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Ongoing Compressional Tectonism and Regional Seismic Hazard Revealed by the 2023 Mw6.1 Jishishan earthquake

Journal of earth Science 2025年第1期36卷 275-290页

作者： Xiaoning Hu Chen Yu Zhenjiang liu Yingying Zhang Zhenhong Li Chuang Song Bingquan Han Haihui liu Jie Li College of Geological engineering and Geomatics Chang'an UniversityXi'an 710054China Key Laboratory of Loess Xi'an 710054China Big Data Center for Geosciences and Satellites Chang'an UniversityXi'an 710054China Key Laboratory of Western China's Mineral Resources and Geological engineering Ministry of EducationXi'an 710054China China earthquake Networks Center Beijing 100045China

On December 18,2023,a Mw6.1 earthquake struck Jishishan County,Gansu Province,China,marking the most significant earthquake in the northeastern edge of the Tibetan Plateau since *** its proximate to the Loess Plateau,which is extremely susceptible to geohazards,this earthquake raises awareness about the seismic hazard of several mega-cities such as Xi'an in Northwest *** this paper,we inferred that the rupture occurred on an east-dipping backthrust,resulting from the regional e-W contraction tectonic *** dynamic model through teleseismic waves and static model through radar displacement measurements together reveal a unilateral,along-strike rupture,encountering a slip barrier at one side of the main slip patch causing a cluster of *** also identified a high-dip structure,which is an early-stage backthrust fault whose dip becomes increasingly high due to regional compressional *** from the loaded fault segments,particularly on the fault linkage,which necessitate continuous examination,a detailed seismic hazard assessment of the west Qinling and Daotanghe-Linxia fault system identifies a seismic gap between Weiyuan and Dingxi with the potential for a Mw7.5 ***,these findings provide valuable insights into the seismic behavior of the seismogenic fault as well as guidance on hazard mitigation in its surrounding fault systems.

关键词： 2023 Jishishan earthquake dynamic rupture process coseismic displacements seismic hazard assessment fault slips mechanics

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Genome-wide CRISPR screens identify CLC-2 as a drug target for anti-herpesvirus therapy:tackling herpesvirus drug resistance

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Science China(Life Sciences) 2025年第2期68卷 515-526页

作者： Fayu Yang Nan Wei Shuo Cai Jing liu Qingping Lan Hao Zhang Lu Shang Bo Zheng Mi Wang Yingchun liu Lifang Zhang Chenzhong Fei Wu Tong Changlong liu ersheng Kuang Guangzhi Tong Feng Gu Shanghai Veterinary Research Institute Chinese Academy of Agricultural SciencesShanghai 200241China Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics Ministry of Agriculture and Rural AffairsShanghai 200241China State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China Institute of Human Virology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China School of Medicine Tsinghua UniversityBeijing 100084China

The emergence of drug resistance to virus(i.e.,acyclovir(ACV)to herpesviruses)has been termed one of the common clinical issues,emphasizing the discovery of new antiviral *** address it,a genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)screening was performed in mouse haploid embryonic stem cells infected with pseudorabies virus(PRV),anα-herpesvirus causing human and pig *** results demonstrated that type 2 voltage-gated chloride channels(CLC-2)encoded by one of the identified genes,CLCN2,is a potential drug target for anti-herpesvirus ***-2 inhibitors,omeprazole(OMe)and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid(DIDS),can efficiently inhibit infection of multiple herpesviruses in cellulo(i.e.,PRV,HSV and eBV),and effectively treat murine herpes simplex encephalitis(HSe).Additionally,DIDS was found to inhibit HSV-1 replication by blocking the PI3K/Akt *** importantly,both DIDS and OMe were able to inhibit ACV-resistant HSV-1 strain *** study's findings suggest that targeting host-cell factors such as CLC-2 may be a promising approach to tackling herpesvirus drug *** discovery of CLC-2 as a potential drug target for anti-herpesvirus therapy provides a new direction for the development of novel antiviral agents.

关键词： herpesviruses CRISPR host-directed therapy CLC-2 DIDS

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The study of antibacterial activity of cationic poly(β-amino ester)regulating by amphiphilic balance

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Chinese Chemical Letters 2025年第2期36卷 332-336页

作者： Chong liu Ling Li Jiahui Gao Yanwei Li Nazhen Zhang Jing Zang Cong liu Zhaopei Guo Yanhui Li Huayu Tian School of Materials Science and engineering Changchun University of Science and Technology School of Materials Science and engineering Xiamen University of Technology Key Laboratory of Polymer ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences College of Chemistry and Chemical engineering Xiamen University

It is well known that cationic polymers have excellent antimicrobial capacity accompanied with high biotoxicity, to reduce biotoxicity needs to decrease the number of cationic groups on polymers, which will influence antimicrobial activity. It is necessary to design a cationic polymer mimic natural antimicrobial peptide with excellent antibacterial activity and low toxicity to solve the above dilemma. Here,we designed and prepared a series of cationic poly(β-amino ester)s(PBAes) with different cationic contents, and introducing hydrophobic alkyl chain to adjust the balance between antimicrobial activity and biotoxicity to obtain an ideal antimicrobial polymer. The optimum one of synthesized PBAe(hydrophilic cationic monomer:hydrophobic monomer = 5:5) was screened by testing cytotoxicity and minimum inhibitory concentration(MIC), which can effectively kill S. aureus and e. coli with PBAe concentration of15 μg/m L by a spread plate bacteriostatic method and dead and alive staining test. The way of PBAe killing bacterial was destroying the membrane like natural antimicrobial peptide observed by scanning electron microscopy(SeM). In addition, PBAe did not exhibit hemolysis and cytotoxicity. In particular, from the result of animal tests, the PBAe was able to promote healing of infected wounds from removing mature S. aureus and e. coli on the surface of infected wound. As a result, our work offers a viable approach for designing antimicrobial materials, highlighting the significant potential of PBAe polymers in the field of biomedical materials.

关键词： Amphiphilic balance Antimicrobial Cationic polymers Michael addition polymerization Poly(β-amino ester)s

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan liu Jing Zhang Jing Yang Jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and engineering Chinese Academy of SciencesNingbo 315201ZhejiangChina Center of Materials Science and Optoelectronics engineering University of Chinese Academy of SciencesBeijing 100049China

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li_(5.4)PS_(4.4)Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S ccm^(-1)and improved chemical stability is synthesized by iodine *** ultra-thin Li_(5.4)PS_(4.4)Cl_(1.4)I_(0.2)membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS ccm^(-1)and low areal resistance of 1.17Ωcm^(-2).Moreover,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li_(5.4)PS_(4.4)Cl_(1.6)from 0.8 to 1.35 mA cm^(-2).The resultant LiCoO_(2)/Li_(5.4)PS_(4.4)Cl_(1.4)I_(0.2)/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g^(-1)and a retention of 80.5% after 1000 *** addition,the assembled LiCoO_(2)/Li_(5.4)PS_(4.4)Cl_(1.4)I_(0.2)membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g^(-1)and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes lodine doping lonic conductivity Stability All-solid-state lithium battery

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Solid-state synthesis of mesoporous metals via mechanochemical coordination self-assembly

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Science China Chemistry 2025年第2期68卷 492-498页

作者： Hailong Xiong Chunyu Qi Lantian Xue Ling Zhang Hanyu liu Zhen-An Qiao State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun 130012China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Mesoporous metals with large surface area,high pore volume,and uniform pore structure hold excellent advantages for various ***,the state-of-the-art synthesis methods are still limited to wet chemistry,which requires excessive solvents and a time-consuming drying ***,we report a facile and general mechanochemical coordination self-assembly strategy to prepare mesoporous metals(e.g.,Rh,Ru,Ir,Pt,Pd,Ag,Co,and Ni)with remarkable porous properties by using metal chlorides and cationic polymer *** with the wet chemistry process,this method proceeds without solvents and does not need complicated experimental conditions and long synthetic periods,which not only greatly reduces the consumption of cost and energy and environmental pollution,but also improves the synthesis efficiency and yield of target *** believe the developed approach will provide a general pathway for the scalable preparation of advanced porous materials.

关键词： mechanochemistry self-assembly mesoporous materials mesoporous metals electrocatalysis

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effectiveness of Lianhua Qingwen Granule and Jingyin Gubiao Prescription in Omicron BA.2 Infection and Hospitalization:A Real-World Study of 56,244 Cases in Shanghai,China

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Chinese Journal of Integrative Medicine 2025年第1期31卷 11-18页

作者： ZHANG Yu-jie liu Guo-jian ZHANG Han liu Chen CHeN Zhi-qiang XIAN Ji-shu SONG Da-li liu Zhi YANG Xue WANG Ju ZHANG Zhe ZHANG Lu-ying FeNG Hua ZHANG Yan-qi TAN Liang Department of Basic Medicine Army Medical UniversityChongqing400038China Department of Radiology The First Affiliated Hospital of the Army Medical UniversityChongqing400038China Department of Pediatrics The First Affiliated Hospital of the Army Medical UniversityChongqing400038China Department of Neurosurgery The First Affiliated Hospital of the Army Medical UniversityChongqing400038China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR519000China Department of Health Statistics College of Military Preventive MedicineArmy Medical UniversityChongqing400038China Department of Critical Care Medicine The First Affiliated Hospital of the Army Medical UniversityChongqing400038China

Objective: To examine the effectiveness of Chinese medicine(CM) Lianhua Qingwen Granule(LHQW) and Jingyin Gubiao Prescription(JYGB) in asymptomatic or mild patients with Omicron infection in the shelter hospital. Methods: This single-center retrospective cohort study was conducted in the largest shelter hospital in Shanghai, China, from April 10, 2022 to May 30, 2022. A total of 56,244 asymptomatic and mild Omicron cases were included and divided into 4 groups, i.e., non-administration group(23,702 cases), LHQW group(11,576 cases), JYGB group(12,112 cases), and dual combination of LHQW and JYGB group(8,854 cases). The length of stay(LOS) in the hospital was used to assess the effectiveness of LHQW and JYGB treatment on Omicron infection. Results: Patients aged 41–60 years, with nadir cycle threshold(CT) value of N gene e fully vaccinated preferred to receive CM therapy. Before or after propensity score matching(PSM), the multiple linear regression showed that LHQW and JYGB treatment were independent influence factors of LOS(both Per PSM, there were significant differences in LOS between the LHQW/JYGB combination and the other groups(Pe results of factorial design ANOVA proved that the LHQW/JYGB combination therapy synergistically shortened LOS(P=0.032). Conclusions: Patients with a nadir CT value ere more likely to accept CM. The LHQW/JYGB combination therapy could shorten the LOS of Omicron-infected individuals in an isolated environment.

关键词： Lianhua Qingwen Granule Jingyin Gubiao Prescription Chinese medicine Omicron COVID-19

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Tremendously enhanced catalytic performance of Fe(Ⅲ)/peroxymonosulfate process by trace Cu(Ⅱ):A high-valent metals domination in organics removal

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Journal of environmental Sciences 2025年第1期147卷 487-497页

作者： Jieli Ou Yiqing liu Linyue Zhang Zhenran Wang Yuqi Tang Yongsheng Fu Dandan Zhao Faculty of Geosciences and environmental engineering Southwest Jiaotong UniversityChengdu 611756China

Dissolved copper and iron ions are regarded as friendly and economic catalysts for peroxymonosulfate(PMS)activation,however,neither Cu(Ⅱ)nor Fe(Ⅲ)shows efficient catalytic performance because of the slow rates of Cu(Ⅱ)/Cu(Ⅰ)and Fe(Ⅲ)/Fe(Ⅱ)***,we observed a significant enhancement on the degradation of organic contaminants when Cu(Ⅱ)and Fe(Ⅲ)were coupled to activate PMS in borate(BA)*** degradation efficiency of Rhodamine B(RhB,20μmol/L)reached up to 96.3%within 10 min,which was higher than the sum of individual Cu(Ⅱ)-and Fe(Ⅲ)-activated PMS *** radical,hydroxyl radical and high-valent metal ions(i.e.,Cu(Ⅲ)and Fe(IV))were identified as the working reactive species for RhB removal in Cu(Ⅱ)/Fe(Ⅲ)/PMS/BA system,while the last played a predominated *** presence of BA dramatically facilitated the reduction of Cu(Ⅱ)to Cu(Ⅰ)via chelating with Cu(Ⅱ)followed by Fe(Ⅲ)reduction by Cu(Ⅰ),resulting in enhanced PMS activation by Cu(Ⅰ)and Fe(Ⅱ)as well as accelerated generation of reactive ***,the strong buffering capacity of BA to stabilize the solution pH was satisfying for the pollutants degradation since a slightly alkaline environment favored the PMS activation by coupling Cu(Ⅱ)and Fe(Ⅲ).In a word,this work provides a brand-new insight into the outstanding PMS activation by homogeneous bimetals and an expanded application of iron-based advanced oxidation processes in alkaline conditions.

关键词： Peroxymonosulfate Bimetallic catalyst Borate High-valent metals Complexation

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Selenate-based heterojunction with cobalt-nickel paired site for electrocatalytic oxidation of 5-hydroxymethylfurfural coupling water splitting to produce hydrogen

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Journal of energy Chemistry 2025年第2期101卷 156-162页

作者： Zhengru Yang Jia Hui Wangxi Fan Pengcheng liu Chunyong Zhang Shuang Dong Zhou Yang Department of Chemistry and Chemical engineering & Jiangsu Key Laboratory of Clean Energy Storage and Conversion Jiangsu University of Technology engineering Technology and Materials Research Center China Academy of Transportation Sciences School of Chemical engineering and Materials Changzhou Institute of Technology

It is very appealing that 5-hydroxymethylfurfural（HMF） is electrocatalytical oxidized as 2,5-furandicarboxylic acid（FDCA） linking to non-classical cathodic hydrogen（H2） ***,the electrocatalysts for electrocatalytic HMF oxidative reaction（e-HMFOR） have been facing low Faradaic efficiency（Fe） and high water splitting ***,we propose a strategy of the NiSeO3@（CoSeO3）4heterojunction by constructing a Co-Ni paired site,where the Co site is in charge of adsorbing for HMF while the electrons are transferred to the Ni site,thus giving the NiSeO3@（CoSeO3）4heterojunction superior electrocata lytic performances for e-HMFOR and water *** optimizing conditions,the NiSeO3@（CoSeO3）4heterojunction has high conversion of 99.7%,high selectivity of 99.9%,and high Fe of 98.4% at 1.3 V,as well as low cell voltage of 1.31 V at 10 mA cm-2in 1 M KOH+0.1 M *** study offers a potential insight for e-HMFOR to high value-added FDCA coupling water splitting to produce H2in an economical manner.

关键词： Co-Ni paired site e-HMFOR FDCA Heterojunction Hydrogen evolution

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Conversion-type cathode materials for high energy density solid-state lithium batteries

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Journal of energy Chemistry 2025年第1期100卷 409-425页

作者： Yuhao Ma Shihong Qing Hongyu liu Chuntao Ma Yuan Yu Chuang Yu Liping Wang School of Materials and energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology Zhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina State Key Laboratory of Advanced electromagnetic engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

Solid-state lithium batteries(SSLBs)are regarded as an essential growth path in energy storage systems due to their excellent safety and high energy *** particular,SSLBs using conversion-type cathode materials have received widespread attention because of their high theoretical energy densities,low cost,and *** the great progress in research and development of SSLBs based on conversiontype cathodes,their practical applications still face challenges such as blocked ionic-electronic migration pathways,huge volume change,interfacial incompatibility,and expensive processing *** review focuses on the advantages and critical issues of coupling conversion-type cathodes with solid-state electrolytes(SSes),as well as state-of-the-art progress in various promising cathodes(e.g.,FeS_(2),CuS,FeF_(3),FeF_(2),and S)in ***,representative research on conversion-type solid-state full cells is discussed to offer enlightenment for their practical ***,the energy density exhibited by the S cathode stands out impressively,while sulfide SSes and halide SSes have demonstrated immense potential for coupling with conversion-type ***,perspectives on conversion-type cathodes are provided at the material,interface,composite electrode,and battery levels,with a view to accelerating the development of conversion-type cathodes for high-energy–density SSLBs.

关键词： Conversion-type cathode Lithium-free cathode Solid-state electrolyte Solid-state lithium battery High energy density

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TavWA1 is critical for wheat growth by modulating cell morphology and arrangement

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Journal of Integrative Plant Biology 2025年第1期67卷 71-86页

作者： Guowei Chang Yue Li Lei Peng Chuncai Shen Yipeng Lu Wan Teng Yangyang liu Yingchun Wang Weiqi Zhu Cuimin liu Xue He Yiping Tong Xueqiang Zhao Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Zhaoxian experiment Station Shijiazhuang Academy of Agricultural and Forestry SciencesZhaoxian 515300China

Plant growth is determined by the production of cells and initiation of new *** genes that control cell number and cell size is of great significance for understanding plant growth *** this study,we characterized two wheat mutants,ah and dl,with abnormal *** ah mutant is a naturally occurring variant characterized by severe dwarfism,increased tiller number,and reduced grain length,while the dl mutant is derived from an ethyl methane sulfonate(eMS)-mutagenized population and exhibits smaller grain size and slightly reduced plant *** analyses revealed abnormal cell number,cell morphology and arrangement in the stems and leaves of the ah mutant,along with reduced cell length in the grains of the dl ***-based cloning identified that both mutants carry mutations in the same gene TavWA1-7D,which encodes a protein with a von Willebrand factor A(vWA)*** ah mutant harbors a 174-bp insertion in the 1,402-bp coding sequence(CDS)of TavWA1-7D,causing premature termination of protein translation,while the dl mutant contains a Glu420Lys *** the TavWA1-7D ahthrough clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated nuclease 9-mediated genome editing leads to a severe dwarfism *** C-terminus of the protein is crucial for its correct subcellular localization and interaction,supporting its critical role for TavWA1-7D *** analysis showed that the dwarf phenotype of the ah mutant is associated with impaired photosynthesis,ribosome function,and nucleosome ***,TavWA1-7D interacts with an e3 ligase,Ta VIP1-3B,the expression levels of which are elevated in both *** and knockout studies of TaVIP1-3B demonstrated its negative regulatory role in cell length and grain ***,our findings suggest that TavWA1-7D plays a vital role in regulating wheat growth and yield-related traits,with the dl mutant's short grain phen

关键词： grain size severe dwarf TaVIP1 TavWA1 wheat

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