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Lysine demethylase 5B transcriptionally regulates TREM1 in human cardiac fibroblasts

BIOCELL 2024年第7期48卷 1105-1113页

作者： CHUNLING LIANG JING chen xiaojie chen WEI YAN JIE YU Department of Emergency Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100102China Department of Radiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China

Background:A differential gene,triggering receptor expressed on myeloid cells 1(TREM1),was identiﬁed in blood sequencing datasets from myocardial infarction patients and healthy controls.Myocardialﬁbrosis following myocardial infarction signiﬁcantly contributes to cardiac dysfunction.Objectives:This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardialﬁbrosis.Methods:Mimicking pathology by angiotensin II(Ang II)treatment of human cardiacﬁbroblasts(HCFs),the impacts of TREM1 knockdown on its proliferation,migration,and secretion of the pro-ﬁbrotic matrix were identiﬁed.Using the Human Transcription Factor Database(HumanTFDB)website,lysine-speciﬁc demethylase 5B(KDM5B)was found to bind to the TREM1 promoter,which was further validated through luciferase reporter and chromatin immunoprecipitation(ChIP).By promoting KDM5B overexpression,its effect on the regulation of TREM1 was examined.Results:TREM1 knockdown suppressed the proliferation,migration,and secretion of the pro-ﬁbrotic matrix in HCFs upon Ang II treatment.KDM5B bound to the TREM1 promoter and upregulated its transcriptional expression.Furthermore,KDM5B overexpression reversed the regulation of the above cellular phenotypes by TREM1 knockdown.Conclusion:This study sheds light on the positive regulation of TREM1 by KDM5B,demonstrating their role in promoting myocardialﬁbrosis.Thisﬁnding provides a theoretical foundation for understanding disease pathology and potentially advancing the development of new targeted therapies.

关键词： Cardiac fibroblasts Fibrosis Myeloid cell receptor Migration Proliferation

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Hydrogen sulfide responsive nanoplatforms: Novel gas responsive drug delivery carriers for biomedical applications

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 1-17页

作者： Jiafeng Zou Zeting Yuan xiaojie chen You chen Min Yao Yang chen Xiang Li Yi chen Wenxing Ding Chuanhe Xia Yuzheng Zhao Feng Gao Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism School of PharmacyEast China University of Science and TechnologyShanghai 200237China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Shanghai Key Laboratory of Functional Materials Chemistry East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China Optogenetics and Synthetic Biology Interdisciplinary Research Center State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237China CAS Center for Excellence in Brain Science Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Research Unit of New Techniques for Live-cell Metabolic Imaging Chinese Academy of Medical SciencesBeijing 100050China

Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter.These studies have mainly focused on the production and pharmacological side effects caused by H_(2)S.Therefore,effective strategies to remove H_(2)S has become a key research topic.Furthermore,the development of novel nanoplatforms has provided new tools for the targeted removal of H_(2)S.This paper was performed to review the association between H_(2)S anddisease,relatedH_(2)S inhibitory drugs,aswell as H_(2)S responsive nanoplatforms(HRNs).This review first analyzed the role of H_(2)S in multiple tissues and conditions.Second,common drugs used to eliminate H_(2)S,as well as their potential for combination with anticancer agents,were summarized.Not only the existing studies on HRNs,but also the inhibition H_(2)S combined with different therapeutic methods were both sorted out in this review.Furthermore,this review provided in-depth analysis of the potential of HRNs about treatment or detection in detail.Finally,potential challenges of HRNs were proposed.This study demonstrates the excellent potential of HRNs for biomedical applications.

关键词： Hydrogen sulfide Disease mechanisms Removal of hydrogen sulfide Responsive nanoplatforms Challenges Biomedical applications

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Two-dimensional transition metal MXene-based gas sensors:A review

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Chinese Chemical Letters 2024年第1期35卷 208-221页

作者： Junfeng Li xiaojie chen xiaojie Zhu Yingchang Jiang Xueting Chang Shibin Sun College of Logistics and Engineering Shanghai Maritime UniversityShanghai 201306China Institute of Marine Materials Science and Engineering Shanghai Maritime UniversityShanghai 201306China

As an emerging star in the family of two-dimensional(2D)materials,2D transition metal carbides,carbonitrides and nitrides,collectively referred to as MXenes,have large specific surface area,rich active sites,metallic conductivity and adjustable surface chemical properties.These features make MXenes promising candidates for gas-sensing materials.For the past few years,MXene-based sensors have drawn increasing attention due to their enhanced sensor performance.Based on this,this review systematically represents the structure,synthesis methods and properties of MXenes,and summarizes their applications in gas sensors.Firstly,the types,structure,main synthesis methods and properties of MXenes are introduced in a comprehensive way.Next,the corresponding design principle and working mechanism of MXene-based gas sensor are clarified.Subsequently,the sensing performances of pristine MXenes and the MXene-based nanocomposite are discussed.Finally,some future opportunities and challenges of MXene-based sensors are pointed out.

关键词： MXene Gas sensors Synthesis Stability Gas-sensing mechanism Gas-sensing performance

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Total-factor energy efficiency of ten major global energy-consuming countries

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Journal of Environmental Sciences 2024年第3期137卷 41-52页

作者： Xuan Wang Yonglong Lu Chunci chen xiaojie Yi Haotian Cui State Key Laboratory of Urban and Regional Ecology Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Marine Environmental Science and Key Laboratory of the Ministry of Education for Coastal Wetland Ecosystems College of the Environment and EcologyXiamen UniversityFujian 361102China University of Chinese Academy of Sciences Beijing 100049China

Improving energy efficiency is regarded as a key path to tackling global warming and achieving the Sustainable Development Goals(SDGs).In 2020,the energy consumption of the world's ten major energy-consuming countries accounted for 66.8%of the global total.This paper applied data envelopment analysis(DEA)to calculate these ten major energyconsuming countries'total-factor energy efficiency(TFEE)at national and sectoral levels from 2001-2020,and explored the infuencing factors of total-factor energy efficiency with the Tobit regression model.The results showed significant difference in the ten countries'energy efficiency.The United States and Germany topped the list for total-factor energy efficiency,while China and India were at the bottom.Meanwhile,the energy efficiency of the industrial subsector has increased significantly over the past two decades,while that of the other subsectors has been relatively fat.The industrial structure upgrading,per capita GDP,energy consumption structure,and foreign direct investment had significant impacts on energy efficiency with national heterogeneity.Energy consumption structure and GDP per capita were determinative factors of energy efficiency.

关键词： Total-factor energy efficiency SBM-UN model Major energy-consuming country Carbon emission reduction

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A 26.5–29.5-GHz Doherty PA with enhanced linearity and efficiency based on adaptive bias circuit for 5G MIMO arrays

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Science China(Information Sciences) 2024年第7期67卷 341-342页

作者： Long WANG Jixin chen Debin HOU xiaojie XU Wei HONG State Key Laboratory of Millimeter Waves Southeast University Misic Microelectronics Co. Ltd.

Power amplifiers (PAs) play a crucial role in achieving key performance metrics such as efficiency, power, and linearity.However, in the millimeter-wave frequency range, the performance of active devices rapidly deteriorates with increasing frequency. The typical Doherty architecture, through load modulation techniques, can achieve high back-off efficiency [1]. To enhance the linearity of the PA, adaptive bias circuits (ADBs) have been widely adopted [2, 3].

关键词： POWER-AMPLIFIER

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Energetic,bio-oil,biochar,and ash performances of co-pyrolysis-gasification of textile dyeing sludge and Chinese medicine residues in response to K_(2)CO_(3),atmosphere type,blend ratio,and temperature

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Journal of Environmental Sciences 2024年第2期136卷 133-150页

作者： Gang Zhang Zhiyun chen Tao chen Shaojun Jiang Fatih Evrendilek Shengzheng Huang xiaojie Tang Ziyi Ding Yao He Wuming Xie Jingyong Liu Engineering Research Center of None-food Biomass Efficient Pyrolysis and Utilization Technology of Guangdong Higher Education Institutes Dongguan University of TechnologyDongguan 523808China School of Environmental Science and Engineering Guangdong University of TechnologyGuangzhou 510006China School of Environment The Environmental Research InstituteMOE Key Laboratory of Theoretical Chemistry of EnvironmentSouth China Normal UniversityGuangzhou 510006China Department of Environmental Engineering Bolu Abant Izzet Baysal UniversityBolu 14052Turkey

Hazardous waste stream needs to be managed so as not to exceed stock-and rate-limited properties of its recipient ecosystems.The co-pyrolysis of Chinese medicine residue(CMR)and textile dyeing sludge(TDS)and its bio-oil,biochar,and ash quality and quantity were characterized as a function of the immersion of K_(2)CO_(3),atmosphere type,blend ratio,and temperature.Compared to the mono-pyrolysis of TDS,its co-pyrolysis performance with CMR(the comprehensive performance index(CPI))significantly improved by 33.9%in the N_(2)atmosphere and 33.2%in the CO_(2)atmosphere.The impregnation catalyzed the co-pyrolysis at 370℃,reduced its activation energy by 77.3 kJ/mol in the N_(2)atmosphere and 134.6 kJ/mol in the CO_(2)atmosphere,and enriched the degree of coke gasification by 44.25%in the CO_(2)atmosphere.The impregnation increased the decomposition rate of the co-pyrolysis by weakening the bond energy of fatty side chains and bridge bonds,its catalytic and secondary products,and its bio-oil yield by 66.19%.Its bio-oils mainly contained olefins,aromatic structural substances,and alcohols.The immersion of K_(2)CO_(3)improved the aromaticity of the copyrolytic biochars and reduced the contact between K and Si which made it convenient for Mg to react with SiO_(2)to form magnesium-silicate.The co-pyrolytic biochar surfaces mainly included-OH,-CH_(2),C=C,and Si-O-Si.The main phases in the co-pyrolytic ash included Ca_(5)(PO_(4))_(3)(OH),Al_(2)O_(3),and magnesium-silicate.

关键词： Chemical impregnation Catalytic pyrolysis Chinese medicine residue Textile dyeing sludge Co-pyrolysis

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Mass transfer process of peanut protein extracted by bis(2-ethylhexyl)sodium sulfosuccinate reverse micelles

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Grain & Oil Science and Technology 2024年第1期7卷 60-67页

作者： chenxian Yang Tianci Li Tingwei Zhu xiaojie Duan Yibao chen Yandong Xu Fusheng chen Kunlun Liu College of Food Science and Engineering Henan University of TechnologyZhengzhouHenan 450001China

The liquid-liquid extraction method using reverse micelles can simultaneously extract lipid and protein of oilseeds,which have become increasingly popular in recent years.However,there are few studies on mass transfer processes and models,which are helpful to better control the extraction process of oils and proteins.In this paper,mass transfer process of peanut protein extracted by bis(2-ethylhexyl)sodium sulfosuccinate(AOT)/isooctane reverse micelles was investigated.The effects of stirring speed(0,70,140,and 210 r/min),temperature of extraction(30,35,40,45,and 50℃),peanut flour particle size(0.355,0.450,0.600,and 0.900 mm)and solidliquid ratio(0.010,0.0125,0.015,0.0175,and 0.020 g/mL)on extraction rate were examined.The results showed that extraction rate increased with temperature rising,particle size reduction as well as solid-liquid ratio increase respectively,while little effect of stirring speed(P>0.05)was observed.The apparent activation energy of extraction process was calculated as 10.02 kJ/mol and Arrhenius constant(A)was 1.91 by Arrhenius equation.There was a linear relationship between reaction rate constant and the square of the inverse of initial particle radius(1/r_(0)^(2))(P<0.05).This phenomenon and this shrinking core model were anastomosed.In brief,the extraction process was controlled by the diffusion of protein from the virgin zone interface of particle through the reacted zone and it was in line with the first order reaction.Mass transfer kinetics of peanut protein extracted by reverse micelles was established and it was verified by experimental results.The results provide an important theoretical guidance for industrial production of peanut protein separation and purification.

关键词： AOT reverse micelles Peanut protein Kinetics Shrinking core model Mass transfer

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The blood-brain barrier:structure,regulation,and drug delivery

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2941-2967页

作者： Di Wu Qi chen xiaojie chen Feng Han Zhong chen Yi Wang Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical University310053HangzhouChina Zhejiang Rehabilitation Medical Center The Third Affiliated Hospital of Zhejiang Chinese Medical University310053HangzhouChina

Blood–brain barrier(BBB)is a natural protective membrane that prevents central nervous system(CNS)from toxins and pathogens in blood.However,the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and biopharmaceuticals have been impeded to enter the brain.Insufficient drug delivery into the brain leads to low therapeutic efficacy as well as aggravated side effects due to the accumulation in other organs and tissues.Recent breakthrough in materials science and nanotechnology provides a library of advanced materials with customized structure and property serving as a powerful toolkit for targeted drug delivery.In-depth research in the field of anatomical and pathological study on brain and BBB further facilitates the development of brain-targeted strategies for enhanced BBB crossing.In this review,the physiological structure and different cells contributing to this barrier are summarized.Various emerging strategies for permeability regulation and BBB crossing including passive transcytosis,intranasal administration,ligands conjugation,membrane coating,stimuli-triggered BBB disruption,and other strategies to overcome BBB obstacle are highlighted.Versatile drug delivery systems ranging from organic,inorganic,and biologics-derived materials with their synthesis procedures and unique physio-chemical properties are summarized and analyzed.This review aims to provide an up-to-date and comprehensive guideline for researchers in diverse fields,offering perspectives on further development of brain-targeted drug delivery system.

关键词： Blood protective barrier

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Resistance index and browning mechanism of apple peel under high temperature stress

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Horticultural Plant Journal 2024年第2期10卷 305-317页

作者： Hui Wang Shuhui Zhang Zidun Wang Dongmei Li Leiyu Yan Yifeng Feng xiaojie Liu Rongxin chen Wenmin Fan Lulong Sun Zhengyang Zhao College of Horticulture Northwest A&F UniversityYanglingShaanxi 712100China College of Horticultural Science and Engineering Shandong Agricultural University State Key Laboratory of Crop BiologyTai'anShandong 271018China

Apples are one of the most important economic crops worldwide.Because of global warming and an aggravation of environmental,abnormally high temperatures occur frequently in fruit-growing season and seriously affect normal fruit growth and reduce fruit quality and yield.We took five-year-old Ruixue’(Qinfu 1×Pink Lady;CNA20151469.1) fruits as test materials,and the ambient temperature during fruit development was monitored.The results showed that during the fruit-growing season,especially during the rapid growth stage (July to August),the maximum daily temperature exceeded 30℃ and lasted for more than 40 days.To determine the effects of high temperature stress on the apple fruit resistance,we treated expanding,veraison,and maturity-period fruits at different temperatures.It was found that the fruits of the expanding period showed strong resistance to high temperature stress,whereas during veraison and maturity,fruit resistance to high temperature stress decreased,and the fruit peel browning phenotype appeared.Meanwhile,the content of malonaldehyde (MDA),hydrogen peroxide (H_(2)O_(2)),and superoxide anion (O._(2)^(-)) in the peel gradually increased with increasing temperature.The content of total phenols,flavanol,and flavonoids in the peel decreased substantially at 45℃.Moreover,it was found that polyphenol oxidase gene (MdPPO1) was most sensitive to high temperature stress in apple.Furthermore,transient and stable MdPPO1 overexpression significantly promoted peel browning.The transgenic materials were more sensitive to high temperatures,and browning was more severe compared to non-genetically modified organism (WT).Stable MdPPO1 knockout calli obtained via clustered regularly interspersed short palindromic repeats (CRISPR/Cas9) gene knockout technology reduced the browning phenotype,and the resultant fruits were not sensitive to the effects of high temperature stress.Thus,MdPPO1 expression may be a key factor of high temperature-related changes observed in the browning phenotype that provides a scientific theoreti

关键词： Malus domestica Borkh High temperature stress Peel Browning MdPPO1

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Chemical composition of oscillatory zoned garnets from the largescale Mengya'a Pb–Zn skarn deposit: implications for fluid physicochemical conditions and formation

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Acta Geochimica 2022年第3期41卷 536-550页

作者： Yan Zhang Cuihua chen Yulong Yang Xuhao Kang Ying Gu Xiang Lai xiaojie chen School of Earth Sciences Chengdu University of TechnologyChengdu 610059SichuanChina

The Mengya’a Lead–zinc deposit is a large skarn deposit in the north of the eastern segment of Gangdese metallogenic belt.The garnet is the main altered mineral in the Mengya’a area.The color of the garnet varies from chartreuse to dark yellow brown and to russet.The brown garnet(Grt1)is related to pyrrhotite and chalcopyrite,and the green garnet(Grt2)is associated with lead–zinc mineralization.LA-ICP-MS is the induced coupled plasma mass spectrometry.This paper has used this technique to investigate Grt1 and Grt2.Grt1 develops core–rim textures with strong oscillation zone occurring in rim,whereas Grt2lacks core–rim textures and featured by oscillation zone.LA–ICP–MS analysis shows that garnets of Mengya’a are rich in CaO(29.90–37.52%)and FeO(21.17–33.35%),but low in Al_(2)O_(3)(0.05–4.85%).The calculated end members belong to grandite(grossular–andradite)garnets andradite.The negative Al(IV)versus Fe^(3+),positive Al(IV)versus total Al stoichiometric number,the positive Al(IV)versus Fe^(3+),and the negative Al(IV)versus total REE,all indicate that the substitution of REEs in garnets is controlled by YAG.All Garnets are depleted in large lithophile elements(e.g.,Rb=0.00–4.01 ppm,Sr=0.03–8.56 ppm).The total REE in Grt1 core is high(ΣREE=233–625 ppm),with HREE enriched pattern(LREE/HREE=0.33–1.69)and weak negative Eu anomalies(δEu=0.21–0.47).In contrast,the total REEs in the Grt1 rim and Grt2 are low(ΣREE=12.4–354 ppm;ΣREE=21.0–65.3 ppm),with LREE enriched pattern(LREE/HREE=0.54–34.4;LREE/HREE=11.4–682)and positive Eu anomalies(δEu=0.35–27.2;δEu=1.02–30.7).After data compilation of garnet chemicals,we found that the early fluid responsible for the core of Grt1 was a relatively closed and chloride-depleted fluid system.It was close-to-neutral,with a low water–rock ratio.The core of garnet was formed by fluid diffusion in metasomatic processes.The fluid was changed into a relatively open system with reduced,chloride-rich,and weakacid fluid.It was fluid infiltration and metasomatism that resulted in the formation of

关键词： Garnet In-situ LA–ICP–MS analysis The Mengya’s Lead–Zinc skarn deposit Tibet

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