检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2022年第5期12卷 2429-2442页

作者： Dong Liang Chen Yu Zhao Ma Xingye Yang Zhenzhen Li Xuhui Dong xiaojun qin Lupei Du Minyong Li Key Laboratory of Chemical Biology(MOE) School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Head and neck squamous cell carcinoma(HNSCC) is one of the most common human cancers;however, its outcome of pharmacotherapy is always very limited. Herein, we performed a batch query in the connectivity map(cMap) based on bioinformatics, queried out 35 compounds with therapeutic potential, and screened out parbendazole as a most promising compound, which had an excellent inhibitory effect on the proliferation of HNSCC cell lines. In addition, tubulin was identified as a primary target of parbendazole, and the direct binding between them was further verified. Parbendazole was further proved as an effective tubulin polymerization inhibitor, which can block the cell cycle, cause apoptosis and prevent cell migration, and it exhibited reasonable therapeutic effect and low toxicity in the in vivo and in vitro anti-tumor evaluation. Our study repositioned an anthelmintic parbendazole to treat HNSCC, which revealed a therapeutic utility and provided a new treatment option for human cancers.

关键词： HNSCC cMap Bioinformatics Parbendazole Drug repositioning Anti-tumor

Recent progress in stability of perovskite solar cells

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2017年第1期38卷 2-10页

作者： xiaojun qin Zhiguo Zhao Yidan Wang Junbo Wu Qi Jiang Jingbi You China Huaneng Group Beijing 100031China China Huaneng Clean Energy-Research Institute Beijing 102209China Key Lab of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

Perovskite solar cells have attracted significant attention in just the past few years in solar cell research fields,where the power conversion efficiency was beyond 22.1%.Now,the most important challenge for perovskite solar cells in practical applications is the stability *** this mini-review,we will summarize the degradation mechanism of perovskite solar cells,including the perovskite material itself and also the *** we also provide our opinion on improving the stability of perovskite solar cells.

关键词： perovskite solar cells stability

Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第7期67卷 1325-1337页

作者： Chengcheng Song Yingying qin Yan Li Bingyi Yang Ting Guo Wenqing Ma Dian Xu Keyan Xu Fangfang Fu Li Jin Yanhua Wu Shuyan Tang xiaojun Chen Feng Zhang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Medical Genetics and GenomicsFudan UniversityShanghai 200011China Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250021China State Key Laboratory of Reproductive Medicine and Offspring Health Key Laboratory of Reproductive Endocrinology of Ministry of EducationNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthShandong UniversityJinan 250021China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China Department of Gynecology the Tenth People’s Hospital of Tongji UniversityShanghai 200072China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health Hospital of China Welfare InstituteShanghai 200030China

Premature ovarian insufficiency(POI)is a heterogeneous female disorder characterized by the loss of ovarian function before the age of *** represents a significant detriment to female ***,the known POI-causative genes currently account for only a fraction of *** elucidate the genetic factors underlying POI,we conducted whole-exome sequencing on a family with three fertile POI patients and identified a deleterious missense variant in *** a subsequent replication study involving 1,030 POI patients,this variant was not only confirmed but also accompanied by the discovery of three additional predicted deleterious RNF111 *** variants collectively account for eight cases,representing 0.78%of the study cohort.A further study involving 500 patients with diminished ovarian reserve also identified two additional RNF111 ***,RNF111 encodes an E3 ubiquitin ligase with a regulatory role in the TGF-β/BMP signaling *** analysis revealed that RNF111/RNF111 is predominantly expressed in the oocytes of mice,monkeys,and *** further investigate the functional implications of RNF111 variants,we generated two mouse models:one with a heterozygous missense mutation(Rnf111+/M)and another with a heterozygous null mutation(Rnf111^(+/-)).Both mouse models exhibited impaired female fertility,characterized by reduced litter sizes and small ovarian ***,RNA-seq and quantitative proteomics analysis unveiled that Rnf111 haploinsufficiency led to dysregulation in female gonad development and negative regulation of the BMP signaling pathway within mouse *** conclusion,our findings strongly suggest that monoallelic deleterious variants in RNF111 can impair female fertility and induce POI in both humans and mice.

关键词： POI RNF111 female fertility ovarian reserve

First small-molecule PROTACs for G protein-coupled receptors:inducing α1A-adrenergic receptor degradation

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2020年第9期10卷 1669-1679页

作者： Zhenzhen Li Yuxing Lin Hui Song xiaojun qin Zhongxia Yu Zheng Zhang Gaopan Dong Xiang Li Xiaodong Shi Lupei Du Wei Zhao Minyong Li Department of Medicinal Chemistry Key Laboratory of Chemical Biology(MOE)School of PharmacyShandong UniversityJinan 250012China Department of Immunology Key Laboratory of Infection and Immunity of Shandong ProvinceSchool of Basic Medical ScienceShandong UniversityJinan 250012China Department of Chemistry University of South FloridaTampaFL 33620USA State Key Laboratory of Microbial Technology Shandong UniversityJinan 250100China

Proteolysis targeting chimeras(PROTACs)are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the ubiquitinproteasome system(UPS),thereby selectively reducing the target protein level by the ubiquitinproteasome ***,small-molecule PROTACs are gaining popularity as tools to desrade pathogenic ***,we present the first small-molecule PROTACs that can induce the alA-adrenergic receptor(α1 A-AR)degradation,which is also the first small-molecule PROTACs for G proteincoupled receptors(GPCRs)to our *** degradation inducers were developed through conjugation of knownα1-adrenergic receptors(α1-ARs)inhibitor prazosin and cereblon(CRBN)ligand pomalidomide through the different *** representative compound 9 c is proved to inhibit the proliferation of PC-3 cells and result in tumor growth regression,which highlighted the potential of our study as a new therapeutic strategy for prostate cancer.

关键词： Small-molecule PROTACs α1A-Adrenergic receptor Ubiquitylation Degradation Prostate cancer

在线全文

学校读者我要写书评

暂无评论

营造林技术在林业发展中的应用

林业科技情报 2023年第4期55卷 58-60页

作者：覃小军广西桂平市白沙镇乡村建设综合服务中心广西桂平537200

营造林技术作为林业发展中的主要技术支撑,它的应用能够改善林木生长区域范围内土壤的质量,提升林业工程管理的水平、保证林木生长的数量和质量,进而推动林业事业的可持续发展。营造林技术可分为植苗造林技术、分殖造林技术和播种造林... 详细信息

营造林技术作为林业发展中的主要技术支撑,它的应用能够改善林木生长区域范围内土壤的质量,提升林业工程管理的水平、保证林木生长的数量和质量,进而推动林业事业的可持续发展。营造林技术可分为植苗造林技术、分殖造林技术和播种造林技术三种。通过科学选择造林树种、良种壮苗、封山育林以及科学营造混交林等技术可提升营造林技术的实际应用效果。

关键词：营造林技术科学选择林业发展

基于“气为血之帅”理论探讨小柴胡汤治疗腰痛气滞血瘀证

在线全文

学校读者我要写书评

暂无评论

中国民间疗法 2022年第6期30卷 10-12页

作者：秦晓君广西中医药大学广西南宁530001

该文从对气为血之帅、腰痛气滞血瘀证的理论认识,以及小柴胡汤组方意义、现代药理学研究及小柴胡汤治疗腰痛气滞血瘀证的作用机制出发,探讨小柴胡汤在腰痛气滞血瘀证中的应用。

关键词：气为血之帅小柴胡汤腰痛气滞血瘀证

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

胆甾相液晶微球光子禁带的动态调控及其应用

物理化学学报 2024年第5期40卷 3-23页

作者：刘晓珺秦朗俞燕蕾复旦大学材料科学系聚合物分子工程国家重点实验室上海200433 复旦大学义乌研究院浙江义乌322000

胆甾相液晶微球是空间结构高度对称的三维光子晶体,能够全方位地选择性反射特定波长的圆偏振光,具有无角度依赖性的光子禁带,作为一种新兴的光学材料在全向激光器、反射式显示和微传感器等领域展现出广阔的应用前景。近年来,毛细管微流... 详细信息

胆甾相液晶微球是空间结构高度对称的三维光子晶体,能够全方位地选择性反射特定波长的圆偏振光,具有无角度依赖性的光子禁带,作为一种新兴的光学材料在全向激光器、反射式显示和微传感器等领域展现出广阔的应用前景。近年来,毛细管微流控技术的蓬勃发展为连续、可控、高通量地制备结构复杂且分子规则取向的单分散胆甾相液晶微球提供了强有力的支持。本综述重点关注利用毛细管微流控技术制备胆甾相液晶微球的相关研究工作,首先分析了毛细管微流控装置在设计微球结构中的决定性作用,阐明了溶液体系的选择与液晶分子取向间的关系以及边界效应对微球尺寸的影响;随后,从胆甾相液晶微球的光学特性切入,介绍了利用温度、溶剂和光等外界刺激调控螺旋结构自组装的原理和策略以及微球之间独有的“光子交叉通讯”现象;最后,总结了现阶段胆甾相液晶微球的潜在应用方向并讨论了该材料体系未来面临的挑战。

关键词：胆甾相液晶结构色微流控微球光子器件

Baseline correction for near-fault ground motion recordings of the 2008 Wenchuan Ms8.0 earthquake

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Geodesy and Geodynamics 2012年第2期3卷 60-70页

作者： Li Heng Wu Jianchao Yao Yunsheng qin xiaojun Key Laboratory of Earthquake Geodesy Institute of SeismologyChina Earthquake AdministrationWuhan 430071China Wuhan Institute of Earthquake Engineering Wuhan 430071China

In this study, both records of a digital accelerometer and a seismograph at a far-field station for the 2008 Ms8.0 Wenchuan earthquake were analyzed, and a pulsive noise model for acceleration record was found. By comparing with the result of a rotary-table tilt test, we concluded that the noises in the acceleration records were caused by ground tilt as a result of rotational ground motion. We analyzed the key noises that may cause baseline offset, and proposed a baseline-correction scheme for preserving the long-period ground motion in accordance with specific pulse positions. We then applied this correction method to some near-field strongmotion acceleration records. The result shows that this method can obtain near-field ground displacements, including permanent displacements, in agreement with GPS data, and that this method is more stable than other methods.

关键词： strong ground motion baseline correction permanent displacement rotational motion tilt

The Feature Parameter Extraction in Palm Shape Recognition System

在线全文

学校读者我要写书评

暂无评论

通讯和计算机（中英文版） 2005年第3期2卷 25-28页

作者： WANG Jianxia ZHOU Wanzhen WANG xiaojun qin Min College of Information Science ＆ Engineering Hebei University of Science and Technology Shijiazhuang 050054 China

To recognize palm by feature parameter of palm shape is a common way. This paper introduces the recognition process of this way, and brings forward the method of picking-up feature parameter of palm shape. Then eight feature parameters are picked up. They are the length of pinkie, the length of ring finger, the length of middle finger, the length of forefinger, the length of thumb, the width of ring finger, the width of middle finger, and the width of palm. Experiment indicates that using these eight feature parameters to recognize palm can reach high veracity and rapidity.

关键词：掌上电脑电子数据采集设备萃取技术电子信息

Improved Performance of CH3NH3PbBr3 Perovskite Solar Cells Utilizing PbI2 Precursors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improved Performance of CH3NH3PbBr3 Perovskite Solar Cells U...