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Anti-Parkinsonian Therapy:Strategies for Crossing the Blood–Brain Barrier and Nano-Biological Effects of Nanomaterials

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Nano-Micro Letters 2022年第6期14卷 350-398页

作者： Guowang cheng Yujing Liu Rui Ma Guopan cheng Yucheng Guan Xiaojia Chen Zhenfeng Wu Tongkai chen Key Laboratory of Modern Preparation of Traditional Chinese Medicine Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004People’s Republic of China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405People’s Republic of China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078People’s Republic of China

Parkinson’s disease(PD),a neurodegenerative disease that shows a high incidence in older individuals,is becoming increasingly prevalent.Unfortunately,there is no clinical cure for PD,and novel anti-PD drugs are therefore urgently required.However,the selective permeability of the blood–brain barrier(BBB)poses a huge challenge in the development of such drugs.Fortunately,through strategies based on the physiological characteristics of the BBB and other modifications,including enhancement of BBB permeability,nanotechnology can offer a solution to this problem and facilitate drug delivery across the BBB.Although nanomaterials are often used as carriers for PD treatment,their biological activity is ignored.Several studies in recent years have shown that nanomaterials can improve PD symptoms via their own nano-bio effects.In this review,we first summarize the physiological features of the BBB and then discuss the design of appropriate brain-targeted delivery nanoplatforms for PD treatment.Subsequently,we highlight the emerging strategies for crossing the BBB and the development of novel nanomaterials with anti-PD nano-biological effects.Finally,we discuss the current challenges in nanomaterial-based PD treatment and the future trends in this field.Our review emphasizes the clinical value of nanotechnology in PD treatment based on recent patents and could guide researchers working in this area in the future.

关键词： Blood-brain barrier Parkinson’s disease Nasal delivery Biomimetic drug delivery Nano-biological effects

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Spreading Behavior and Hot Cracking Mechanism of Single Tracks in High Strength Al–Cu–Mg–Mn Alloy Fabricated by Laser Powder Bed Fusion

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金属学报:英文版 2023年第9期36卷 1454-1464页

作者： xiaojia Nie Ze chen Yang Qi Hu Zhang Haihong Zhu College of Ship and Ocean Naval University of EngineeringWuhan430033China Department of Basic Courses Naval University of EngineeringWuhan430033China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan430074China

Laser powder bed fusion(LPBF)technology is a high-precision metal additive manufacturing(AM)technology.Due to the high specific strength of high strength aluminum alloys,high strength aluminum alloys fabricated by LPBF have broad application prospects in the field of light weighting.However,high strength aluminum alloys have high hot cracking susceptibility.In this study,an analysis of the hot cracking susceptibility as a function of processing parameters is presented for single tracks of LPBF processed(LPBFed)high strength Al–Cu–Mg–Mn alloy.The hot cracking in single tracks of LPBFed Al–Cu–Mg–Mn alloy is solidification cracking based on the experimental observations of microstructure.Combining Rosenthal simulations and spreading behavior of a single droplet,the critical scanning speed of single track with balling phenomenon was obtained.It was found that when the laser power was 200 W,the scanning speed exceeded 440.1 mm/s,the droplet will not be able to spread completely,which is consistent with the experimental result of 500 mm/s.Through the calculation and analysis of the microstructure and the existence time of the molten pool,it was pointed out that the reduction in the liquid phase caused by the high scanning speed,the shortening of the solidification time and the high stress caused by the high-temperature gradient promoted the generation of hot cracking.In summary,this work contains a practical guide to optimize processing parameters of LPBFed Al–Cu–Mg–Mn alloys,which provides a basis for fabricating thin walls and cubic samples without hot cracking.

关键词： Laser powder bed fusion High strength aluminum alloy Hot cracking Single track

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Spatio-Temporal Characteristics of Heat Transfer of Methanation in Fluidized Bed for Pyrolysis and Gasification Syngas of Organic Solid Waste

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Journal of Renewable Materials 2023年第10期11卷 3659-3680页

作者： Danyang Shao xiaojia Wang Delu chen Fengxia An Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy&EnvironmentSoutheast UniversityNanjing210096China China Energy Science and Technology Research Institute Co. Ltd.Nanjing210023China

Methanation is an effective way to efficiently utilize product gas generated from the pyrolysis and gasification of organic solid wastes.To deeply study the heat transfer and mass transfer mechanisms in the reactor,a successful three-dimensional comprehensive model has been established.Multiphase flow behavior and heat transfer mechanisms were investigated under reference working conditions.Temperature is determined by the heat release of the reaction and the heat transfer of the gas-solid flow.The maximum temperature can reach 951 K where the catalyst gathers.In the simulation,changes in the gas inlet velocity and catalyst flow rate were made to explore their effects on CO conversion rate and temperature for optimization purposes.As the inlet gas velocity increases from 2.78 to 4.79 m/s,the CO conversion rate decreases from 81.6%to 72.4%.However,more heat is removed from the reactor,and the temperature rise increases from 78.03 to 113.49 K.When the catalyst flow rate is increased from 7.18 to 17.96 kg/(m^(2)·s),the mass of the catalyst in the reactor is increased from 0.0019 to 0.0042 kg,and the CO conversion rate is increased from 66.8%to 81.5%.However,this increases the maximum temperature in the reactor from 940.0 to 966.4 K.

关键词： Organic solid waste methanation reactor multiphase flow three-dimensional simulation

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Geochemistry and Petrogenesis of Late Cretaceous–Paleocene Granites from the Tengchong Block, Western Yunnan: Implications for Angle-switching of Subducting Slab

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Acta Geologica Sinica(English Edition) 2022年第5期96卷 1600-1614页

作者： chen Xijie MENG Yuanku CAI Zhihui LI Huaqi LIU xiaojia Development and Research Center of China Geological Survey Beijing 100037China Key Laboratory of Deep-Earth Dynamics of Ministry of Natural Resources Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China State Key Laboratory for Mineral Deposits Research Nanjing UniversityNanjing 210023China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China

The Cenozoic geological hallmark of Western Yunnan is the characteristic voluminous Late Cretaceous-Eocene granites;however, their geological background and petrogenesis have not been well constrained and elucidated. In this study, we present new zircon U-Pb dating, along with geochemical and Sr-Nd-Hf isotopic data for granites from the Tengchong–Lianghe granitoid belt(as abbreviated to Tengliang belt) and West Yingjiang batholiths from the Tengchong block. The mineralogical and geochemical features of the Tengliang granites and the West Yingjiang batholiths are ascribed to aluminous S-type granites and weak peraluminous I-type, respectively. Zircon U-Pb analyses yielded consistent ages ranging from 67.5 Ma, 68.4 Ma and 66.2 Ma from the Tengliang granitoid belt and 50.4 Ma to 60.8 Ma for three samples from the west Yingjiang batholiths. The Tengliang granites were emplaced during the Late Cretaceous(68-66 Ma) and demonstrate negative ε_(Hf)(t) values(-24 to-4) and initial ~(87)Sr/~(86)Sr ratios of 0.7101–0.7139 and significant negative ε_(Nd)(t) values from-8.91 to-13.2, indicating a Proterozoic sedimentary source or enriched components. The hornblende-bearing I-type granites from West Yingjiang are characterized by lower initial ~(87)Sr/~(86)Sr ratios of 0.7076–0.7106, compared to Tengliang granite and negative whole-rock ε_(Nd)(t) values from-4.0 to-11.9. The early Eocene west Yingjiang gneissic granites show wide ranges of ε_(Hf)(t) values from +7.4 to-8.5 and T_(2DM) of 1.30–0.65 Ga, indicating partial melting of ancient crust with contributions of depleted mantle materials. In combination with the regional background and previous studies, we propose that such a spatio-temporal distribution of the Tengchong granitoid belt might be related to the rollback or angleswitching of the Neo-Tethyan subducting slab. This study sheds new light on the evolutionary history of the Tengchong block.

关键词： petrogenesis gneissic granite subduction angle switch Tengchong block Cenozoic Neo-Tethyan

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Giant magnetic enhancement across a ferroelectricantiferroelectric phase boundary in Bi_(1-x)Y_xFeO_3

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Science China(Physics,Mechanics & Astronomy) 2012年第3期55卷 404-408页

作者： XiaoKun chen YuJie Wu Jing Zhang Xiaojia Chen S China Univ Technol Dept Phys Guangzhou 510640 Guangdong Peoples R China

The structural,vibrational,and magnetic properties of well prepared Bi 1 x Y x FeO 3(x=0-0.1) powders are investigated by combining the X-ray diffraction,Raman scattering,differential scanning calorimetry,and magnetometry measurements.A structural symmetric breaking from the rhombohedral R3c to orthorhombic Pnma between x=0.07 and 0.1 is identified from the X-ray and Raman measurements,accompanying a ferroelectric-antiferroelectric phase transition.The remnant magnetization of Bi 0.9 Y 0.1 FeO 3 is about 15 times higher in magnitude compared to the pure BiFeO 3.Such a giant enhancement is suggested to result from the destruction of the spin cycloid accompanied with the structured transition.

关键词：反铁电磁增强相边界差示扫描量热法 BiFeO3 磁学性质拉曼散射光谱测量

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Gallium-based liquid metal micro/nanoparticles for photothermal cancer therapy

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Journal of Materials Science & Technology 2023年第11期142卷 22-33页

作者： Mingming Fu Yifeng Shen Hao Zhou xiaojia Liu Wenjun chen Xing Ma School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Sauvage Laboratory for Smart Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China

Gallium-based liquid metals have attracted significant interest in the biomedical field due to their unique properties such as low viscosity,good fluidity,high thermal/electrical conductivity,and good biocompatibility.Meanwhile,photothermal therapy has made great development in the field of antitumor with its advantages of low adverse effects,high specificity,and repeatable treatment.The photothermal capability possessed by gallium-based liquid metals makes them show unparalleled advantages in photothermal therapy.Liquid metal-based photothermal therapy has progressed in recent years and can perform a vital role in accurate and noninvasive antitumor therapy.Herein,a review of the major preparation methods of liquid metal micro/nanoparticles,the mechanism of liquid metal photothermal conversion,and discussions on the factors affecting the photothermal properties of liquid metals are presented.The biological applications of liquid metal photothermal therapy in synergy with other therapies are discussed,as well as the current challenges and opportunities for the clinical translation of liquid metals in biomedical applications.

关键词： Gallium-based materials Photothermal conversion principle Photothermal therapy Synergistic therapy

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Robust boron nanoplatform provokes potent tumoricidal activities via inhibiting heat shock protein

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Asian Journal of Pharmaceutical Sciences 2022年第5期17卷 728-740页

作者： Yuying Zhao Ning Liu Piaoxue Liu Taojian Fan Rui Ma Huijie Hong Xiaojia Chen Zhongjian Xie Han Zhang Qi Wang Tongkai chen Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405China Institute of Microscale Optoelectronics Collaborative Innovation Centre for Optoelectronic Science&TechnologyKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen Key Laboratory of Micro-Nano Photonic Information TechnologyGuangdong Laboratory of Artificial Intelligence and Digital Economy(SZ)Shenzhen UniversityShenzhen 518060China College of Health Science and Environmental Engineering School of Shenzhen Technology UniversityShenzhen 518118China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Institute of Pediatrics Shenzhen Children’s HospitalShenzhen 518038China Shenzhen International Institute for Biomedical Research Shenzhen 518116China

Near-infrared(NIR)-light-triggered photothermal therapy(PTT)is a promising treatment for breast cancer.However,its therapeutic efficiency is often compromised due to the heatinduced up-regulation of heat shock proteins,which confer photothermal resistance.To solve this urgent problem,PEGylated two-dimensional boron nanosheets(B-PEG)-which allow both multimodal imaging and photothermal conversion-were loaded with gambogic acid(GA),which can inhibit heat shock protein 90(Hsp90).Experimental findings indicated that this combination of B-PEG and GA could serve as an integrated drug delivery system for cancer diagnosis and treatment.It could be used to administer mild PTT as well as chemotherapy for breast cancer,provide improved anti-tumor effects,and reduce the toxicity of PTT,all while inhibiting breast cancer growth.This drug delivery system could offer a novel tool for administering chemotherapy combined with PTT while avoiding the adverse effects of traditional PTT.

关键词： Mild photothermal therapy Chemotherapy Boron nanosheets Heat shock proteins Breast cancer

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Cell Membrane Coating Technology:A Promising Strategy for Biomedical Applications

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Nano-Micro Letters 2019年第4期11卷 720-765页

作者： Yao Liu Jingshan Luo Xiaojia Chen Wei Liu Tongkai chen Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405People’s Republic of China Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhou 510405People’s Republic of China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoPeople’s Republic of China Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan 430072People’s Republic of China

Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties,and is an active area of ongoing research readily applicable to nanoscale biomedicine.Nanoparticles(NPs)coated with cell membranes offer an opportunity to unite natural cell membrane properties with those of the artificial inner core material.The coated NPs not only increase their biocompatibility but also achieve effective and extended circulation in vivo,allowing for the execution of targeted functions.Although cell membrane-coated NPs offer clear advantages,much work remains before they can be applied in clinical practice.In this review,we first provide a comprehensive overview of the theory of cell membrane coating technology,followed by a summary of the existing preparation and characterization techniques.Next,we focus on the functions and applications of various cell membrane types.In addition,we collate model drugs used in cell membrane coating technology,and review the patent applications related to this technology from the past 10 years.Finally,we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology.

关键词： Cell membrane Biomimetic nanoparticles Cancer therapy Immune modulation Detoxification

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Experimental and numerical study on microcrack detection using contact nonlinear acoustics

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Frontiers of Structural and Civil Engineering 2009年第2期3卷 137-141页

作者： Xiaojia Chen Yuanlin WANG School of Transportation Wuhan University of TechnologyWuhan 430063China

This paper introduces a non-classical nonlinear acoustic theory for microcrack detection in materials,comparing contact nonlinearity with material nonlinearity.The paper's main work concentrates on the experimental and numerical verification of the effectivity of contact nonlinear acoustic detection by using the contact nonlinear parameter fl',which can be represented by the ratio of the second-harmonic amplitude to the square of the firstharmonic amplitude.Both experiments and numerical tests are performed.The results show that fl'is sensitive to the initiation of microcracks and varies with the development of the microcracks.The numerical test illustrates the decline offl'when microcracks penetrate each other.

关键词： microcrack detection contact nonlinearity numerical analysis

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Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation

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Asian Journal of Pharmaceutical Sciences 2020年第4期15卷 518-528页

作者： Sha Xiong Wei Liu Yile Zhou Yousheng Mo Yao Liu Xiaojia Chen Huafeng Pan Dongsheng Yuan QiWang Tongkai chen Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhou 510405China Institute of Chinese Medical Sciences University of MacaoMacaoChina

Resveratrol(RES),a non-flavonoid polyphenol extracted from a wide variety of plants,exhibits neuroprotective activities against Parkinson’s disease(PD).However,undesirable water solubility of RES reduces its oral bioavailability and demonstrates lowefficacy in blood and brain,thus limiting its application.In present study,a nanocrystal formulation of RES(RES-NCs)was developed to enhance its oral bioavailability and delivery into brain for PD treatment.RES-NCs were fabricated with hydroxypropyl methylcellulose(HPMC)stabilizer via antisolvent precipitation approach.The obtained RES-NCs displayed the particle size of 222.54±1.66 nm,the PDI of 0.125±0.035,the zeta potential of−9.41±0.37mV,and a rapid in vitro dissolution rate.Molecular dynamics simulation of RES and HPMC revealed an interaction energy of−68.09 kJ/mol and a binding energy of−30.98±0.388 kJ/mol,indicating that the spontaneous binding between the two molecules is through van der Waals forces.RES-NCs conferred enhanced cellular uptake as well as improved permeability relative to pure RES.In addition,RES-NCs were able to protect neurons against cytotoxicity induced by MPP+.Meanwhile,RES-NCs exerted no significant toxic effects on zebrafish embryos and larvae,and did not influence their survival and hatching rates.When orally administered to rats,RES-NCs exhibited more favorable pharmacokinetics than pure RES,with higher plasma and brain concentrations.More importantly,MPTP-induced PD mice showed notable improvements in behavior,attenuated dopamine deficiency,and elevated levels of dopamine and its metabolites after the treatment with RES-NCs.Furthermore,immunoblot analysis revealed that the neuroprotective role of RES-NCsmay be at least partially mediated by Akt/Gsk3βsignaling pathway.Taken altogether,RES-NCs can serve as a potential treatment modality for PD,offering means of improving RES oral bioavailability and brain accumulation.

关键词： Nanocrystals Resveratrol Oral absorption Brain permeability Anti-Parkinsonian efficacy

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