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High-fat diet impairs gut barrier through intestinal microbiota-derived reactive oxygen species

Science China(Life Sciences) 2024年第5期67卷 879-891页

作者： Nianyi Zeng Fan Wu Junqi Lu Xiang Li Shaomei Lin Lang Zhou Zhongwei Wang Guangyan Wu Qingfa Huang Daowen Zheng Jie Gao Shan Wu xiaojiao chen Muxuan chen Fanguo Meng Haitao Shang Yan He Peng chen Hong Wei Zhuang Li Hongwei Zhou Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Department of Environmental Health Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public Health and Tropical MedicineSouthern Medical UniversityGuangzhou 510515China Redox Medical Center for Public Health Soochow UniversitySuzhou 215301China Precision Medicine Institute The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Gut barrier disruption is a key event in bridging gut microbiota dysbiosis and high-fat diet(HFD)-associated metabolic ***,the underlying mechanism remains *** the present study,by comparing HFD-and normal diet(ND)-treated mice,we found that the HFD instantly altered the composition of the gut microbiota and subsequently damaged the integrity of the gut *** sequencing revealed that the HFD upregulates gut microbial functions related to redox reactions,as confirmed by the increased reactive oxygen species(ROS)levels in fecal microbiota incubation in vitro and in the lumen,which were detected using in vivo fluorescence *** microbial ROS-producing capability induced by HFD can be transferred through fecal microbiota transplantation(FMT)into germ-free(GF)mice,downregulating the gut barrier tight ***,mono-colonizing GF mice with an Enterococcus strain excelled in ROS production,damaged the gut barrier,induced mitochondrial malfunction and apoptosis of the intestinal epithelial cells,and exacerbated fatty liver,compared with other low-ROS-producing Enterococcus *** administration of recombinant high-stability-superoxide dismutase(SOD)significantly reduced intestinal ROS,protected the gut barrier,and improved fatty liver against the *** conclusion,our study suggests that extracellular ROS derived from gut microbiota play a pivotal role in HFD-induced gut barrier disruption and is a potential therapeutic target for HFD-associated metabolic diseases.

关键词： fatty liver disease gut microbiota gut barrier high-fat diet oxidative stress reactive oxygen species

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站在大国重器前的民族脊梁——读黄传会的《仰望星空——共和国功勋孙家栋》有感

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现代艺术 2024年第5期 126-128页

作者：陈小娇福州市文学艺术界联合会福建省漆艺文化研究会

作家写孙家栋,就是写中国航天史。孙家栋不仅是中国航天事业的缔造者、参与者与领导者,也是中国航天事业的见证者。他本身就是一部浓缩的当代中国航天史,作家正是按照这个思路,梳理出中国航天事业发展的主要线索,抓住了人造卫星研发、... 详细信息

作家写孙家栋,就是写中国航天史。孙家栋不仅是中国航天事业的缔造者、参与者与领导者,也是中国航天事业的见证者。他本身就是一部浓缩的当代中国航天史,作家正是按照这个思路,梳理出中国航天事业发展的主要线索,抓住了人造卫星研发、制造和上天,讲述几代中国航天人不同历史阶段的“飞天梦”。

关键词：中国航天事业孙家栋人造卫星中国航天人仰望星空民族脊梁飞天梦见证者

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单元整体教学理念下高中英语单元作业的设计策略研究——以Unit 3 The world meets China为例

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英语教师 2024年第20期24卷 72-74页

作者：陈晓姣天津外国语大学附属外国语学校天津300230

阐述单元作业的内涵。论述在单元整体教学理念下,高中英语单元作业设计的理论依据和原则,即整体性与关联性原则、多样化原则、层次性原则、体现多元批改评价的原则。以外研版(新标准)高中《英语》选择性必修第四册Unit 3 The world meet... 详细信息

阐述单元作业的内涵。论述在单元整体教学理念下,高中英语单元作业设计的理论依据和原则,即整体性与关联性原则、多样化原则、层次性原则、体现多元批改评价的原则。以外研版(新标准)高中《英语》选择性必修第四册Unit 3 The world meets China为例,探究单元作业设计的实施策略,即构建单元整体教学流程图,明确单元主题语境,确立单元教学目标和单元作业目标,设计课时作业。

关键词：单元整体教学高中英语单元作业设计

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2012年-2022年TBTV、TVDV、TBTVsatRNA和TVDVaRNA在云南主要烟区的发生与分布

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植物保护 2024年第2期50卷 296-302,331页

作者：杨亚辉杨洁罗恒明刘芳吕婧陈平陈海如陈小姣李凡云南农业大学植物保护学院昆明650201

烟草丛顶病(tobacco bushy top disease,TBTD)是一种由烟草丛顶病毒(tobacco bushy top virus,TBTV)及其卫星RNA(tobacco bushy top virus satellite RNA,TBTVsatRNA)和烟草扭脉病毒(tobacco vein distorting virus,TVDV)及其伴随RNA(tobacco vein distorting virus associated RNA,TVDVaRNA)共同侵染引起的危险性病害,曾在云南很多烟区造成严重损失。本研究对烟草丛顶病及其相关病原物在云南烟草上的发生情况进行了多年的调查研究,力图对烟草丛顶病及其相关病原物的发生与分布进行追踪和分析。结果表明,2012年-2022年,烟草丛顶病在云南各大烟区仅零星发生,2019年以来已很难发现。烟草丛顶病的相关病原物主要在曾经暴发流行过病害的楚雄、保山和大理发现,且TBTV、TVDV、TBTVsatRNA和TVDVaRNA在烟草上并不总是同时被检出,其中引起烟草丛顶病典型症状的TBTV+TVDV+TBTVsatRNA+TVDVaRNA检出率在5%以下,TVDV的检出率最高,达30.44%,TBTVsatRNA的检出率最低,为7.68%。TBTV、TVDV、TBTVsatRNA和TVDVaRNA不能同时感染同一烟株可能是当前烟草丛顶病很少发生的主要原因。

关键词：烟草丛顶病毒烟草扭脉病毒烟草丛顶病毒卫星RNA 烟草扭脉病毒伴随RNA 发生与分布

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Evaluating user cognition of network diagrams

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Visual Informatics 2021年第4期5卷 26-33页

作者： xiaojiao chen Xiaoteng Tang Zijing Luo Jiayi Zhang School of Art and Archaeology Zhejiang UniversityHangzhouchina College of Computer Science and Technology Zhejiang UniversityHang zhouChina School of Mechanical Engineering Southeast UniversityNanjingChina

Edges crossing and nodes overlapping have a significant effect on the users’recognition and comprehension of network *** this study,we propose a visual evaluation method for users’cognition of network ***,this method carries out a set of cognitive experiments to collect the user’s cognitive performance that affects the variables,including accuracy and response *** user’s pupil diameter is measured through an eye tracker to reflect their cognitive ***,the significance test points out the visual features as independent variables and then establishes an evaluation regression *** experimental results show that the number of edges,edge length,node visual interference,and edge occlusion contribute to the evaluation models of response time,and edge occlusion and the number of node connections contribute to the accuracy ***,these evaluation models demonstrate good predictability when assessing users’cognition of network diagrams and provide practical recommendations for their use.

关键词： Network diagram Shortest path Eye tracking Cognitive evaluation

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烟草扭脉病毒云南分离物rtp基因克隆及序列分析

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植物医学 2024年第2期3卷 38-48页

作者：杨亚辉杨洁陈平陈海如陈小姣李凡云南农业大学植物保护学院昆明650201

探究来自云南不同时间和不同地区的烟草扭脉病毒(TVDV)各分离物间rtp基因序列差异,分析烟草丛顶病近年在田间发生趋势减缓的原因.以2020—2022年从云南楚雄、大理、保山及红河采集的染病烟草样品为材料,对TVDV的rtp基因进行扩增和序列分... 详细信息

探究来自云南不同时间和不同地区的烟草扭脉病毒(TVDV)各分离物间rtp基因序列差异,分析烟草丛顶病近年在田间发生趋势减缓的原因.以2020—2022年从云南楚雄、大理、保山及红河采集的染病烟草样品为材料,对TVDV的rtp基因进行扩增和序列分析,共得到TVDV 7个不同分离物的rtp基因序列,长度均为2172 nt,包含618 nt的cp基因及1554 nt的rtd区;推导的TVDVRTP蛋白共编码722个氨基酸,其中包含CP蛋白的205个氨基酸,RTD的517个氨基酸.多重序列比对结果发现,获得的7个TVDV分离物与GenBank上登录的其他TVDV分离物间cp基因核苷酸序列一致性为98.71%~100%,不同TVDV分离物间CP蛋白的氨基酸序列一致性为98.05%~100%,存在4个氨基酸的差异.获得的7个TVDV分离物与GenBank数据库登录的其他TVDV分离物间rtd区核苷酸序列一致性为96.68%~99.81%,RTD蛋白的氨基酸序列一致性为96.52%~100%,存在39个氨基酸的差异.这些TVDV分离物rtp基因的变异可能会对TVDV的蚜虫传播效率产生影响,进而影响到烟草丛顶病在田间的发生与流行.

关键词：烟草扭脉病毒烟草丛顶病通读蛋白分子变异蚜虫传播

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Beamspace maximum likelihood algorithm based on sum and difference beams for elevation estimation

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Journal of Systems Engineering and Electronics 2024年第3期35卷 589-598页

作者： chen Sheng ZHAO Yongbo HU Yili PANG xiaojiao National Laboratory of Radar Signal Processing Xidian UniversityXi’an 710071China

Beamspace super-resolution methods for elevation estimation in multipath environment has attracted significant attention, especially the beamspace maximum likelihood(BML)algorithm. However, the difference beam is rarely used in superresolution methods, especially in low elevation estimation. The target airspace information in the difference beam is different from the target airspace information in the sum beam. And the use of difference beams does not significantly increase the complexity of the system and algorithms. Thus, this paper applies the difference beam to the beamformer to improve the elevation estimation performance of BML algorithm. And the direction and number of beams can be adjusted according to the actual needs. The theoretical target elevation angle root means square error(RMSE) and the computational complexity of the proposed algorithms are analyzed. Finally, computer simulations and real data processing results demonstrate the effectiveness of the proposed algorithms.

关键词： elevation estimation beamspace multipath environment maximum likelihood

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基于网络药理学分析糖平散治疗2型糖尿病的机制研究

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中国医药科学 2024年第15期14卷 8-11,28页

作者：陈小娇熊国芬吕碧君羊忠山卞瑶云南省中西医结合慢病防治重点实验室云南昆明650500 云南中医药大学云南昆明650500

目的糖平散治疗2型糖尿病(T2DM)在临床上疗效确切,本文运用网络药理学的方法探索其潜在活性成分、靶点和机制研究。方法基于软件筛选糖平散的有效成分、找到T2DM疾病相关的基因、找出中药活性化合物与疾病的交叉点,进行网络拓扑学分析,... 详细信息

目的糖平散治疗2型糖尿病(T2DM)在临床上疗效确切,本文运用网络药理学的方法探索其潜在活性成分、靶点和机制研究。方法基于软件筛选糖平散的有效成分、找到T2DM疾病相关的基因、找出中药活性化合物与疾病的交叉点,进行网络拓扑学分析,做蛋白相互作用网络图(PPI),对京都基因与基因组百科全书(KEGG)功能和基因本体(GO)进行富集分析。结果糖平散主要有效成分共有33种,糖平散药物有效成分作用靶点有364个靶点;T2DM靶点基因有13790个;中药活性化合物-作用靶点-疾病的交集靶点共348个。结论糖平散有可能对T2DM产生疗效是由于其能够综合多种物质、多个目标并利用各种路径来协同工作所致,为进一步的研究提供了有力的依据。

关键词：网络药理学糖平散 2型糖尿病机制研究

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The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice

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Acta Pharmaceutica Sinica B 2022年第1期12卷 182-196页

作者： Rui Li Li Xie Lei Li xiaojiao chen Tong Yao Yuanxin Tian Qingping Li Kai Wang chenyang Huang Cui Li Yifan Li Hongwei Zhou Neil Kaplowitz Yong Jiang Peng chen Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical ScienceSouthern Medical UniversityGuangzhou 510515China Division of Hepatobiliopancreatic Surgery Department of General SurgeryNanfang HospitalSouthern Medical UniversityGuangzhou 510515China USC Research Center for Liver Disease Department of MedicineKeck School of Medicine of USCLos AngelesCA 90089USA Microbiome Medicine Center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China

Hepatic ischemia/reperfusion injury(HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development of liver injury. Herein, we investigated the potential contribution of gut microbes to ***/reperfusion surgery was performed to establish a murine model of HIRI. 16 S r RNA gene sequencing and metabolomics were used for microbial analysis. Transcriptomics and proteomics analysis were employed to study the host cell responses. Our results establish HIRI was significantly increased when surgery occurred in the evening(ZT12, 20:00) when compared with the morning(ZT0, 08:00);however, antibiotic pretreatment reduced this diurnal variation. The abundance of a microbial metabolite3,4-dihydroxyphenylpropionic acid was significantly higher in ZT0 when compared with ZT12 in the gut and this compound significantly protected mice against HIRI. Furthermore, 3,4-dihydroxyphenylpropionic acid suppressed the macrophage pro-inflammatory response in vivo and in vitro. This metabolite inhibits histone deacetylase activity by reducing its phosphorylation. Histone deacetylase inhibition suppressed macrophage pro-inflammatory activation and diminished the diurnal variation of HIRI. Our findings revealed a novel protective microbial metabolite against HIRI in mice. The potential underlying mechanism was at least in part, via 3,4-dihydroxyphenylpropionic acid-dependent immune regulation and histone deacetylase(HDAC) inhibition in macrophages.

关键词： Hepatic ischemia/reperfusion injury Diurnal variation 3,4-Dihydroxy phenylpropionic acid Gut microbiota

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Radiation Spectral Analysis of 3D Dust Molecular Clusters(PAHs)and Peptoids under Ionization and Electric Field in ISM

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Research in Astronomy and Astrophysics 2024年第1期24卷 70-77页

作者： Ruiqing Wu Chunhua Zhu Guoliang Lü xiaojiao Zhang Xizhen Lu Jinlong Yu Wujin chen Mengqiu Long School of Physics and Electronics Central South UniversityChangsha 410083China School of Physical Science and Technology Xinjiang UniversityUrumqi 830046China School of Microelectronics and Physics Hunan University of Technology and BusinessChangsha 410205China College of Mechanical and Electronic Engineering Tarim UniversityAlar 843300China School of Medicine Xinjiang Medical UniversityUrumqi 830011China

Polycyclic aromatic hydrocarbons(PAHs),PANHs,and peptoids dust spectral calculations from the interstellar medium(ISM)are important for dust observations and *** goal is to calculate the radiation spectrum of spherical PAHs dust clusters in a vacuum containing ionized and applied in the presence of an electric *** propose a new simple computational model to calculate the size of three-dimensional spherical dust clusters formed by different initial dust *** the Vienna Ab-initio Simulation Package code,the density functional theory with the generalized approximation was used to calculate the electron density gradient and obtain the radiation spectrum of *** the radius of spherical dust clusters is~[0.009-0.042]μm,the dust radiation spectrum agrees well with the Z=0.02 mMMP stellar spectra,and the PAHs radiation spectrum of NGC 4676 at wavelengths of(0-5]μm and(5-10]μm,*** the ionized state,the N-PAH,C_(10)H_(9)N,2(C_(4)H_(4))^(1+),and peptoids 4(CHON),(C_(8)H_(10)N_(2)O_(5))^(1+)dust clusters at 3.3μm,while the 2(C_(22)H_(21)N_(3)O_(2))^(1+),4(CHON)dust clusters at 5.2μm have obvious *** is a characteristic of part of PAHs and peptoids clusters radiation at the nearinfrared wavelength of 2μ***,especially after applying an electric field to the dust,the emission spectrum of the dust increases significantly in the radiation wavelength range[3-10]μ***,the dust clusters of PAHs,PANHs,and peptoids of the radius size~[0.009-0.042]μm are likely to exist in the ISM.

关键词： ISM:structure ISM:molecules radiation mechanisms:general (ISM:)dust extinction

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