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升温速率和固溶时间对超高强铝合金挤压材组织性能的影响

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铸造技术 2018年第3期39卷 687-690页

作者：黄鹏许晓静崔熙贵贾伟杰杜东辉张冲江苏大学先进制造与现代装备技术工程研究院江苏镇江212013

采用金相组织分析、EBSD分析、维氏硬度测试、电导率测试、室温拉伸性能等,将Al-10.78Zn-2.78Mg-2.59Cu-0.221Zr-0.047Sr合金分别以3.6℃/h和180℃/h的升温速率升温至470℃,保温2 h和24 h,研究了升温速率和固溶时间对组织和性能的影响... 详细信息

采用金相组织分析、EBSD分析、维氏硬度测试、电导率测试、室温拉伸性能等,将Al-10.78Zn-2.78Mg-2.59Cu-0.221Zr-0.047Sr合金分别以3.6℃/h和180℃/h的升温速率升温至470℃,保温2 h和24 h,研究了升温速率和固溶时间对组织和性能的影响。结果表明,快速升温短保温时间的热处理工艺更佳,合金的硬度为218.1 HV,电导率为25.9%IACS,抗拉强度为735.6 MPa,屈服强度为691.7 MPa,伸长率为6.1%。为保证合金性能,应在快速升温时选择低固溶时间,在慢速升温时选择长固溶保温时间。

关键词： 7xxx系铝合金升温速率保温时间组织性能

肝细胞核因子1α基因多态位点与上海地区2型糖尿病相关临床性状的关系

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上海医学 2008年第8期31卷 536-539页

作者：张蓉王从容胡承方启晨马晓静贾伟平项坤三上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病研究所200233

目的肝细胞核因子(HNF)-1α基因单核苷酸多态(SNP)位点可能与2型糖尿病及其相关性状相关,对以往发现的HNF-1α基因6个标签SNP进行糖尿病相关数量性状分析,以进一步探讨其与糖脂代谢及体脂分布的潜在关系。方法245名无亲缘关系的上海地... 详细信息

目的肝细胞核因子(HNF)-1α基因单核苷酸多态(SNP)位点可能与2型糖尿病及其相关性状相关,对以往发现的HNF-1α基因6个标签SNP进行糖尿病相关数量性状分析,以进一步探讨其与糖脂代谢及体脂分布的潜在关系。方法245名无亲缘关系的上海地区中国人,包括152例早发/多发糖尿病家系先证者(病例组)及93名糖调节正常者(正常对照组)。采用直接测序或聚合酶链反应(PCR)-限制性片段长度多态性(RFLP)方法检测受试者基因型,并测定所选人群的糖脂代谢及体脂分布指标。对不同基因型亚组间进行标签SNP的单点和单倍型数量性状分析。结果正常对照组中,rs1169294、rs1169301和rs2259820的各基因型亚组间的体质指数(BMI)、腰臀比(WHR)和腰股比(WFR)的差异均有统计学意义(P值均<0.05),且经性别、年龄校正后差异仍有统计学意义(P值均<0.05)。此外,rs1169289的基因型亚组间WFR的差异有统计学意义(P<0.05)。单倍型分析发现,正常对照组中最常见单倍型GCGC携带者的BMI较非GCGC携带者显著降低(P=0.006 5),且经年龄和性别校正后,差异仍有统计学意义(P=0.017 0)。结论HNF-1α多态位点与中国人体脂分布相关。

关键词：肝细胞核因子1α 2型糖尿病单核苷酸多态单倍型

Exploring age and gender disparities in cardiometabolic phenotypes and lipidomic signatures among Chinese adults: a nationwide cohort study

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Life Metabolism 2024年第5期3卷 61-74页

作者： xiaojing jia Hong Lin Ruizhi Zheng Shuangyuan Wang Yilan Ding Chunyan Hu Mian Li Yu Xu Min Xu Guixia Wang Lulu Chen Tianshu Zeng Ruying Hu Zhen Ye Lixin Shi Qing Su Yuhong Chen Xuefeng Yu Li Yan Tiange Wang Zhiyun Zhao Guijun Qin Qin Wan Gang Chen Meng Dai Di Zhang Bihan Qiu Xiaoyan Zhu Jie Zheng Xulei Tang Zhengnan Gao Feixia Shen Xuejiang Gu Zuojie Luo Yingfen Qin Li Chen Xinguo Hou Yanan Huo Qiang Li Yinfei Zhang Chao Liu Youmin Wang Shengli Wu Tao Yang Huacong Deng jiajun Zhao Yiming Mu Shenghan Lai Donghui Li Weiguo Hu Guang Ning Weiqing Wang Yufang Bi Jieli Lu for theC Study Group Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People's Republic of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Endocrine and Metabolic Diseases The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Endocrine and Metabolic Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Zhejiang Provincial Center for Disease Control and Prevention HangzhouZhejiang 310051China Department of Endocrine and Metabolic Diseases Affiliated Hospital of Guiyang Medical CollegeGuiyangGuizhou 550004China Department of Endocrine and Metabolic Diseases Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Endocrine and Metabolic Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Endocrine and Metabolic Diseases Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Department of Endocrine and Metabolic Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Endocrine and Metabolic Diseases The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Department of Endocrine and Metabolic Diseases Fujian Provincial HospitalFujian Medical UniversityFuzhouFujian 350003China Department of Endocrine and Metabolic Diseases The First Hospital of Lanzhou UniversityLanzhouGansu 730000China Department of Endocrine and Metabolic Diseases Dalian Municipal Central HospitalDalianLiao

Understanding sex disparities in modifiable risk factors across the lifespan is essential for crafting individualized intervention *** aim to investigate age-related sex disparity in cardiometabolic phenotypes in a large nationwide Chinese cohort.A total of 254,670 adults aged 40 years or older were selected from a population-based cohort in *** sex disparities in the prevalence of metabolic diseases were observed across different age strata,particularly for dyslipidemia and its com*** additive models were employed to characterize phenotype features,elucidating how gender differences evolve with advancing *** of the 16 phenotypes consistently exhibited no sex differences,while four(high-density lipoprotein[HDL]cholesterol,apolipoprotein A1,diastolic blood pressure,and fasting insulin)displayed significant sex differences across all age ***,apolipoprotein B,non-HDL cholesterol,and total cholesterol demonstrated significant age-dependent sex dis***,premenopausal females exhibited significant age-related differences in lipid levels around the age of 40-50 years,contrasting with the relatively stable associations observed in males and postmenopausal *** played an important but not sole role in age-related sex differences in blood *** duration also had an age-and sex-dependent impact on *** analysis and K-means clustering further revealed that 58.6%of the 263 measured lipids varied with sex and age,with sphingomyelins,cholesteryl esters,and triacylglycerols being the most profoundly influenced lipid species by the combined effects of age,sex,and their *** findings underscore the importance of age consideration when addressing gender disparities in metabolic diseases and advocate for personalized,age-specific prevention and management.

关键词： sex difference aging metabolic diseases modifiable risk factors lipidomics

地黄叶总苷胶囊联合盐酸贝那普利片治疗儿童紫癜性肾炎60例疗效观察

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中国实用医刊 2017年第21期44卷 95-97页

作者：赵丽君潘晋兵贾晓静李娜冯杏田勇丽山西省儿童医院肾内科太原030013 深圳市人民医院儿科 518020 山西医科大学儿科医学系太原030001

目的观察地黄叶总苷胶囊联合盐酸贝那普利片治疗儿童紫癜性肾炎的临床疗效，为临床治疗提供新的治疗方法及指导。方法将60例确诊为紫癜性肾炎、临床分型为血尿和蛋白尿型的患儿随机分为两组，治疗组30例给予地黄叶总苷胶囊联合贝那普利... 详细信息

目的观察地黄叶总苷胶囊联合盐酸贝那普利片治疗儿童紫癜性肾炎的临床疗效，为临床治疗提供新的治疗方法及指导。方法将60例确诊为紫癜性肾炎、临床分型为血尿和蛋白尿型的患儿随机分为两组，治疗组30例给予地黄叶总苷胶囊联合贝那普利片治疗，对照组30例单纯给予贝那普利片治疗，均治疗12周。观察两组治疗前后尿微量白蛋白、24 h尿蛋白定量、尿沉渣红细胞计数、血清白蛋白和肌酐的变化及不良反应发生情况，评价两组疗效。结果治疗组总有效率为93.33%，对照组为73.33%，两组比较差异有统计学意义（P〈0.05）。治疗后12周，两组患儿尿微量白蛋白、24 h尿蛋白定量及尿沉渣红细胞计数水平均显著降低，且治疗组低于对照组（P〈0.05）。治疗前后两组白蛋白略有增高，但差异均未见统计学意义（P均〉0.05）；治疗前后两组血肌酐比较差异未见统计学意义（P〉0.05）。结论地黄叶总苷胶囊联合贝那普利片治疗血尿和蛋白尿型紫癜性肾炎疗效优于单用贝那普利，能更显著地降低尿蛋白、减轻血尿，且无明显不良反应。

关键词：紫癜性肾炎地黄叶总苷贝那普利儿童

骨髓间充质干细胞对慢性肾衰竭大鼠的修复作用

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中华临床医师杂志（电子版） 2016年第19期10卷 2877-2882页

作者：崔建军贾晓静潘晋兵李娜李秀花韩艳冯杏山西省儿童医院肾内科太原030013 山西医科大学儿科医学系太原030001 山西省儿童医院病理科太原030013 山西医科大学公共卫生学院太原030001

目的探讨经尾静脉移植骨髓间充质干细胞(BM-MSCs)对腺嘌呤所致慢性肾衰竭(CRF)大鼠的修复作用。方法经密度梯度离心法结合贴壁筛选法于体外分离培养并纯化BM-MSCs。36只雄性Wistar大鼠按随机数字表法分为正常对照组、CRF组、BM-MSCs移植... 详细信息

目的探讨经尾静脉移植骨髓间充质干细胞(BM-MSCs)对腺嘌呤所致慢性肾衰竭(CRF)大鼠的修复作用。方法经密度梯度离心法结合贴壁筛选法于体外分离培养并纯化BM-MSCs。36只雄性Wistar大鼠按随机数字表法分为正常对照组、CRF组、BM-MSCs移植组,每组12只。采用腺嘌呤200 mg·kg-1·d-1灌胃法制作大鼠CRF模型。造模成功24 h,正常对照组和CRF组经尾静脉注射1 ml磷酸盐缓冲液(PBS),BM-MSCs移植组经尾静脉注射1×106个BM-MSCs。8周后采血检测各组大鼠的肾功能,收集肾组织称重,计算大鼠的肾脏系数,并用JG12免疫组化检测肾小球毛细血管密度,酶联免疫吸附试验(ELISA)法检测血管内皮生长因子(VEGF)的含量,并比较三组间各指标的差异。结果移植BM-MSCs 8周后,BM-MSCs移植组的肾脏系数较CRF组明显降低(0.99±0.10 vs.1.32±0.20,P=0.019)。BM-MSCs移植组尿素氮(BUN)和血肌酐(SCr)均较CRF组降低[BUN:(11.23±1.45)mmol/L vs.(14.25±1.23)mmol/L,P=0.033;SCr:(122.45±15.37)μmol/L vs.(183.33±41.66)μmol/L,P=0.028]。CRF组肾小球中JG12表达较正常对照组显著降低(33.85±2.28 vs.66.93±3.98,P<0.001),移植BM-MSCs后肾小球中JG12表达有所增加(50.84±1.29vs.33.85±2.28,P<0.001),血清VEGF的含量升高[(86.55±5.18)pg/ml vs.(55.74±2.74)pg/ml,P<0.001]。结论腺嘌呤所致CRF大鼠移植BM-MSCs后,肾小球毛细血管密度增加,肾功能改善;其作用可能与其旁分泌促血管生成因子VEGF有关。

关键词：间质干细胞肾功能衰竭,慢性慢性肾疾病血管内皮生长因子血管新生

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抚育间伐对华北落叶松人工林林分结构的影响

中南林业科技大学学报 2022年第5期42卷 54-64页

作者：陈哲魏浩亮周庆营王海东丁万林李艳茹贾晓静徐满王超陈瑜谷建才河北农业大学林学院河北保定071000 河北省木兰围场国有林场河北承德068450 新疆能源研究院有限公司新疆乌鲁木齐830000

【目的】研究抚育间伐对华北落叶松人工林林分结构的影响,探究适合华北落叶松人工林的最佳抚育间伐强度,以期为华北落叶松人工林经营管理提供理论依据。【方法】以36年生华北落叶松人工林为研究对象,设置对照及22%、38%抚育间伐强度样地... 详细信息

【目的】研究抚育间伐对华北落叶松人工林林分结构的影响,探究适合华北落叶松人工林的最佳抚育间伐强度,以期为华北落叶松人工林经营管理提供理论依据。【方法】以36年生华北落叶松人工林为研究对象,设置对照及22%、38%抚育间伐强度样地,分别于伐后1 a、伐后3 a、伐后5 a、伐后7 a进行林分结构指标的定期调查,分析各处理样地的林分生长和径级结构。【结果】抚育间伐促进了林分胸径和单株材积年均生长量。22%间伐、38%间伐的胸径年均生长量分别比对照增长了25.6%、52.0%;22%间伐、33%间伐的单株材积年均生长量分别比对照增长了29.0%、88.7%。各处理样地的树高年均生长量之间无显著差异(P>0.05),抚育间伐对树高生长无明显影响。林分蓄积量、胸高断面积年均生长量以及生物量和碳储量年均增长量都随着抚育间伐强度的增加而减少,但从时间变化来看,随着时间的延长,对照样地增长率逐渐降低,抚育间伐样地增长率逐渐增加。对照、22%间伐、38%间伐样地直径分布范围分别为6~22、10~22、12~22 cm,随着抚育间伐强度的加大,林木向更大径阶方向偏移。KS检验结果表明,对照样地均符合正态分布,22%间伐样地以对数正态分布拟合效果最佳,其次为伽玛分布;38%间伐样地正态分布拟合效果最好,其次为Weibull分布。【结论】抚育间伐可以促进林分的生长,改善林分结构,使林分结构向更高径阶方向发展,综合考虑采用38%间伐强度为宜。

关键词：华北落叶松抚育间伐生长结构径级结构

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Integrated analysis of transcriptomic and proteomic data from tree peony(***)seeds reveals key developmental stages and candidate genes related to oil biosynthesis and fatty acid metabolism

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Horticulture Research 2019年第1期6卷 344-362页

作者： xiaojing Wang Haiying Liang Dalong Guo Lili Guo Xiangguang Duan Qishi jia Xiaogai Hou College of Agriculture/College of Tree Peony Henan University of Science and TechnologyLuoyang 471023China Department of Genetics and Biochemistry Clemson UniversityClemsonSC 29634-0318USA College of Forestry Henan University of Science and TechnologyLuoyang 471023China

Tree peony(Paeonia section Moutan DC.)seeds are an excellent source of beneficial natural compounds that promote health,and they contain high levels of alpha-linolenic acid(ALA).In recent years,tree peony has been emerging as an oil ***,combined analysis of the transcriptome and proteome of tree peony(***)seeds at 25,32,39,53,67,81,88,95,and 109 days after pollination(DAP)was conducted to better understand the transcriptional and translational regulation of seed development and oil biosynthesis.A total of 38,482 unigenes and 2841 proteins were identified.A total of 26,912 differentially expressed genes(DEGs)and 592 differentially expressed proteins(DEPs)were clustered into three groups corresponding to the rapid growth,seed inclusion enrichment and conversion,and late dehydration and mature stages of seed *** lipid metabolism pathways were identified at both the transcriptome and proteome *** enrichment analysis revealed that a period of rapid fatty acid biosynthesis occurred at 53–88 ***,211 genes and 35 proteins associated with the fatty acid metabolism pathway,63 genes and 11 proteins associated with the biosynthesis of unsaturated fatty acids(UFAs),and 115 genes and 24 proteins associated with ALA metabolism were *** analysis revealed that 16 putative fatty acid desaturase(FAD)-encoding genes clustered into four FAD groups,eight of which exhibited the highest expression at 53 DAP,suggesting that they play an important role in ALA ***-qPCR analysis indicated that the temporal expression patterns of oil biosynthesis genes were largely similar to the RNA-seq *** expression patterns of fatty acid metabolism-and seed development-related proteins determined by MRM were also highly consistent with the results obtained in the proteomic *** analysis indicated significant differences in the number and abundance of DEGs and DEPs but a high level of consistency in

关键词： tree analysis consistency

An efficient and mild recycling of waste melamine formaldehyde foams by alkaline hydrolysis

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Green Energy & Environment 2024年第5期9卷 919-926页

作者： Shaodi Wu Ning Zhang Chizhou Wang Xianglin Hou Jie Zhao Shiyu jia jiancheng Zhao xiaojing Cui Haibo Jin Tiansheng Deng Shanxi Engineering Research Center of Biorefinery Institute of Coal ChemistryChinese Academy of Sciences27 South Taoyuan RoadTaiyuan030001China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Department of Chemistry and Chemical Engineering Taiyuan Institute of TechnologyTaiyuanShanxi030008China Beijing Key Laboratory of Fuels Cleaning and Advanced Catalytic Emission Reduction Technology/College of New Materials and Chemical Engineering Beijing Institute of Petrochemical TechnologyBeijing102617China

Melamine formaldehyde foam(MFF)generates many poisonous chemicals through the traditional recycling methods for organic resin ***,a high MFF degradation ratio of ca.97 wt.%was achieved under the mild conditions(160℃)in a NaOH–H2O system with ammelide and ammeline as the main degradation *** alkaline solvent had an obvious corrosion effect for MFF,as indicated by scanning electron microscopy(SEM).The reaction process and products distribution were studied by Fourier-transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS),and ^(13)C nuclear magnetic resonance(NMR).Besides,the MFF degradation products that have the similar chemical structures and bonding performances to those of melamine can be directly used as the raw material for synthesis of melamine urea-formaldehyde resins(MUFs).Moreover,the degradation system demonstrated here showed the high degradation efﬁciency after reusing for 7 *** degradation process generated few harmful pollutants and no pre-or post-treatments were required,which proves its feasibility in the safe removal or recovery of waste MFF.

关键词： Melamine formaldehyde foam Degradation Alkaline hydrolysis Recycling

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

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Frontiers of Medicine 2021年第3期15卷 460-471,F0004页

作者： Lingli Cai Jun Yin xiaojing Ma Yifei Mo Cheng Li Wei Lu Yuqian Bao jian Zhou Weiping jia Department of Endocrinology and Metabolism Shanghai Clinical Center for DiabetesShanghai Diabetes InstituteShanghai Key Laboratory of Diabetes MellitusShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Lifestyle interventions,including dietary adjustments and exercise,are important for obesity *** study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet(LCD)or exercise is more effective in metabolism ***-five eligible subjects were randomly divided into an LCD group(n=22)and an exercise group(EX,n=23).The subjects either adopted LCD(carbohydrate intake<50 g/day)or performed moderate-to-vigorous exercise(≥30 min/day)for 3 *** the interventions,LCD led to a larger weight loss than EX(−3.56±0.37 kg vs.−1.24±0.39 kg,P<0.001),as well as a larger reduction in fat mass(−2.10±0.18 kg vs.−1.25±0.24 kg,P=0.007)and waist circumference(−5.25±0.52 cm vs.−3.45±0.38 cm,P=0.008).Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin *** decreased in both two groups,whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX *** glycemic parameters,including serum glycated albumin,mean sensor glucose,coefficient of variability(CV),and largest amplitude of glycemic excursions,substantially declined in the LCD *** CV slightly decreased after *** pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin *** with exercise,LCD might be more efficient for weight loss and glucose homeostasis in people with obesity.

关键词： low-carbohydrate diet obesity nonalcoholic fatty liver disease continuous glucose monitoring mean sensor glucose