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Effects of in-situZrB_2 nanoparticles and scandium on microstructure and mechanical property of 7N01 aluminum alloy

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Journal of Rare Earths 2024年第3期42卷 612-620,I0007页

作者： Xizhou Kai Yuhui Wang Ruikun Chen Yanjie Peng Anjun Shi Ran tao Xiangfeng Liang Guirong Li Gang Chen xiaojing Xu Yutao Zhao School of Material Science and Engineering Jiangsu UniversityZhenjiang212013China Institute for Advanced Manufacturing and Modern Equipment Technology Jiangsu UniversityZhenjiang212013China

In this study, the in-situ synthesized ZrB_(2) nanoparticles and rare earth Sc were introduced to enhance the strength and ductility of 7N01 aluminum alloy, via the generation of high-melting and uniform nanodispersoids. The microstructure and mechanical property evolution of the prepared composites and the interaction between ZrB_(2) and Sc were studied in detail. The microstructure investigation shows that the introduction of rare earth scandium(Sc) can promote the distribution of ZrB_(2) nanoparticles, by improving their wettability to the Al melt. Meanwhile, the addition of rare earth Sc also modifies the coarse Al Zn Mg Mn Fe precipitated phases, refines the matrix grains and generates high-melting Al_3(Sc,Zr)/Al_3Sc nanodispersoids. Tensile tests of the composites show that with the combinatorial introduction of ZrB_(2) and Sc, the strength and ductility of the composites are improved simultaneously compared with the corresponding 7N01 alloy, ZrB_(2) /7N01 composite and Sc/7N01 alloy. And the optimum contents of ZrB_(2) and Sc are 3 wt% and 0.2 wt% in this study. The yield strength, ultimate strength and elongation of(3 wt% ZrB_(2) +0.2 wt% Sc)/7N01 composite are 477 MPa, 506 MPa and 9.8%, increased about 18.1%, 12.2%and 38% compared to 7N01 alloy. Furthermore, the cooperation strengthening mechanisms of ZrB_(2) and Sc are also discussed.

关键词： 7N01 aluminum alloy In-situ ZrB_(2)nanoparticles Rare earth Sc Microstructure Mechanical property Mechanism

基于TEA算法的地理信息数据安全保护技术及验证分析

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测绘通报 2022年第7期 154-157,167页

作者：陶肖静上海中侨职业技术大学建筑工程学院上海201514 同济大学测绘与地理信息学院上海200092

地理信息数据是国家国防建设和国民经济发展的重要基础数据,随着数字化、信息化及云计算等技术的发展,地理信息数据的安全威胁日益严峻,本文面对移动平台上地理信息数据安全存储、高效传输和实时信息解密及处理等挑战,提出了一种基于TE... 详细信息

地理信息数据是国家国防建设和国民经济发展的重要基础数据,随着数字化、信息化及云计算等技术的发展,地理信息数据的安全威胁日益严峻,本文面对移动平台上地理信息数据安全存储、高效传输和实时信息解密及处理等挑战,提出了一种基于TEA算法的地理信息数据安全保护技术,该技术采用循环迭代的移位和异或运算实现对地理信息数据的加密和解密,可以实现移动平台端地理信息数据的高安全加密存储和高性能实时解密处理,并采用该算法对SRTM数据进行处理和分析。试验结果表明,基于TEA算法的地理信息数据加密技术可以有效实现地理信息数据的加密及解密处理,满足移动系统对地形数据的高安全存储和高性能处理的要求。

关键词： TEA算法地理信息安全高安全存储数据实时解密

通脉乐口服液中黄芪和丹参成分薄层色谱鉴别方法

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亚太传统医药 2024年第8期20卷 65-68页

作者：李秋萍李倩张蓓谭柳萍陶晓静张新林张洪平陆世银柳州市中医医院(柳州市壮医医院)药学部柳州市中药(壮瑶药)制剂研发重点实验室柳州市中药(壮瑶药)制剂开发工程技术研究中心广西中医药大学

目的:建立通脉乐口服液中黄芪、丹参成分的薄层色谱鉴别方法，完善其质量标准。方法:分别以黄芪甲苷、丹酚酸B为对照品，以硅胶G及硅胶GF254为固定相，建立通脉乐口服液中黄芪、丹参的薄层色谱鉴别方法，并对其进行色谱条件耐用性考察... 详细信息

目的:建立通脉乐口服液中黄芪、丹参成分的薄层色谱鉴别方法，完善其质量标准。方法:分别以黄芪甲苷、丹酚酸B为对照品，以硅胶G及硅胶GF254为固定相，建立通脉乐口服液中黄芪、丹参的薄层色谱鉴别方法，并对其进行色谱条件耐用性考察。结果:在供试品色谱图中，黄芪、丹参各组分分离良好、斑点对称、清晰圆整，阴性对照无干扰。结论:通脉乐口服液黄芪和丹参成分薄层色谱方法专属性强，操作简便，可用于通脉乐口服液质量控制。

关键词：通脉乐口服液黄芪甲苷丹酚酸B TLC

CBTC无线通信传输技术的改进与使用LTE技术的可行性分析

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城市轨道交通研究 2017年第B8期20卷 8-13页

作者：陶小婧上海地铁维护保障有限公司通号分公司上海工程师200235

随着城市轨道交通运行控制系统向系统化、网络化、信息化、智能化方向的发展,基于通信的列车控制(CBTC)系统已成为城市轨道交通主流的信号系统,可实现车地连续式双向通信。结合实际使用情况,阐述了现CBTC系统使用的2.4 GHz无线通信的性... 详细信息

随着城市轨道交通运行控制系统向系统化、网络化、信息化、智能化方向的发展,基于通信的列车控制(CBTC)系统已成为城市轨道交通主流的信号系统,可实现车地连续式双向通信。结合实际使用情况,阐述了现CBTC系统使用的2.4 GHz无线通信的性能,通过对比上海现使用的泰雷兹和卡斯柯两套CBTC系统2.4 GHz无线通信实际使用及故障情况,提出了针对性的改进方案。针对LTE(长期演进)通信技术在CBTC系统无线通信中的使用进行了初步分析,并提出相应的2种通信方案。

关键词：城市轨道交通基于通信的列车控制无线通信传输长期演进技术

Effects of miR-24 on the expression of vascular endothelial nitric oxide synthase and nitric oxide level in rats

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广西医科大学学报 2018年第4期35卷 421-425页

作者： Yongxiong Zhong Xuelan Luo xiaojing tao Feng Shen Dan Li Yuanyuan Yan Hesheng Ou College of Pharmacy Guangxi Medical UniversityNanning 530021China Guangxi International Zhuang Hospital Nanning530001China

Objective:To investigate the effects of miR-24 on the expression of vascular endothelial nitric oxide synthase(eNOS)and plasma nitric oxide(NO)level in ***:The miR-24 over-expression plasmid was *** healthy male Sprague-Dawley rats were randomly divided into two groups:miR-24 group and blank plasmid *** were injected with plasmid DNA in saline via the tail *** eight weeks,the rat artery was removed and HE staining was used to observe the morphological *** protein expression and activity of eNOS were detected by immunohistochemistry and enzyme-linked immunosorbent assay(ELISA),respectively,and the NO level in plasma was determined by nitrate reduction ***:Compared with the blank plasmid group,the expression and activity of eNOS as well as the NO production in the miR-24 group was significantly decreased(P <0.05 or P <0.01).No significant difference in the morphology of vascular tissue was noted between the two ***:Up-regulation of miR-24 inhibits the expression of eNOS and NO production in rat vascular *** may provide a bio-target for the development of drugs to treat cardiovascular diseases such as hypertension.

关键词： miR-24 eNOS NO cardiovascular disease

城市轨道交通通号专业设备故障智能化管理研究

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城市轨道交通研究 2021年第S1期24卷 7-11页

作者：陶小婧上海轨道交通维护保障有限公司通号分公司上海200235

随着城市轨道交通线网往网络级,甚至超大网络级规模发展,客流量的急剧攀升对设备的可靠性和安全性提出了更高的要求。分析了通号设备维保现状和维保管理面临的问题,以及通号设备故障智能化管理需求;在此基础上,提出了城市轨道交通通号... 详细信息

随着城市轨道交通线网往网络级,甚至超大网络级规模发展,客流量的急剧攀升对设备的可靠性和安全性提出了更高的要求。分析了通号设备维保现状和维保管理面临的问题,以及通号设备故障智能化管理需求;在此基础上,提出了城市轨道交通通号专业设备故障智能化管理体系,介绍了该体系建设所需的先进技术,以及体系的架构和相应的业务功能。通过城市轨道交通通号专业设备故障智能化管理建设,能够实现快速诊断、定位故障,提升维护效率;能够实现维保模式从故障修、计划修向状态修转变,提升维保质量。

关键词：城市轨道交通通信信号智能运维故障管理

Effects and mechanism of miRNA-24 on the proliferation,migration and tube formation of vascular endothelial cells

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广西医科大学学报 2018年第7期35卷 901-906页

作者： xiaojing tao Feng Shen Peng Yang Xuelan Luo Dan Li Yuanyuan Yan Yongxiong Zhong Hesheng Ou College of Pharmacy Guangxi Medical UniversityNannin 530021China Guangxi International Zhuang Medical Hospital Nanning 530001China

Objective:To investigate the effect and mechanism of miRNA-24 on the proliferation,migration and tube formation of vascular endothelial ***:Human umbilical vein endothelial cells(HUVECs)were assigned into control,microRNA(miR)-24 overexpression and anti-miR-24 *** proliferation and migration abilities of HUVECs were detected by methyl thiazolyl tetrazolium(MTT)assay and scratch wound healing assay,*** ability of HUVECs to form tubular structures was evaluated by a tube formation *** mRNA and protein expressions of vascular endothelial growth factor(VEGF)and transcription factor Sp1 were determined by RT-PCR,immunocytochemistry and western blotting,***:The miR-24 overexpression group exhibited decreased cell proliferation and migration,and expressions of VEGF and Sp1 compared with the control group(P <0.01).No tube-like network structure was formed in the miR-24 overexpression ***,inhibition of miR-24 in HUVECs markedly increased cell proliferation and migration,enhanced tube formation and expressions of VEGF and Sp1(P<0.05 or P<0.01).Conclusion:MiR-24 suppressed the proliferation,migration and tube formation of HUVECs,and the mechanism might be related to the down-regulation of VEGF ***1 might participate in this regulation process.

关键词： miRNA-24 vascular endothelial growth factor Sp1 endothelial cells tube formation

脱氢卡维丁对CCl_(4)诱导的肝纤维化大鼠的改善作用

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湖南中医药大学学报 2024年第2期44卷 220-226页

作者：覃妮周柳李俊伟吴腾李秋萍陶晓静黄灵聪韦西玲张洪平陆世银柳州市中医医院(柳州市壮医医院) 中药(壮瑶药)制剂研发重点实验室广西柳州545026 柳州市中医医院(柳州市壮医医院) 中药(壮瑶药)制剂开发工程技术研究中心广西柳州545026

目的探讨脱氢卡维丁对四氯化碳(carbon tetrachloride,CCl_(4))诱导的肝纤维化大鼠的改善作用及可能机制。方法将SD大鼠随机分为正常组、模型组、水飞蓟宾组(30 mg/kg)、脱氢卡维丁组(50 mg/kg),每组6只。除正常组外,其他各组采用30%CCl... 详细信息

目的探讨脱氢卡维丁对四氯化碳(carbon tetrachloride,CCl_(4))诱导的肝纤维化大鼠的改善作用及可能机制。方法将SD大鼠随机分为正常组、模型组、水飞蓟宾组(30 mg/kg)、脱氢卡维丁组(50 mg/kg),每组6只。除正常组外,其他各组采用30%CCl_(4)橄榄油溶液(1 mL/kg)腹腔注射复制肝纤维化模型,每周2次,连续14周。各给药组于造模第13、14周每天按设定剂量灌胃相应药物进行干预。正常组与模型组大鼠灌胃等体积的生理盐水。末次给药12 h后,测定各组大鼠肝脾指数;采用HE染色与Masson染色观察肝组织病理学变化,比色法检测大鼠血清丙氨酸转氨酶(alanine aminotransferase,ALT)、天冬氨酸转氨酶(aspartate aminotransferase,AST)、丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)的含量;采用ELISA检测血清透明质酸(hyaluronic acid,HA)、层黏连蛋白(laminin,LN)、Ⅲ型前胶原蛋白(typeⅢprocollagen,PCⅢ)及Ⅳ型胶原蛋白(collagenⅣ,ColⅣ)的表达水平;Western blot法检测肝组织转化生长因子-β1(transforming growth factor-β1,TGF-β1)、α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)、E-钙黏蛋白(E-cadherin)、N-钙黏蛋白(N-cadherin)的表达情况。结果与正常组相比,模型组大鼠肝脾指数显著增加(P<0.001),肝组织纤维化进展明显,胶原容积分数明显增加(P<0.001),血清中ALT、AST、MDA、LN、HA、PCⅢ和ColⅣ水平显著升高(P<0.001),SOD明显下降(P<0.001);肝组织TGF-β1、α-SMA及N-cadherin蛋白表达水平明显上升(P<0.001),E-cadherin蛋白表达明显下降(P<0.001)。与模型组比较,脱氢卡维丁组大鼠肝脾指数明显降低(P<0.001),肝组织病理学损伤和纤维增生有效改善,胶原容积分数明显下降(P<0.001),血清ALT、AST、MDA含量显著降低(P<0.001),血清SOD的表达水平明显升高(P<0.001),LN、HA、PCⅢ、ColⅣ的表达明显下调(P<0.05,P<0.001),肝组织TGF-β1、α-SMA和N-cadherin蛋白表达显著下降(P<0.001),而E-cadherin蛋白表达明显升高(P<0.001)。结论脱氢卡维丁对肝纤维化大鼠具有良好的改善作用,其机制可能与调节氧化应激反应、下调N-cadherin、α-SMA、TGF-β1蛋白表达及上调E-cadherin蛋白表达有关。

关键词：脱氢卡维丁肝纤维化氧化应激 E-钙黏蛋白、N-钙黏蛋白 α-平滑肌肌动蛋白转化生长因子-β1

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New role of platelets in schizophrenia:predicting drug response

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General Psychiatry 2024年第2期37卷 197-206页

作者： Yamin Zhang Yanghao Zheng Peiyan Ni Sugai Liang xiaojing Li Hua Yu Wei Wei Xueyu Qi Xueli Yu Rui Xue Liansheng Zhao Wei Deng Qiang Wang Wanjun Guo tao Li Department of Neurobiology Zhejiang University School of Medicine Affiliated Mental Health Centre&Hangzhou Seventh People's HospitalHangzhouZhejiangChina Liangzhu Laboratory Zhejiang University MOE Frontier Science Center for Brain Science and Brain Machine IntegrationHangzhouZhejiangChina Mental Health Center and Psychiatric Laboratory West China Hospital of Sichuan UniversityChengduSichuanChina

Background Elevated platelet count(PLTc)is associated with first-episode schizophrenia and adverse outcomes in individuals with precursory ***,the impact of antipsychotic medications on PLTc and its association with symptom improvement remain *** We aimed to investigate changes in PLTc levels following antipsychotic treatment and assess whether PLTc can predict antipsychotic responses and metabolic changes after accounting for other related *** A total of 2985 patients with schizophrenia were randomised into seven *** group received one of seven antipsychotic treatments and was assessed at 2,4 and 6 *** symptoms were evaluated using the positive and negative syndrome scale(PANSS).Additionally,we measured blood cell counts and metabolic parameters,such as blood *** measures analysis of variance was used to examine the effect of antipsychotics on PLTc changes,while structural equation modelling was used to assess the predictive value of PLTc on PANSS *** PLTc significantly increased in patients treated with aripiprazole(F=6.00,p=0.003),ziprasidone(F=7.10,p<0.001)and haloperidol(F=3.59,p=0.029).It exhibited a positive association with white blood cell count and metabolic *** baseline PLTc was observed in non-responders,particularly in those defined by the PANSS-negative *** the structural equation model,PLTc,white blood cell count and a latent metabolic variable predicted the rate of change in the PANSS-negative subscale ***,higher baseline PLTc was observed in individuals with less metabolic change,although this association was no longer significant after accounting for baseline metabolic *** Platelet parameters,specifically PLTc,are influenced by antipsychotic treatment and could potentially elevate the risk of venous thromboembolism in patients with *** PLTc levels and associated factors may impede symptom improvement by

关键词： schizophrenia assessed treatment