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Cancer Biology & Medicine 2019年第1期16卷 166-172页

作者： Hairong Xu Zhen Huang Yuan Li Qing Zhang Lin Hao xiaohui niu Department of Orthopedic Oncology Surgery Beijing Ji Shui Tan Hospital Peking University

Objective: Anti-angiogenic drugs are an emerging treatment option against malignant tumors. The aim of this study was to determine whether the addition of perioperative rh-endostatin to chemotherapy could improve the probability of distant metastasis-free survival(DMFS) and overall survival(OS) in patients newly diagnosed with non-metastatic conventional ***: This was a controlled non-randomized clinical study that included 388 patients without clinically detectable metastatic disease enrolled from January 2008 to April 2012. The control treatment group had 272 patients; 180 were male and 92, female,with a median age of 17 years. The treatment group had 58 patients; 36 were male and 22, female, with a median age of 16 *** control group received preoperative chemotherapy followed by surgery and postoperative chemotherapy. The treatment group received 4 cycles of rh-endostatin perioperatively in addition to chemotherapy as per the control group. Patients were followed up from 6-101 months with a median follow-up period of 50.2 ***: The 5-year DMFS of the control group(61%) was significantly lower than that of the rh-endostatin group(79%)(P = 0.013). The 5-year OS of the control group(74%) was significantly lower than that of the rh-endostatin treatment group(87%)(P = 0.029). No difference in adverse drug reactions was found between these 2 ***: The addition of perioperative rh-endostatin to chemotherapy could significantly improve the DMFS and OS of patients with non-metastatic osteosarcoma.

关键词： Osteosarcoma rh-endostatin perioperative distant metastasis overall survival

Offlattice Model in the Prediction of Protein 3D Structure

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Wuhan University Journal of Natural Sciences 2007年第2期12卷 235-238页

作者： SHI Feng LI Nana niu xiaohui School of Science Huazhong Agricultural University Wuhan 430070 Hubei China

3-dimension HPNX offiattice model is developed from the 2-dimension HP offiattice model. In the HP model, 20 types of amino acid monomers are divided into two classes, H （non-polar monomer） and P （polar monomer）. In the HPNX model, polar monomers are split into positively charged （P）, negatively charged （N） and neutral （X） monomers. A new evolutionary algorithm is applied to study long chains of the HPNX offiattice protein model. This method successfully predict the structures of several proteins in the 3-dimension space that are similar to the structures gotten by X-Ray Crystallography and NMR and published in the PDB（Protein Data Bank）.

关键词： offlattice protein folding 3D structure

Analysis of The Impact of Interventional Nursing on The Therapeutic Effect, Negative Emotions, and Quality of Life of Patients Undergoing Cardiovascular and Cerebrovascular Interventional Therapy

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Journal of Clinical and Nursing Research 2024年第4期8卷 44-49页

作者： xiaohui niu Department of Encephalology(Department of Neurology) Beijing JianGong HospitalBeijing 100052China

Objective: To explore the impact of interventional nursing on the therapeutic effect, negative emotions, and quality of life of patients undergoing cardiovascular and cerebrovascular interventional therapy. Methods: A total of 106 patients who underwent cardiovascular and cerebrovascular interventional treatment were collected and randomly divided into Group A (control) and Group B (observation), with 53 cases each. Group A received the routine nursing intervention and Group B received the interventional nursing intervention. The clinical efficacy, complications, negative emotions, quality of life, and nursing satisfaction of the two groups of patients were evaluated. Results: The total clinical effective rate of Group B (52/98.12%) was higher than that of Group A (45/84.91%) (χ^(2)= 4.371, P < 0.05). The total incidence of complications in Group B (2/3.78%) was lower than that of Group A (9/16.98%) (χ^(2)= 4.970, P < 0.05). The self-rating anxiety (SAS) score and self-rating depression (SDS) of Group B were lower than those of Group A (P < 0.001). The quality of life of Group B was significantly higher than that of Group A (P < 0.001). The nursing satisfaction of group B (51/96.22%) was higher than that of group A (43/81.13%) (χ^(2)= 6.014, P < 0.05). Conclusion: In the care of patients undergoing cardiovascular and cerebrovascular interventional therapy, interventional nursing intervention effectively improved the patient’s clinical efficacy, reduced the incidence of complications, reduced negative emotions, improved the quality of life, and increased nursing satisfaction.

关键词： Interventional nursing Cardiovascular and cerebrovascular Interventional treatment Efficacy

Guidance for use of weights: an analysis of different types of weights and their implications when using SAS PROCs

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General Psychiatry 2019年第1期32卷 49-55页

作者： Sabrina Richardson Tuo Lin Yangyi Li xiaohui niu Manfei Xu Valerie Stander Xin M Tu The Henry M.Jackson Foundation for the Advancement of Military Medicine Inc BethesdaMarylandUnited States Military Population Health Naval Health Research CenterSan DiegoCaUnited States Clinical and Translational Research Institute University of California San DiegoSan DiegoCaliforniaUSA School of Mathematical and Statistical Sciences Clemson UniversityClemsonSouth CarolinaUSA College of Informatics Huazhong Agriculture UniversityWuhanChina Shanghai Mental Health Center Medical CollegeShanghai Jiao Tong UniversityShanghaiChina

SAS and other popular statistical packages provide support for survey data with sampling weights. For example, PROC MEANS and PROC LOGISTIC in SAS have their counterparts PROC SURVEYMEANS and PROC SURVEYLOGISTIC to facilitate analysis of data from complex survey studies. On the other hand, PROC MEANS and many other classic SAS procedures also provide an option for including weights and yield identical point estimates, but different standard errors (SEs), as their corresponding survey procedures. This paper takes an in-depth look at different types of weights and provides guidance on use of different SAS procedures.

关键词： Guidance use of weights analysis

Metachronous multicentric giant cell tumor of bone with retroperitoneal metastasis

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Chinese Medical Journal 2014年第14期127卷 2713-2715页

作者： Zhiping Deng Yi Ding Fajun Yang xiaohui niu Department of Orthopaedic Oncology Beijing Jishuitan Hospital Peking University Beijing 100035 China. Department of Pathology Beijing Jishuitan Hospital Peking University Beijing 100035 China. Email: dingmail@***.

Giant cell tuenor （GCT）of bone is a benign but locally aggressive tumor that usually involves the epiphysis of long bones.1Rarely,these tumors metastasize to the lung, and these metastases generally have the same benign histological appearance as the primary tumor. Multicentric giant cell tumor （M-GCT） is rarer. We herein report a case of M-GCT involving the left distal radius, with retroperitoneal metastasis, and subsequent lesions in the left proximal and distal femur. The patient and family members were informed that data concerning the case would be submitted for publication, and they consented.

关键词： giant cell tumors retroperitoneal neoplasms neoplasm metastasis

A comparative study of calcium sulfate artificial bone graft versus allograft in the reconstruction of bone defect after tumor curettage

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Chinese Medical Journal 2014年第17期127卷 3092-3097页

作者： Yang Yongkun niu xiaohui Zhang Qing Hao Lin Ding Yi Xu Hairong Department of Orthopedic Oncology Surgery Beijing Ji Shui Tan Hospital Peking University Beijing 100035 China

Background Cavity reconstruction after benign bone tumor removal is varied and *** is widely used but is associated with *** bone substitutes,such as calcium sulfate artificial bone,have been introduced for bone tumor ***,the bone healing response of artificial bone has not been compared with allograft *** therefore compared calcium sulfate grafts （study group） with bone allografts （control group） for the treatment of benign bone *** We retrospectively reviewed 50 patients who underwent calcium sulfate reconstruction and 50 patients who underwent allograft cancellous bone *** two groups were well *** mean follow-up time of the study group was 19.9 （12-55） *** investigated bone healing response,complications,and factors affecting bone *** At the last follow-up,84％（42/50） of cases in the study group and 62％（31/50） of cases in the control group had achieved clinical healing （P=0.013）.The initial healing rate showed no significant difference between the two groups （100％ vs.96％,P=0.153）.The mean healing times for calcium sulfate and allograft bone were 9.6 （3-42） months and 13.8 （3-36） months,respectively （P ＜0.01）.Complications in the study group were minor and *** volume was a significant factor affecting bone *** The calcium sulfate bone substitute showed a satisfactory healing outcome and safety profile in reconstruction of bone defects after benign bone tumor curettage,especially in smaller cavities.

关键词： calcium sulfate allograft bone tumor reconstruction

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骨肿瘤的外科边界

中华医学杂志 2019年第37期99卷 2881-2884页

作者：牛晓辉北京积水潭医院骨肿瘤科北京100035

大多数恶性骨肿瘤的主要治疗是外科治疗,而外科治疗的核心是外科边界。本文从恶性骨肿瘤的外科分期开始,对外科边界的概念和与其有关的重要问题,如复发、转移、预后等方面进行阐述。

关键词：骨肿瘤外科边界复发转移预后

Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution

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Chinese Medical Journal 2015年第1期128卷 111-118页

作者： Wei Zhang Qing Zhang Xiaohuang Tian Haitao Zhao Wei LU Jiancun Zhen xiaohui niu Departments of Clinical Pharmacology Beijing Jishuitan Hospital Beijing 100035 China Orthopaedic Oncology Beijing Jishuitan Hospital Beijing 100035 China Department of Pharmaceutical Science University Health Science Center Beijing 100191 China

Background：High-dose methotrexate （HD-MTX） with folinic acid （leucovorin） rescue is the gold standard therapy in the treatment of *** plasma concentration of MTX is closely related to efficacy and *** are large individual *** authors have described the pharmacokinetic （PK） profile of MTX regarding osteosarcoma under a variety of ***,no data concerning Chinese osteosarcoma patient PKs using the nonlinear mixed effects models （NONMEM） have been previously *** goals of this study were to establish the population pharmacokinetics （PPK） of HD-MTX treatment in Chinese osteosarcoma patients,and to explore the influence of patient covariates and between-occasion variability on drug disposition.Methods：An intravenous HD-MTX solution （10 g/m2） was given 274 times to 148 osteosarcoma *** plasma concentrations were measured at 0,6,12,24,48 and 72 h after commencement of the infusion,and the fluorescence polarization immunoassay was used to determine MTX plasma *** PPK model and parameters were estimated using NONMEM *** effects of fixed-effect factors were evaluated,and the final regression model was obtained.Results：The following population parameters were obtained using a two-compartment model：CL1 （clearance of central compartment）：（CL1）i =CL1 Tv × [1-θCt-MTXNUM × MTXNUM] × [1-θCL1-CrCl1 × （CrCl1-1.89）] × e^ηCLi （L/h）.V1 （central volume）：（V11）i =V1TV × e^ηV1i （L）.CL2 （clearance of peripheral compartment）：（CL2）i =CL2TV × [1-θCL2-BODYAREA × （bodyarea-1.62）] × e^ηCL2i （L/h）.V2 （peripheral compartment）：（V2）i =V2Tv × [1-θV2-bodyarea × （bodyarea-1.62）] × e^ηV2i （L）.The PPK parameters （RSD%） were CL1,V1,CL2 and V2 with values of 6.20 L/h （8.48%）,19.6 L （extremely small）,0.0172 L/h （50.9%） and 0.515 L （39.1%）,*** clearance and the number of methotrexate chemotherapy cycles before MTX infusion had a significant effect on the CL 1,and body surface area had a

关键词： Methotrexate Osteosarcoma Population Pharmacokinetics

Massive allograft replacement in management of bone tumors

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The Chinese-German Journal of Clinical Oncology 2008年第3期7卷 159-163页

作者： xiaohui niu Lin Hao Qing Zhang Yi Ding Department of Orthopaedic Oncology Beijing Jishuitan Hospital Beijing 100035 China

Objective： To evaluate the functional outcome and complications of allograft replacement in management of bone tumors. Methods： Between March 1992 and September 2002, 164 patients underwent bone tumor resection and massive allograft reconstruction of bone defects. The length of the resected part ranged from 5-35 cm. The resections were classified as marginal or wide resections of the tumor on the basis of the Musculoskeletal Tumor Society staging system. Fresh-frozen allografts were employed as osteoarticular grafts （n = 95）, hemi-condylar （n = 15）, massive （n = 23）, allograft-prosthesis composite （n = 12）, intercalary grafts （n = 15） or hemi-pelvic grafts （n = 4）. Most of the lesions were osteosarcoma and giant cell tumor of bone and located in proximal and distal femur, proximal tibia and humerus. Results： At a median follow-up of 47 months （range, 12 to 168 months） after the operation, 154 of the patients in the study were free of disease and 10 died of disease. Twenty-one （12.8%） patients had local recurrence and 38 （23.2%） nonunion. Late complications included 11 （6.7%） fractures of the allograft and 18 （11.0%） infections of the graft, instability of the joint in the form of subluxation was noted in 13 （7.9%） patients. Ten extremities were amputated due to local recurrence or severe infection. Conclusion： AIIografts can be used for reconstruction of bony defects after tumor resection. AIIograft has nearly similar shape, strength, osteo-inductivity and osteo-conductivity with host bone. AIIograft implantation is a high complication reconstruction method, and the dsk of recurrence increases when less surgical margin achieves.

关键词： bone neoplasms bone transplantation allografts

2020版NCCN《骨肿瘤临床实践指南》解读

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中华外科杂志 2020年第6期58卷 430-434页

作者：牛晓辉北京积水潭医院骨肿瘤科 100035

我国骨肿瘤专业近年来发展迅速,但由于骨肿瘤发病率低且我国各地区医疗发展不平衡,骨肿瘤专业的诊治不规范问题仍比较突出。NCCN《骨肿瘤临床实践指南》内容涵盖骨肉瘤、尤文肉瘤、软骨肉瘤、骨巨细胞瘤及脊索瘤等常见骨肿瘤,经过数年... 详细信息

我国骨肿瘤专业近年来发展迅速,但由于骨肿瘤发病率低且我国各地区医疗发展不平衡,骨肿瘤专业的诊治不规范问题仍比较突出。NCCN《骨肿瘤临床实践指南》内容涵盖骨肉瘤、尤文肉瘤、软骨肉瘤、骨巨细胞瘤及脊索瘤等常见骨肿瘤,经过数年的更新,比较成熟,可为我国相关专业的医务人员提供参考。NCCN《骨肿瘤临床实践指南》注重多学科协作策略,建议骨肉瘤行外科治疗和化疗为主的综合治疗,脊索瘤以外科治疗为主,而因地舒单抗的出现,骨巨细胞瘤从单纯依靠外科治疗,转变为药物治疗配合外科治疗。本文以NCCN指南为基础,对常见骨肿瘤的核心诊治内容进行阐述和解读。

关键词：骨肿瘤指南解读

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