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Human leukocyte antigen compatibility and incidence of donorspecific antibodies in pediatric liver transplant recipients

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World Journal of Gastroenterology 2024年第33期30卷 3837-3845页

作者： Melina u Melere Flavia H Feier Jorge Neumann Antônio N Kalil Juliana de M Montagner Luiza S Nader Carolina S da Silva Marco Aurélio F Junior Gabriela P Coral Guilherme P Bobsin Cristina T Ferreira Department of Hepatology and Liver Transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Rio Grande do SulBrazil Department of Hepato-biliary-pancreatic Surgery and Liver Transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Postgraduation Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil Laboratory of Transplantation Immunology Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil

BACKGROuND Antibody-mediated rejection following liver transplantation(LT)has been increasingly recognized,particularly with respect to the emergence of de novo donor-specific antibodies(DSAs)and their impact on graft *** substantial evidence for adult populations exists,research focusing on pediatric LT outcomes remains *** To investigate the prevalence of human leukocyte antigen(HLA)mismatches and DSA and evaluate their association with rejection episodes after pediatric *** A cohort of pediatric LT recipients underwent HLA testing at Santa Casa de Porto Alegre,Brazil,between December 2013 and December *** patients who survived for>30 days after LT with at least one DSA analysis were *** classes I and II and cross-matches were *** presence of de novo DSA(dnDSA)was evaluated at least 3 months after LT using the Luminex®single antigen bead method,with a positive reaction threshold set at 1000 *** episodes were confirmed by liver *** Overall,67 transplanted children were analyzed;61 received grafts from living donors,85%of whom were related to ***-transplant DSA(class I or II)was detected in 28.3%of patients,and dnDSA was detected in 48.4%.The median time to DSA detection after LT was 19.7[interquartile range(IQR):4.3-35.6]*** rejection occurred in 13 patients at follow-up,with C4d positivity observed in 5/13 Liver *** median time to rejection was 7.8(IQR:5.7-12.8)*** presence of dnDSA was significantly associated with rejection(36%vs 3%,Purvival rates at 12 and 24 months were 76%vs 100%and 58%vs 95%for patients with dnDSA anti-DQ vs those without,*** Our findings highlight the importance of incorporating DSA assessment into pre-and post-transplantation protocols for pediatric LT *** implications may include immunosuppression minimization strategies based on this analysis in pediatric LT recip

关键词： Human leukocyte antigens Donor-specific antibodies Liver transplantation Pediatric Rejection

Surface Water Quality Profiling using Physicochemical Parameters in Open Defecation Free and Non-Open Defecation Free Local Government Areas in Benue State, Nigeria

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Open Journal of Modern Hydrology 2024年第3期14卷 174-191页

作者： Moses T. Asoo Celestine u. Aguoru Innocent O. Ogbonna Hyacinth O.A. Oluma Benue State Ministry of Health Makurdi Nigeria Department of Plant Science and Biotechnology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria Department of Microbiology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria

Physicochemical parameters of surface water sources in the study of local government areas (LGAs) were assessed using standard procedures. The mean physicochemical parameters for pH (5.49), NO2 (0.23 mg/L), SO4 (0.77 mg/L), Na (28.72 mg/L), Ca (28.94 mg/L), Mg (17.50 mg/L), Cl (11.65 mg/L), TSS (6.27 mg/L), TDS (104.23 mg/L), BOD (2.83 mg/L) and F (0.87 mg/L) were below WHO standards irrespective of their defecation status. The values for electrical conductivity (EC) (2770.50 µs/cm, turbidity (481.24 NTu), dissolved oxygen (DO) (5.32 mg/L), chemical oxygen demand (COD) (445.50 mg/L), K (125.06 mg/L), PO4 (0.78 mg/L) and Fe (0.57 mg/L) were above the WHO limits for safe water. Higher EC and COD values obtained in the study is evidence of pollution of the water sources by organic matter.

关键词： Open Defecation Surface Water Water Quality Standard Physicochemical Parameters

Zircon SHRIMP u-Pb geochronology and petrogenesis of the plagiogranites from the Lagkor Lake ophiolite,Gerze,Tibet,China

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Chinese Science Bulletin 2007年第5期52卷 651-659页

作者： ZHANG YuXiu1,2, ZHANG KaiJun1,3, LI Bing1,2, WANG Yang1,2, WEI QingGuo1,2 & TANG XianChun1,2 1 Key Laboratory of Marginal Sea Geology, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China 2 Graduate university, Chinese Academy of Sciences, Beijing 100039, China 3 Department of Earth Sciences, Nanjing university, Nanjing 210093, China Key Laboratory of Marginal Sea Geology Guangzhou Institute of GeochemistryChinese Academy of Sciences Guangzhou 510640 China

地关系与 petrographical 一起， petrological ，和 geochemicalcharacteristics ，和锆石人口，显示从在 Bangong-Nujiang 缝术地区的 Lagkor Lakeophiolite 的 plagiogranites (～ Gerze 县的 20 km 南方，中央西藏，中国)，由在海洋的外壳的运输期间的可锻的砍源于含水的斑粝岩的 anatexis 。因此，这种 plagiogranite 比传播海洋的外壳晚对或很少同时代。锆石虾 166 ±使 2.5 妈变老因为 plagiogranites 显示海洋的盆在中间的侏罗记在 Bangong-Nujiang 地区的西方的部分存在。

关键词：西藏改则县拉果错湖泊蛇绿岩斜长花岗岩锆SHRIMP u-Pb地质年代岩石成因

Circuit Model with Current Interruption for Hybrid High Voltage DC Circuit Breakers to Achieve Precise Current Experiments

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CSEE Journal of Power and Energy Systems 2022年第4期8卷 1250-1260页

作者： Zhonghao Dongye Lei Qi Bing Ji xiaoguang Wei Xiang Cui State Key Laboratory of Altermate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China School of Engineering University of LeicesterLE17RH LeicesterU.K State Key Laboratory of Advanced Power Transmission Technology Global Energy Interconection Research Institute Co.Ld.Beijing 102209China

The current interruption test based on an LC resonance circuit for hybrid DC circuit breakers(HVDC CBs)is widely employed to characterize the current interruption capability of *** order to ensure a high-fidelity replica of the fault current in a high voltage application,this paper first proposes an equivalent model of the test circuit,where not only parasitic resistances but also the threshold voltages and on-state resistances of various semiconductor devices are ***,the analytical formula of the test current is derived by including the working principle of the HVDC ***,the parameter extraction method,which combines finite element analysis and measurements by an impedance analyzer,is given in this *** extracted result implies that,in current interruption transients,equivalent resistances of 500 kV CB are as large as 535 mS,which have a significant influence on current ***,the 34 kV/25 kA current interruption test for the 500 kV CB is *** measured results are proved to be consistent with the analytical results obtained from the proposed model,and the relative error is less than 2%.

关键词： Current interruption test high voltage DC circuit breaker

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar u.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

Application of vertically integrated sampling approach to study of new production via ^(234)Th -^(238)u disequilibria

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Acta Oceanologica Sinica 2000年第2期19卷 37-44页

作者： Chen Feizhou1 Huang Yipu2 Chen Min2 (1. College of Fishery Science, Shanghai Fisheries university, Shanghai 200090, China 2. Department of Oceanography, Xiamen university, Xiamen 361005, China) College of Fishery Science Shanghai Fisheries University Shanghai 200090 China

The spatial and temporal distributions of new production vary largely in different sea areas. To understand the level of new production in the sea area studied better, an estimate of new production must be obtained in large spatial and temporal scales. The ~234Th/ ~238u disequilibrium is an effective method for the study of new production. Two sampling strategies, vertically integrated sampling ap proach based on trapezoidal integration principle and discrete layer sampling approach, were compared in the studies of the xiamen Bay and the northern South China Sea. The scavenging fluxes and removal fluxes of ~234Th and the residence times for dissolved and particulate ~234Th were calculated. The coinci dent results from two Sampling approach suggest that vertically integrated sampling approach is not only effective and reliable, but also significantly reduces the number and volume of samples. It allows us to study new production by ba ^(234)Th - ^(238)u disequilibria in large spatial scale.

关键词： New production vertically integrated Sampling approach, ^(234)Th - ^(238)u disequilibria Xia men Bay northern South China Sea

ADVANCED QuALITY CONCEPTS AND COMPOSITE RELIABILITY THROuGH STATISTICALPROCESS CONTROL

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Acta Metallurgica Sinica(English Letters) 1997年第3期10卷 263-269页

作者： D. Evans (CCLRC, Rutherford Appleton Laboratory, Chilton, Oxon. OX14 2HQ u.K.) Rutherford Appleton Lab Oxon United Kingdom

The physical properties of thermosetting resins and resin based composites may be influenced by changes in any one of the mang formulating or process related variables involved in their manufacture. When resins and composite materials are required to perform in aggressive environments, reliable and predicable performance is essential and therefore these materials must be prepared and tested in accorkance with a strictquality plan. This paper outlines the elements of statistical process control (S.P.C.)as it may be applied to non-metallic materials and discusses the concept of Capability Index (Cp).

关键词： physical property composite process control cryogenic application

Genesis of sandstone-type uranium deposits along the northern margin of the Ordos Basin,China

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Geoscience Frontiers 2020年第1期11卷 215-227页

作者： Ruoshi Jin Xueming Teng xiaoguang Li Qinghong Si Wei Wang Tianjin Center China Geological SurveyTianjin 300170China Key Laboratory of uranium Geology China Geological SurveyTianjin 300170China

Sandstone-type u mineral resources are among the important sources for nuclear *** u deposits in the Ordos Basin in China form part of the northern segment of the sandstone-hosted Central Asian uranium *** types of mineralizations are recognized in this basin:"phreatic permeable type"and"interlayer permeable type",both exhibiting features equivalent to roll-front ***"interlayer permeable type"is widely accepted as the dominant mineralization type for sandstone-type uranium deposits within large-scale basins,also designated as the"interlayer oxidation zone type",based on the horizontal color zoning model representing changing redox *** we synthesize data from several drill holes within the Ordos Basin,which suggest that major Mesozoic tectonic movements controlled the evolution of the sedimentary system in the *** tectonic movements contributed to the formation of three angular unconformities and four parallel unconformities as inferred from the stratigraphic *** addition,other features such as vertical color zoning,paleo-channel controlled tabular or lentoid ore bodies(without roll-type)and a group interlayer horizontal zoning of altered minerals are also *** stratigraphic analysis indicates that the Ordos Basin generally witnessed four cycles of water level variations during *** the variations,three high water level and three low water level events were *** characteristics imply that the Ordos Basin went through multiple arid to humid climatic evolutions during *** the newly documented features with some novel concepts on the hydrodynamic mechanism for supergene ore-forming fluids,we propose a metallogenic model which invokes the importance of tectonic movements and water level fluctuations to explain the genesis of uranium deposits along the northern margin of the Ordos Basin.

关键词： Sequence stratigraphic analysis Hydrodynamic mechanisms Metallogenic model Tectonic history Ordos Basin

A general finite element model for numerical simulation of structure dynamics

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Science China(Physics,Mechanics & Astronomy) 2006年第4期49卷 440-450页

作者： WANG Fujun1, LI Yaojun1, Han K.2 & Feng Y.T.2 1. College of Water Conservancy and Civil Engineering, China Agricultural university, Beijing 100083, China 2. Civil & Computational Engineering Centre, university of Wales Swansea, Swansea SA2 8PP, u.K. College of Water Conservancy Civil Engineering China Agricultural University Beijing 100083 China Civil & Computational Engineering Centre University of Wales Swansea Swansea SA2 8PP UK

A finite element model used to simulate the dynamics with continuum and discontinuum is presented. This new approach is conducted by constructing the general contact model. The conventional discrete element is treated as a standard finite element with one node in this new method. The one-node element has the same features as other finite elements, such as element stress and strain. Thus, a general finite element model that is consistent with the existed finite element model is set up. This new model is simple in mathematical concept and is straightforward to be combined into the existing standard finite element code. Numerical example demonstrates that this new approach is more effective to perform the dynamic process analysis in which the interactions among a large number of discrete bodies and continuum objects are included.

关键词： finite element method, discrete element method, structure dynamics, numerical simulation.