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Isolation,identification and application of Aspergillus oryzae BL18 with high protease activity as starter culture in doubanjiang(broad bean paste)fermentation

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Food Bioscience 2023年第1期51卷 248-257页

作者： Chengtuo Niu Xianlei xing xiaohong Yang Feiyun Zheng Chunfeng Liu Jinjing Wang Qi Li Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi214122China Lab of Brewing Science and Technology School of BiotechnologyJiangnan UniversityWuxi214122China School of Biotechnology Jiangnan UniversityWuxi214122China

This study aimed to obtain an Aspergillus oryzae strain with high protease activity and to evaluate its potential to apply as starter culture in bean-based fermented foods(BBFFs)production using doubanjiang fermentation as research *** BL18 with higher protease activity than the commonly used starter *** 3.042 was obtained through two rounds of ***,this strain was also proved to be safe to apply in BBFFs fermentation due to the lack of the ability to produce aflatoxin B1 through genomic and experimental *** BL18 was optimal to grow under 0-12%salinity,25-40℃ and *** koji-making,*** BL18 had stronger ability to produce spores(4.19×10^(8)spores/g dry weight)and to secrete protease(4654.35 U/g)than *** 3.042(2.89×10^(8)spores/g dry weight and 3604.40 U/g).Significantly higher concentrations of umami amino acids and volatile flavor compounds were found in doubanjiang fermentation inoculated by *** BL18 while better sensory characteristics were ***,*** BL18 might be a promising starter to apply in fermentation of doubanjiang or other BBFFs.

关键词： A.oryzae BL18 Doubanjiang Koji-making Fermentation Proteases Safety

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夜间长时血液透析患者透析感受的现象学研究

上海护理 2019年第4期19卷 26-29页

作者：邢小红彭飞陈静接艳青刘玲玲江一逍宫婵娟海军军医大学附属长征医院上海200003

目的探讨夜间长时血液透析患者的透析感受,为相关医院开展夜间透析及为夜间透析患者提供优质护理提供参考。方法采用质性研究中的现象学研究方法,于2018年3—4月选取在海军军医大学附属长征医院同时接受过日间常规透析和夜间长时透析的1... 详细信息

目的探讨夜间长时血液透析患者的透析感受,为相关医院开展夜间透析及为夜间透析患者提供优质护理提供参考。方法采用质性研究中的现象学研究方法,于2018年3—4月选取在海军军医大学附属长征医院同时接受过日间常规透析和夜间长时透析的14例患者进行半结构式访谈,根据Colaizzi 7步分析法对原始资料进行整理分析。结果夜间血液透析有利于减少相关并发症、促进患者更好地回归社会,但夜间透析患者的睡眠障碍问题有待进一步解决。结论夜间长时透析可有效缓解医疗资源压力,促进患者回归社会。医护人员可将夜间透析患者的睡眠质量问题作为突破口,进一步提升患者的生活质量。

关键词：终末期肾脏病肾脏替代治疗血液透析夜间长时血液透析质性研究

Effect of SiC Particle Size on Properties of SiC Porous Ceramics

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Journal of Wuhan University of Technology(Materials Science) 2022年第1期37卷 13-22页

作者： XU xiaohong LIU xing WU Jianfeng MA Sitong LIU Shaoheng CHEN Tiantian State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China

We used different SiC particle size as raw materials and via reaction bonding technique to prepare porous SiC membrane *** phase composition,microstructure,bending strength,open porosity,and pore size distribution were investigated as a function of SiC particle size and firing *** is found that the reduction of SiC particle size not only dramatically enhances the bending strength of porous SiC membrane supports,but also slightly reduces the firing temperature duo to smaller SiC particle with higher specific surface area and higher reaction ***,the open porosity and pore size distribution are dependent on the firing temperature,but insensitive to the SiC particle size due to the pore related characters mainly controlled by the *** bending strength increases with the increasing of the firing temperature and with the decreasing of SiC particle *** the firing temperature was 1500℃and SiC average particle size was 447.75μm,the optimal performance were achieved,the bending strength was 15.18 MPa,the open porosity was 36.02%,the pore size distributed at 3.09-112.47μm,and the mean pore size was 14.16μm.

关键词： membrane supports SiC particle size bending strength

Retrospective Analysis of Diagnosis by Intraoperative Frozen Section and Routine Paraffin Embedded Tissue in 638 Thyroid Disease Patients

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Clinical oncology and cancer researeh 2009年第5期6卷 359-361页

作者： Chunyan xing Liwu Dong xiaohong Wang Wei Li Department of Pathology Longnan Hospital of Daqing Oilfield General Hospital Group and the Fifth Affiliated Hospital of Qiqihar Medical College Daqing 163453 Heilongjiang Province China. Department of Stomatology General Hospital of Daqing Oilfield General Hospital Daqing163001 Heilongjiang Province China.

OBJECTIVE To summarize a common pathogenefic condition, the pathologic characteristics shown in frozen section and our experience utilizing 2 different common thyroid diseases （TD）. diagnostic methods in cases of METHODS Data from 638 cases with frozen sections from thyroid tissue were retrospectively analyzed. The intraoperative frozen sections of the patients and postoperative diagnostic results of routine paraffin sections were compared. RESULTS In the 683 patients, the gender ratio of females to males was 2.64 ： 1, and the ratio between the patients with nodular goiter （NG） and the patients with thyroid adenoma was 1.5 ： 1. The oldest age group of patients with thyroid cancer （TC） ranged from 40 to 49 years. Frozen section pathologic examination has been employed more and more in the diagnosis of thyroid diseases, and the detection rate of TC has increased year by year, i.e., the rate increased to 6.45%, 7.58%, 14.55% and 16.57%, respectively, in 2005, 2006, 2007 and 2008. Thyroid papillary carcinoma （TPC） was the most commonly seen malignant tumor of the thyroid （MTT）, which accounted for approximately 94.8% of MTTs and 11.44% of the total TDs. Micropapillary carcinoma accounted for 27.4% of TPC, and multifocal carcinomas accounted for 15.58% of TCs. Many of the TCs （19.48%） were complicated by benign diseases such as adenoma, NG and thyroiditis. The coincidence rate of diagnoses made by frozen section and paraffin embedding for thyroid disease was 98.59%. Calcification was rather common in NG and TPC, and there were significant differences in psammoma bodies （PMB） between the calcifications of TPC and NG （P 〈 0.01）. CONCLUSION TPC ranks first in the incidence of MTTs and accounts for 94.8% of all MTTs. About 1/4 of TPCs are micropapillary carcinoma, while 1/5 are accompanied by benign disease, such as adenorna, NG and thyroiditis. PMB are of importance and of significance in the diagnosis of TPC.

关键词： thyroid disease intra-operative frozen section paraffin imbedding pathologic analysis.

miR-204-5p、miR-1233-3p在妊娠期高血压疾病孕妇中的表达及临床意义

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中国医药导报 2021年第29期18卷 90-93,111页

作者：吴桂梅李冀云金燕刘红玲王文杰邢晓红曹艳敏河北省沧州市中心医院产科河北沧州061000

目的探讨miR-204-5p、miR-1233-3p在妊娠期高血压疾病(HDCP)中的诊断价值。方法选择2018年12月至2020年6月河北省沧州市中心医院(以下简称"我院")收治的197例HDCP患者为研究对象,其中妊娠期高血压102例为妊娠期高血压组,子痫前期95例为... 详细信息

目的探讨miR-204-5p、miR-1233-3p在妊娠期高血压疾病(HDCP)中的诊断价值。方法选择2018年12月至2020年6月河北省沧州市中心医院(以下简称"我院")收治的197例HDCP患者为研究对象,其中妊娠期高血压102例为妊娠期高血压组,子痫前期95例为子痫前期组;另随机选择同期于我院产科门诊规律围产期保健并入院待产的82名正常足月单胎妊娠孕妇为对照组。检测受试者外周血清miR-204-5p、miR-1233-3p表达及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。分析miR-204-5p、miR-1233-3p表达与HDCP患者临床参数及IL-6、TNF-α的相关性及miR-204-5p、miR-1233-3p对HDCP的诊断价值。结果子痫前期组、妊娠期高血压组血清miR-204-5p、miR-1233-3p表达及IL-6、TNF-α水平高于对照组(P<0.05);子痫前期组血清miR-204-5p、miR-1233-3p表达及IL-6、TNF-α水平高于妊娠期高血压组(P<0.05)。HDCP患者miR-204-5p、miR-1233-3p表达与分娩孕龄、新生儿体重呈负相关(r_(mi R-204-5p)=-0.403、-0.395,r_(mi R-1233-3p)=-0.321、-0.354,P<0.05);与收缩压、舒张压、24 h尿蛋白定量、IL-6、TNF-α呈正相关(r_(mi R-204-5p)=0.653、0.619、0.597、0.594、0.601,r_(mi R-1233-3p)=0.624、0.609、0.543、0.615、0.631,P<0.05)。miR-204-5p、miR-1233-3p联合诊断HDCP的曲线下面积值大于miR-204-5p、miR-1233-3p单独检测(P<0.05)。结论 miR-204-5p、miR-1233-3p高表达与分娩孕龄、新生儿体重、炎症因子均有关,对HDCP诊断具有较高应用价值。

关键词：妊娠期高血压疾病 miR-204-5p miR-1233-3p

Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries

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Acta Pharmaceutica Sinica B 2023年第6期13卷 2369-2382页

作者： Bingbing Li Chao Teng Huiling Yu xiaohong Jiang Xuyang xing Qi Jiang Chenshi Lin Zongmin Zhao Ruifeng Zhang Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Department of Anesthesiology Affiliated Drum Tower of Nanjing UniversityNanjing 210008China Department of Pharmaceutical Sciences College of PharmacyUniversity of Illinois at ChicagoChicagoIL 60612USA Department of Respiratory Medicine Zhongda Hospital of Southeast UniversityNanjing 210009China Department of Anesthesiology Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjing 210004China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Pulmonary hypertension(PH)is an insidious pulmonary vasculopathy with high mortality and morbidity and its underlying pathogenesis is still poorly *** hyperproliferation and apoptosis resistance of pulmonary artery smooth muscle cells(PASMCs)contributes to pulmonary vascular remodeling in pulmonary hypertension,which is closely linked to the downregulation of forkhead box transcriptional factor O1(FoxO1)and apoptotic protein caspase 3(Cas-3).Here,PA-targeted co-delivery of a FoxO1 stimulus(paclitaxel,PTX)and Cas-3 was exploited to alleviate monocrotaline-induced pulmonary *** co-delivery system is prepared by loading the active protein on paclitaxel-crystal nanoparticles,followed by a glucuronic acid coating to target the glucose transporter-1 on the *** co-loaded system(170 nm)circulates in the blood over time,accumulates in the lung,effectively targets the PAs,and profoundly regresses the remodeling of pulmonary arteries and improves hemodynamics,leading to a decrease in pulmonary arterial pressure and Fulton's *** mechanistic studies suggest that the targeted co-delivery system alleviates experimental pulmonary hypertension primarily via the regression of PASMC proliferation by inhibiting cell cycle progression and promoting *** together,this targeted co-delivery approach offers a promising avenue to target PAs and cure the intractable vasculopathy in pulmonary hypertension.

关键词： Pulmonary hypertension Pulmonary artery smooth muscle cells Fork-head box transcriptional factor O1 Caspase 3 Co-delivery

Comprehensive multi-omics profiling identifies novel molecular subtypes of pancreatic ductal adenocarcinoma

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Genes & Diseases 2024年第6期11卷 315-330页

作者： xing Wang Jinshou Yang Bo Ren Gang Yang xiaohong Liu Ruiling Xiao Jie Ren Feihan Zhou Lei You Yupei Zhao Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100023China Key Laboratory of Research in Pancreatic Tumor Chinese Academy of Medical SciencesBeijing 100023China National Science and Technology Key Infrastructure on Translational Medicine in Peking Union Medical College Hospital Beijing 100023China

Pancreatic cancer,a highly fatal malignancy,is predicted to rank as the second leading cause of cancer-related death in the next *** highlights the urgent need for new insights into personalized diagnosis and *** molecular subtypes of pancreatic cancer were well established in genomics and transcriptomics,few known molec-ular classifications are translated to guide clinical strategies and require a paradigm ***,chronically developing and continuously improving high-throughput technologies and systems serve as an important driving force to further portray the molecular landscape of pancreatic cancer in terms of epigenomics,proteomics,metabonomics,and ***,a more comprehensive understanding of molecular classifications at multiple levels using an integrated multi-omics approach holds great promise to exploit more potential ther-apeutic *** this review,we recapitulated the molecular spectrum from different omics levels,discussed various subtypes on multi-omics means to move one step forward towards bench-to-beside translation of pancreatic cancer with clinical impact,and proposed some methodological andscientific challengesinstore.

关键词： Molecular characterization Molecular subtyping Multi-omics Pancreatic cancer Precision medicine

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蜂胶总黄酮在心血管疾病中的应用

吉林中医药 2018年第8期38卷 951-953页

作者：孙光伟邢晓虹孙文瑞崔洪涛隋欣王伟楠何天竺姜铁超吉林省中医药科学院第一临床医院长春130021 吉林大学长春130000 吉林大学中日联谊医院长春130033 吉林大学第一医院长春130000 长春中医药大学长春130117

目的总结国外对蜂胶现代药理研究进展。方法对蜂胶总黄酮抗氧化、抗炎等生物学特性及治疗活性,与其他作用于心血管疾病机理研究进行归纳探讨,总结蜂胶总黄酮作用于心血管相关疾病的国内外研究进展;并探讨中医痰饮、瘀血、经络因素在心... 详细信息

目的总结国外对蜂胶现代药理研究进展。方法对蜂胶总黄酮抗氧化、抗炎等生物学特性及治疗活性,与其他作用于心血管疾病机理研究进行归纳探讨,总结蜂胶总黄酮作用于心血管相关疾病的国内外研究进展;并探讨中医痰饮、瘀血、经络因素在心系疾病中的病因病机,阐发有形与无形之痰都是心系疾病的重要病因。结果瘀血日久会导致心力衰竭等危重疾病的发生,经络相关疾病多以心痛为发病热点,蜂胶总黄酮能够减轻心肌缺血范围和心肌缺血的程度,且有抗炎、抗心肌缺血等功效。结论蜂胶可以在多种心系疾病中辨证应用。

关键词：蜂胶总黄酮心肌缺血心系疾病

ISPD 2020版制订高质量、目标导向的腹膜透析处方指南要点解读

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上海护理 2020年第11期20卷 1-6页

作者：王雯雯曹艳佩尹祎宇葛霄琳袁立黄晓敏汪海燕邢小红顾爱萍复旦大学护理学院上海200032 复旦大学附属华山医院上海200040 上海交通大学医学院附属瑞金医院上海200025 海军军医大学第一附属医院上海200433 海军军医大学第二附属医院上海200003 上海交通大学医学院附属仁济医院上海200120

2020年5月,国际腹膜透析学会(International Society for Peritoneal Dialysis,ISPD)发布了《制订高质量、目标导向腹膜透析处方的指南推荐》,本文主要从指南发布的背景、制订高质量腹膜透析处方的推荐意见,以及相关推荐意见在临床应用... 详细信息

2020年5月,国际腹膜透析学会(International Society for Peritoneal Dialysis,ISPD)发布了《制订高质量、目标导向腹膜透析处方的指南推荐》,本文主要从指南发布的背景、制订高质量腹膜透析处方的推荐意见,以及相关推荐意见在临床应用中的问题等方面进行解读,以期为帮助临床腹膜透析专科护理人员更好地了解指南、应用指南,更深入地开展腹膜透析患者管理提供参考。

关键词：国际腹膜透析学会(ISPD) 腹膜透析处方指南解读