验结果表明,所提方法相比其他传统方法在多站点自闭症诊断中具有更高的准确率。

关键词：联邦学习多站点领域自适应自闭症诊断聚类学习

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融合文本和表情符号特征的社交网络用户性别识别

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复杂系统与复杂性科学 2022年第4期19卷 17-24页

作者：王浩许小可大连民族大学信息与通信工程学院辽宁大连116600

为了提升社交网络用户性别识别的准确性,先将单用户的文本特征和表情符号特征进行融合识别用户性别,然后提取多用户的交互特征信息进一步提升性别识别的准确性。实验结果表明融合多用户交互特征后用户性别识别准确率提升了6.8%。说明表... 详细信息

为了提升社交网络用户性别识别的准确性,先将单用户的文本特征和表情符号特征进行融合识别用户性别,然后提取多用户的交互特征信息进一步提升性别识别的准确性。实验结果表明融合多用户交互特征后用户性别识别准确率提升了6.8%。说明表情符号和多用户交互特征对提升用户性别识别准确性有很大帮助,提高了社交网络用户性别信息识别的准确率。

关键词：社交网络表情符号性别识别交互特征

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Characterization of PM_(2.5)/PM_(2.5-10) and source tracking in the juncture belt between urban and rural areas of Beijing

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Chinese Science Bulletin 2009年第14期54卷 2506-2515页

作者： WANG HaiLin ZHOU YuMin ZHUANG YaHui WANG xiaoke hao ZhengPing Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Coarse (PM2.5-10) and fine (PM2.5) atmospheric particulate samples were collected in summer and winter during 2005―2007 in the juncture belt between urban and rural areas of Beijing. Elements, ions, organic/elemental carbon (OC/EC) and polynuclear aromatic hydrocarbons (PAHs) were determined to obtain some latest information about the particulate pollution in the juncture belt of Beijing. Particulate matter levels at this site were high as compared with the levels at other sampling sites in Beijing. Pollution elements, secondary ions and PAHs were enriched in fine particles rather than in coarse particles. An obvious seasonal variation of the chemical composition of PM was observed. Source apportionment results showed that secondary components were the largest mass contributor of PM2.5, accounting for 28%; whereas soil-related sources were the largest contributor of PM2.5-10, explaining about 49% of the total mass. The abnormal levels of soil heavy metals at the electronic waste disassembly site in the upwind villages suggested the potential impact of such activities to the environment.

关键词：农村地区北京城市 PM2.5 大气颗粒物土壤重金属追踪表征

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Recent advances in the improvement of g-C_(3)N_(4) based photocatalytic materials

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Chinese Chemical Letters 2021年第1期32卷 13-20页

作者： Yupeng Xing xiaoke Wang Shuhua hao Xueli Zhang Xiao Wang Wenxuan Ma Gang Zhao Xijin Xu School of Physics and Technology University of JinanJi’nan 250022China

g-C_(3)N_(4) have been widely used in the fields of photocatalytic hydrogen production,photocatalytic degradation of dyes and oxidative degradation of toxic gases due to their excellent performance.It has attracted extensive attention in recent years due to its highly efficient photocatalytic capacity of hydrogen generation,water oxidation,carbon dioxide reduction and degradation of organic pollutants.Because of the abundant carbon and nitrogen composition of the earth,large-scale production and industrial applications of this material are possible.The modification of this material makes its performance more excellent so that this new material can obtain a steady stream of vitality.These outstanding works have become important materials and milestones on the road to mankind's photocatalytic hydrogen production.This review will begin with the basic idea of designing,synthesizing and improving g-C_(3)N_(4) based photocatalytic materials,and introduce the latest development of g-C_(3)N_(4) photocatalysts in hydrogen production from four aspects of controlling the carbon/nitrogen ratio,morphology,element doping and heterojunction structure of g-C_(3)N_(4) materials.

关键词： Carbon nitride Modification Enhancement Photocatalyst Hydrogen evolution reaction

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基于患者数据的实时质量控制建立原则及研究进展

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中华检验医学杂志 2022年第1期45卷 82-86页

作者：温冬梅郝晓柯上海森栩医学科技有限公司上海200042 西北大学检验医学系西安710127

基于患者数据的实时质量控制(PBRTQC)是一种使用患者临床标本检测结果以实时、连续监测检测过程分析性能的质量控制方法。2020年国际临床化学和检验医学联合会PBRTQC工作组建议将该方法广泛应用于临床,但国内临床实验室对PBRTQC的认知... 详细信息

基于患者数据的实时质量控制(PBRTQC)是一种使用患者临床标本检测结果以实时、连续监测检测过程分析性能的质量控制方法。2020年国际临床化学和检验医学联合会PBRTQC工作组建议将该方法广泛应用于临床,但国内临床实验室对PBRTQC的认知、研究与应用尚有一定的差距。本文从PBRTQC的研究进展、运算类型、临床应用价值、国内外行标指南建议、PBRTQC程序建立、性能验证、实施原则、应用现状及展望等方面进行阐述,以促进PBRTQC在国内临床实验室的认知、接受、借鉴和广泛应用。

关键词：实验室技术和方法基于患者数据的实时质量控制

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Hollow polyhedron structure of amorphous Ni-Co-S/Co(OH)_(2) for high performance supercapacitors

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Chinese Chemical Letters 2021年第8期32卷 2453-2458页

作者： Xixi Zhang Guangmeng Qu Zonghua Wang Guotao Xiang Shuhua hao xiaoke Wang Xijin Xu Wenxuan Ma Gang Zhao School of Physics and Technology University of JinanJi’nan 250022China

In power storage technology,ion exchange is widely used to modify the electronic structures of electrode materials to stimulate their electrochemical properties.Here,we proposed a multistep ion exchange(cation exchange and anion exchange) strategy to synthesize amorphous Ni-Co-S and β-Co(OH)_(2) hybrid nanomaterials with a hollow polyhedron structures.The synergistic effects of different components and the remarkable superiorities of hollow structure endow Ni-Co-S/Co(OH)_(2) electrode with outstanding electrochemical performance,including ultra-high specific capacity(1440.0 C/g at 1 A/g),superior capacitance retention rate(79.1% retention at 20 A/g) and long operating lifespan(81.4% retention after5000 cycles).Moreover,the corresponding hybrid supercapacitor enjoys a high energy density of 58.4 Wh/kg at the power density of 0.8 kW/kg,and a decent cyclability that the capacitances are maintained at80.8% compared with the initial capacitance.This research presents a high-performance electrode material and provides a promising route for the construction of electrode materials for supercapacitors with both structural and component advantages.

关键词： Ion exchange Amorphous β-Co(OH)2 Hollow polyhedron Supercapacitor

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