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Two-dimensional transition metal MXene-based gas sensors:A review

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Chinese Chemical Letters 2024年第1期35卷 208-221页

作者： Junfeng Li xiaojie chen xiaojie Zhu Yingchang Jiang Xueting Chang Shibin Sun College of Logistics and Engineering Shanghai Maritime UniversityShanghai 201306China Institute of Marine Materials Science and Engineering Shanghai Maritime UniversityShanghai 201306China

As an emerging star in the family of two-dimensional(2D)materials,2D transition metal carbides,carbonitrides and nitrides,collectively referred to as MXenes,have large specific surface area,rich active sites,metallic conductivity and adjustable surface chemical *** features make MXenes promising candidates for gas-sensing *** the past few years,MXene-based sensors have drawn increasing attention due to their enhanced sensor *** on this,this review systematically represents the structure,synthesis methods and properties of MXenes,and summarizes their applications in gas ***,the types,structure,main synthesis methods and properties of MXenes are introduced in a comprehensive ***,the corresponding design principle and working mechanism of MXene-based gas sensor are ***,the sensing performances of pristine MXenes and the MXene-based nanocomposite are ***,some future opportunities and challenges of MXene-based sensors are pointed out.

关键词： MXene Gas sensors Synthesis Stability Gas-sensing mechanism Gas-sensing performance

Phenolic-enabled nanotechnology:a new strategy for central nervous system disease therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第10期25卷 890-913页

作者： Yuyi ZHENG xiaojie chen Yi WANG Zhong chen Di WU Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Zhejiang Rehabilitation Medical Center the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310009China

Polyphenolic compounds have received tremendous attention in biomedicine because of their good biocompatibility and unique physicochemical *** recent years,phenolic-enabled nanotechnology(PEN)has become a hotspot of research in the medical field,and many promising studies have been reported,especially in the application of central nervous system(CNS)*** compounds have superior anti-inflammatory and antioxidant properties,and can easily cross the blood‒brain barrier,as well as protect the nervous system from metabolic damage and promote learning and cognitive ***,although great advances have been made in this field,a comprehensive review regarding PEN-based nanomaterials for CNS therapy is lacking.A systematic summary of the basic mechanisms and synthetic strategies of PEN-based nanomaterials is beneficial for meeting the demand for the further development of novel treatments for CNS *** review systematically introduces the fundamental physicochemical properties of PEN-based nanomaterials and their applications in the treatment of CNS *** first describe the different ways in which polyphenols interact with other substances to form high-quality products with controlled sizes,shapes,compositions,and surface chemistry and *** application of PEN-based nanomaterials in the treatment of CNS diseases is then described,which provides a reference for subsequent research on the treatment of CNS diseases.

关键词： Phenolic-enabled nanotechnology(PEN) Metal-phenolic network Polydopamine Central nervous system(CNS) Drug delivery system

Coarse-grained simulations on interactions between spectrins and phase-separated lipid bilayers

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Chinese Physics B 2021年第6期30卷 703-710页

作者： Xuegui Lin xiaojie chen Qing Liang Center for Statistical and Theoretical Condensed Matter Physics and Department of Physics Zhejiang Normal UniversityJinhua 321004China Department of Industrial Automation Guangdong Polytechnic CollegeZhaoqing 526100China

Spectrin, the principal protein of the cytoskeleton of erythrocyte, plays a crucial role in the stability and flexibility of the plasma membrane of erythrocyte. In this work, we investigate the interactions between spectrins and phase-separated lipid bilayers using coarse-grained molecular dynamics simulation. We focus on the preference of spectrins with different lipids, the effects of the anionic lipids and the residue mutation on the interactions between spectrins and the lipid bilayers. The results indicate that spectrins prefer to contact with phosphatidylethanolamine(PE) lipids rather than with phosphatidylcholine(PC) lipids, and tend to contact with the liquid-disordered(Ld) domains enriched in unsaturated ***, the anionic lipids, which show specific interaction with the positively charged or polar amino acids on the surface of the spectrins, can enhance the attraction between the spectrins and lipid domains. The mutation leads to the decrease of the structural stability of spectrins and increases the curvature of the lipid bilayer. This work provides some theoretical insights into understanding the erythrocyte structure and the mechanism of some blood diseases.

关键词： protein lipid bilayer interaction molecular dynamics simulation

Interactions between amphiphilic nanoparticles coated with striped hydrophilic/hydrophobic ligands and a lipid bilayer

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Communications in Theoretical Physics 2023年第6期75卷 127-137页

作者： Lijuan Sun Yu Cao xiaojie chen Qing Liang Department of Physics and Key Laboratory of Solid Optoelectronic Devices of Zhejiang Province Zhejiang Normal UniversityJinhua 321004China Department of Industrial Automation Guangdong Polytechnic CollegeZhaoqing 526100China

Due to their unique physicochemical properties,nanoparticles play an important role in the fields of nanomedicine and so *** this paper,the interactions between the nanoparticles coated with striped hydrophilic and hydrophobic ligands and a lipid bilayer are investigated by using the coarse-grained molecular dynamics *** study focuses on the effects of the density of the ligands,the ratio of the hydrophilic ligands to the hydrophobic ligands,and the rigidity of the ligands on the interactions of the nanoparticles with the lipid *** results show that the nanoparticles interact with the lipid bilayer in two different *** nanoparticle with a small size,a large ratio of hydrophilic ligands to the hydrophobic ligands,and flexible ligands can readily be inserted into the lipid bilayer,and the nanoparticle rotation is very crucial to the insertion of the nanoparticle into the ***,the nanoparticle with a large size,a small ratio of hydrophilic ligands to hydrophobic ligands,and rigid ligands can only be adsorbed on the surface of the lipid *** work provides an effective method to modulate the interactions of the amphiphilic nanoparticles with the lipid bilayers and some insights into the applications of the nanoparticles in drug delivery,cell imaging,etc.

关键词： biomembrane nanoparticle molecular dynamics interaction

The blood-brain barrier:structure,regulation,and drug delivery

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2941-2967页

作者： Di Wu Qi chen xiaojie chen Feng Han Zhong chen Yi Wang Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical University310053HangzhouChina Zhejiang Rehabilitation Medical Center The Third Affiliated Hospital of Zhejiang Chinese Medical University310053HangzhouChina

Blood–brain barrier(BBB)is a natural protective membrane that prevents central nervous system(CNS)from toxins and pathogens in ***,the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and biopharmaceuticals have been impeded to enter the *** drug delivery into the brain leads to low therapeutic efficacy as well as aggravated side effects due to the accumulation in other organs and *** breakthrough in materials science and nanotechnology provides a library of advanced materials with customized structure and property serving as a powerful toolkit for targeted drug ***-depth research in the field of anatomical and pathological study on brain and BBB further facilitates the development of brain-targeted strategies for enhanced BBB *** this review,the physiological structure and different cells contributing to this barrier are *** emerging strategies for permeability regulation and BBB crossing including passive transcytosis,intranasal administration,ligands conjugation,membrane coating,stimuli-triggered BBB disruption,and other strategies to overcome BBB obstacle are *** drug delivery systems ranging from organic,inorganic,and biologics-derived materials with their synthesis procedures and unique physio-chemical properties are summarized and *** review aims to provide an up-to-date and comprehensive guideline for researchers in diverse fields,offering perspectives on further development of brain-targeted drug delivery system.

关键词： Blood protective barrier

Treatment of exfoliative cheilitis with Traditional Chinese Medicine：a systematic review

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Journal of Traditional Chinese Medicine 2017年第2期37卷 147-158页

作者： Sun Kai Liu Lijun chen xiaojie Jiang Weiwen Department of Oral Mucosal Diseases Shanghai Ninth People'sHospital Shanghai Jiao Tong University School of MedicineShanghai 200011 China

OBJECTIVE:To systematically review treatments of exfoliative cheilitis based on symptom patterns in terms of Traditional Chinese ***:Pub Med, Cochrane Central Register of Controlled Trials and Wanfang data were screened for case reports, case series or clinical trials that were published in English or Chinese from January,1973 to September, *** keyword of "exfoliative cheilitis or scaling cheilitis or factitious cheilitis" was *** or ineffectiveness was investigated as outcome for Meta analysis, which is based on effective index in each *** to treatment was described for case reports or case ***:From 38 screened studies, 17 were randomized controlled trials(RCTs), 5 were single-arm trials, and 16 were case reports or case *** RCTs were eligible for Meta analysis and all of them compared managements between Traditional Chinese Medicine and corticosteroids for exfoliative cheilitis, which involved 223 ***, data of Meta analysis showed similar effect of Traditional Chinese Medicine and corticosteroids for patients with exfoliative cheilitis [relative risk ratio:1.10; 95% CI(1.00-1.21), P = 0.06].CONCLUSION:Traditional Chinese Medicine might be a substitute for corticosteroids on exfoliative ***, the evidence and recommendation of exfoliative cheilitis managements need to be taken with caution because of the low quality of evidence in the studies obtained.

关键词： Evidence-based medicine Dentistry Exfoliative syndrome Cheilitis Therapeutics Medicine Chinese traditional Adrenal cortex hormone Review

Asymmetric Thermally Activated Delayed Fluorescence Materials Rendering High-performance OLEDs Through both Thermal Evaporation and Solution-processing

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Chemical Research in Chinese Universities 2022年第6期38卷 1526-1531页

作者： GAO Shiyuan chen xiaojie GE Xiangyu chen Zhu ZHAO Juan CHI Zhenguo State Key Laboratory of OEMT School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou510275P.R.China State Key Laboratory of OEMT School of ChemistrySun Yat-sen UniversityGuangzhou510275P.R.China

Exploring high-efficiency thermally activated delayed fluorescence(TADF)materials is of great importance regarding to organic light-emitting diode(OLED).Herein,we present a design strategy for developing asymmetric TADF materials based on a diphenyl sulfone-phenoxazine structure,resulting in efficient TADF emitters(CzPXZ and t-CzPXZ)with aggregation-induced emission properties,while t-CzPXZ is modified with tert-butyl *** two compounds exhibit high solid-state luminescence,efficient TADF,and significantly impressive device performances by both thermal evaporation and solution *** an instance,CzPXZ and t-CzPXZ enable the thermally-evaporated OLEDs with high external quantum efficiencies(EQEs)of over 20%.Meanwhile,t-CzPXZ allows the solution-processed device with a high EQE of 16.3%with low-efficiency roll-off,attributing to the enhanced molecular solubility and suppressed excitons quenching through tert-butyl modification on *** results reveal that the proposed asymmetric structure is a promising approach for developing high-efficiency TADF materials and OLEDs.

关键词： Thermally activated delayed fluorescence Asymmetric strategy Organic light-emitting diode Thermal evaporation Solution processing

Application of alginate oligosaccharide produced by enzymatic hydrolysis in the preservation of prawns

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Food Bioscience 2022年第5期49卷 636-643页

作者： Fen Yan Jinfu Zhong Junying chen Wenjing Liu xiaojie chen College of Biological Science and Engineering Fuzhou UniversityFuzhouFujian350108China

Alginate oligosaccharide(AOS)was enzymatically prepared and had a degree of polymerization(DP)of *** exhibited evident antioxidant efficacy in ABTS+scavenging activity,hydroxyl radical scavenging capacity,and total reducing *** freshness of the prawns,which were treated with AOS andε-polylysine(ε-PL),was evaluated by measuring indicators such as total viable bacteria(TVC),pH,total volatile basic nitrogen(TVB-N),sensory,texture,and melanosis during storage *** texture properties and sensory scores of prawns treated with AOS andε-PL were significantly improved(P<0.05)in comparison with the control ***,the increase in TVC,pH,TVB-N,and melanosis scores of prawns treated with AOS andε-PL were effectively delayed(P<0.05)in comparison with control ***,the quality of prawns treated with 8 g/L AOS was better than that of prawns treated with 6 g/*** could prolong the shelf life of prawns by 2 days at ***,AOS is a natural biological preservative in providing an effective and safe way to preserve freshness of prawns.

关键词： Alginate oligosaccharides Antioxidant ability Prawns Shelf life

Lysine demethylase 5B transcriptionally regulates TREM1 in human cardiac fibroblasts

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BIOCELL 2024年第7期48卷 1105-1113页

作者： CHUNLING LIANG JING chen xiaojie chen WEI YAN JIE YU Department of Emergency Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100102China Department of Radiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China

Background:A differential gene,triggering receptor expressed on myeloid cells 1(TREM1),was identiﬁed in blood sequencing datasets from myocardial infarction patients and healthy ***ﬁbrosis following myocardial infarction signiﬁcantly contributes to cardiac ***:This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardialﬁ***:Mimicking pathology by angiotensin II(Ang II)treatment of human cardiacﬁbroblasts(HCFs),the impacts of TREM1 knockdown on its proliferation,migration,and secretion of the pro-ﬁbrotic matrix were identiﬁ*** the Human Transcription Factor Database(HumanTFDB)website,lysine-speciﬁc demethylase 5B(KDM5B)was found to bind to the TREM1 promoter,which was further validated through luciferase reporter and chromatin immunoprecipitation(ChIP).By promoting KDM5B overexpression,its effect on the regulation of TREM1 was ***:TREM1 knockdown suppressed the proliferation,migration,and secretion of the pro-ﬁbrotic matrix in HCFs upon Ang II ***5B bound to the TREM1 promoter and upregulated its transcriptional ***,KDM5B overexpression reversed the regulation of the above cellular phenotypes by TREM1 ***:This study sheds light on the positive regulation of TREM1 by KDM5B,demonstrating their role in promoting myocardialﬁ***ﬁnding provides a theoretical foundation for understanding disease pathology and potentially advancing the development of new targeted therapies.

关键词： Cardiac fibroblasts Fibrosis Myeloid cell receptor Migration Proliferation