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Efficacy of fire needle on acute gouty arthritis induced by monosodium urate in rats

Journal of Traditional Chinese Medicine 2021年第4期41卷 564-570页

作者： CheN Hua ZHOU Gexuan he xiaojin GUO Feng CheN Jianmei QIAN Xian First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023China Nursing College Nanjing University of Chinese MedicineNanjing 210023China Department of Rheumatology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China

OBJECTIVE:To explore the therapeutic effect and inflammatory mechanism of fire needles on gouty ***:Sixty male Sprague-Dawley rats were divided into four groups,that is,control group,the model group,the colchicine group,and the fire needle treatment *** gouty arthritis was prepared by injection of monosodium urate in the ankle *** inflammation-related protein[toll-like receptor 4(TLR4),pyrin domain-containing protein 3(NLRP3),interleukin(IL)-1β,myeloid differentiation factor 88(My D88),nuclear factorkappa B(NF-κB),phosphorylated NF-κB(p-NF-κB),caspase-1,and p-caspase-1]in swollen tissues,the inflammation-related m RNAs indicators(TLR4,NLRP3,NF-κB,and caspase-1)and the inflammatory factors[IL-1β,IL-6,IL-8,tumor necrosis factor-α(TNF-α),and C-reactive protein(CRP)]in the serum were detected by Western blot,real-time quantitative polymerase chain reaction,and enzyme-linked immunosorbent assay,***:The fire needle treatment could reduce joint swelling,increase mechanical pain threshold and decrease the inflammation index score in the fire needle treatment *** could also significantly decreased the protein expression of IL-1β,TLR4,My D88,p-NF-κB and NLRP3 in joint tissue,markedly downregulated the m RNA levels of TLR4 and NLRP3 in joint tissue,and significantly reduce serum levels of IL-1β,IL-6,IL-8,TNF-α,and ***:The fire needle treatment had positive effect of treating gouty arthritis,and its underlying mechanism might be associated with NF-κB activation and related inflammatory response.

关键词： arthritis gouty fire needle inflammation NF-kappa B

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Effect of Gubi prescription on caveolin-1 expression and phosphoinositide 3 kinase/protein kinase B and Fas signal pathways in rats with knee osteoarthritis

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Journal of Traditional Chinese Medicine 2020年第2期40卷 224-235页

作者： he xiaojin Wang Lei Zhou Xueping Xu Luzhou Cao Jing Wang Ruirui Wang Min Xie Guoqian Rheumatology Department Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjing 210029China Sports Medicine Center Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Department of Traumatology&Orthopedics Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China

OBJECTIVE: To investigate the effects of Gubi prescription on the expression of caveolin-1, and the phosphoinositide 3 kinase/protein kinase B(PI3 K/Akt) and Fas signal pathways in rats with knee osteoarthritis(KOA).METHODS: Forty KOA model rats were established using a modification of Hulth's method. Rats were divided into five groups by the random number method: model, positive drug(Vicolli group), and high-, medium-, and low-dose Gubi prescription groups(n = 8/group). In the sham surgery group(n = 8), only anterior and posterior cruciate ligaments of rats were exposed during surgery. A normal group(n = 8) consisted of rats with no treatment. Rats were intragastrically administered corresponding drugs once every day for eight consecutive weeks. Then, rat synovial membranes were extracted and histomorphological changes were recorded. m RNA expression was measured by *** superoxide dismutase(SOD), malondialdehyde(MDA), nitric oxide(NO), and interleukin 1β(IL-1β) levels were measured. Western blotting determined the effects of Gubi prescription on protein expressions of caveolin-1, Bax, Bcl-2, Fas, and caspase-3 in chondrocytes from KOA rats. The knee cartilage of rats was excised and cultured under aseptic conditions. After coincubation of chondrocytes with Gubi prescription-containing serum, IL-1β, and si RNA, Western blotting was used to determine the protein expressions of caveolin-1, Bax, Bcl-2, Fas, and ***: The morphological score of the articular synovium in the model group was significantly higher than in the normal group(P he morphological score in the high-and mediumdose Gubi prescription groups was lower than in the model group(P he decoction-containing serum group had a lower expression of Bax(P her expressions of Bcl-2(P he model group. Chondrocytes in the decoction-containing serum group had higher expressions of Bax and Bcl-2(P <

关键词： Osteoarthritis,knee Caveolin 1 Phosphatidylinositol 3-kinase Superoxide dismutase Malondialdehyde Nitric oxide Interleukin-1beta Gubi prescription

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Clinical Observation of rhIL-2 Combined with Zhenqi Fuzheng and BaofuKang Suppository in the Treatment of Cervical Intraepithelial Neoplasia II with HPV Infection

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Open Journal of Obstetrics and Gynecology 2020年第8期10卷 1045-1055页

作者： Yu Cai Jianjun Zhai Jinping Xun xiaojin he Department of Gynecology and Obstetrics BeiJing TongRen Hospital Capital Medical University Beijing China Department of Pathology BeiJing TongRen Hospital Capital Medical University Beijing China

Objective: To investigate the clinical effects of recombinant human interleukin-2 (rhIL-2) combined with Zhenqi Fuzheng and Baofukang on cervical intraepithelial neoplasia II (CINII) combined with human papilloma virus infection. Methods: There were 593 patients diagnosed with CINII with HPV infection, including 296 in the control group and 297 in the experimental group. The control group was given only Zhenqi Fuzheng oral and Baofukang suppository vaginal medicine. The experimental group was treated with rhIL-2 injection in addition to Zhenqi Fuzheng oral and Baofukang suppository vaginal medicine which is treated for 3 months. After 3 months, Thinprep cytologic test (TCT), human papilloma virus (HPV) quantitative examination and colposcopy biopsy were reviewed. Results: After 3 months of treatment, the negative conversion rate and total effective rate of HPV in the control group were 58.11% and 70.95% respectively, and the negative conversion rate and total effective rate of the experimental group were 79.46% and 90.57% respectively. There was significant difference between the two groups (p = 0.000). The curative rate of cervical lesions was significantly higher in the test group than in the control group, 89.56%, 68.91%, respectively. The statistical difference between the two groups is significant (p = 0.000). Conclusion: It has an essential clinical value that HPV infection patients and cervical intraepithelial neoplasia II associated with

关键词： Cervical Intraepithelial Neoplasia II Human Papilloma Virus Recombinant Human Interleukin-2 Zhenqi Fuzheng Baofukang

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茂金属聚烯烃弹性体POE研究进展

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化工新型材料 2011年第2期39卷 32-35,65页

作者：贺小进中国石化股份有限公司北京北化院燕山分院北京102500

聚烯烃弹性体(POE)是杜邦道弹性体公司采用限定几何构型茂金属催化剂(CGC)合成的乙烯-辛烯共聚弹性体,具有优良的力学性能、加工性能和优异的耐老化性能。对POE国内外发展趋势进行了概述,对POE的性能、结构特点进行了介绍,对POE聚合工... 详细信息

聚烯烃弹性体(POE)是杜邦道弹性体公司采用限定几何构型茂金属催化剂(CGC)合成的乙烯-辛烯共聚弹性体,具有优良的力学性能、加工性能和优异的耐老化性能。对POE国内外发展趋势进行了概述,对POE的性能、结构特点进行了介绍,对POE聚合工艺特点、不同公司用主催化剂和助催化剂种类以及聚合催化剂的合成进行了详细阐述,并就POE项目发展提出了见解。

关键词： POE CGC茂金属催化剂 Insite工艺

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Novel compound heterozygous variants in dynein axonemal heavy chain 17 cause asthenoteratospermia with sperm flagellar defects

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Journal of Genetics and Genomics 2020年第11期47卷 713-717页

作者： Bing Song Chunyu Liu Yang Gao Jordan Lee Marley Weiyu Li Xiaoqin Ni Wangjie Liu Yujie Chen Jiajia Wang Chao Wang Ping Zhou Zhaolian Wei xiaojin he Feng Zhang Yunxia Cao Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefei230032China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Anhui Medical UniversityHefei230032China Ministry of Education Key Laboratory of Population health Across Life Cycle Anhui Medical UniversityHefei230032China Anhui Province Key Laboratory of Reproductive health and Genetics Hefei230032China Biopreservation and Artificial Organs Anhui Provincial Engineering Research CenterAnhui Medical UniversityHefei230032China Obstetrics and Gynecology Hospital NHC Key Laboratory of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research)Fudan UniversityShanghai200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai200011China State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing211116China Wellcome Centre for Mitochondrial Research Biosciences InstituteNewcastle UniversityNewcastle upon TyneNE24HHUK

The axoneme of the human sperm has a very similar ultrastructure to motile cilia,the"9+2"structure,comprising nine peripheral double microtubules plus two central pairs(Nicastro et al.,2006;Ishikawa,2017).A proteomics analysis identified more than700 proteins exclusively in the sperm tail,and abnormal expression of related genes can cause male infertility with multiple morphological abnormalities of flagella(MMAF),including absent,coiled,short,and irregular-caliber flagella(Baker et al.,2013;Coutton et al.,2015).

关键词： al. compound ultrastructure

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Deficiency of MFSD6L, an acrosome membrane protein, causes oligoasthenoteratozoospermia in humans and mice

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Journal of Genetics and Genomics 2024年第10期51卷 1007-1019页

作者： Dapeng Zhou Huan Wu Lingbo Wang Xuemei Wang Shuyan Tang Yiling Zhou Jiaxiong Wang Bangguo Wu Jianan Tang Xuehai Zhou Shixiong Tian Shuang Liu Mingrong Lv xiaojin he Li Jin Hujuan Shi Feng Zhang Yunxia Cao Chunyu Liu State Key Laboratoyf Genetic Engineering Human Phenome InsttuteZhangjiang Fudan Interational Innovation CenterFudan UniversityShanghai 200438China Institute of Medical Genetics and Genomics Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Anhui Medical UniversityHefeiAnhui 230032China Key Laboratory of Population health Across Life Cycle Anhui Medical UniversityMinistry of Education of the People's Republic of ChinaHefeiAnhui 230032China Shanghai Key Laboratory of Metabolic Remodeling and health Institute of Metabolism and Integrative BiologyInstitute of Reproduction and DevelopmentObstetrics andGynecologyHospitalFudan UniversityShanghai 200433China Shanghai-MOST Key Laboratory of health and Disease Genomics NHC Key Lab of Reproduction RegulationShanghai Institute for Biomedical and Pharmaceutical TechnologiesSchool of PharmacyFudan UniversityShanghai 200237China State Key Laboratory of Reproductive Medicine The Affiliated Suzhou Hospitalof Nanjing Medical UniversitySuzhouJiangsu 2002China Suzhou Municipal Hospital SuzhouJiangsu 215002China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Shanghai Key Laboratory of Embryo Original Diseases Soong Ching Ling Institute of Maternity and Child HealthInternational Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China

Oligoasthenoteratozoospermia is an important factor affecting male fertility and has been found to be associated with genetic ***,there are stll a proportion of oligoasthenoteratozoospermia cases that cannot be explained by known pathogenic genetic ***,we perform genetic analyses and identify bi-allelic loss-of-function variants of MFSD6L from an oligoasthenoteratozoospermia-affected ***6l knock-out male mice also present male subfertility with reduced sperm concentration,motility,and deformed *** mechanistic analyses reveal that MFsD6L,as an acrosome membrane protein,plays an important role in the formation of acrosome by interacting with the inner acrosomal membrane protein ***,poor embryonic development is consistently observed after intracytoplasmic sperm injection treatment using spermatozoa from the MFSD6L-deficient man and male ***,our findings reveal that MFSD6L is required for the anchoring of sperm acrosome and head *** deficiency of MFsD6L affects male fertility and causes oligoasthenoter-atozoospermia in humans and mice.

关键词： Male fertility Oligoasthenoteratozoospermia MFSD6L Acrosome ICSI

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村镇银行发展的制度约束及优化设计

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农业经济问题 2010年第8期31卷 57-62页

作者：王修华贺小金何婧对外经济贸易大学金融学院湖南大学金融与统计学院长沙410079

本文以农村金融增量改革为研究背景,在分析村镇银行基本情况和实践效果的基础上,重点探讨村镇银行进一步发展所面临的发起机构主体过于单一、发起机构条件过于苛刻、基础系统和支持政策不完备等一系列制度约束,并提出相应的优化建议。

关键词：农村金融增量改革村镇银行发起机构制度约束

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Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia

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Journal of Genetics and Genomics 2019年第1期46卷 53-56页

作者： Wangjie Liu Huan Wu Li Wang Xiaoyu Yang Chunyu Liu xiaojin he Weiyu Li Jiajia Wang Yujie Chen Hongyan Wang Yang Gao Shuyan Tang Shenmin Yang Li Jin Feng Zhang Yunxi Cao Obstetrics and Gynecology Hospital NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research) School of Life Sciences Fudan University Center for Global health School of Public Health Nanjing Medical University Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Reproductive Medicine Center Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical University Anhui Province Key Laboratory of Reproductive health and Genetics Anhui Medical University Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs Clinical Center of Reproductive Medicine The First Affiliated Hospital of Nanjing Medical University Center for Reproduction and Genetics The Affiliated Suzhou Hospital of Nanjing Medical University Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical University

Male infertility, as a major issue of human reproduction health, prevents successful natural conception. Asthenoteratospermia mainly presents one or multiple anomalies in head, neck and tail of spermatozoa, and impairs sperm function and motility (Coutton et al., 2015). Recurrent abnormalities of the fibrous sheath lead to multiple morphological abnormaliries of the sperm flagella (MMAF), which is a quite frequent type of asthenoteratospermia in male infertility (Chemes et al., 1987;Ben Khelifa et al, 2014).

关键词： Male infertility reproduction health Recurrent abnormalities

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胎儿甲状腺肿大合并甲状腺功能减退的产前诊断及干预:3例分析

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中华围产医学杂志 2023年第9期26卷 760-765页

作者：李琴李亮贺小进袁静安徽医科大学第一附属医院产前诊断中心合肥230031 安徽医科大学第一附属医院超声科合肥230031 安徽医科大学第一附属医院生殖中心合肥230031

目的总结胎儿甲状腺肿大合并甲状腺功能减退的产前诊断、临床干预及妊娠结局。方法回顾性纳入2021年1月至2022年12月安徽医科大学第一附属医院产前诊断的3例甲状腺肿大合并甲状腺功能减退胎儿。产前超声发现胎儿甲状腺肿大后,行脐血甲... 详细信息

目的总结胎儿甲状腺肿大合并甲状腺功能减退的产前诊断、临床干预及妊娠结局。方法回顾性纳入2021年1月至2022年12月安徽医科大学第一附属医院产前诊断的3例甲状腺肿大合并甲状腺功能减退胎儿。产前超声发现胎儿甲状腺肿大后,行脐血甲状腺功能检测评估胎儿甲状腺功能;诊断胎儿甲状腺肿大合并甲状腺功能减退后给予孕妇口服左甲状腺素,并监测胎儿甲状腺超声影像学和脐血甲状腺功能的变化情况。总结临床表现、妊娠结局及生后随访情况。采用描述性统计分析。结果病例1、2和3分别在孕24、21和23周^(+5)通过产前超声检查发现胎儿甲状腺肿大,且伴丰富血流信号;脐血甲状腺功能检测提示促甲状腺激素异常升高,诊断为先天性胎儿甲状腺功能减退。给予孕妇口服左甲状腺素,复查产前超声未提示胎儿肿大的甲状腺明显缩小,但是血流丰富度较前明显减轻;脐血甲状腺功能尤其是促甲状腺激素明显降低。除病例2孕34周^(+)因社会因素外院引产终止妊娠外;病例1和3均足月分娩。新生儿出生时以及生后随访(分别为12和18月龄)甲状腺功能均在正常范围内。结论超声结合脐血甲状腺功能检测有助于胎儿甲状腺肿大合并甲状腺功能减退的产前诊断;通过给予孕妇口服左甲状腺素可能有助于改善胎儿甲状腺功能。

关键词：甲状腺肿先天性甲状腺功能减退症胎儿疾病产前诊断甲状腺素

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卵子成熟障碍、受精失败与早期胚胎发育阻滞遗传学研究进展

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中华生殖与避孕杂志 2022年第12期42卷 1297-1304页

作者：刘丽婷高阳贺小进安徽医科大学第一附属医院妇产科生殖医学中心生殖健康与遗传安徽省重点实验室国家卫生健康委配子及生殖道异常研究重点实验室合肥230032

卵子成熟障碍、受精失败与早期胚胎发育阻滞是生殖医学的研究热点。卵子发生和胚胎发育是非常复杂的过程。卵子成熟障碍、受精失败与胚胎发育阻滞是由包括遗传学因素在内的多种因素所导致。首例人卵母细胞成熟障碍被报道已有30年历史,... 详细信息

卵子成熟障碍、受精失败与早期胚胎发育阻滞是生殖医学的研究热点。卵子发生和胚胎发育是非常复杂的过程。卵子成熟障碍、受精失败与胚胎发育阻滞是由包括遗传学因素在内的多种因素所导致。首例人卵母细胞成熟障碍被报道已有30年历史,直到近年来,卵母细胞成熟障碍的致病基因和分子机制在人类和小鼠模型中被广泛研究,进一步对于受精失败或胚胎发育阻滞的研究也取得了重要进展。本文结合近期最新的关于卵子成熟障碍、受精失败与胚胎发育阻滞的遗传学研究进行简要综述。

关键词：卵母细胞不育,女性遗传学卵母细胞发育停滞胚胎发育

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