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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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陕西省宝鸡香泉铜矿地质特征及控矿因素探讨

陕西地质 2022年第1期40卷 51-55页

作者：任建梅陈元李晓国李忠运王彪陕西地矿第三地质队有限公司宝鸡市721300 陕西省地矿集团有限公司西安710054

宝鸡香泉铜矿处于华北地层大区陇山小区,北祁连-北秦岭早古生代-中生代铜铅锌矿成矿带,区内主要地层为震旦—奥陶系葫芦河群中浅变质岩(基—酸性火山岩),侵入岩为中粗粒二长花岗岩、似斑状钾长花岗岩,铜矿体主要受岩体内接触带和断裂构... 详细信息

宝鸡香泉铜矿处于华北地层大区陇山小区,北祁连-北秦岭早古生代-中生代铜铅锌矿成矿带,区内主要地层为震旦—奥陶系葫芦河群中浅变质岩(基—酸性火山岩),侵入岩为中粗粒二长花岗岩、似斑状钾长花岗岩,铜矿体主要受岩体内接触带和断裂构造控制,共圈出了6条含铜蚀变碎裂岩带。通过铜矿体的地质特征、岩石学特征等来探讨铜矿床的控矿因素,认为宝鸡香泉铜矿为一构造蚀变岩型铜矿。

关键词：香泉铜矿震旦-奥陶系二长花岗岩

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Control of Corner Separation for a linear Compressor Cascade via Bionic Slanting Riblets at the Endwall

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Journal of Thermal Science 2025年第1期34卷 129-144页

作者： ZHANG Peng li Yonghong CHENG Rixin Key Laboratory of Civil Aircraft Airworthiness Technology Civil Aviation University of China College of Aeronautical Engineering Civil Aviation University of China

A new passive control approach,utilizing bionic slanting riblets,is employed to mitigate the flow close to the blade endwall in a linear cascade,and its effectiveness and mechanism in controlling corner separation are investigated through numerical *** slanting riblets are positioned at the endwall upstream of the cascade channel,and the influence of riblet height,yaw angle and relative position on the control of corner separation is *** findings indicate that the application of slanting riblets can efficiently counteract corner separation across the stable operational ***,the introduction of riblets with a height of merely 0.1 times the boundary layer thickness results in a significant reduction in total pressure loss by up to 14.53%,while simultaneously enhancing the static pressure coefficient by 21.74%.Flow analysis reveals that minute vortices produced within the riblet channels tend to coalesce,forming a potent large-scale vortex near the boundary layer's base *** phenomenon results in reduced additional losses compared to conventional vortex ***,the induced vortex promotes enhanced mixing between the mainstream flow and boundary layer,inhibiting the lateral displacement of low-energy fluids within the endwall boundary ***,this delays the onset of separation vortex formation and eliminates vortex rings in the corner region,ultimately enhancing the aerodynamic efficiency of the cascade.

关键词： additional losses compressor cascade corner separation slanting riblets vortex generator

广东惠州东山海人工鱼礁对附近海域潮汐动力影响研究

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南方水产科学 2018年第6期14卷 17-26页

作者：陈钰祥黎小国佟飞唐振朝袁华荣曾雷陈丕茂中国水产科学研究院南海水产研究所中国水产科学研究院海洋牧场技术重点实验广东省海洋休闲渔业工程技术研究中心农业农村部南海渔业资源环境科学观测实验站广东广州510300

为了探明人工鱼礁对局地潮汐动力等因素的影响规律和机制,根据2016年7月东山海人工鱼礁区内外2个站位的25 h连续观测流速和水位数据,结合数值模拟方法,分析了广东惠州东山海人工鱼礁区建成后对礁区及周边海域潮汐动力等造成的影响。基... 详细信息

为了探明人工鱼礁对局地潮汐动力等因素的影响规律和机制,根据2016年7月东山海人工鱼礁区内外2个站位的25 h连续观测流速和水位数据,结合数值模拟方法,分析了广东惠州东山海人工鱼礁区建成后对礁区及周边海域潮汐动力等造成的影响。基于数值模拟,对建礁前后模拟结果对比分析获得了潮汐潮流等因子的变化情况。结果显示,模型模拟结果与实测值吻合良好;人工鱼礁区建成后对研究区域的潮汐调和常数和潮汐特性几乎没有影响;人工鱼礁区的部分分潮潮流椭圆会改变方向和转向,礁区外则几乎没有影响;建礁后礁区内部余流方向改变不大,礁区整体余流呈减小趋势;礁区附近水平流场改变明显,但对礁区外部影响范围有限,礁区迎流面有明显上升流,大潮涨急时刻底层上升流最大可达1.2 cm·s^(–1),礁区后部则出现下降流。

关键词：人工鱼礁数值模拟潮汐潮流上升流东山海

颈后路微型钛板配合中药治疗多节段脊髓型颈椎病

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中医学报 2010年第5期25卷 841-842页

作者：李晓国宿显良赵务生河南省职工医院骨科河南郑州450000

目的:评价单开门颈椎管扩大减压椎管成型微型钢板固定术治疗多节段脊髓型颈椎病的临床效果。方法:对62例多节段脊髓型颈椎病患者行单开门颈椎管扩大椎板成形术,于开门侧行微型钛板固定于棘突根部及侧块,根据术前、术后、随访时颈椎SCT片... 详细信息

目的:评价单开门颈椎管扩大减压椎管成型微型钢板固定术治疗多节段脊髓型颈椎病的临床效果。方法:对62例多节段脊髓型颈椎病患者行单开门颈椎管扩大椎板成形术,于开门侧行微型钛板固定于棘突根部及侧块,根据术前、术后、随访时颈椎SCT片,观察扩大椎管直径变化,48例患者随访0.5-3.0a,平均1.25a,以JOA评分评价神经功能改善情况。结果:术前JOA评分平均9.3,随访时JOA评分平均15.6,其中优39例(81.2%),良7例(14.5%),可2例(4.3%)。术后SCT示,椎管直径扩大3.5-7.0mm,平均5.2mm,无再关门现象,脊髓受压解除。结论:颈椎后路单开门椎管扩大减压椎板成型微钛板固定术是治疗多节段脊髓型颈椎病安全有效的手术方法,椎管扩大稳定持久,效果显著。

关键词：脊髓型颈椎病椎板成型术退行性

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting Lv Hongfu li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： lingxiao li Jing li Yanqi Song Sujuan Qin Qiaoyan Wen Fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing