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Cryo-electron microscopy reconstructions of two types of wild rabbit hemorrhagic disease viruses characterized the structural features of Lagovirus

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Protein & Cell 2010年第1期1卷 48-58页

作者： Zhongjun Hu xiaojuan tian Yujia Zhai Wei Xu Dong Zheng Fei Sun National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Department of Biochemistry and Molecular Biology College of Life SciencesBeijing Normal UniversityBeijing 100875China

Rabbit hemorrhagic disease was described in China in 1984 and can cause hemorrhagic necrosis of the liver within two or three days after *** etiological agent,rabbit hemorrhagic disease virus(RHDV),belongs to the Lagovirus genus in the Caliciviridae *** to other calicivirus,such as rNV and SMSV,the structure of Lagovirus members is not well *** this report,structures of two types of wild RHDV particles,the intact virion and the core-like particle(CLP),were reconstructed by cryo-electron microscopy at 11Åand 17Å,*** is the first time the 3D structure of wild caliciviruses CLP has been provided,and the 3D structure of intact RHDV virion is the highest resolution structure in *** of the intact virion and CLP structures clearly indicated that CLP was produced from the intact virion with the protrusion *** contrast with the crystal structures of recombinant Norovirus and San Miguel sea lion virus,the capsomers of RHDV virion exhibited unique structural features and assembly *** P1 and P2 subdomains have interactions inside the AB capsomer,while only P2 subdomains have interaction inside CC *** pseudo atomic models of RHDV capsomers were constructed by homology modeling and density map fitting,and the rotation of RHDV VP60 P domain with respect to its S domain,compared with SMSV,was ***,our cryo-electron microscopic studies of RHDV provide close insight into the structure of Lagovirus,which is important for functional analysis and better vaccine development in the future.

关键词： rabbit hemorrhagic disease virus calicivirus Lagovirus core-like particle cryo-electron microscopy reconstruction

儿童局灶性脑动脉病的临床特点及预后影响因素分析

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中华儿科杂志 2025年第2期63卷 174-179页

作者：卓秀伟于泽谋孟令丙周季张炜华任长红巩帅代丽芳杨欣英张珅刘明程华田小娟李久伟国家儿童医学中心、首都医科大学附属北京儿童医院神经内科北京100045 北京清华长庚医院心脏内科、清华大学临床医学院北京102218

目的总结儿童局灶性脑动脉病(FCA)的临床特点并分析其预后的影响因素。方法回顾性队列研究。收集2015年9月至2024年8月首都医科大学附属北京儿童医院神经内科住院的40例FCA患儿的临床资料,在2024年10月通过门诊或互联网进行集中随访,根... 详细信息

目的总结儿童局灶性脑动脉病(FCA)的临床特点并分析其预后的影响因素。方法回顾性队列研究。收集2015年9月至2024年8月首都医科大学附属北京儿童医院神经内科住院的40例FCA患儿的临床资料,在2024年10月通过门诊或互联网进行集中随访,根据儿童卒中结局量表(PSOM)评价患儿转归并分为神经功能正常组及神经功能异常组。采用Mann-WhitneyU检验、Fisher确切概率法分析组间差异,采用单因素Logistic回归分析寻找FCA患儿神经功能结局的影响因素。结果40例FCA患儿中男、女各20例,起病年龄9.2(6.8,12.5)岁。12例(30%)患儿有卒中前1年内水痘病史。40例患儿中,23例(58%)以短暂性脑缺血发作或反复波动症状起病,3例(8%)在发病第1个月内表现为进展性脑卒中,受累血管部位以大脑中动脉的M1段为最常见[16例(40%)],8例(20%)患儿存在动脉闭塞。36例进行腰椎穿刺的患儿中6例脑脊液白细胞升高。23例患儿完成了磁共振血管壁成像(VWI),均存在动脉管壁环形强化。28例(70%)接受抗血小板或抗凝治疗,16例(40%)接受激素治疗。入院时美国国立卫生研究院儿童卒中量表(PedNIHSS)评分为6.0(2.0,8.8)分,出院时降至0.5(0,3.0)分。随访时间为1.6(0.8,4.9)年,1例失访,完成随访的39例患儿中神经功能正常组23例(59%)、神经功能异常组16例(41%)。1例曾有复发,表现为短暂性脑缺血发作。29例患儿影像学复查,23例末次磁共振动脉血管成像(MRA)示原有的动脉狭窄保持稳定或好转,其中6例病程早期动脉狭窄曾短暂恶化(病程2个月内);6例末次复查MRA提示动脉狭窄进展,其中1例为进展性脑动脉病。神经功能异常组头痛、意识改变及失语的比例,入院及出院PedNISS评分均高于神经功能正常组(均P6分是神经功能异常的影响因素(OR=20.58,95%CI 3.93~107.70,P6分与远期神经功能异常有关。

关键词：儿童局灶性脑动脉病卒中预后

Correlations between Light Rare Earth Elements in Soil and Navel Orange Tree System in Gannan Area

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Asian Agricultural Research 2018年第6期10卷 75-80页

作者： Xiaoling WANG xiaojuan tian Zhu GAO Institute of Biological Resources Jiangxi Academy of Sciences College of Landscape Architecture and Art Jiangxi Agricultural University

The total content of light rare earth elements( LREEs) in the soil of navel orange orchards of Gannan area is greater than that of heavy rare earth elements( HREEs). Appropriate content of LREE can not only promote the growth of navel oranges,and it is also conducive to human health. On the basis of exploring the correlations between the content of LREE in the soil of navel orange orchards of Gannan area and the contents of LREE in navel orange leaves and fruit,the influence mechanism of LREEs on the quality of navel oranges was revealed. In this study,with two Newhall navel orange orchards with different soil LREEs background levels in Xinfeng County as the research object,the changes in the content of LREE( lanthanum,La; cerium,Ce; praseodymium,Pr; neodymium,Nd) in leaves and fruit of navel orange at different growth stages were analyzed using Inductively Coupled Plasma-Mass Spectrometry( ICP-MS),and the correlations between the content of LREE in the soil,navel orange leaves and navel orange fruit were studied. The results showed that the contents of the four kinds of LREEs in the soil ranked as Ce > La > Nd > Pr,and there were significant differences among them( P < 0. 01). Navel orange leaves and fruit have selective and heterogenic absorption for LREEs. At different growth stages,La showed the highest accumulation amount in the leaves and fruit of navel orange; and the content of LREE in the leaves of navel orange increased first and then decreased,while that in the fruit of navel orange showed continuous decrease. During the migration of LREEs from soil to leaves to fruit,the content of LREE decreased rapidly as the migration distance increased. The accumulation amount of LREE in navel orange was positively correlated with the content of LREE in the soil. The correlation between the content of LREE in the leaves and fruit of navel orange was greatest. Among the four kinds of LREEs,the correlation of La was greatest,followed by Ce,indicating that the accumulat

关键词： Light rare earth element Navel orange Soil Correlation

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai Meng tian Huali Yu Xiaoxiao He xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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论商周时期的玉石容器

中国国家博物馆馆刊 2015年第7期 71-83页

作者：田小娟陕西历史博物馆西安710061

商周玉石容器在大型墓葬偶有发现,与同时期的容器在形制、纹饰、尺寸大小上极为相近。本文就玉石器皿的器型、纹饰、年代等问题,结合墓葬出土的青铜器、陶器等进行类比,认为玉石容器与青铜礼器的相似性主要表现在簋、盘、豆、觯这几种... 详细信息

商周玉石容器在大型墓葬偶有发现,与同时期的容器在形制、纹饰、尺寸大小上极为相近。本文就玉石器皿的器型、纹饰、年代等问题,结合墓葬出土的青铜器、陶器等进行类比,认为玉石容器与青铜礼器的相似性主要表现在簋、盘、豆、觯这几种器型上,纹饰方面也尽量模仿青铜器但较为简单,但也有器物仿陶器。商代的玉石器皿以实用器为主,主要出土于殷墟,西周则主要发现于周原地区,均为把玩的小器皿,而非实用器。

关键词：商周玉石容器造型纹饰

Using piezoelectric technology to harvest energy from pavement: A review

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Journal of Traffic and Transportation Engineering(English Edition) 2025年第01期 68-86页

作者： Keliang Mou Xiaoping Ji Jie Liu Haoyu Zhou Haochen tian xiaojuan Li Honghui Liu School of Highway Chang'an University Xinjiang Communications Planning SurveyDesign and Research Institute Co.Ltd. Technology Development Group Co. Ltd.Shaanxi Transportation Holding Group Xi'an Highway Research Institute Co. Ltd.

A key point in building a contemporary energy system is the search for sustainable and green energy. Many green energy sources exist in the road or pavement domain, such as solar, thermal, wind, and mechanical energy, etc. Under the repeated vehicle loads,stresses and strains are generated in the pavement, which can generate substantial mechanical energy. In recent two decades, there has been a growing scholarly preference for utilizing the piezoelectric effect to convert mechanical energy from pavement into electricity to supply low-power transportation facilities, pavement sensors, etc. This paper provides an in-depth review of state-of-the-art advances in road piezoelectric energy harvesters. The basic principle of piezoelectric energy harvesting and common piezoelectric materials were briefly introduced. The piezoelectric energy harvesters suitable for roads are thoroughly reviewed from five perspectives: structure, finite element analyses,protective packaging, management circuit, and application. Finally, the challenges faced by piezoelectric energy harvesters for pavements were summarized, and the potential research directions were also proposed. This review serves as a valuable reference for advancing road piezoelectric harvesting technology development.

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二氧化锰基纤维状超级电容器的研究进展

复合材料学报 2023年第6期40卷 3187-3196页

作者：田晓娟程新跃魏取福江南大学纺织科学与工程学院无锡214122

二氧化锰(MnO_(2))具有高容量、环保、低成本等优点,是一种极具发展前景的超级电容器电极材料。随着智能可穿戴技术的不断发展,纤维状超级电容器由于其灵活性和可编织性受到广泛关注。将高性能的MnO_(2)电极材料构建纤维状超级电容器作... 详细信息

二氧化锰(MnO_(2))具有高容量、环保、低成本等优点,是一种极具发展前景的超级电容器电极材料。随着智能可穿戴技术的不断发展,纤维状超级电容器由于其灵活性和可编织性受到广泛关注。将高性能的MnO_(2)电极材料构建纤维状超级电容器作为可穿戴技术的重要组成部分也被不断研究和拓展创新。根据目前MnO_(2)基纤维状超级电容器的发展和可穿戴能源产品的需求,本文对温和中性电解质中MnO_(2)的储能机制进行分析,针对MnO_(2)基纤维状超级电容器在实际可穿戴应用中存在的连续化生产困难、实际利用率低等问题,提出了解决策略,深入分析了各种解决策略的利弊及方案中材料的协同作用,为未来的研究方向提供新的思路,最后对其面临的挑战和未来的发展进行了归纳总结,MnO_(2)基纤维状超级电容器有望在今后取得重大进展,成为新一代能源纺织品的高效供能体系。

关键词：二氧化锰(MnO_(2)) 纤维状超级电容器智能可穿戴应用解决策略

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妇科疾病患者经阴道自然腔道内镜手术的护理

护理学杂志 2018年第10期33卷 39-41页

作者：田小娟刘霞北京协和医院妇科北京100730

目的总结妇科疾病患者经阴道自然腔道内镜手术(NOTES)的护理经验。方法对10例妇科疾病患者行经阴道自然腔道内镜手术,术前做好心理护理、皮肤准备,充分的阴道和肠道准备;术后注意体位护理,加强出血及引流管护理、排尿及排便护理、并发... 详细信息

目的总结妇科疾病患者经阴道自然腔道内镜手术(NOTES)的护理经验。方法对10例妇科疾病患者行经阴道自然腔道内镜手术,术前做好心理护理、皮肤准备,充分的阴道和肠道准备;术后注意体位护理,加强出血及引流管护理、排尿及排便护理、并发症护理。结果 10例患者手术顺利完成,手术时间81.6min,术后无阴道大出血、感染及脏器损伤等并发症发生;切口均愈合良好,未出现盆腹腔及切口感染,患者均顺利出院。结论妇科疾病经阴道自然腔道内镜手术创伤小、恢复快、体表不留瘢痕。护理人员根据手术特点开展针对性护理,可保障手术效果,促进患者康复。

关键词：妇科宫颈病变子宫肌瘤卵巢囊肿阴道经自然腔道内镜手术围手术期护理

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DSP直流牵引控制器在防爆铲车上的应用

煤矿安全 2016年第2期47卷 130-132页

作者：田晓娟山西电力职业技术学院电力工程系山西太原030021

介绍了煤矿短壁开采用防爆蓄电池铲车的DSP直流牵引控制器设计方案,通过对铲车双串励绕组直流牵引电机的调速控制程序编写,实现蓄电池动力车辆的正反向运行;增加了油泵电机软启动功能,降低了油泵电机起动电流,减少了机械冲击。

关键词：短壁开采防爆蓄电池铲车直流牵引控制器双串励绕组软启动