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Progress in Resource Utilization of River Sediment in the Field of Building Materials

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Asian Agricultural Research 2024年第6期16卷 22-24页

作者： Chenhao LIANG Qiangbin CHENG xiaohong xiong Ruqi YI Chen WANG College of Urban Construction Jiangxi University of TechnologyNanchang 330022China Organization Department of the Party Committee of Jiangxi University of Technology Nanchang 330022China College of Culture and Media Jiangxi University of TechnologyNanchang 330022China

At present,there is a great demand for building materials in the market,and the market prospect of building materials is relatively *** studying the composition of river sediment and its resource utilization in the field of building materials,this paper expounds the current domestic scholars research on river sediment in building materials,and summarizes the current problems and challenges,so as to provide a reference for the sustainable development of river sediment in the field of building materials.

关键词： River sediment Building materials Resource utilization

时滞Fisher方程的保结构Du Fort-Frankel差分格式及其分析

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计算数学 2024年第2期46卷 189-212页

作者：熊小红邓定文南昌航空大学数学与信息科学学院南昌330063

本文首先对一维时滞Fisher方程建立了保非负性的DuFort-Frankel差分格式。运用数学归纳法证明了当网格比r_(x)=(ε△t)/h^(2)_(x)≤1/2时,它的数值解大于或者等于零.这里ε,△t和h分别是扩散系数,时间和空间方向上的网格步长其次,运用... 详细信息

本文首先对一维时滞Fisher方程建立了保非负性的DuFort-Frankel差分格式。运用数学归纳法证明了当网格比r_(x)=(ε△t)/h^(2)_(x)≤1/2时,它的数值解大于或者等于零.这里ε,△t和h分别是扩散系数,时间和空间方向上的网格步长其次,运用截断技巧修正由保非负性的Du FortFrankel差分格式获得的数值解,从而设计了一类既保非负性又保最大界的差分方法.运用数学归纳法证明了当r_(x)≤1/2时,它的数值解落在区间[0,1]内.运用能量分析法,我们证明这两类方法在最大范数下均有O(△t+(△t/h_(x))^(2)+h^(2)_(x))的收敛阶.再次,类似地,我们对二维问题建立了保非负性的Du Fort-Frankel差分格式和既保非负性又保最大界的差分法,及其理论.最后,数值结果验证了理论的正确性和新算法的高效性。

关键词：时滞Fisher方程 DuFortFrankel差分格式非负性有界性收敛性

Rational tuning of thorium-organic frameworks by reticular chemistry for boosting radionuclide sequestration

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Nano Research 2022年第2期15卷 1472-1478页

作者： Han Feng xiaohong xiong Lele Gong Huiping Zhang Ying Xu Xuefeng Feng Feng Luo School of Chemistry Biology and Materials ScienceEast China University of TechnologyNanchang 330013China

The reticular chemistry strategy presents a powerful molecule-design tool to tailor the physical and chemical properties of metal-organic framework(MOF).In this work,we for the first time investigated the effect of organic ligands on the radionuclide sequestration(TcO_(4)^(-))of thorium-organic *** a coordination modulation technique,two novel isoreticular thorium-organic frameworks,namely Th-MOF-67 and Th-MOF-68,were *** to the antetype MOF of Th-MOF-66 that shows extremely low uptake of ReO_(4)^(-)(a chemical surrogate of radioactive TcO_(4)^(-)),the isoreticular MOFs of Th-MOF-67 and Th-MOF-68 enable ultrahigh uptake of ReO_(4)^(-),giving an impressively 36.8-fold or 56-fold enhancement,*** adsorption capacity of Th-MOF-68 is as high as 560 mg/g,exceeding most reported adsorbents for such *** mechanism for such exceptional outstanding performance,as unveiled by both the single crystal X-ray diffraction and theoretical calculation,is due to coordination interaction for Th-MOF-67,when a tetrazolate ligand was used,or a combined effect from both coordination interaction and anion-exchange for Th-MOF-68,if using a triazolate ligand.

关键词： thorium-organic framework ligand effect defect site anion exchange radionuclide sequestration

小建中汤加味联合西药疗法治疗脾胃虚寒型消化性溃疡的效果

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中外医药研究 2024年第11期3卷 100-102页

作者：祝河霞熊晓红李伟查方勇十堰市郧西县中医医院湖北十堰442600

目的:探讨小建中汤加味联合西药疗法治疗脾胃虚寒型消化性溃疡的效果。方法:选取2020年6月—2022年6月郧西县中医医院收治的脾胃虚寒型消化性溃疡患者60例作为研究对象,随机分为对照组和观察组,各30例。对照组给予常规西药治疗,观察组... 详细信息

目的:探讨小建中汤加味联合西药疗法治疗脾胃虚寒型消化性溃疡的效果。方法:选取2020年6月—2022年6月郧西县中医医院收治的脾胃虚寒型消化性溃疡患者60例作为研究对象,随机分为对照组和观察组,各30例。对照组给予常规西药治疗,观察组在对照组基础上给予小建中汤加味治疗。比较两组临床疗效、中医证候积分、不良反应发生率与疾病复发率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.030);治疗后,两组胃痛、胃胀、纳差、乏力评分低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率、疾病复发率低于对照组,差异有统计学意义(P<0.05)。结论:常规西医疗法联合小建中汤加味治疗脾胃虚寒型消化性溃疡临床效果较好,能够改善患者的临床症状,减少不良反应,降低复发率。

关键词：消化性溃疡脾胃虚寒型小建中汤加味

Evaluation and attribution of trends in compound dry-hot events for major river basins in China

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Science China Earth Sciences 2024年第1期67卷 79-91页

作者： Shaotang xiong Tongtiegang ZHAO Chengchao GUO Yu TIAN Fang YANG Wenlong CHEN xiaohong CHEN Key Laboratory of Water Security Guarantee in Guangdong-Hong Kong-Marco Greater Bay Area of Ministry of Water Resources&Sun Yatsen University/Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Guangzhou 510275China China Institute of Water Resource and Hydropower Research Beijing 100038China Pearl River Hydraulic Research Institute Guangzhou 510611China

Concurrent compound dry and hot events(CDHEs)amplified more damange on the ecosystems and human society than individual *** climate change,compound dry and hot events become more frequent on a global *** paper proposes a mathematical method to quantitatively attribute changes of CDHEs to changes of precipitation,change in temperature and change in the dependence between precipitation and *** attribution is achieved by formulating the total differential equation of the return period of CDHEs among Meta-gaussian model.A case study of China is devised based on monthly precipitation and temperature data during the period from 1921 to 2020 for 80 major river *** is found that temperature is the main driving factor of increases in CDHEs for 49 major river basins in China,except for the upper and middle reaches of the Yangtze *** West China,precipitation changes drove the increase in CDHEs in 18 river basins(23%),particularly in parts of North Xinjiang,Qinghai and *** the other hand,dependence between precipitation and temperature dominated changes of CDHEs in 13 river basins(16%)of China with other factors,including parts of South China,East China and Northwestern ***,changes in both the mean and spread of precipitation and temperature can also contribute to changes in CDHEs.

关键词： Climate extreme Compound dry and hot extreme Precipitation Temperature Return period

Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application

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Acta Pharmaceutica Sinica B 2024年第2期14卷 623-634页

作者： Jiacheng xiong Rongrong Cui Zhaojun Li Wei Zhang Runze Zhang Zunyun Fu xiaohong Liu Zhenghao Li Kaixian Chen Mingyue Zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China College of Computer and Information Engineering Dezhou UniversityDezhou 253023China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215000China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Aldehyde oxidase(AOX)is a molybdoenzyme that is primarily expressed in the liver and is involved in the metabolism of drugs and other ***-mediated metabolism can result in unexpected outcomes,such as the production of toxic metabolites and high metabolic clearance,which can lead to the clinical failure of novel therapeutic *** models can assist medicinal chemists in rapidly evaluating the AOX metabolic risk of compounds during the early phases of drug discovery and provide valuable clues for manipulating AOX-mediated metabolism *** this study,we developed a novel graph neural network called AOMP for predicting AOX-mediated *** integrated the tasks of metabolic substrate/non-substrate classification and metabolic site prediction,while utilizing transfer learning from 13C nuclear magnetic resonance data to enhance its performance on both *** significantly outperformed the benchmark methods in both cross-validation and external *** AOMP,we systematically assessed the AOX-mediated metabolism of common fragments in kinase inhibitors and successfully identified four new scaffolds with AOX metabolism liability,which were validated through in vitro ***,for the convenience of the community,we established the first online service for AOX metabolism prediction based on AOMP,which is freely available at https://***.

关键词： Drugmetabolism Aldehyde oxidase Transferlearning Graph neural network Kinase inhibitor

EZH2 is a prognostic factor associated with tumor stemness and immune infiltration in skull base chordoma

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Genes & Diseases 2024年第5期11卷 85-87页

作者： Qian Liu Mingxuan Li Yujia xiong Yutao Shen Tianshun Ma Tianhao Zhang xiaohong R.Yang Yazhuo Zhang Jiwei Bai Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Division of Cancer Epidemiology and Genetics National Cancer InstituteNIHDHHSBethesdaMD 20892USA

Enhancer of zeste homolog 2(EZH2),an epigenetic regulator that inhibits transcription primarily through trimethylation of Lys-27 in histone 3(H3K27me3),has been reported to play an important role in the regulation of cell cycle,autophagy,and apoptosis,and DNA damage repair.1 EZH2 is highly expressed in a variety of cancers including prostate cancer,breast cancer,and renal clear cell carcinoma,and is associated with adverse prognosis.1 Moreover,it has been reported that EZH2 might increase tumor stemness and metastasis capacity and inhibit antitumor immunity by affecting T cells,NK cells,macrophages,and immune checkpoints.2,3 However,the prognostic value and the mechanism of EZH2 have not been investigated in *** this study,RNA sequencing and whole genome sequencing data based on 48 skull base chordomas as well as immunohistochemistry of paraffin sections were analyzed to elucidate the role of EZH2 in skull base *** found copy number gain mediated high EZH2 expression is associated with tumor stemness,M2 macrophage infiltration,and adverse prognosis in ***,we demonstrated that EZH2 promotes the proliferation,migration,and invasion of chordoma cells in in vitro cell experiments.

关键词： EZH2 immunity invasion