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Long-term adjuvant administration of temozolomide impacts serum ions concentration in high-grade glioma

Chinese Neurosurgical Journal 2022年第2期8卷 111-119页

作者： Liyun Zhong Pei Yang Chuanbao Zhang Zheng Wang Tao Jiang Baoshi Chen Xia Shan Xiaoguang Qiu Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Chinese Glioma Genome Atlas Network(CGGA)and Asian Glioma Genome Atlas Network(AGGA) BeijingChina Center of Brain Tumor Beijing Institute for Brain DisordersBeijingChina China National Clinical Research Center for Neurological Diseases 119 South 4th Ring Road WestBeijing 100070China Department of Radiotherapy Beijing Tiantan HospitalCapital Medical University119 South 4th Ring Road WestBeijing 100070China

Background:Adjuvant temozolomide(TMZ)chemotherapy with standard regimen remarkably improves survival in patients with high-grade glioma(HGG).However,the influence of long-term TMZ chemotherapy on serum ions concentration is unclear.Methods:One hundred and thirty-eight patients with HGG were included.Their blood samples were collected for blood biochemistry and routine test.The alteration in serum ions concentration,total protein,albumin,globin,and blood cells counts were used to identify the impact of long-term TMZ chemotherapy.Results:Through the comparation of quantitative value of diverse parameters among different chemotherapy cycles,we identified that serum potassium concentration had a downward trend after TMZ administration(1st vs.6th,p<0.001;1st vs.12th,p<0.001).Additionally,the correlation analysis showed that platelets was negatively correlated with chemotherapy cycles(r=−0.649,p=0.023).The hematological adverse events mainly centered on grade 1 to 2.Conclusion:Long-term administration of TMZ may lead to serum ions disturbance.Besides the myelosuppression,we should pay attention to the alteration in serum ions concentration,and give patients proper symptomatic treatment when necessary.

关键词： High-grade glioma(HGG) Temozolomide(TMZ) Chemotherapy Toxicity

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High-dose radiation associated with improved survival in IDH-wildtype lowgrade glioma

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Chinese Neurosurgical Journal 2021年第2期7卷 126-130页

作者： Shuai Liu Yanwei Liu Guanzhang Li Jin Feng Li Chen Xiaoguang Qiu Department of Radiation Oncology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China

Background:As molecular advances have deepened the knowledge on low-grade glioma(LGG),we investigated the effect of higher radiation dose on the survival of IDH-wildtype(IDHwt)LGG.Methods:In the current study,52 IDHwt LGG patients who received radiotherapy were enrolled from the Chinese Glioma Genome Atlas dataset.Radiation doses>54 Gy were defined as high-dose,whereas doses≤54 Gy were defined as low-dose.We performed univariate and multivariate survival analyses to examine the prognostic role of high-dose radiotherapy.Results:In total,the radiation dose ranged from 48.6 Gy to 61.2 Gy,with a median of 55.8 Gy,and 31 patients were grouped into high-dose radiation.Univariate survival analysis indicated that high-dose radiotherapy(p=0.015),tumors located in the frontal lobe(p=0.009),and pathology of astrocytoma(p=0.037)were significantly prognostic factors for overall survival.In multivariate survival analysis,high-dose radiotherapy(p=0.028)and tumors located in the frontal lobe(p=0.016)were independently associated with better overall survival.Conclusions:In conclusion,high-dose radiotherapy independently improved the survival of IDHwt LGG.This can guide treatments for glioma with known molecular characteristics.

关键词： Radiation dose IDH-wildtype Low-grade glioma Survival

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PTPRZ1-METFUsion GENe(ZM-FUGEN)trial:study protocol for a multicentric,randomized,open-label phase II/III trial

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Chinese Neurosurgical Journal 2023年第4期9卷 315-319页

作者： Zhaoshi Bao Shouwei Li Liang Wang Bisi Zhang Peilong Zhang Hepeng Shi Xiaoguang Qiu Tao Jiang Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Chinese Glioma Genome Atlas Network(CGGA)and Asian Glioma Genome Atlas Network(AGGA) BeijingChina Department of Neurosurgery Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China Department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi’anChina Beijing Pearl Biotechnology Limited Liability Company BeijingChina Department of Radio‑Therapy Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China Center of Brain Tumor Beijing Institute for Brain DisordersBeijing 100069China China National Clinical Research Center for Neurological Diseases Beijing 100050China

Background PTPRZ1-MET fusion was reported to associate with glioma progression from low-grade to high-grade glioma,which was a target by a MET inhibitor vebreltinib.However,little is known about the further efficacy of vebreltinib among more glioma patients.This trial aims to evaluate the safety and efficacy of vebreltinib enteric-coated capsules in the treatment of sGBM/IDH mutant glioblastoma patients with the ZM fusion gene.Methods This multicentric,randomized,open-label,controlled trial plans to include 19 neurosurgical centers and recruit 84 sGBM or IDH mutant glioblastoma patients with the ZM fusion gene.This trial enrolls sGBM or IDH mutant glioblastoma patients with the inclusion criteria and without the exclusion criteria.It was registered with ***(CTR20181664).The primary efficacy endpoint is overall survival(OS).The secondary endpoints are progression-free survival(PFS)and objective response rate(ORR).Discussion If proven effective,this targeted multifaceted intervention protocol will be extended for more glioma patients as a protocol to evaluate the safety and efficacy of MET inhibitors.Trial registration It was registered with ***(CTR20181664).

关键词： Glioblastoma IDH mutation PTPRZ1-MET Vebreltinib Phase II/III Clinical trial

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Risk factors and treatments for brain metastasis in patients with adenocarcinoma of the lung: a retrospective analysis of 373 patients

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Chinese Neurosurgical Journal 2018年第2期4卷 76-83页

作者： Bo Li Zhaoxia Dai Shuai Liu Xuenan Gu Yanwei Liu Xiaoguang Qiu Department of Radiation Oncology Beijing Tiantan Hospital affiliated to Capital Medical UniversityNo.6Tiantan XiliDongcheng DistrictBeijing 100050China Department of Medical Oncology The Second Hospital of Dalian Medical UniversityNo.467Zhongshan RoadShahekou DistrictDalian 116027Liaoning ProvinceChina

Background: Risk factors and treatments for brain metastasis (BM) in patients with adenocarcinoma have not been fully profiled in previous studies because of the enrolment of patients with tumours of mixed histology. Thus, we specifically addressed the issue in patients with adenocarcinoma. Methods: Clinical data for 373 patients with pathologically confirmed adenocarcinoma were studied retrospectively. Factors including age (≤60 vs.＞60), gender (male vs. female), stage at diagnosis, T status (T1-2 vs. T3-4), N status (N0-1 vs. N2-3), epidermal growth factor receptor (EGFR) mutation status (wild-type vs. mutant) and smoking status (never vs. current) were analyzed. Results: In multivariate analysis, age (P=0.006) and N status (P=0.041) were independent risk factors for BM. In patients with BM, adding systemic therapy to local therapy improved median post-brain-metastasis survival (mPBMS) (P=0.02). However, if stratification was conducted according to the recursive partitioning analysis (RPA) classification or graded prognostic assessment (GPA) scoring, only patients in RPA class Ⅱ (P=0.020) or with GPA score 1.5-2.5 (P=0.032) could benefit from local plus systemic therapy. Those who received both pemetrexed and tyrosine kinase inhibitors (TKIs) as systemic therapies had a longer mPBMS than those who received TKIs alone, regardless of whether local therapy was applied. In patients with EGFR-sensitive mutations, TKIs therapy led to a longer mPBMS than conventional chemotherapy (P=0.002). Conclusions: Adenocarcinoma patients who were younger than 60 years of age and those with N2-3 disease have a significantly higher risk of BM. The addition of systemic therapy to local therapy can significantly prolong mPBMS, but the survival benefit confined in certain populations. Patients with opportunity to receive both pemetrexed and TKIs had the longest mPBMS.

关键词： Non-small cell lung cancer Risk factor Adenocarcinoma Brain metastasis Epidermal growth factor receptor

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Design method of organizational structure for MAVs and UAVs heterogeneous team with adjustable autonomy

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Journal of Systems Engineering and Electronics 2018年第2期29卷 286-295页

作者： CHEN Jun qiu Xunjie RONG Jia GAO xiaoguang School of Electronics and Information Northwestern Polytechnical University Centre of Applied Informatics College of Engineering and Science Victoria University

The increasingly complex battlefield environment requests much closer connection in a team having both manned and unmanned aerial vehicles(MAVs and UAVs). This special heterogeneous team structure causes demands for effective organizational structure design solutions. Implementing adjustable autonomy in the organizational structure, the expected evaluation function is established based on the physical resource, intelligent resource, network efficiency, network vulnerability and task execution reliability. According to the above constraints, together with interaction latency, decision-making information processing capacity, and decision-making latency, we aim to find a preferential organizational structure. The proposed organizational structure includes cooperative relationships, supervisory control relationships, and decision-making authorization relationships. In addition,by considering the influence on the intelligent support capabilities and the task execution reliability created by adjustable autonomy, it helps to build the proposed organizational structure designed with certain degree of flexibility to deal with the potential changes in the unpredictable battlefield environment. Simulation is conducted to confirm our design to be valid. And the method is still valid under different battlefield environments and interventions.

关键词： organizational structure cooperative relationship supervisory control relationship decision-making authorization relationship adjustable autonomy

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Risk factors of brain metastasis of lung squamous cell carcinoma:a retrospective analysis of 188 patients from single center

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Chinese Neurosurgical Journal 2018年第1期4卷 7-15页

作者： Bo Li Yanwei Liu Shuai Liu Xuenan Gu Xiaoguang Qiu Department of Radiation Oncology Beijing Tiantan Hospital affiliated to Capital Medical UniversityNo. 6Tiantan XiliDongcheng DistrictBeijing 100050China

Background:To explore risk factors and the efficacy of treatment strategies for brain metastasis (BM) in squamous cell carcinoma (SCC) of the lung.Methods:The clinical data of 188 pathologically confirmed as squamous cell carcinoma or adenosquamous carcinoma patients were studied retrospectively. Factors including age (<60 vs.≥60), gender, stage at diagnosis, T status (T1-2 vs. T3-4), N status (N0-1 vs. N2-3), histology (squamous vs. adenosquamous), smoking history (non-smoker vs. currentsmoker) and serum tumor markers (normal vs. elevated) were analyzed.Results:The incidence of BM was 19.1％(36/188) in our cohort. Patients who were female (p=0.005), had advanced disease at diagnosis (p<0.001), had adenosquamous carcinoma histology (p=0.033) or had elevated serum level of CEA at diagnosis (p<0.001) had significantly higher incidence of BM. In multivariate analysis, female (p=0.034, HR=18.874) and elevated serum level of CEA at diagnosis (p=0.009, HR=19.824) were independent risk factors of BM. BM patients who received additional systemic therapy after local therapy had significantly longer post-BM survival than those who received local therapy only (p=0.004, HR=0.058). Gemcitabine/platinum-containingregimen (GP) and taxans/platinum-containing regimen (TP) led to comparable brain-metastasis-free survival (BMFS) (p=0.10).Conclusions:Females and patients with elevated serum level of CEA at diagnosis had a higher risk of developing BM. The following systemic therapy after local therapy prolonged the survival of BM patient, but the efficacy of GP and TP was comparable in terms of preventing BM.

关键词： Brain metastasis Chemotherapy Non-small cell lung cancer Risk factor Squamous cell carcinoma

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Emergency irradiation of 3.4Gy/2f in pineal gland germinoma patients with symptomatic hydrocephalus

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Chinese Neurosurgical Journal 2019年第3期5卷 144-150页

作者： Bo Li Youqi Li Chunde Li Yanwei Liu Shuai Liu Xiaoguang Qiu Shiqi Luo Department of Radiation Oncology Beijing Tiantan HospitalCapital Medical UniversityNo.119 South 4th Ring West RoadFengtai DistrictBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityNo.119 South 4th Ring West RoadFengtai DistrictBeijing 100070China

Surgical interventions including ventriculostomy and ventriculo-peritoneal shunt were usually administrated in pineal germ cell tumor patients with symptomatic hydrocephalus. Considering higher sensitivity of germinoma to anti-tumor therapy, we explored emergency irradiation as non-invasive measure in this situation. Methods: Data of 35 germinoma patients with symptomatic hydrocephalus who received emergency irradiation of 3. 4 Gy/2f were studied retrospectively. The maximum width of frontal horn and the minimum width of trunk of corpus cal osum (TCC) were measured to evaluate hydrocephalus changing. Besides, mean deviation (MD) of Humphrey perimetry was employed to evaluate visual field defect. Correlations between hydrocephalus changing and clinical factors, including age, percentage of tumor regression, radiographic re-evaluation interval, and serum beta-human chorionic gonadotropin (β-HCG) level, were analyzed. Results: The median maximum diameter and volume of pineal lesions was 27 mm (range 10–55 mm) and 6.5cm3 (range 0.4–74.1 cm3), respectively. At median 8 days after irradiation, the median percentage of tumor remission was 55% (range 10–100%). The median maximum width of FN and the median minimum width of TCC were 11.6 mm and 39.0 mm, and 8.0 mm and 31.4 mm, before and after irradiation, respectively. The improvement of both parameters reached significant level (p < 0.001). However, none clinical factor was found to have correlation with their improvement. In 14 patients with paired data of pre- and post-irradiation MD, its change did not reach the significant level for both eyes. Al patients successful y received subsequent chemoradiotherapy without surgical intervention. Conclusions: Emergency irradiation of 3.4 Gy/2f was an effective non-invasive measure to relief hydrocephalus in pineal germinoma patients.

关键词： Germinoma β-HCG Chemotherapy Radiotherapy Hydrocephalus Visual field defect

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Modeling of High-frequency Electromagnetic Oscillation for DC Fault in MMC-HVDC Systems

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 1151-1160页

作者： Hong Shen Zhonghao Dongye Lei Qi Muxue Wang Xiangyu Zhang Peng qiu xiaoguang Wei State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China Electric Power Research Institute State Grid Zhejiang Electric Power CompanyHangzhou 310014China State Key Laboratory of Advanced Power Transmission Technology Global Energy Interconnection Research Institute Co.Ltd.Beijing 102209China

DC short-circuit faults pose a hazard to the operation of a modular multilevel converter(MMC)-based high voltage direct current(HVDC)system,necessitating reliable fault clearing solutions with rapid reaction.However,because the parasitic capacitances of the main equipment oscillate with the lumped inductances of the HVDC system,strong electromagnetic oscillations with multiple frequencies occur during clearance transients.These oscillations will disturb the HVDC system’s protection and control systems.Therefore,this paper focuses on the modeling of these oscillations.First,an equivalent circuit for the MMC-based HVDC system is proposed,taking into account the parasitic capacitances of the system’s major components,such as DC reactors,connecting cables,and DC circuit breakers(DCCBs).Second,four distinct oscillation stages are postulated based on action coordination of MMCs and DCCBs,and the associated analytical equations for the oscillation frequencies are derived.Third,a 200 kV MMC-based DC converter station is subjected to an 6ms/6kA pole-to-pole(PTP)short-circuit test.Electromagnetic oscillations have a frequency range of several kHz to several hundreds of kHz.The measured waveforms correspond well with simulated results,including the parasitic characteristics.Additionally,the relative errors between the simulated and measured frequencies are less than 5%.

关键词： DC short-circuit fault electromagnetic oscillation MMC-HVDC parasitic parameter wide-band model

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PPP模式中特殊目的公司(SPV)治理法律问题

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国家检察官学院学报 2019年第5期27卷 144-158页

作者：仇晓光吉林财经大学法学院中国人民大学法学院博士后流动站

PPP模式的特殊性决定了特殊目的公司(SPV)治理在PPP项目建设中居于核心地位。与普通公司侧重内部权利义务分配及组织结构组建的治理模式相比,融资模式选择、投资风险防控、剩余控制权配置等外部因素的治理对于特殊目的公司(SPV)更具影... 详细信息

PPP模式的特殊性决定了特殊目的公司(SPV)治理在PPP项目建设中居于核心地位。与普通公司侧重内部权利义务分配及组织结构组建的治理模式相比,融资模式选择、投资风险防控、剩余控制权配置等外部因素的治理对于特殊目的公司(SPV)更具影响。本文从公司治理的范畴出发,考量PPP模式中特殊目的公司(SPV)内外部共同治理模式,为PPP模式中特殊目的公司(SPV)设立形式选择、融资风险规避、参与主体利益均衡、融资担保机制构建、股权结构优化等方面提供治理思路。

关键词：特殊目的公司公司治理股权结构融资风险剩余控制权

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Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging

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Chinese Journal of Cancer Research 2015年第3期27卷 231-238页

作者： Chenlu Feng Peiyi Gao Xiaoguang Qiu Tianyi Qian Yan Lin Jian Zhou Binbin Sui Department of Radiology Beijing Tiantan HospitalCapital Medical University Beijing Neurosurgical Institute Department of Radiotherapy Beijing Tiantan HospitalCapital Medical University MR Collaboration NE Asia Siemens Healthcare

Objective： To evaluate the feasibility of dynamic contrast-enhanced magnetic resonance imaging（DCEMRI） for predicting tumor response to radiotherapy in patients with suspected primary central nervous system（CNS） germ cell tumors（GCTs）.Methods： DCE-MRI parameters of 35 patients with suspected primary CNS GCTs were obtained prior to diagnostic radiation, using the Tofts and Kermode model. Radiosensitivity was determined in tumors diagnosed 2 weeks after radiation by observing changes in tumor size and markers as a response to MRI. Taking radiosensitivity as the gold standard, the cut-off value of DCE-MRI parameters was measured by receiver operating characteristic（ROC） curve. Diagnostic accuracy of DCE-MRI parameters for predicting radiosensitivity was evaluated by ROC curve.Results： A significant elevation in transfer constant（K^trans） and extravascular extracellular space（Ve）（P=0.000）, as well as a significant reduction in rate constant（Kep）（P=0.000） was observed in tumors. K^trans, relative K^trans, and relative Kep of the responsive group were significantly higher than non-responsive groups. No significant difference was found in Kep, Ve, and relative Ve between the two groups. Relative K^trans showed the best diagnostic value in predicting radiosensitivity with a sensitivity of 100%, specificity of 91.7%, positive predictive value（PPV） of 95.8%, and negative predictive value（NPV） of 100%.Conclusions： Relative K^trans appeared promising in predicting tumor response to radiation therapy（RT）. It is implied that DCE-MRI pre-treatment is a requisite step in diagnostic procedures and a novel and reliable approach to guide clinical choice of RT.

关键词： Dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI） extravascular extracellular space germ cell tumors （GCTs） radiosensitivity rate constant transfer constant

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