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Highly efficient separation of Sc3+ and y3+ in acid solution by a graphene oxide membrane with interlayer sieving

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Journal of Rare Earths 2024年第11期42卷 2166-2171页

作者： Huixiong Jiang Jin-Hang Liu Xiudong Chen xiaohua Cao Xiushen ye Guosheng Shi School of Chemistry and Chemical Engineering Jiangxi Province Engineering Research Center of Ecological Chemical IndustryJiujiang University Shanghai Applied Radiation Institute State Key Lab.Advanced Special SteelShanghai University Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt LakesChinese Academy of Sciences

Sc and y are key rare earth elements and are widely used in lamp phosphors,lasers and high-performance ***,highly efficient extraction and separation of Sc3+and y3+is laborious,harmful,slow,and costly,strongly necessitating more efficient extraction and separation ***,we produced hydrated Sc3+-and hydrated y3+-controlled graphene oxide（GO） membranes and find that both hydrated cations were completely self-rejected by the *** combining this selfrejection effect of the larger hydrated y3+-controlled GO membrane and the rapid passage of the membrane through the smaller hydrated Sc3+,we proposed a strategy to separate Sc3+and y3+by using a hydrated y3+-controlled GO *** experimental results show that the permeation rate of Sc3+exceeds that of y3+when the separation factor reaches 4.02,which can be attributed to the interlayer sieving effects of the GO *** finding illustrates the use of a forward osmosis process with a GO membrane for the efficient separation of Sc3+and y3+by interlayer sieving,which provides a new effective and eco-friendly method for the separation of rare earth elements.

关键词： Forward osmosis Graphene oxide membrane Interlayer spacing Membrane separation Rare earths

Determination of Chlorogenic Acid,Geniposide,Total Flavonoids and Total Triterpenes in Wulan-13

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Medicinal Plant 2024年第2期15卷 6-9页

作者： xiaohua WU Burenbatu College of Clinical Medicine Inner Mongolia Minzu UniversityTongliao 028000China Affiliated Hospital of Inner Mongolia Minzu University Tongliao 028000China

[Objectives]This study was conducted to establish a method for the determination of chlorogenic acid,geniposide,total flavonoids and total triterpenes in Wulan-13.[Methods]The contents of chlorogenic acid and geniposide were determined by HPLC,and the contents of total flavonoids and total triterpenes were determined by an ultraviolet spectrophotometer.[Results]There was a good linear relation between the mass of chlorogenic acid reference substance and the peak area in the range of 0.05-0.45μg,and the regression equation was y=2524.1X+3.1943,(r=0.9998).A good linear relationship was found between the mass of gardenoside reference substance and the peak area in the range of 0.776-6.984μg,and the regression equation was y=1670.5X+64.804,(r=0.9998).There was also a good linear relation between the mass of rutin reference substance and its absorbance in the range of 0.00808-0.04848 mg,and the regression equation was y=12.916X+0.014,(r=0.999).The mass of oleanolic acid reference substance had a good linear relation with its absorbance in the range of 0.00418-0.0209 mg,and the regression equation was y=51.89X-0.0839,(r=0.9991).[Conclusions]The content determination method is simple,reliable and reproducible,and suitable for controlling the contents of chlorogenic acid,geniposide,total flavonoids and total triterpenes in Wulan-13.

关键词： Wulan-13 HPLC Ultraviolet spectrophotometer Content determination

Matrix-Mediated Color-Tunable Ultralong Organic Room Temperature Phosphorescence of 7H-Benzo[c]carbazole Derivatives

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CCS Chemistry 2024年第3期6卷 798-811页

作者： Chen Qian Xue Zhang Zhimin Ma xiaohua Fu Zewei Li Huiwen Jin Mingxing Chen Hong Jiang Zhiy.ng Ma Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic–Inorganic CompositesCollege of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871

Building on the recent systematic research on 1Hbenzo[f]indole(Bd),an important advancement in constructing ultralong organic room temperature(UORTP)materials with a universal strategy via a readily obtained unit(7H-Benzo[c]carbazole,BCz)is proposed in this *** powders of BCz and its derivatives merely exhibit blue fluorescence at ambient ***,when BCz and its derivatives are dispersed into polymer or powder matrixes,strong photo-activated green UORTP can be observed from their doped systems at room ***,the UORTP color can be tuned between green and yellow depending on the *** ultralong phosphorescence originates from the generation of charge-separated states via *** matrixes play a key role in both stabilizing charge-separated states and controlling UORTP *** interestingly,when using polymethyl methacrylate as matrix,the doped films achieve stronger photo-activated ultralong phosphorescence underwater than in air at room *** Bd,BCz achieves better performance not only in ultralong phosphorescence properties but also in practical *** work gains a deeper insight into the mechanism of UORTP and paves a new approach to apply.ng organic phosphorescent materials to underwater coating and imaging.

关键词： 7H-Benzo[c]carbazole ultralong organic room temperature phosphorescence ion radical matrix-mediated color tunning underwater application

Flood Forecasting Experiment Based on EC and WRF in the Bailian River Basin

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Meteorological and Environmental Research 2024年第3期15卷 53-59页

作者： Zhiyuan yIN Fang y.ng xiaohua LI China Meteorological Administration Basin Heavy Rainfall Key Laboratory/Hubei Key Laboratory for Heavy Rain Monitoring and Warning Research Institute of Heavy RainChina Meteorological AdministrationWuhan 430205China Huanggang Meteorological Bureau of Hubei Province Huanggang 438020China Hubei Province Meteorological Information and Support Centre Wuhan 430074China

In order to extend the forecasting period of flood and improve the accuracy of flood forecasting,this paper took Bailian River Reservoir which located in Huanggang City of Hubei Province as an example and carried out basin flood simulation and forecasting by coupling the quantitative precipitation forecasting products of numerical forecast operation model of Institute of Heavy Rain in Wuhan(WRF)and the European Center for Medium-range Weather Forecasts(ECMWF)with the three water sources Xin an River *** experimental results showed that the spatiotemporal distribution of rainfall predicted by EC is closer to the actual situation compared to WRF;the efficiency coefficient and peak time difference of EC used for flood forecasting are comparable to WRF,but the average relative error of flood peaks is about 14%smaller than ***,the precipitation forecasting products of the two numerical models can be used for flood forecasting in the Bailian River *** forecasting indicators have certain reference value,and there is still significant room for improvement in the forecasting effects of the two models.

关键词： Hydrometeor EC WRF Xin an River model Bailian River

Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1542-1559页

作者： Xiaolan Xu Jiaming Zhang Tao Wang Jing Li yukang Rong yanfang Wang Chenxia Bai Qing yan xiaohua Ran y.ngli Wang Tianhong Zhang Jin Sun Qikun Jiang Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Education University of NottinghamNottingham NG72RDUK Department of Pharmacy Linyi People's HospitalShandong UniversityLinyi 276000China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100871China

The non-selective cytotoxicity of toxins limits the clinical relevance of the *** recent years,toxins have been widely used as warheads for antibody-drug conjugates(ADCs)due to their eff-cient killing activity against various cancer *** ADCs confer certain targeting properties to the toxins,low drug loading capacity,possible immunogenicity,and other drawbacks also limit the po-tential application of ***,non-ADC delivery strategies for toxins have been extensively *** further understand the application of toxins in anti-tumor,this paper provided an over-view of prodrugs,nanodrug delivery systems,and biomimetic drug delivery *** addition,toxins and their combination strategies with other therapies were ***,the prospect and challenge of toxins in cancertreatmentwerealso summarized.

关键词： Toxins Non-antibody-drug conjugates Delivery strategies Prodrugs Nano drug delivery systems Biomimetic drugdelivery systems Combination strategies Cancer treatment

MeCP2诱导的视网膜色素上皮细胞转录组和m6A的改变

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中华实验眼科杂志 2024年第5期42卷 408-416页

作者：张咏雅李晓华赵雪茹李雪郑州大学人民医院眼科、河南省人民医院眼科、河南省立眼科医院、河南省眼科与视觉科学重点实验室、河南省医学科学院眼科研究所郑州450003

目的探讨重组人甲基CpG结合蛋白2(MeCP2)处理的视网膜色素上皮(RPE)细胞中mRNA和N6-甲基腺嘌呤(m6A)改变及其机制。方法将传代ARPE-19细胞贴壁培养后分为正常对照组和MeCP2组,正常对照组细胞采用正常培养液培养,MeCP2组细胞于含终质量浓... 详细信息

目的探讨重组人甲基CpG结合蛋白2(MeCP2)处理的视网膜色素上皮(RPE)细胞中mRNA和N6-甲基腺嘌呤(m6A)改变及其机制。方法将传代ARPE-19细胞贴壁培养后分为正常对照组和MeCP2组,正常对照组细胞采用正常培养液培养,MeCP2组细胞于含终质量浓度20 ng/ml重组人MeCP2蛋白培养液中,连续培养72 h。提取细胞内总RNA进行转录组测序(RNA-seq)和甲基化免疫共沉淀测序(MeRIP-seq)分析。采用edgeR软件包根据P<0.05筛选差异表达基因(DEGs)和差异甲基化基因(DMGs)。采用基因本体论(GO)富集分析对差异基因进行生物学功能描述,采用京都基因和基因组百科全书(KEGG)进行通路富集分析。筛选出DEGs与DMGs交集的基因,采用实时荧光定量PCR技术检测各组差异基因mRNA表达水平。结果共筛选出DEGs 100个,DMGs 7441个,富集分析发现DEGs与细胞外基质(ECM)-受体相互作用、细胞分裂、细胞周期和磷脂酰肌醇3激酶/蛋白激酶B(PI3K/AKT)信号通路等相关,DMGs与微管细胞骨架、血管生成、表皮生长因子受体(ErbB)信号通路、晚期糖基化终末产物(AGEs)-糖基化终末产物受体(RAGE)信号通路、哺乳动物雷帕霉素靶蛋白(mTOR)信号通路、Notch信号通路和转化生长因子β(TGF-β)信号通路等相关。DEGs中24个基因表达增加,76个基因表达减少;DMGs中5个基因含有高甲基化峰,7439个基因含有低甲基化峰,注释峰后,正常对照组有7626个基因发生m6A甲基化,MeCP2组有8006个基因发生m6A甲基化,2个组间有7360个交集基因。正常对照组和MeCP2组的m6A甲基化富集于转录本的CDS、内含子和3'-非翻译区(3'UTR)区域,其甲基化比例分别为23.62%/22.27%、48.53%/48.35%和23.66%/25.28%。联合分析发现2个上皮-间充质转化(EMT)相关基因CSPG 5和RBP1的mRNA和m6A水平均降低。荧光定量PCR结果显示,MeCP2组GSPG5、RBP1、ZNF484 mRNA相对表达量均明显低于正常对照组,差异均有统计学意义(t=7.885、7.613、7.345,均P<0.01)。结论RPE细胞中MeCP2对EMT的调控机制与m6A甲基化修饰相关。CSPG 5和RBP 1基因可能是m6A甲基化的靶基因,参与MeCP2调控的EMT过程。

关键词：增生性玻璃体视网膜病变视网膜色素上皮细胞 MeCP2 m6A MeRIP-seq 上皮-间充质转化

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高寒地区蔓竹根系固土护坡效应研究

四川水利 2024年第4期45卷 12-16页

作者：向晓华赵鑫四川水利职业技术学院四川崇州611231

为了研究高寒地区植物根系对土体抗剪强度的增强作用,通过选取云南省昭通市巧家县药山自然保护区高寒区不同海拔(3400 m和3800 m)自然分布的蔓竹开展根-土复合体直剪试验,分析蔓竹根系参数对抗剪强度及其指标的影响。结果表明:根系布设... 详细信息

为了研究高寒地区植物根系对土体抗剪强度的增强作用,通过选取云南省昭通市巧家县药山自然保护区高寒区不同海拔(3400 m和3800 m)自然分布的蔓竹开展根-土复合体直剪试验,分析蔓竹根系参数对抗剪强度及其指标的影响。结果表明:根系布设方向与水平面夹角为45°的抗剪强度比布设方向与水平面夹角为90°的抗剪强度略高,随着加入根径的变大,土壤在不同法向压力下,其内聚力和内摩擦角随着加入根径的增加而呈现递增趋势,且在相同垂直压力和根级下,根-土复合体的内聚力在3800 m处要大于3400 m处,并且最大内摩擦角在3800 m处也大于3400 m处,都远大于素土的内摩擦角。说明蔓竹根系的存在显著提高了土壤的抗剪切破坏能力,起到了很好的固土保土作用。研究结果为高寒高海拔地区防治水土流失,预防滑坡、泥石流等自然灾害的发生,提供理论基础及技术支持。

关键词：高寒地区蔓竹根系根-土复合体抗剪强度

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基于贝叶斯网络的结构易损性智能推理

自然灾害学报 2024年第3期33卷 130-136页

作者：方圣恩俞其康张笑华林友勤福州大学土木工程学院福建福州350108 福州大学土木工程防震减灾信息化国家地方联合工程研究中心福建福州350108

为实现结构易损性的智能化推理,提出以贝叶斯网络(Bayesian networks,BNs)重构桁架结构的易损性分析体系。首先,分别定义外荷载、体系和杆件为网络顶层父节点、中间节点和底层子节点,节点间通过有向弧表示因果关系,形成BN拓扑;接着,提... 详细信息

为实现结构易损性的智能化推理,提出以贝叶斯网络(Bayesian networks,BNs)重构桁架结构的易损性分析体系。首先,分别定义外荷载、体系和杆件为网络顶层父节点、中间节点和底层子节点,节点间通过有向弧表示因果关系,形成BN拓扑;接着,提出以杆件“大损伤”替代传统的“概念移除”方式,考虑杆件参数及外荷载的不确定性,结合抽样实现对节点间条件概率表的学习,完成BN的构建;然后将特定杆件的观测状态作为证据输入BN,同步推理其他杆件的节点状态概率,进而计算杆件的重要性系数,并定义所有杆件的重要性系数之和为体系的易损性系数;最后,提出杆件易损指标,作为预测桁架体系最可能失效路径的依据。研究结果表明:所提方法能更合理地评价各杆件在体系中的重要性,推理得到的杆件破坏路径与试验观测一致,所计算的试验桁架体系易损性系数远小于杆件数目,表明当前荷载组合下特定杆件的损伤引起体系发生连续性倒塌的可能性较小。

关键词：结构工程贝叶斯网络杆件重要性系数体系易损性系数杆件易损指标

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Kinetically-Induced Hexagonality in Chemically Grown Silicon Nanowires

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Nano Research 2009年第7期2卷 575-582页

作者： xiaohua Liu Dunwei Wang Department of Chemistry Merkert Chemistry CenterBoston College2609 Beacon St.Chestnut HillMA 02467USA

Various silicon crystal structures with different atomic arrangements from that of diamond have been observed in chemically synthesized *** structures are typified by mixed stacking mismatches of closely packed Si *** of viewing them as defects,we define the concept of hexagonality and describe these structures as Si *** small transverse dimensions of a nanowire make this approach *** among the polymorphs are cubic symmetry diamond and hexagonal symmetry wurtzite *** diffraction studies conducted with Au as an internal reference unambiguously confirm the existence of the hexagonal symmetry Si *** energy calculations suggest that the wurtzite polymorph is the least stable and the diamond polymorph is the most *** energies of intermediate polymorphs follow a linear trend with respect to their structural *** identify the driving force in the polymorph formations as the growth *** longitudinal elongation during the growth freezes stacking mismatches and thus leads to a variety of Si *** results are expected to shed new light on the importance of growth kinetics in nanomaterial syntheses and may open up ways to produce structures that are uncommon in bulk materials.

关键词： Silicon nanowires hexagonality polytypes cohesive energy chemical vapor deposition kinetics