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Shen Qi Wan attenuates renal interstitial fibrosis through upregulating AQP1

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Chinese Journal of Natural Medicines 2023年第5期21卷 359-370页

作者： LIN Yiyou WEI Jiale ZHANG Yehui HUANG Junhao WANG Sichen LUO Qihan YU Hongxia JI Liting zhou xiaojie LI Changyu School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Academy of Chinese Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China

Renal interstitial fibrosis(RIF)is the crucial pathway in chronic kidney disease(CKD)leading to the end-stage renal failure.However,the underlying mechanism of Shen Qi Wan(SQW)on RIF is not fully understood.In the current study,we investigated the role of Aquaporin 1(AQP1)in SQW on tubular epithelial-to-mesenchymal transition(EMT).A RIF mouse model induced by adenine and a TGF-β1-stimulated HK-2 cell model were etablished to explore the involvement of AQP 1 in the protective effect of SQW on EMT in vitro and in vivo.Subsequently,the molecular mechanism of SQW on EMT was explored in HK-2 cells with AQP1 knockdown.The results indicated that SQW alleviated kidney injury and renal collagen deposition in the kidneys of mice induced by adenine,increased the protein expression of E-cadherin and AQP1 expression,and decreased the expression of vimentin andα-smooth muscle actin(α-SMA).Similarly,treatmement with SQW-containing serum significantly halted EMT process in TGF-β1 stimulated HK-2 cells.The expression of snail and slug was significantly upregulated in HK-2 cells after knockdown of AQP1.AQP1 knockdown also increased the mRNA expression of vimentin andα-SMA,and decreased the expression of E-cadherin.The protein expression of vimentin increased,while the expression of E-cadherin and CK-18 significantly decreased after AQP1 knockdown in HK-2 cells.These results revealed that AQP1 knockdown promoted EMT.Furthermore,AQP1 knockdown abolished the protective effect of SQW-containing serum on EMT in HK-2 cells.In sum,SQW attentuates EMT process in RIF through upregulation of the expression of AQP1.

关键词： Shen Qi Wan Chronic kidney disease Renal interstitial fibrosis Epithelial to mesenchymal transition Aquaporin 1

Analysis Method of Multi-scale Frequency Spectral Latent Feature based on the Mutual Information

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Analysis Method of Multi-scale Frequency Spectral Latent Fea...

内河混合动力船舶智能能效管理系统研制及应用

2015 3rd International Conference on Machinery,Materials and Information Technology Applications(ICMMITA 2015)

作者： Zhuo Liu Jian Tang Meiying Jia xiaojie zhou State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Research Institute of Computing Technology Beifang Jiaotong University

Heavy rotating mechanical devices, such as ball mills in the mineral grinding process, produce strong mechanical vibration and acoustic signals. These signals consist of multiple components with different time scales and physical interpretations. Frequency spectra of these multi-scale sub-signals contain interesting information related to some difficulty-to-measure process parameters. Latent feature extraction methods based on principal component analysis and partial least squares with their kernel versions are used widely for high dimensional spectra data. How to estimate their effect and select important sub-signals are important issues. Thus, aim to these problems, mutual information is used in this paper. Analysis results based on the shell vibration frequency spectra of a laboratory-scale wet ball mill shows that the proposed method is helpful and effective.

关键词： Multi-scale Frequency Spectra Latent Features extraction Mutual Information

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柴油机 2024年第1期46卷 53-60页

作者：徐家润刘佳彬周晓洁杨峰仲国强上海船用柴油机研究所上海201108

以7500吨级混合动力散货船为研究对象,开发一套适用于内河混合动力船舶的智能能效管理系统,通过采用能效评估算法和灰盒航速优化算法,实现能效分析评估功能和航速优化功能,并提供燃料信息管理和报告管理等辅助功能。在实船应用中经过模... 详细信息

以7500吨级混合动力散货船为研究对象,开发一套适用于内河混合动力船舶的智能能效管理系统,通过采用能效评估算法和灰盒航速优化算法,实现能效分析评估功能和航速优化功能,并提供燃料信息管理和报告管理等辅助功能。在实船应用中经过模型训练和运营测试验证,该系统能够为船舶提供有效的航速优化建议,降低3.07%的油耗。

关键词：智能能效管理系统内河船舶混合动力节油效果

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应用型高校新进青年教师提升教学水平的研究

江苏科技信息 2024年第9期41卷 48-51页

作者：李新恒周小杰刘晓伟郭家稳孙雯安徽科技学院电气与电子工程学院安徽蚌埠233000

目前,国内一些普通高等院校对硕士研究生担任教学岗位的招聘仍有一定的需求,新进硕士研究生到高校承担教学任务,在教学经验和水平方面存在诸多不足。因此,针对如何快速有效提高新进教师的教学水平,文章以安徽科技学院为例,综合考虑学校... 详细信息

目前,国内一些普通高等院校对硕士研究生担任教学岗位的招聘仍有一定的需求,新进硕士研究生到高校承担教学任务,在教学经验和水平方面存在诸多不足。因此,针对如何快速有效提高新进教师的教学水平,文章以安徽科技学院为例,综合考虑学校、学院、个人和学生4个维度,提出4点建议:一是强化学校和学院课堂教学的监督及指导作用;二是建立学院内部“一徒多师”的师带徒团队;三是积极发挥新进教师个人的主观能动性;四是采用学生反馈式教学方法,实现闭环式教学模式。通过采用上述建议,可在一定程度上为提高新进硕士研究生的教学水平提供有益且有效的帮助。

关键词：硕士研究生高校新进教师教学水平

北京市东城区2009—2019年蝇类生态学监测结果分析及其预测方法探讨

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中华卫生杀虫药械 2024年第3期30卷 262-267页

作者：魏绪强李秋红马卓阙燃王云波周小洁北京市东城区疾病预防控制中心北京100019 北京市预防医学研究中心北京市疾病预防控制中心北京100013

目的掌握北京市东城区2009—2019年蝇种类、密度、分布及其季节消长规律,探讨基于生态学监测的蝇类密度预测方法,为东城区蝇类预测与科学防控提供依据。方法收集整理东城区2009—2019年蝇类生态学监测数据并进行分析;利用MATLAB R2018... 详细信息

目的掌握北京市东城区2009—2019年蝇种类、密度、分布及其季节消长规律,探讨基于生态学监测的蝇类密度预测方法,为东城区蝇类预测与科学防控提供依据。方法收集整理东城区2009—2019年蝇类生态学监测数据并进行分析;利用MATLAB R2018b软件构建的季节性差分自回归移动平均模型(SARIMA)对2019年4—10月的蝇类密度进行预测并与实际监测值进行比较,验证模型预测效果。结果 2009—2019年东城区各生态学监测点蝇类年平均密度为7.09只/笼,优势蝇种为麻蝇科,占捕获蝇总数的56.82%,占比超过5%以上的蝇种类依次为厩腐蝇(11.74%)、家蝇(10.17%)、丝光绿蝇(8.99%)和大头金蝇(6.93%);不同生境中,宾馆饭店蝇类密度最高,为11.86只/笼,餐饮外环境最低,为2.20只/笼,麻蝇科在不同生境中均为优势种群;蝇类密度高峰主要出现在7月和8月。基于历史生态学监测数据构建的最优模型SARIMA(0,1,4)(2,1,3)12预测2019年4—10月的蝇类密度与实际密度基本一致,实际监测值均落在预测值95%置信区间内,模型评价指标均方根误差(RMSE)和平均绝对误差(MAE)分别为1.379和1.014,预测效果较好。结论 2009—2019年北京市东城区以麻蝇科为优势种群,宾馆饭店是蝇类防控的重点场所,活动高峰主要出现在7—8月;通过对SARIMA模型效果评价,该方法可用于蝇类密度短期变化趋势预测。

关键词：蝇密度季节性差分自回归移动平均模型预测密度监测

Co-pyrolysis of Sewage Sludge with Paint Sludge: Kinetics and Thermodynamic Analysis via Iso-conversional Methods

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 716-727页

作者：周尚群赵青林 YU Tian YAO xiaojie State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China School of Mate-rials Science and Engineering Wuhan University of TechnologyWuhan 430070China

This study explored the synergistic interaction of sewage sludge(SS)and automotive paint sludge(PS)during co-pyrolysis for the optimized treatment of sewage sludge in cement kiln systems,utilizing thermogravimetric analysis(TGA)and thermogravimetric-mass spectrometry(TGA-MS).The result reveals the coexisting synergistic and antagonistic effects in the co-pyrolysis of SS/PS.The synergistic effect arises from hydrogen free radicals in SS and catalytic components in PS,while the main source of the antagonistic effect is that,during the mechanical mixing process,the SS/PS is converted from the particulate form into a dough-like rubbery which contributes to the film-forming effect,hindering the volatilization of volatile components.SS/PS co-pyrolysis reduces the yielding of tar production while increasing coke and gas.This study will provide some in-depth insights into the co-pyrolysis of SS/PS,and offer theoretical support for the subsequent research on the collaborative disposal processes in cement kilns.

关键词： sewage sludge co-pyrolysis automotive paint sludge evolved gas analysis

Total-factor energy efficiency of ten major global energy-consuming countries

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Journal of Environmental Sciences 2024年第3期137卷 41-52页

作者： Xuan Wang Yonglong Lu Chunci Chen xiaojie Yi Haotian Cui State Key Laboratory of Urban and Regional Ecology Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Marine Environmental Science and Key Laboratory of the Ministry of Education for Coastal Wetland Ecosystems College of the Environment and EcologyXiamen UniversityFujian 361102China University of Chinese Academy of Sciences Beijing 100049China

Improving energy efficiency is regarded as a key path to tackling global warming and achieving the Sustainable Development Goals(SDGs).In 2020,the energy consumption of the world's ten major energy-consuming countries accounted for 66.8%of the global total.This paper applied data envelopment analysis(DEA)to calculate these ten major energyconsuming countries'total-factor energy efficiency(TFEE)at national and sectoral levels from 2001-2020,and explored the infuencing factors of total-factor energy efficiency with the Tobit regression model.The results showed significant difference in the ten countries'energy efficiency.The United States and Germany topped the list for total-factor energy efficiency,while China and India were at the bottom.Meanwhile,the energy efficiency of the industrial subsector has increased significantly over the past two decades,while that of the other subsectors has been relatively fat.The industrial structure upgrading,per capita GDP,energy consumption structure,and foreign direct investment had significant impacts on energy efficiency with national heterogeneity.Energy consumption structure and GDP per capita were determinative factors of energy efficiency.

关键词： Total-factor energy efficiency SBM-UN model Major energy-consuming country Carbon emission reduction

海上油气田注水及混输海管水样分析及结垢倾向预测

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涂层与防护 2024年第2期45卷 29-33页

作者：缪磊刘博周小杰王伟杰汉继程徐慧赵起锋闫言海洋石油工业腐蚀防护重点实验室江苏常州213016 中海油常州涂料化工研究有限公司江苏常州213016

结垢问题是石油和天然气生产和输送中一个常见且影响巨大的问题。本研究对某海上油气田注水及混输海管多年的采样分析数据进行了统计,掌握了海管水质变化特性,并为减小采样分析过程误差而利用软件校正了分析条件。基于校正后的分析条件... 详细信息

结垢问题是石油和天然气生产和输送中一个常见且影响巨大的问题。本研究对某海上油气田注水及混输海管多年的采样分析数据进行了统计,掌握了海管水质变化特性,并为减小采样分析过程误差而利用软件校正了分析条件。基于校正后的分析条件,软件模拟得到海管中可能生成的不同类型垢物的最大结垢量和结垢倾向随时间的变化,为能够在生产过程中抑制结垢,提供了数据基础。

关键词：结垢倾向最大结垢量采样分析

Infrared Photodissociation Spectroscopy of Carbonyl Bonding on Oxophilic Metal Centers

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Infrared Photodissociation Spectroscopy of Carbonyl Bonding ...