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An Effective Security Comparison Protocol in Cloud Computing

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Computers, Materials & Continua 2023年第6期75卷 5141-5158页

作者： Yuling Chen Junhong Tao Tao Li Jiangyuan Cai xiaojun ren State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550000China Guangxi Key Laboratory of Cryptography and Information Security Guilin University of Electronic TechnologyGuilin550000China POWERCHINA Guizhou Electric Power Engineering Co. Ltd.Guiyang550000China Blockchain Laboratory of Agricultural Vegetables Weifang University of Science and TechnologyWeifang261000China

With the development of cloud computing technology,more and more data owners upload their local data to the public cloud server for storage and calculation.While this can save customers’operating costs,it also poses privacy and security challenges.Such challenges can be solved using secure multi-party computation(SMPC),but this still exposes more security issues.In cloud computing using SMPC,clients need to process their data and submit the processed data to the cloud server,which then performs the calculation and returns the results to each client.Each client and server must be honest.If there is cooperation or dishonest behavior between clients,some clients may profit from it or even disclose the private data of other clients.This paper proposes the SMPC based on a Partially-Homomorphic Encryption(PHE)scheme in which an addition homomorphic encryption algorithm with a lower computational cost is used to ensure data comparability and Zero-Knowledge Proof(ZKP)is used to limit the client’s malicious behavior.In addition,the introduction of Oblivious Transfer(OT)technology also ensures that the semi-honest cloud server knows nothing about private data,so that the cloud server of this scheme can calculate the correct data in the case of malicious participant models and safely return the calculation results to each client.Finally,the security analysis shows that the scheme not only ensures the privacy of participants,but also ensures the fairness of the comparison protocol data.

关键词： Secure comparison protocols zero-knowledge proof homomorphic encryption cloud computing

Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis

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Protein & Cell 2022年第9期13卷 683-688页

作者： Li Yang Jin Chen Jianqing Liang Yufeng Zhang Qingzhe Wang xiaojun ren Jinsong Wei Qianchun Gong Jiting Zhang Ning Jiang Xinhua Lin Jin Li Bing Zhao State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China bioGenous Biotechnology Inc.Hangzhou 311231China Obstetrics and Gynecology Hospital of Fudan University Shanghai Key Laboratory of Female Reproductive Endocrine Related DiseasesFudan UniversityShanghai 200011China

Dear Editor,Hepatoblastoma(HB)is a predominant hepatic neoplasm that develops in children from 0 to 4 years of age at the rate of 2.16 per 1,000,000.It originates from abnormal differentiation of hepatocyte precursors(hepatoblasts)during embryogenesis(Sumazin et al.,2017).Approximately 20%of children with HB have metastasis in lung at diagnosis,which indicates poor prognosis(Angelico et al.,2019).While surgery in combination of chemotherapy and/or metastasectomy is the most popular therapy,relapse happens in a significant portion of HB patients(Zhang et al.,2021).Therefore,novel and less aggressive therapies targeting the pathogenesis of HB should be explored to prolong patients’s disease-free survival as well as to improve their quality of life.

关键词： fetal diagnosis chemotherapy

基于网络药理学及分子对接探讨仙鹤草改善慢性萎缩性胃炎的作用机制

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现代药物与临床 2024年第1期39卷 49-56页

作者：任小军张曼玲赵慧慧时昭红湖北中医药大学湖北武汉430065 湖北中医药大学附属武汉市中西医结合医院湖北武汉430022

目的运用网络药理学和分子对接技术探讨仙鹤草改善慢性萎缩性胃炎的物质基础及作用机制。方法通过TCMSP数据库筛选仙鹤草的活性成分并预测其作用靶点;通过GeneCards、OMIM数据库筛选慢性萎缩性胃炎相关靶点;将活性成分靶点与慢性萎缩... 详细信息

目的运用网络药理学和分子对接技术探讨仙鹤草改善慢性萎缩性胃炎的物质基础及作用机制。方法通过TCMSP数据库筛选仙鹤草的活性成分并预测其作用靶点;通过GeneCards、OMIM数据库筛选慢性萎缩性胃炎相关靶点;将活性成分靶点与慢性萎缩性胃炎靶点取交集,通过String 12.0数据库构建蛋白相互作用(PPI)网络,并运用Cytoscape 3.10.1软件构建“中药–疾病–化合物–交集靶标”网络图;通过R软件对核心靶点进行基因本体(GO)和京都基因与基因组百科全书(KEGG)富集分析以预测作用机制;通过AutoDock软件进行分子对接验证。结果从仙鹤草中筛选出5个活性成分,作用于90个靶点,其中仙鹤草改善慢性萎缩性胃炎的核心活性成分为鞣花酸、山柰酚、儿茶素、木犀草素、槲皮素;核心靶点为B淋巴细胞瘤-2(Bcl-2)、半胱氨酸天冬氨酸蛋白酶-3(CASP3)、表皮生长因子受体(EGFR)、缺氧诱导因子-1A(HIF-1A)、原癌基因(MYC)等;作用机制主要涉及抗肿瘤、调节免疫、调节脂代谢、抗病毒等多条信号通路;分子对接显示,仙鹤草核心活性成分与核心靶点具有较高亲和力。结论仙鹤草可能通过调节细胞增殖、凋亡、炎症、代谢等相关基因及通路发挥多靶点、多通路的治疗作用。

关键词：仙鹤草慢性萎缩性胃炎网络药理学分子对接鞣花酸山柰酚儿茶素木犀草素槲皮素

胆汁酸诱导胃癌的发生机制及丹参提取物潜在作用的研究进展

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中外医药研究 2024年第8期3卷 156-158页

作者：李静任小军罗云达州市中西医结合医院四川达州635000

胆汁反流可导致胃黏膜发生炎性反应、癌变。胆汁酸可以通过激活各种受体和信号通路来诱导胃癌的发生。传统中药丹参提取物可以起到预防胆汁酸诱导胃癌的作用。文章对近年来胆汁酸在胃癌发生中的作用机制进行分析,胃黏膜长时间暴露于胆... 详细信息

胆汁反流可导致胃黏膜发生炎性反应、癌变。胆汁酸可以通过激活各种受体和信号通路来诱导胃癌的发生。传统中药丹参提取物可以起到预防胆汁酸诱导胃癌的作用。文章对近年来胆汁酸在胃癌发生中的作用机制进行分析,胃黏膜长时间暴露于胆汁酸中会导致黏膜损伤及炎性反应,导致慢性胃炎、肠化生、异型增生和胃癌;丹参提取物在预防和治疗胆汁酸诱导的胃癌中具有潜在优势,丹参素通过调节多种涉及炎症、氧化应激、DNA损伤和细胞凋亡的信号通路,可以预防胆汁反流引起胃炎和胃癌。

关键词：胆汁反流胃癌丹参提取物

First-Principles Study on Stability and Magnetism of MAl<sub>n</sub>(M = Ni, Cu) (n = 1 - 9) Clusters

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World Journal of Condensed Matter Physics 2012年第4期2卷 267-273页

作者： Baoxing Li xiaojun ren Xiao Zhang Zhiwei Ma Jiaojiao Gu Guobao Li Department of Physics Microfluidic Chip Institute Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal University Hangzhou China

We have investigated the structures, stabilities and magnetism of NiAln and CuAln (n = 1 - 9) clusters systematically by using first-principles density functional theory. Our calculated results indicate that most of the ground state structures for the Al clusters doped with one nickel or copper atom are different from those of the corresponding pure Al clusters. NiAln and CuAln (n = 1 - 9) cluster ions have similar geometrical configurations to the corresponding neutral clusters, except for positive NiAl9 ion. The magnetic moments of NiAln (n = odd number) and CuAln (n = even number) cluster anions, neutrals and cations are 0, 1 μB, and 2 μB, respectively. The magnetic moments of NiAl4 and NiAl6 cluster anions, neutrals and cations are associated with 1 μB, 2 μB, and 3 μB, respectively. NiAl2, NiAl8 and CuAln (n = odd number) clusters do not have any net magnetic moment. But, NiAl2 and NiAl8 cluster ions have the net magnetic moment of 1 μB.

关键词： NiAl Cluster CuAl Cluster Stable Structure Magnetism

红细胞分布宽度β_(2)-微球蛋白与维持性血液透析患者认知障碍的相关性研究

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实用医技杂志 2024年第1期31卷 8-13,I0001页

作者：刘高虹田云凤梁捧元吕艳任小军山西省人民医院肾内科太原030012 阳泉煤业(集团)有限责任公司总医院肾内科阳泉045000 山西医科大学第三医院(山西白求恩医院山西医学科学院同济山西医院)肾内科太原030032

目的探讨红细胞分布宽度(RDW)、β_(2)-微球蛋白(β_(2)-MG)与维持性血液透析(MHD)患者认知障碍(CI)之间的关系。方法收集2022年1月至6月于山西医科大学第三医院血液净化中心MHD患者195例临床及实验室资料,进行简易智力状态检查量表... 详细信息

目的探讨红细胞分布宽度(RDW)、β_(2)-微球蛋白(β_(2)-MG)与维持性血液透析(MHD)患者认知障碍(CI)之间的关系。方法收集2022年1月至6月于山西医科大学第三医院血液净化中心MHD患者195例临床及实验室资料,进行简易智力状态检查量表筛查。Logistic回归分析MHD患者发生CI的危险因素、受试者工作特征(ROC)曲线分析RDW、β_(2)-MG对MHD患者CI预测价值。结果 195例MHD患者中CI71例(36.4%)。Logistic回归分析显示RDW、β_(2)-MG是MHD患者发生CI的独立危险因素。RDW预测MHD认知功能障碍的灵敏度80.3%、特异度为83.1%,曲线下面积(95%CI)为0.856(0.803,0.909)(P<0.05)。β_(2)-MG预测MHD患者认知功能障碍的灵敏度87.3%、特异度为78.2%,曲线下面积(95%CI)为0.872(0.821,0.922)(P<0.05)。RDW联合β_(2)-MG预测MHD认知功能障碍灵敏度85.9%、特异度为88.0%,曲线下面积(95%CI)为0.949(0.922,0.975)(P<0.05)。结论高RDW、β_(2)-MG对MHD患者认知障碍有一定预测价值,且两者联合检测对MHD患者认知障碍预测价值更高。

关键词：血液透析,维持性认知障碍红细胞分布宽度 β_(2)-微球蛋白

Reorganization of 3D genome architecture provides insights into pathogenesis of early fatty liver disease in laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1086-1100页

作者： Yanli Liu Zhuqing Zheng Chaohui Wang Yumeng Wang Xi Sun Zhouzheng ren Xin Yang xiaojun Yang College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Agricultural Biotechnology Jingchu University of TechnologyJingmen 448000China

Background Fatty liver disease causes huge economic losses in the poultry industry due to its high occurrence and lethality rate.Three-dimensional(3D)chromatin architecture takes part in disease processing by regulating tran-scriptional reprogramming.The study is carried out to investigate the alterations of hepatic 3D genome and H3K27ac profiling in early fatty liver(FLS)and reveal their effect on hepatic transcriptional reprogramming in laying hens.Results Results show that FLS model is constructed with obvious phenotypes including hepatic visible lipid deposi-tion as well as higher total triglyceride and cholesterol in serum.A/B compartment switching,topologically associat-ing domain(TAD)and chromatin loop changes are identified by high-throughput/resolution chromosome conforma-tion capture(HiC)technology.Targeted genes of these alternations in hepatic 3D genome organization significantly enrich pathways related to lipid metabolism and hepatic damage.H3K27ac differential peaks and differential expres-sion genes(DEGs)identified through RNA-seq analysis are also enriched in these pathways.Notably,certain DEGs are found to correspond with changes in 3D chromatin structure and H3K27ac binding in their promoters.DNA motif analysis reveals that candidate transcription factors are implicated in regulating transcriptional reprogram-ming.Furthermore,disturbed folate metabolism is observed,as evidenced by lower folate levels and altered enzyme expression.Conclusion Our findings establish a link between transcriptional reprogramming changes and 3D chromatin struc-ture variations during early FLS formation,which provides candidate transcription factors and folate as targets for FLS prevention or treatment.

关键词： 3D chromatin architecture Fatty liver disease Folate H3K27ac profiling Transcription reprogramming

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Emulsifying property,antioxidant activity,and bitterness of soybean protein isolate hydrolysate obtained by Corolase PP under high hydrostatic pressure

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Food Science and Human Wellness 2024年第3期13卷 1271-1278页

作者： Haining Guan Chunmei Feng Min ren xiaojun Xu Dengyong Liu Xiaoqin Diao College of Food Science and Technology Bohai UniversityJinzhou 121013China

Enzymatic hydrolysis of proteins can enhance their emulsifying properties and antioxidant activities.However,the problem related to the hydrolysis of proteins was the generation of the bitter taste.Recently,high hydrostatic pressure(HHP)treatment has attracted much interest and has been used in several studies on protein modification.Hence,the study aimed to investigate the effects of enzymatic hydrolysis by Corolase PP under different pressure treatments(0.1,100,200,and 300 MPa for 1-5 h at 50℃)on the emulsifying property,antioxidant activity,and bitterness of soybean protein isolate hydrolysate(SPIH).As observed,the hydrolysate obtained at 200 MPa for 4 h had the highest emulsifying activity index(47.49 m^(2)/g)and emulsifying stability index(92.98%),and it had higher antioxidant activities(44.77%DPPH free radical scavenging activity,31.12%superoxide anion radical scavenging activity,and 61.50%copper ion chelating activity).At the same time,the enhancement of emulsion stability was related to the increase of zeta potential and the decrease of mean particle size.In addition,the hydrolysate obtained at 200 MPa for 4 h had a lower bitterness value and showed better palatability.This study has a broad application prospect in developing food ingredients and healthy foods.

关键词： Soybean protein isolate High hydrostatic pressure Emulsification Antioxidant Bitter taste

Noble-metal nanocluster as enzyme-mimetic catalyst for diagnostic analysis

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Science China(Technological Sciences) 2019年第12期62卷 2306-2309页

作者： ren xiaojun WANG ShiZheng SU DongDong GAO Liang YUAN Qing GAO XueYun Department of Chemistry and Chemical Engineering Beijing University of Technology

Noble-metal nanoclusters,which consist of only several to a few hundred metal atoms,have attracted a great deal of scientific interest due to their fascinating optical properties,biocompatibility and low toxicity[1].Intriguingly,na-noclusters have been recently reported possessing intrinsic enzyme-mimetic properties,mainly including peroxidase-like activity,which can convert hydrogen peroxide into hy-droxyl radicals,and catalase-like activity,which can convert hydrogen peroxide into water and oxygen.As low-cost al-ternatives to natural enzymes,nanoclusters can overcome several drawbacks of natural enzymes,such as sensitivity of catalytic activity to environmental conditions,low stability leaded by denaturation and digestion and high cost.

关键词： cluster convert catalyst