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公路隧道泡沫混凝土减震层减震效果评价

土木工程与管理学报 2024年第3期41卷 36-42页

作者：刘继国崔庆龙柯小华张军杨雪中交第二公路勘察设计研究院有限公司湖北武汉430056 中交集团隧道与地下空间工程技术研发中心湖北武汉430056 华中科技大学土木与水利工程学院湖北武汉430074

近年来泡沫混凝土材料因优良的抗震性能逐渐被推广应用于隧道减震层结构,本研究分析了强震作用下公路隧道泡沫混凝土减震层的减震机理。使用ABAQUS有限元软件建立精细化隧道结构模型,其中泡沫混凝土减震层采用可表征泡沫混凝土受压行为... 详细信息

近年来泡沫混凝土材料因优良的抗震性能逐渐被推广应用于隧道减震层结构,本研究分析了强震作用下公路隧道泡沫混凝土减震层的减震机理。使用ABAQUS有限元软件建立精细化隧道结构模型,其中泡沫混凝土减震层采用可表征泡沫混凝土受压行为的可压缩泡沫本构模型,用于分析强震作用下隧道二次衬砌结构损伤。结果表明,隧道结构在水平向与竖向地震荷载共同作用下的损伤比水平向荷载单独作用的情况严重,泡沫混凝土减震层虽不能从根本上改变隧道结构受力状态,但可显著降低二次衬砌的内力幅值。其次对比了不同厚度泡沫混凝土减震层的减震效果得出,对于穿越高烈度地震区公路隧道,当采用厚度为0.4 m的泡沫混凝土减震层时,其在强震作用下减震效能最高。

关键词：泡沫混凝土减震层公路隧道地震响应隧道损伤

Decreased LDHB expression in breast tumor cells causes NK cell activation and promotes tumor progression

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Cancer Biology & Medicine 2024年第6期21卷 513-540页

作者： Zhihong Luo xiaohua Huang Xinyi Xu kefeng Wei Yi Zheng ke Gong Wenhua Li Hubei key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhan 430072China Wuhan University Shenzhen Research Institute Shenzhen 518057China Central Laboratory University of Chinese Academy of Sciences-Shenzhen HospitalShenzhen 518107China Hubei Province key Laboratory of Allergy and Immunology and Department of Immunology School of Basic Medical SciencesWuhan UniversityWuhan 430071China

Objective: Abnormal metabolism is the underlying reason for breast cancer progression. Decreased lactate dehydrogenase B(LDHB) has been detected in breast cancer but the function of LDHB remains ***: Western blot was used to analyze LDHB expression in breast cancer cells. The impact of LDHB on tumor cell migration and invasion was determined using Transwell assays, wound healing assays, and a mouse lung metastasis model. Subcutaneous tumor formation, a natural killer(NK) cell cytotoxicity assay, and flow cytometry evaluated NK cell activation. Immunofluorescence and quantitative real-time PCR detected NK cell activation markers. Kaplan-Meier analysis evaluated the effect of immune cell infiltration on prognosis. Single-sample gene set enrichment analysis determined NK cell activation scores. A support vector machine predicted the role of LDHB in NK cell ***: In this study we showed that LDHB inhibits the breast cancer cell metastasis and orchestrates metabolic reprogramming within tumor cells. Our results revealed that LDHB-mediated lactic acid clearance in breast cancer cells triggers NK cell activation within the tumor microenvironment. Our findings, which were confirmed in a murine model, demonstrated that LDHB in tumor cells promotes NK cell activation and ultimately results in the eradication of malignant cells. Clinically, our study further validated that LDHB affects immune cell infiltration and function. Specifically, its expression has been linked to enhanced NK cell-mediated cytotoxicity and improved patient survival. Furthermore, we identified LDHB expression in tumors as an important predictor of NK cell activation, with strong predictive ability in some ***: Our results suggest that LDHB is a promising target for activating the tumor immune microenvironment in breast cancer, where LDHB-associated lactic acid clearance leads to increased NK cell activity. This study highlights the critical role of LDHB in regula

关键词： Breast cancer lactate dehydrogenase B lactic acid NK cells tumor immunity

Relationship between environmental evolution and human activities in the northeastern Qinghai-Xizang Plateau throughout the past millennium and its implications for the onset of the Anthropocene

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Science China Earth Sciences 2024年第11期67卷 3536-3549页

作者： Yang PU Xueqiong WEI Jianbao LIU ke ZHANG Beibei LI Zhudeng WEI Mengmeng ZHANG Tong HE Yanjun WANG xiaohua SHAO School of Geographical Sciences Nanjing University of Information Science and Technology key Laboratory of Alpine Ecology Institute of Tibetan Plateau Research Chinese Academy of Sciences State key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology Chinese Academy of Sciences

In current research on the Anthropocene, assessing the impact of human activities via stratigraphic records of sediments and demarcating the Anthropocene epoch globally are critical scientific issues that urgently need to be addressed. The northeastern Qinghai-Xizang Plateau(QXP), where humans first settled permanently in large numbers in the QXP, has varying sedimentary environments that are extremely sensitive to human activities. In contrast to other regions of the QXP, the northeastern sector boasts a richer array of climatic and environmental reconstruction sequences. This distinctive feature renders it an exemplary locale for investigating the stratigraphic boundary of the Anthropocene. Through in-depth analysis and integration of existing paleoclimate and paleoenvironment sequences in the northeastern QXP, we draw the following conclusions:(1) Throughout the past millennium, the impact of human activities on the environment of the northeastern QXP has become increasingly significant, especially in the past 200–300 years, gradually overshadowing climatic factors.(2) Since AD 1950,multiple physicochemical indicators related to human activities in the northeastern QXP have shown exponential growth,forming a distinct peak within the past millennium and clearly depicting the global “Great Acceleration” phenomenon and its development process.(3) Intensified human activities have driven swift environmental shifts and “decoupled” the interplay between climatic variations and the ecological environment, propelling the northeastern QXP into the “Early Anthropocene”from the “Late Holocene”. On the basis of the above findings, we construct a model suitable for identifying the stratigraphic boundary of the Anthropocene in the northeastern QXP and note that since the ecological environment in the northeastern QXP has entered the “Early Anthropocene”, the climate signals of certain physicochemical indicators in sediments are gradually becoming weaker, whereas the signals of

关键词： Anthropocene Qinghai-Xizang Plateau (QXP) Climate change Environmental evolution Human activities

New insights into the correlations between circulating tumor cells and target organ metastasis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 211-233页

作者： Qinru Zhan Bixia Liu xiaohua Situ Yuting Luo Tongze Fu Yanxia Wang Zhongpeng Xie Lijuan Ren Ying Zhu Weiling He Zunfu ke Department of Pathology The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Institute of Precision Medicine The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Zhongshan School of Medicine Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Department of Radiology The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Department of Microbiology and Immunology Weill Cornell MedicineNew YorkNY 10065USA School of Medicine Xiang’an Hospital of Xiamen UniversityXiamen University361000 XiamenFujianP.R.China

Organ-specific metastasis is the primary cause of cancer patient *** distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their *** an intermediate stage of metastasis,circulating tumor cells(CTCs)are released into the bloodstream from primary and metastatic *** harboring aggressive or metastatic features can extravasate to remote sites for continuous colonizing growth,leading to further *** the past decade,numerous studies demonstrated that CTCs exhibited huge clinical value including predicting distant metastasis,assessing prognosis and monitoring treatment response et ***,increasingly numerous experiments are dedicated to identifying the key molecules on or inside CTCs and exploring how they mediate CTC-related organ-specific *** on the above molecules,more and more inhibitors are being developed to target CTCs and being utilized to completely clean CTCs,which should provide promising prospects to administer advanced ***,the application of various nanomaterials and microfluidic technologies in CTCs enrichment technology has assisted to improve our deep insights into the phenotypic characteristics and biological functions of CTCs as a potential therapy target,which may pave the way for us to make practical clinical *** the present review,we mainly focus on the role of CTCs being involved in targeted organ metastasis,especially the latest molecular mechanism research and clinical intervention strategies related to CTCs.

关键词： metastasis organs insight

应用于知识管理事务的六度分隔理论验证系统的构建和研究

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科技管理研究 2009年第7期29卷 519-521页

作者：柯晓华广东外语外贸大学信息学院广东广州510420

"六度分隔"理论是构建社会网络服务系统(SNS)的基础,并被广泛应用于组织内外部的经济和知识管理事务中。本文探讨如何建立一个基于R IP路由算法的SNS系统,在实施"六度分隔"理论应用的同时结合阻尼因素自动计算"分隔"的新度数,最后就如... 详细信息

"六度分隔"理论是构建社会网络服务系统(SNS)的基础,并被广泛应用于组织内外部的经济和知识管理事务中。本文探讨如何建立一个基于R IP路由算法的SNS系统,在实施"六度分隔"理论应用的同时结合阻尼因素自动计算"分隔"的新度数,最后就如何应用"六度分隔"理论到组织管理活动中提出若干策略。

关键词：六度知识管理阻尼社会网络服务

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论组织知识与知识组织

图书馆 2004年第4期 34-37页

作者：柯小华广东医学院图书馆广东湛江524023

本文从社会系统的角度论证了组织知识是人类知识活动的一种基本需求 ,是社会设立图书馆的目的 ;同时从图书馆系统角度揭示了知识组织是图书馆对客观知识的知识单元进行整序的活动与过程 ,是图书馆实现图书馆目的的根本手段 ;

关键词：图书馆组织知识知识组织知识创新

Completion and stimulation trends in North American unconventional plays and resulting impact on well productivity

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钻探工程 2021年第10期48卷 1-12页

作者： Roman Galchenko Qing Liu Yan Gao Yu Liu David He Josh Zhang Huailiang Liu xiaohua ke CNPC USA Houston TX 77042USA CNPC Engineering Technology R&D Company Limited Beijing 102206China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing 102249China

过去十年,非常规油气勘探开发在全球范围内大幅扩张。水平钻井和多级水力压裂技术也在不断地发展和创新,使得超长水平井成为可能。同时,因为压裂强度不断增加,作业者可以最大限度地提高储层接触面积和对储层的改造体积(SRV)。然而,完井... 详细信息

过去十年,非常规油气勘探开发在全球范围内大幅扩张。水平钻井和多级水力压裂技术也在不断地发展和创新,使得超长水平井成为可能。同时,因为压裂强度不断增加,作业者可以最大限度地提高储层接触面积和对储层的改造体积(SRV)。然而,完井优化方面的挑战仍然存在,作业者持续不断地尝试和试验各种完井与增产参数组合,以确保非常规油气藏开发的经济可行性。优选最佳的完井与增产参数组合是一项非常关键的任务,应结合油气田的具体储层特征进行优化。本文总结了2014—2020年间北美9个主要非常规油气藏的压裂增产趋势,包括Marcellus,Haynesville,Barnett,Utica,Bone Spring,Bakken,Wolfcamp Midland,Eagle Ford,Scoop/Stack。分析了各油气田几个关键的完井和增产参数的整体趋势,同时还评估了单个参数(如水平段压裂长度、支撑剂强度、段间距等)对井产能的影响。然后对比分析相应的初始井产量(90天平均初始产量),评估各个参数对产能的影响,从而确定每个完井参数的最佳范围,以实现产能最优化。

关键词：水力压裂多级完井增产趋势井产能水平段长度支撑剂强度用液强度段间距井间距非常规油气北美

Recess-free enhancement-mode AlGaN/GaN RF HEMTs on Si substrate

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Journal of Semiconductors 2024年第6期45卷 81-86页

作者： Tiantian Luan Sen Huang Guanjun Jing Jie Fan Haibo Yin Xinguo Gao Sheng Zhang ke Wei Yankui Li Qimeng Jiang Xinhua Wang Bin Hou Ling Yang xiaohua Ma Xinyu Liu High-Frequency High-Voltage Device and Integrated Circuits R&D Center Institute of Microelectronics of Chinese Academy of SciencesBe i-jing 100029China School of integrated Circuits University of Chinese Academy of SciencesBeijing 100049China Faculty of integrated Circuits Xidian UniversityXi’an 710071China

Enhancement-mode(E-mode)GaN-on-Si radio-frequency(RF)high-electron-mobility transistors(HEMTs)were fabri-cated on an ultrathin-barrier(UTB)AlGaN(<6 nm)/GaN heterostructure featuring a naturally depleted 2-D electron gas(2DEG)*** fabricated E-mode HEMTs exhibit a relatively high threshold voltage(VTH)of+1.1 V with good uniformity.A maxi-mum current/power gain cut-off frequency(fT/fMAX)of 31.3/99.6 GHz with a power added efficiency(PAE)of 52.47%and an out-put power density(Pout)of 1.0 W/mm at 3.5 GHz were achieved on the fabricated E-mode HEMTs with 1-μm gate and Au-free ohmic contact.

关键词： AlGaN/GaN heterostructure ultrathin-barrier enhancement-mode radio-frequency power added efficiency silicon substrate

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试探析“基于设计的研究”的理论归属

开放教育研究 2008年第4期14卷 50-53页

作者：柯小华李红波广西师范大学教育科学学院广西桂林541004

本文通过辨析教育研究范式与研究方法论的区别与联系,认为"基于设计的研究"是一种实用主义研究范式,"干预设计"是其独特话语,学习科学是其研究域,但是"基于设计的研究"想要成为一种成熟的教育研究范式仍需要研究者的持续努力。

关键词：基于设计的研究理论归属范式方法论实用主义