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Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway

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Science China(Life Sciences) 2024年第7期67卷 1427-1440页

作者： Hongfeng Guo Qihang Sun Xiaoli Huang xiaohao wang Feng Zhang Wenzheng Qu Jinling Liu Xuejun Cheng Qiang Zhu Wen Yi Qiang Shu Xuekun Li The Children’s Hospital National Clinical Research Center for Child HealthSchool of MedicineZhejiang UniversityHangzhou 310052China The Institute of Translational Medicine School of MedicineZhejiang UniversityHangzhou 310029China College of Life Sciences Zhejiang UniversityHangzhou 310058China Binjiang Institute of Zhejiang University Hangzhou 310053China Zhejiang University Cancer Center Zhejiang UniversityHangzhou 310029China

Fucosyltransferase 8(Fut8)and core fucosylation play critical roles in regulating various biological processes,including immune response,signal transduction,proteasomal degradation,and energy metabolism.However,the function and underlying mechanism of Fut8 and core fucosylation in regulating adult neurogenesis remains unknown.We have shown that Fut8 and core fucosylation display dynamic features during the differentiation of adult neural stem/progenitor cells(aNSPCs)and postnatal brain development.Fut8 depletion reduces the proliferation of a NSPCs and inhibits neuronal differentiation of aNSPCs in vitro and in vivo,respectively.Additionally,Fut8 deficiency impairs learning and memory in mice.Mechanistically,Fut8 directly interacts with integrinα6(Itga6),an upstream regulator of the PI3kAkt signaling pathway,and catalyzes core fucosylation of Itga6.Deletion of Fut8 enhances the ubiquitination of Itga6 by promoting the binding of ubiquitin ligase Trim21 to Itga6.Low levels of Itga6 inhibit the activity of the PI3K/Akt signaling pathway.Moreover,the Akt agonist SC79 can rescue neurogenic and behavioral deficits caused by Fut8 deficiency.In summary,our study uncovers an essential function of Fut8 and core fucosylation in regulating adult neurogenesis and sheds light on the underlying mechanisms.

关键词： Fut8 adult neural stem/progenitor cells neurogenesis Itga6 PI3K/Akt

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MODELS: a six-step framework for developing an infectious disease model

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贫困所致传染病(英文) 2024年第2期13卷 1-11页

作者： Rui Jia Li Kangguo Wei Hongjie Guo xiaohao Zhao Zeyu wang Yao Song Wentao Abudunaibi Buasiyamu Chen Tianmu State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine Laboratory School of Public Health Xiamen University Xiamen city China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Innovation Platform for Industry-Education Integration in Vaccine Research Xiamen University Xiamen City China

Since the COVID-19 pandemic began, a plethora of modeling studies relatedto COVID-19 have been released. While some models stand out due to their innovative approaches, others are flawed in their methodology. To assist novices, frontline healthcare workers, and public health policymakers in navigating the complex landscape of these models, we introduced a structured framework named MODELS. This framework is designed to detail the essential steps and considerations for creating a dependable epidemic model, offering direction to researchers engaged in epidemic modeling endeavors.

关键词： Epidemic models Model construction MODELS framework

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Bio-cementation for tidal erosion resistance improvement of foreshore slopes based on microbially induced magnesium and calcium precipitation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1696-1708页

作者： xiaohao Sun Junjie wang Hengxing wang Linchang Miao Ziming Cao Linyu Wu Institute of Geotechnical Engineering Southeast UniversityNanjing211189China School of Civil Engineering and Architecture Wuhan Polytechnic UniversityWuhan430070China

In most coastal and estuarine areas,tides easily cause surface erosion and even slope failure,resulting in severe land losses,deterioration of coastal infrastructure,and increased floods.The bio-cementation technique has been previously demonstrated to effectively improve the erosion resistance of slopes.Seawater contains magnesium ions(Mg^(2+))with a higher concentration than calcium ions(Ca^(2+));therefore,Mg^(2+)and Ca^(2+)were used together for bio-cementation in this study at various Mg^(2+)/Ca^(2+)ratios as the microbially induced magnesium and calcium precipitation(MIMCP)treatment.Slope angles,surface strengths,precipitation contents,major phases,and microscopic characteristics of precipitation were used to evaluate the treatment effects.Results showed that the MIMCP treatment markedly enhanced the erosion resistance of slopes.Decreased Mg^(2+)/Ca^(2+)ratios resulted in a smaller change in angles and fewer soil losses,especially the Mg^(2+)concentration below 0.2 M.The decreased Mg^(2+)/Ca^(2+)ratio achieved increased precipitation contents,which contributed to better erosion resistance and higher surface strengths.Additionally,the production of aragonite would benefit from elevated Mg^(2+)concentrations and a higher Ca^(2+)concentration led to more nesquehonite in magnesium precipitation crystals.The slopes with an initial angle of 53°had worse erosion resistance than the slopes with an initial angle of 35°,but the Mg^(2+)/Ca^(2+)ratios of 0.2:0.8,0.1:0.9,and 0:1.0 were effective for both slope stabilization and erosion mitigation to a great extent.The results are of great significance for the application of MIMCP to improve erosion resistance of foreshore slopes and the MIMCP technique has promising application potential in marine engineering.

关键词： Bio-cementation Erosion resistance Foreshore slope stabilization Magnesium ions Calcium ions

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Piezoelectric soft robot driven by mechanical energy

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Nano Research 2023年第4期16卷 4970-4979页

作者： Jiangfeng Lu Zicong Miao Zihan wang Ying Liu Dekuan Zhu Jihong Yin Fei Tang xiaohao wang Wenbo Ding Min Zhang Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhen 518055China Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentsTsinghua UniversityBeijing100084China

Power sources and energy-harvesting schemes are still grand challenges for soft robots.Notably,compared with other power sources,triboelectric nanogenerators(TENGs)have shown great potential because of their low manufacturing and fabrication costs,outstanding resilience,remarkable stability,and environmental friendliness.Herein,a triboelectric effect-driven piezoelectric soft robot(TEPSR)system is proposed,which integrates a rotary freestanding triboelectric nanogenerator(RFTENG)to drive a soft robot comprising a piezoelectric unimorph and electrostatic footpads.Based on the natural triboelectrification,through converting mechanical energy into electricity,TENG provides a unique approach for actuation and manipulation of the soft robot.The perfect combination provides the most straightforward way for creating a self-powered system.Experimentally,under the power of RF-TENG,the soft robot reaches a maximum moving speed of 10 cm per second and a turning rate of 89.7°per second,respectively.The actuation and manipulation demonstration are intuitively accomplished by maneuvering the robot around a maze with a 71 cm track within 28 s.For autonomous feedback controls,one practical application is carrying two infrared sensors on board to realize obstacle avoidance in an unstructured environment.Moreover,a micro-camera was equipped with the soft robot to provide real-time“first-person”video streaming,enhancing its detection capability.

关键词： triboelectric nanogenerator piezoelectric soft robot rapid actuation agile trajectory manipulation energy efficiency

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Glycerol solutions of highly concentrated biomineral counter-ions towards water-responsive mineralization: Demonstration on bacterial cellulose and its application in hard tissue repair

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Nano Research 2024年第3期17卷 2154-2163页

作者： Yunfei Zhao xiaohao Liu Zhi Zhou Chaobo Feng Nan Luo Jiajun Yan Shuo Tan Yang Lu Feng Chen Bing-Qiang Lu Shisheng He Department of Orthopedic Spinal Pain Research InstituteShanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Preventive Dentistry Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai 200011China

Mineralization has found widespread use in the fabrication of composite biomaterials for hard tissue regeneration.The current mineralization processes are mainly carried out in neutral aqueous solutions of biomineral counter-ions(a pair of cation and anion that form the corresponding minerals at certain conditions),which are stable only at very low concentrations.This typically results in inefficient mineralization and weak control over biomineral formation.Here,we find that,in the organic solvent glycerol,a variety of biomineral counter-ions(e.g.,Ca/PO_(4),Ca/CO_(3),Ca/SO_(4),Mg/PO_(4),or Fe/OH)corresponding to distinct biominerals at significantly high concentrations(up to hundreds-fold greater than those of simulated body fluid(SBF))are able to form translucent and stable solutions(mineralizing solution of highly concentrated counter-ions(MSCIs)),and mineralization can be triggered upon them with external solvents(e.g.,water or ethanol).Furthermore,with pristine bacterial cellulose(BC)membrane as a model,we demonstrate an effective and controllable mineralization performance of MSCIs on organic substrates.This approach not only forms the homogeneous biominerals on the BC fibers and in the interspaces,but also provides regulations over mineralization rate,mineral content,phase,and dopants.The resulting mineralized BC membranes(MBCs)exhibit high cytocompatibility and favor the proliferation of rat bone marrow mesenchymal stem cells(rBMSC).Following this,we prepare a mineralized bone suture(MBS)from MBC for non-weight bearing bone fixation,which then is tested on a rabbit median sternotomy model.It shows firm fixation of the rabbit sternum without causing discernible toxicity or inflammatory response.This study,by extending the mineralization to the organic solution system of highly concentrated counter-ions,develops a promising strategy to design and build targeted mineral-based composites.

关键词： biomineralization organic solvent bacterial cellulose(BC) hard tissue repair

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Mercury removals by existing pollutants control devices of four coal-fired power plants in China

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Journal of Environmental Sciences 2011年第11期23卷 1839-1844页

作者： Juan wang Wenhuawang Wei Xu xiaohao wang Song Zhao School of Environmental Science ＆ Engineering Shanghai Jiao Tong University Shanghai 200240 China Shanghai Environmental Monitoring Center Shanghai 200030 China

The mercury removals by existing pollution control devices and the mass balances of mercury in four coal-fired power plants of China were carried out based on a measurement method with the aluminum matrix sorbent.All the plants are equipped with a cold-side electrostatic precipitator （ESP） and a wet flue gas desulfurization （FGD） in series.During the course of coal stream,the samples,such as coal,bottom ash,fly ash,gypsum and flue gas,were collected.The Hg concentrations in coals were measured by CVAAS after appropriate preparation and acid digestion.Other solid samples were measured by the RA-915 ＋ Zeeman Mercury Spectrometer.The vapor phase Hg was collected by a sorbent trap from flue gas and then measured using CVAAS followed by acid leaching.The mercury mass balances were estimated in this study were 91.6%,77.1%,118% and 85.8% for the four power plants,respectively.The total Hg concentrations in the stack gas were ranged from 1.56–5.95 μg/m 3.The relative distribution of Hg in bottom ash,ESP,WFGD and stack discharged were ranged between 0.110%–2.50%,2.17%–23.4%,2.21%–87.1%,and 21.8%–72.7%,respectively.The distribution profiles were varied with the coal type and the operation conditions.The Hg in flue gas could be removed by ESP and FGD systems with an average removal efficiency of 51.8%.The calculated average emission factor was 0.066 g/ton and much lower than the results obtained ten years ago.

关键词： mercury power plant mass balance distribution removal efficiency emission factor

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汕头市礐石花岗岩地貌特征及其成因

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热带地理 2024年第3期44卷 403-414页

作者：邱明昆王为温小浩陈敏王晨冯静华南师范大学地理科学学院广州510623 西藏大学生态环境学院拉萨850000 深圳职业技术学院建筑工程学院广东深圳518055

以广东汕头礐石地区景区内各类花岗岩地貌为研究对象,利用地表调查和洞穴调查,在国内外已有研究的基础上,对礐石地区花岗岩的地貌特征、成因及形成年代进行探讨。结果表明:礐石山由燕山晚期花岗岩构成,于中更新世晚期之前就受风化作用;... 详细信息

以广东汕头礐石地区景区内各类花岗岩地貌为研究对象,利用地表调查和洞穴调查,在国内外已有研究的基础上,对礐石地区花岗岩的地貌特征、成因及形成年代进行探讨。结果表明:礐石山由燕山晚期花岗岩构成,于中更新世晚期之前就受风化作用;礐石花岗岩石节理的性质和礐石地区高温多雨的热带季风气候下产生的风化作用,是形成礐石花岗岩地貌的基本因素;礐石地区花岗岩山体主要分为石蛋山、峰林山、馒头山3种类型;洞穴可划分石核洞,崩塌洞穴,裂隙洞和龛4类。

关键词：花岗岩地貌控制因素形成年代石蛋山礐石汕头

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嵌套集合建模能力和数字表征对儿童贝叶斯推理的影响

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心理科学 2024年第2期47卷 274-280页

作者：史滋福陈枭豪湖南师范大学心理学系长沙410081 认知与人类行为湖南省重点实验室长沙410081

为进一步探讨数字表征对贝叶斯推理的影响,特别是自然频数促进效应的作用机制,以285名小学生为被试,考察不同嵌套集合建模能力儿童在解决三种数字表征的贝叶斯推理问题时的表现。结果发现:(1)具有高嵌套集合建模能力的儿童能更好地解决... 详细信息

为进一步探讨数字表征对贝叶斯推理的影响,特别是自然频数促进效应的作用机制,以285名小学生为被试,考察不同嵌套集合建模能力儿童在解决三种数字表征的贝叶斯推理问题时的表现。结果发现:(1)具有高嵌套集合建模能力的儿童能更好地解决贝叶斯推理问题;(2)相比于概率和几率格式,儿童在自然频数格式下的推理表现更好;(3)概率格式下高低嵌套集合建模能力被试的推理表现无差异,但在自然频数和几率格式下,高嵌套集合建模能力被试的推理成绩好于低嵌套集合能力被试。这表明在适当的数字表征下,嵌套集合建模能力是影响儿童进行贝叶斯推理的关键因素。

关键词：儿童贝叶斯推理嵌套集合建模能力数字表征

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梁桂阳王萧融墓志考证——兼以桂阳王妃亲族信息证史

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中国国家博物馆馆刊 2024年第5期 92-103页

作者：计小豪清华大学人文学院北京100084

本文结合相关史事分析拓片图像和原石照片,对南京市博物馆藏梁桂阳王萧融墓志的死亡日期作考证,认为初刻萧融墓志时,萧融的具体死亡日期并未知晓,可能代替以其兄萧懿的死亡日期永元二年十月十三日。访得死期后在桂阳王妃附葬时重刻,根... 详细信息

本文结合相关史事分析拓片图像和原石照片,对南京市博物馆藏梁桂阳王萧融墓志的死亡日期作考证,认为初刻萧融墓志时,萧融的具体死亡日期并未知晓,可能代替以其兄萧懿的死亡日期永元二年十月十三日。访得死期后在桂阳王妃附葬时重刻,根据刻写情况推测萧融死亡日期是“永元三年三月二日”,享年当为三十一。将墓志所载仕履信息和死亡时间放于齐末历史的时间线中,可详考萧融参与的历史事件。本文还根据桂阳王妃墓志末所附萧氏与张氏的亲族信息,发现梁末历史人物张缵与桂阳嗣王萧慥的舅甥关系,为《南史·梁宗室列传》一处误并的记载提供佐证。

关键词：萧融萧融墓志墓志重刻萧融仕履墓志证史

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Application of Dynamic Linear Detecting Method in Data Processing of the Portable Blood Sugar Analyzer

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稀有金属材料与工程 2006年第A3期35卷 80-82页

作者： xiaohao wang Ran Liu Fei Tang Yangchun Yu Zhaoying Zhou State Key Laboratory of Precision Measurement Technology and Instruments Dept. of Precision Instruments Tsinghua Univ. Beijing 100084 China Dept. of Biomedical Engineering Tsinghua Univ. Beijing 100084 China

In this paper,a dynamic linear detecting method,that the non-linear coefficient NL% was led and the non-linearity of data were estimated continuously and dynamically and determined when NL% exceeded reference value (5%),was used for data processing and could solve the problem caused by the phenomenon of substrate depleting occurred following the redox reaction in portable blood sugar analyzer.By contrast to the conventional end-point method,the dynamic linear detecting method is based on multipoint data collecting.Experiments of measuring the calibration glucose solution with 8 various concentrations from 50 mg/dl to 400 mg/dl were carried out with the analyzer developed by our group.The linear regression curve,whose correlation for the data was 0.9995 and the residual was 2.8080,were obtained.The obtained correlation,residual, and the computation workload are all fit for the portable blood sugar analyzer.

关键词： data processing portable blood sugar analyzer dynamic linear detecting method

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