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Effect of Yajieshaba,a preparation of Dai indigenous medicine,on enhanced liver detoxification

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Journal of Traditional Chinese Medicine 2015年第2期35卷 197-205页

作者： duan xiaohua Zheng Jin Wang Hui Cheng Haifeng Zhang Chao Yu Zepu the Key Modern Research Laboratory for Ethno-pharmacognosy of Yunnan Higher School Yunnan University of Traditional Chinese Medicine

OBJECTIVE:To explore the mechanistic effects of Yajieshaba(YJSB) on enhanced liver ***:The effects of YJSB on alanine aminotransferase(ALT) and aspartate aminotransferase(AST) were assayed in five acute chemical liver injury models[carbon tetrachloride(CCU),D-galactosamine(D-Glan),4-acetamidophenol(AAP),thioacetamide(TAA) and 1-naphthyl isothiocyanate(ANIT)].Sleep latency and sleep time of pentobarbital sodium were tested in control mice and CCL model miceafter oral YJSB *** effects of YJSB on drug metabolism enzymes of liver microsomes were tested in control rats and CCI_4model *** levels of cytochrome P450(CYP450) and Cyt b5 in liver microsomes were assayed using the method by Omura and Sato,and activities of erythromycin N-demethylase(ERD)and aminopyrine N-demethyl(ADM) were evaluated by Nash *** substrate-based high performance liquid chromatography(HPLC)methods were established for CYP3A4 and ***:The level of serum ALT was reduced by YJSB at 3.51 g/kg in the five models as follows:CCl_4 > D-Glan,AAP,ANIT > *** treatment did not reduce the level of serum *** at 3.51 g/kg prolonged the sleep latency in control mice and shortened the sleep time of control mice and CCl_4 model *** control rats,YJSB at 2.43 g/kg increased the levels of CYP450 and Cyt b5 and induced the activities of ERD and ADM;for liver injuries induced by CCI_4 in rats,YJSB at 2.43 g/kg increasedthe levels of CYP450 and Cyt *** results suggest that YJSB at 2.43 g/kg induces CYP3A4 and ***:These results suggest that YJSB enhanced liver detoxification and the mechanisms may be partially related to CYP3A4 and CYP1A2 induction.

关键词： Cytochrome P-450 enzyme system Chromatography high pressure liquid Liver detoxification Yajieshaba

Neuroprotective effect of ethyl acetate extract from gastrodia elata against transient focal cerebral ischemia in rats induced by middle cerebral artery occlusion

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Journal of Traditional Chinese Medicine 2015年第6期35卷 671-678页

作者： duan xiaohua Wang Weili Liu Xiaoqing Yan Hanwen Dai Rong Lin Qing the Key Modern Research Laboratory for Ethno-pharmacognosy of Yunnan Higher School Yunnan University of Traditional Chinese Medicine the Department of Pharmacology Yunnan University of Traditional Chinese Medicine Center for Neuron and Disease Frontier Institute of Science and TechnologyXi'an Jiaotong University

OBJECTIVE: To investigate the protective effect of neuroprotection against transient focal cerebral ischemia of the extract from Tianma(Rhizoma Gastrodiae) and the possible mechanisms underlying the ***: Cerebral ischemia-reperfusion injury was induced through middle cerebral artery occlusion(MCAO). Adult male Sprague-Dawley rats were randomly divided into four groups: sham-operated,ischemia-reperfusion model, 102.6 mg/kg extract treated and 11.4 mg/kg extract treated groups. The extract was prepared from gastrodia elata with ethyl acetate. The effect of the extract tested on rat neurological de fi cits and Cerebral index, cerebral infarct volume, brain injury, terminal dexynucleotidyl transferase-mediated d UTP nick end labeling(TUNEL) and B-cell lymphoma-2(Bcl-2) positive ***: The extract was able to reduce neurological scores, cerebral index and cerebral infarction rate. The brain injury was also relieved by the extract. The results of immunofluorescence staining analysis indicated that the extract increased the expression of Bcl-2 and reduced TUNEL-positive cells significantly in the extract treated ***: These results suggested that the extract relieved ischemic injury induced by transient focal cerebral ischemia in rats, and this neuroprotective effect might be partially due to the attenuated apoptosis pathway.

关键词： Ethyl acetate Gastrodia Neuroprotec-tive agents Reperfusion injury Apoptosis

Comments on ‘An airway organoid-based screen identifies a role for the HIF1α‒glycolysis axis in SARS-CoV-2 infection’

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Journal of Molecular Cell Biology 2022年第1期14卷 60-61页

作者： xiaohua duan Hui Wang David D.Ho Robert E.Schwartz Todd Evans Shuibing Chen Department of Surgery Weill Cornell Medicine1300 York Ave.New YorkNY 10065USA State Key Laboratory of Oncogenes and Related Genes Center for Single-Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China Aaron Diamond AIDS Research Center Columbia University Vagelos College of Physicians and SurgeonsNew YorkNY 10032USA Division of Gastroenterology and Hepatology Department of MedicineWeill Cornell Medicine1300 York Ave.New YorkNY 10065USA Department of Physiology Biophysics and Systems BiologyWeill Cornell Medicine1300 York Ave.New YorkNY 10065USA

Coronavirus disease 2019(COVID-19)has been an ongoing public health crisis since the end of 2019;besides vaccine development,there have been major research efforts focused on developing antiviral *** was the first US Food and Drug Administration(FDA)-approved antiviral drug for ***,the FDA granted emergency use authorization(EUA)for three monoclonal antibody treatments,including sotrovimab or a combination of casirivimab and imdevimab,or bamlanivimab and etesevimab,each of which targets the coronavirus spike protein to block viral *** recently,Britain granted conditional authorization for the ribonucleoside analog molnupiravir,developed by Merck as a viral replication *** protease inhibitor PF-07321332 developed by Pfizer and boosted by ritonavir showed promising results in a phase III clinical trial,reducing the risk of hospitalization or death by 89%compared with placebo.

关键词： Pfizer Merck vaccine

Advances in Studies on Treatment of Chronic Renal Failure with Ethnic Medicines

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Medicinal Plant 2019年第1期10卷 13-16页

作者： xiaohua duan Yanni WANG Deqiang FENG Yunnan University of Traditional Chinese Medicine

At present, the incidence of the chronic renal failure(CRF) is on the rise, and ethnic medicines have made significant achievements in the CRF treatment. In view of this, this paper reviewed the progress of ethnic medicines in the CRF treatment, to provide certain references for the personalized treatment of the CRF. Finally, it came up with the new recommendations for proper development and utilization of ethnic medicines.

关键词： Ethnic medicines Chronic renal failure(CRF) Advances in studies

Advances in Treatment of Myoma of Uterus

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Medicinal Plant 2018年第6期9卷 97-100页

作者： xiaohua duan Maomao ZHANG Jinglin HE Deqiang FENG Yunnan University of Traditional Chinese Medicine

Myoma of uterus has the highest incidence in gynecological *** incidence rate is increasing year by year,which is the main indication for ***-surgical treatment is often adopted for young patients with fertility *** t... 详细信息

关键词： Myoma of uterus Minimally invasive treatment Drug therapy

A targetable pathway to eliminate TRA-1-60^(+)/TRA-1-81^(+)chemoresistant cancer cells

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Journal of Molecular Cell Biology 2023年第6期15卷 25-39页

作者： Lei Tan xiaohua duan Pratyusha Mutyala Ting Zhou Sadaf Amin Tuo Zhang Brian Herbst Gokce Askan Tomer Itkin Zhaoying Xiang Fabrizio Michelassi Michael D.Lieberman Christine AIacobuzio-Donahue Steven DLeach Todd Evans Shuibing Chen Department of Surgery Weill Cornell MedicineNew YorkNY 10065USA Center for Energy Metabolism and Reproduction Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Genomic Health Weill Cornell MedicineNew YorkNY 10065USA The SKI Stem Cell Research Facility The Center for Stem Cell Biology and Developmental Biology ProgramMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Genomic Resource Core Facility Weill Cornell Medical CollegeNew YorkNY 10065USA Rubenstein Center for Pancreatic Cancer Research Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Division of Regenerative Medicine Hartman Institute for Therapeutic Organ RegenerationAnsary Stem Cell InstituteDepartment of MedicineWeill Cornell MedicineNew YorkNY 10065USA Dartmouth Cancer Center Darmouth CollegeHanoverNH 03755USA

Chemoresistance is a primary cause of treatment failure in pancreatic *** cell surface markers specifically expressed in chemoresistant cancer cells(CCCs)could facilitate targeted therapies to overcome *** performed an antibody-based screen and found that TRA-1-60 and TRA-1-81,two‘stemness’cell surface markers,are highly enriched in ***-more,TRA-1-60^(+)/TRA-1-81^(+)cells are chemoresistant compared to TRA-1-60^(-)/TRA-1-81^(-)*** profiling identified UGT1A10,shown to be both necessary and sufficient to maintain TRA-1-60/TRA-1-81 expression and *** a high-content chemical screen,we identified Cymarin,which downregulates UGT1A10,eliminates TRA-1-60/TRA-1-81 expression,and increases chemosensitivity both in vitro and in ***,TRA-1-60/TRA-1-81 expression is highly specific in primary cancer tissue and positively correlated with chemoresistance and short survival,which highlights their potentiality for targeted ***,we discovered a novel CCC surface marker regulated by a pathway that promotes chemoresistance,as well as a leading drug candidate to target this pathway.

关键词： pancreatic cancer TRA-1-60/TRA-1-81 chemoresistance UGT1A10 Cymarin

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服务业R&D的投入强度及其国际比较

中国科技论坛 2005年第4期 131-135页

作者：段小华柳卸林中国科技促进发展研究中心北京100038

服务业多样性使得R&D的投入方式与制造业有显著的不同,如何测算服务业的R&D,是需要在实践中认真探索的问题。世界各国的服务业的R&D投入强度整体上远低于制造业,与服务业在经济体系中的份额和创新速度并不相称。改进服务业的R&D统计方... 详细信息

服务业多样性使得R&D的投入方式与制造业有显著的不同,如何测算服务业的R&D,是需要在实践中认真探索的问题。世界各国的服务业的R&D投入强度整体上远低于制造业,与服务业在经济体系中的份额和创新速度并不相称。改进服务业的R&D统计方法是非常必要的。本文分析了现在有关服务业通用的统计方法及存在的问题,并提出了作者对改进服务业统计观点。

关键词：服务业R&D 投入强度国际比较

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高校创新基地发展中的经验、问题及建议

中国科技论坛 2010年第7期 22-25页

作者：段小华刘彦中国科学院科技政策与管理研究所北京100080 中国科学技术发展战略研究院北京100038

高校是我国创新体系中的重要主体之一。对高校创新基地的调研表明,以国家重点实验室、国家工程技术中心为代表的高校创新基地发挥了科研项目、学科建设和人才培养相结合的优势,成为高校创新活动的主要载体。高校创新基地已经形成了独具... 详细信息

高校是我国创新体系中的重要主体之一。对高校创新基地的调研表明,以国家重点实验室、国家工程技术中心为代表的高校创新基地发挥了科研项目、学科建设和人才培养相结合的优势,成为高校创新活动的主要载体。高校创新基地已经形成了独具特色的建设和运行模式,初步具备承担国家重大科研任务、服务区域经济发展的能力。政府部门应进一步优化创新基地布局,完善人才发展环境,建立稳定的财政支持渠道,不断推进科研条件建设,更有效地发挥高校在国家创新体系中的作用。

关键词：高校创新基地发展经验

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欧洲国家创新网络化的两种模式及启示

中国科技论坛 2013年第3期 134-137,144页

作者：黄伟段小华科学技术部发展计划司北京100862 吉林大学商学院吉林长春130012 中国科学技术发展战略研究院北京100038

整合相关要素形成创新网络是提高创新效率的重要方式。本文在概括有关创新网络内涵、形态和功能等文献的基础上,分析了欧洲国家创新网络化的两种新模式:一是建立开放式的创意网络,形成跨领域的创新平台;二是建立孵化器网络,对接公共资... 详细信息

整合相关要素形成创新网络是提高创新效率的重要方式。本文在概括有关创新网络内涵、形态和功能等文献的基础上,分析了欧洲国家创新网络化的两种新模式:一是建立开放式的创意网络,形成跨领域的创新平台;二是建立孵化器网络,对接公共资源和产业创新需求。结合中国创新资源集成、整合的要求,提出了从基地建设、服务体系建设和集群建设等角度,推进我国创新资源网络化的建议。

关键词：欧洲创新网络模式启示