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Safety of SARS-CoV-2 vaccines in patients with chronic myeloid leukemia: a multicenter survey in China

Chinese Medical Journal 2022年第12期135卷 1498-1499页

作者： Yunfan Yang Yanli Zhang Qian Jiang Li Meng Weiming Li Bingcheng Liu Xiaoli Liu Li Zhou Rong Liang xiaojian zhu Na Xu Pu Kuang Ting Lin Huanling zhu Department of Hematology Institute of HematologyWest China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Hematology Affiliated Cancer Hospital of Zhengzhou UniversityHenan Provincial Tumor HospitalZhengzhouHenan 450000China Department of Hematology Peking University People’s HospitalPeking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100000China Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430000China Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430000China Department of Leukemia National Clinical Research Center for Blood DiseaseInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical SciencesTianjin 300020China Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510000China Department of Leukemia Shanghai Institute of HematologyState Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 201100China Department of Hematology Xijing HospitalAir Force Medical University of PLAXi’anShaanxi 710000China

To the Editor:As of July 4,2021,the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)pandemic has affected>0.18 billion individuals and caused>3.9milliondeaths worldwide.ll Currently,the only method to radically overcome this pandemic is extensive vaccination.However,the clinical trials assessing most vaccines against SARS-CoV-2 have excluded patients with hematological tumors.

关键词： vaccines patients acute

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Nanoscale resistive switching devices for memory and computing applications

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Nano Research 2020年第5期13卷 1228-1243页

作者： Seung Hwan Lee xiaojian zhu Wei D.Lu Department of Electrical Engineering and Computer Science The University of MichiganAnn ArborMichigan 48109USA

With the slowing down of the Moore’s law and fundamental limitations due to the von-Neumann bottleneck,continued improvements in computing hardware performance become increasingly more challenging.Resistive switching(RS)devices are being extensively studied as promising candidates for next generation memory and computing applications due to their fast switching speed,excellent endurance and retention,and scaling and three-dimensional(3D)stacking capability.In particular,RS devices offer the potential to natively emulate the functions and structures of synapses and neurons,allowing them to efficiently implement neural networks(NNs)and other in-memory computing systems for data intensive applications such as machine learning tasks.In this review,we will examine the mechanisms of RS effects and discuss recent progresses in the application of RS devices for memory,deep learning accelerator,and more faithful brain-inspired computing tasks.Challenges and possible solutions at the device,algorithm,and system levels will also be discussed.

关键词： resistive switching oxygen vacancy metal cation memory application in-memory computing bio-inspired application

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Neural connectivity inference with spike-timing dependent plasticity network

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Science China(Information Sciences) 2021年第6期64卷 70-79页

作者： John MOON Yuting WU xiaojian zhu Wei D.LU Department of Electrical Engineering and Computer Science University of Michigan

Knowing the connectivity patterns in neural circuitry is essential to understand the operating mechanism of the brain, as it allows the analysis of how neural signals are processed and flown through the neural system. With the recent advances in neural recording technologies in terms of channel size and time resolution, a simple and efficient system to perform neural connectivity inference is highly desired, which will enable the process of high dimensional neural activity recording data and reduction of the computational time and cost. In this work, we show that the spike-timing dependent plasticity(STDP) algorithm can be used to reconstruct neural connectivity patterns in a biological neural network, with higher accuracy and efficiency than statistic-based inference methods. The biologically inspired STDP learning rules are natively implemented in a second-order memristor network and are used to estimate the type and the direction of neural connections. When stimulated by the recorded neural spike trains, the memristor device conductance is modulated by the proposed STDP learning rules, which in turn reflects the correlation of the spikes and the possibility of neural connections. By compensating for the different levels of neural activity, highly reliable inference performance can be achieved. The proposed approach offers real-time and local learning, resulting in reduced computational cost/time and strong tolerance to variations of the neural system.

关键词： spike-timing dependent plasticity neural connectivity memristor online learning second-order memristor

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白细胞衍生性指标在儿童肺炎严重程度及预后评估中的应用观察

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实用医技杂志 2024年第5期31卷 360-365页

作者：朱小健万浩余倩上饶市妇幼保健院检验科上饶334000 江西医学高等专科学校第一附属医院骨科上饶334000

目的分析白细胞衍生性指标在儿童肺炎严重程度及预后评估中的应用价值。方法选取2022年1月至2023年1月本院收治的60例肺炎患儿,根据肺炎严重指数(PSI)评分将其分为低危组(25例)、中危组(21例)和高危组(14例)。采集患儿静脉血,检测3组... 详细信息

目的分析白细胞衍生性指标在儿童肺炎严重程度及预后评估中的应用价值。方法选取2022年1月至2023年1月本院收治的60例肺炎患儿,根据肺炎严重指数(PSI)评分将其分为低危组(25例)、中危组(21例)和高危组(14例)。采集患儿静脉血,检测3组患儿外周血乳酸脱氢酶(LDH)、降钙素原(PCT)、白细胞介素-6(IL-6)水平、C-反应蛋白(CRP)及血常规,计算中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、淋巴细胞与单核细胞比值(LMR)。采用Pearson相关系数分析上述指标与临床肺部感染评分(CPIS)之间的相关性。于出院时评估患儿预后效果,并根据评估结果将患儿分为预后良好组(47例)和预后不良组(13例),比较2组上述指标差异;采用多因素回归分析上述指标与儿童肺炎严重程度相关性;并应用受试者工作特征(ROC)曲线分析LDH、IL-6、CRP、NLR、PLR在儿童肺炎预后评估中的价值。结果中、高危组LDH、PCT、IL-6、CRP、NLR、PLR、MLR及CPIS评分均高于低危组(P<0.05),高危组LDH、PCT、IL-6、CRP、NLR、PLR、MLR及CPIS评分均高于中危组(P<0.05);肺炎患儿血清LDH、PCT、IL-6、CRP、NLR、PLR、MLR水平与CPIS评分均呈正相关(r=0.625、0.429、0.358、0.413、0.676、0.465、0.645,P<0.05);预后良好组LDH、PCT、IL-6、CRP、NLR、PLR、MLR水平均低于预后不良组(P<0.01);多因素回归分析显示,LDH、IL-6、CRP、NLR以及PLR水平升高是影响儿童肺炎预后的独立危险因素(P<0.05);LDH、IL-6、CRP、NLR、PLR及联合检测在预测肺炎患儿预后方面效能较高,其中LDH预测效能最高。结论 LDH、PCT、IL-6、CRP、NLR、PLR、MLR水平与肺炎患儿病情严重程度呈正相关,LDH、IL-6、CRP、NLR、PLR水平升高是影响肺炎患儿预后的独立危险因素,应早期监测上述指标,以改善患儿预后。

关键词：肺炎儿童白细胞衍生性指标肺炎严重指数严重程度预后

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基于“强有力的知识”的高中地理项目式教学设计——以“地域文化与城乡景观”为例

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地理教学 2024年第1期 33-37页

作者：林银斌陈晓欣蓝泳杰朱潇剑汕头金中海湾学校广东汕头515057 广州市番禺区金海岸学校广东广州511400 汕头市金山中学广东汕头515071

近年来,“强有力的知识”理论引起学者们的广泛讨论。学习“强有力的知识”能够帮助学生更好地应对真实生活中的复杂情境。然而,目前的研究对如何让该抽象的理论知识服务高中地理教学,帮助教师落实地理学科核心素养的培育关注较少。本... 详细信息

近年来,“强有力的知识”理论引起学者们的广泛讨论。学习“强有力的知识”能够帮助学生更好地应对真实生活中的复杂情境。然而,目前的研究对如何让该抽象的理论知识服务高中地理教学,帮助教师落实地理学科核心素养的培育关注较少。本文分析了通过高中地理项目式教学构建“强有力的知识”的实施路径,并以“地域文化与城乡景观”为例提供教学设计案例,以期为项目式教学深化落实“强有力的知识”提供可行方案。

关键词：强有力的知识项目式教学高中地理教学设计地域文化与城乡景观

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Achieving a high magnetization in sub-nanostructured magnetite films by spin-flipping of tetrahedral Fe3. cations

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Nano Research 2015年第9期8卷 2935-2945页

作者： Tun Seng Herng Wen Xiao Sock Mui Poh Feizhou He Ronny Sutarto xiaojian zhu Runwei Li Xinmao Yin Caozheng Diao Yang Yang Xuelian Huang xiaojiang Yu Yuan Ping Feng AndrivoRusydi Jun Ding Department of Materials Science and Engineering National University of Singapore 7 Engineering Drive I Singapore 119260 Singapore Singapore Synchrotron Light Source National University of Singapore 5 Research Link Singapore 117603 Singapore NUSNNI-Nanocore Department of Physics National University of Singapore 2 Science Drive 3 Singapore 117542 Singapore Department of Physics National University of Singapore 2 Science Drive 3 Singapore 117542 Singapore Canadian Light Source Saskatoon Saskatchewan S7N 2V3 Canada Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Materials Technology and Engineering Ningbo 31520 I China

Magnetite Fe304 （ferrite） has attracted considerable interest for its exceptional physical properties： It is predicted to be a semimetallic ferromagnetic with a high Curie temperature, it displays a metal-insulator transition, and has potential oxide-electronics applications. Here, we fabricate a high-magnetization （〉 1 Tesla） high-resistance （-0.1 Ωcm） sub-nanostructured （grain size 〈 3 nm） Fe304 film via grain-size control and nano-engineering. We report a new phenomenon of spin- flipping of the valence-spin tetrahedral FeB＊ in the sub-nanostructured Fe304 film, which produces the high magnetization. Using soft X-ray magnetic circular dichroism and soft X-ray absorption, both at the Fe L3,2- and O K-edges, and supported by first-principles and charge-transfer multiple calculations, we observe an anomalous enhancement of double exchange, accompanied by a suppression of the superexchange interactions because of the spin-flipping mechanism via oxygen at the grain boundaries. Our result may open avenues for developing spin- manipulated giant magnetic Fe304-based compounds via nano-grain size control.

关键词： magnetite,X—ray magnetic circulardichroism(XMCD),giant magnetization,nanosuctured—Fe3O4,ferrite,spin—flipping

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Combined inhibition of Notch and FLT3 produces synergistic cytotoxic effects in FLT3/ITD^(+)acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2185-2196页

作者： Dan Li Tongjuan Li Zhen Shang Lei Zhao Qian Xu Jiaqi Tan Yun Qin Yuanyuan Zhang Yang Cao Na Wang Liang Huang xiaojian zhu Kuangguo Zhou Liting Chen Chunrui Li Ting Xie Yi Yang Jue Wang Jianfeng Zhou Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Division of Pathology and Experimental Hematology and Cancer Biology Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45248USA Immunotherapy Research Center for Hematologic Diseases of Hubei Province WuhanHubei 430030China Department of geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Medical Research Institute Wuhan UniversityWuhan 430071China

Internal tandem duplication(ITD)mutations of FMS-like tyrosine kinase-3(FLT3)are the most frequent genetic alterations in acute myeloid leukemia(AML)and predict a poor prognosis.FLT3 tyrosine kinase inhibitors(TKIs)provide short-term clinical responses,but the long-term prognosis of FLT3/ITD^(+)AML patients remains poor.Notch signaling is important in numerous types of tumors.However,the role of Notch signaling in FLT3/ITD^(+)AML remains to be elucidated.In the current study,we found that Notch signaling was activated upon FLT3-TKI treatment in FLT3/ITD^(+)cell lines and primary cells.As Notch signaling can be blocked byγ-secretase inhibitors(GSIs),we examined the combinatorial antitumor efficacy of FLT3-TKIs and GSIs against FLT3/ITD^(+)AML and explored the underlying molecular mechanisms.As a result,we observed synergistic cytotoxic effects,and the treatment preferentially reduced cell proliferation and induced apoptosis in FLT3/ITD^(+)AML cell lines and in primary AML cells.Furthermore,the combination of FLT3-TKI and GSI eradicated leukemic cells and prolonged survival in an FLT3/ITD^(+)patient-derived xenograft AML model.Mechanistically,differential expression analysis suggested that CXCR3 may be partially responsible for the observed synergy,possibly through ERK signaling.Our findings suggest that combined therapies of FLT3-TKIs with GSI may be exploited as a potential therapeutic strategy to treat FLT3/ITD^(+)AML.

关键词： FLT3 Notch treatment

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Hierarchical Semantic-Category-Tree Model for Chinese-English Machine Translation

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China Communications 2012年第12期9卷 80-92页

作者： zhu xiaojian Jin Yaohong Institute of Chinese Information Processing Beijing Normal University Beijing 100875 P. R. China CPIC-BNU Joint Laboratory of Machine Translation Beijing Normal University Beijing 100875 P. R. China

We introduce a novel Semantic-CategoryTree(SCT) model to present the semantic structure of a sentence for Chinese-English Machine Translation(MT).We use the SCT model to handle the reordering in a hierarchical structure in which one reordering is dependent on the others.Different from other reordering approaches,we handle the reordering at three levels:sentence level,chunk level,and word level.The chunk-level reordering is dependent on the sentence-level reordering,and the word-level reordering is dependent on the chunk-level reordering.In this paper,we formally describe the SCT model and discuss the translation strategy based on the SCT model.Further,we present an algorithm for analyzing the source language in SCT and transforming the source SCT into the target SCT.We apply the SCT model to a rule-based patent text MT to evaluate the ability of the SCT model.The experimental results show that SCT is efficient in handling the hierarchical reordering operation in MT.

关键词：汉英机器翻译语义分类树模型中国 SCT 分层结构算法分析应用模型

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Bright dual-color electrochemiluminescence of a structurally determined Pt1Ag18 nanocluster

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Aggregate 2024年第1期5卷 345-352页

作者： Bing Yin Lirong Jiang xiaojian Wang Ying Liu Kaiyang Kuang Mengmeng Jing Chunmin Fang Chuanjun Zhou Shuang Chen Manzhou zhu Institutes of Physical Science and Information Technology and Centre for Atomic Engineering of Advanced Materials Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationDepartment of Chemistry and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized MaterialsAnhui UniversityHefeiChina

Metal nanoclusters possess excellent electrochemical,optical,and catalytic properties,but correlating these properties remains challenging,which is the foundation to generate electrochemiluminescence(ECL).Herein,we report for the first time that a structurally determined Pt1Ag18 nanocluster generates intense ECL and simultaneously enhances the ECL of carbon dots(CDs)via an electrocatalytic effect.Pt^(1)Ag_(18)nanocluster show aggregation-induced emission enhancement and aggregation-induced ECL enhancement under light and electrochemical stimulation,respectively.In the presence of tripropylamine(TPrA)as a coreactant,solid Pt1Ag18 shows unprecedented ECL efficiency,which is more than nine times higher than that of 1 mM Ru(bpy)32+with the same TPrA concentration.Potential-resolved ECL spectra reveal two ECL emission bands in the presence of TPrA.The ECL emission centered at 650 nm is assigned to the solid Pt_(1)Ag_(18)nanocluster,consistent with the peak wavelength in self-annihilation ECL and photoluminescence of the solid state.The ECL emission centered at 820 nm is assigned to the CDs on the glassy carbon electrode.The electrocatalytic effect of the nanoclusters enhanced the ECL of the CDs by a factor of more than 180 in comparison to that without nanoclusters.Based on the combined optical and electrochemical results,the ECL generation pathways and mechanisms of Pt1Ag18 and CDs are proposed.These findings are extremely promising for designing multifunctional nanocluster luminophores with strong emissions and developing ratiometric sensing devices.

关键词： AIECLE AIEE electrochemiluminescence nanocluster photoluminescence structure

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不同治疗方式对T淋巴母细胞淋巴瘤的疗效影响

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中华器官移植杂志 2024年第2期45卷 75-81页

作者：付安蝶朱晓健杨漾黄丽芳徐金环曹阳肖毅孟凡凯张东华张义成华中科技大学同济医学院附属同济医院血液科武汉430030

目的探讨常规化学药物治疗、自体造血干细胞移植(auto-HSCT)及异基因造血干细胞移植(allo-HSCT)对T淋巴母细胞淋巴瘤(T-LBL)的疗效差异。方法回顾性分析2012年1月至2022年12月在华中科技大学同济医学院附属同济医院接受治疗的82例T-LBL... 详细信息

目的探讨常规化学药物治疗、自体造血干细胞移植(auto-HSCT)及异基因造血干细胞移植(allo-HSCT)对T淋巴母细胞淋巴瘤(T-LBL)的疗效差异。方法回顾性分析2012年1月至2022年12月在华中科技大学同济医学院附属同济医院接受治疗的82例T-LBL患(受)者的临床资料,根据不同的治疗方法分为未移植组(49例)和移植组(33例),移植组又根据不同移植方式分为allo-HSCT组(22例)和auto-HSCT组(11例),未移植组绝大部分患者采用环磷酰胺+美司钠+阿霉素+地塞米松+长春新碱/甲氨蝶呤+阿糖胞苷(Hyper CAVD A/B)方案进行诱导缓解,6例使用环磷酰胺+阿糖胞苷+6-巯基嘌呤(CAT)、依托泊苷+长春新碱+多柔比星+环磷酰胺+泼尼松(EPOCH)、大剂量甲氨蝶呤+地塞米松,长春新碱+吡柔比星+环磷酰胺+培门冬酶+泼尼松(VDCLP)等方案为基础进行诱导缓解,移植组在接受多药联合强化诱导治疗后进行造血干细胞移植。通过观察患(受)者的总存活率和无进展存活(progression free survival,PFS)率等,对其进行疗效和生存分析。结果共纳入82例患(受)者,男64例,女18例,年龄为23岁(11~74)岁。62例(75.61%)临床分期为Ⅲ~Ⅳ期,43例(53.44%)起病时有发热、盗汗、体重减轻的全身症状(B症状),其中骨髓受累50例(61.00%),Ann Arbor分期Ⅲ期及以上33例(80.5%);东部肿瘤协作组(ECOG)评分≤2分的共65例(79.27%),>2分的共17例(20.73%);国际预后指数(IPI)≤3分的共63例(76.83%),>3分的共19例(23.17%)。全部82例患(受)者的随访时间为27.5个月(5~118)个月,3年总存活率、无进展存活(PFS)率分别为53.64%(95%CI:42.35%~64.62%)和47.56%(95%CI:36.53%~58.82%)。未移植组、移植组3年总存活率比较差异有统计学意义[42.86%(95%CI:29.12%~57.71%)比69.70%(95%CI:51.13%~83.79%),P=0.014],3年PFS率分别为38.76%(95%CI:25.54%~53.76%)和60.61%(95%CI:42.24%~76.57%),差异有统计学意义(P=0.032)。结论T-LBL患者接受造血干细胞移植巩固治疗相较于单纯化疗可改善长期预后,但auto-HSCT和allo-HSCT的疗效相似。

关键词：造血干细胞移植 T淋巴母细胞淋巴瘤疗效化学药物治疗

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