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Unlocking G-quadruplexes as Targets and Tools against COVID-19

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Chinese Journal of Chemistry 2023年第5期41卷 560-568页

作者： Geng Qin Chuanqi Zhao jie Yang Zhao Wang Jinsong Ren xiaogang qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry ChineseAcademyof ScienceChangchunJilin 130022 University of Science and Technology of China HefeiAnhui 230026China

The applicability of G-quadruplexes(G4s)as antiviral targets,therapeutic agents and diagnostic tools for coronavirus disease 2019(COVID-19)is currently being evaluated,which has drawn the extensive attention of the scientific *** the COVID-19 pandemic,research in this field is rapidly *** this review,we summarize the latest achievements and breakthroughs in the use of G4s as antiviral targets,therapeutic agents and diagnostic tools for COVID-19,particularly using G4 ***,strength and weakness regarding G4s in anti-SARS-CoV-2 field are highlighted for prospective future projects.

关键词： G-quadruplexes Viruses Nucleic acids Drug discovery Aptamers

Cancer nanomedicine in preoperative therapeutics:Nanotechnology-enabled neoadjuvant chemotherapy,radiotherapy,immunotherapy,and phototherapy

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Bioactive Materials 2023年第6期24卷 136-152页

作者： xiaogang qu Dong Zhou Jianpu Lu Duotian Qin Jun Zhou Hai-Jun Liu Department of General Surgery Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu215500China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA

Surgical resection remains a mainstay in the treatment of malignant solid ***,the use of neoadjuvant treatments,including chemotherapy,radiotherapy,phototherapy,and immunotherapy,either alone or in combination,as a preoperative intervention regimen,have attracted increasing attention in the last *** randomized,controlled trials in some tumor settings have not shown a significant difference between the survival rates in long-term neoadjuvant therapy and adjuvant ***,this has not hampered the increasing use of neoadjuvant treatments in clinical practice,due to its evident downstaging of primary tumors to delineate the surgical margin,tailoring systemic therapy response as a clinical tool to optimize subsequent therapeutic regimens,and decreasing the need for surgery,with its potential for increased *** recent expansion of nanotechnology-based nanomedicine and related medical technologies provides a new approach to address the current challenges of neoadjuvant therapy for preoperative *** review not only summarizes how nanomedicine plays an important role in a range of neoadjuvant therapeutic modalities,but also highlights the potential use of nanomedicine as neoadjuvant therapy in preclinical and clinic settings for tumor management.

关键词： Neoadjuvant treatment Preoperative preparation Surgical resection Nanotechnology

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碘量法标定硫化物的讨论

山西化工 2024年第2期44卷 95-97,100页

作者：崔媛媛王晗瞿晓刚李海平钢研纳克检测技术股份有限公司北京100081 抚顺特殊钢股份有限公司辽宁抚顺113000

针对硫化物标准GB/T 16489—1996、GB/T 5750.5—2023、HJ/T 200—2005、SL 89—1994、DZ/T 0064.67—2021、HJ 1226—2021中都含有用碘量法测定硫化物标准溶液的方法,对1000 mg/L硫化物标准溶液用以上标准中碘量法分别进行标定,通过结... 详细信息

针对硫化物标准GB/T 16489—1996、GB/T 5750.5—2023、HJ/T 200—2005、SL 89—1994、DZ/T 0064.67—2021、HJ 1226—2021中都含有用碘量法测定硫化物标准溶液的方法,对1000 mg/L硫化物标准溶液用以上标准中碘量法分别进行标定,通过结果分析,找到标准HJ 1226—2021中影响硫化物标定准确性的原因,并提出解决方案。

关键词：硫化物碘量法标定

Earthquake potential across the North–South seismic belt of China

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Science Bulletin 2024年第2期69卷 179-182页

作者： Yanchuan Li Xinjian Shan Chunyan qu Guohong Zhang xiaogang Song State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China

The elastic rebound theory,which frames our understanding of earthquakes,suggests that the accumulated elastic strain on faults will ultimately be released through earthquakes[1].As such,identifying the location,rate,and accumulation of slip deficit on faults constitutes a basis for seismic potential assessment[2].Interseismic coupling(ISC)refers to the ratio of the slip deficit rate on a fault to the far-field loading rate,where full and no coupling correspond to 100%and 0%slip deficits,respectively.

关键词： seismic belt fault

New insights into nanomaterials combating bacteria: ROS and beyond

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Science China(Life Sciences) 2019年第1期62卷 150-152页

作者： Zhengwei Liu xiaogang qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences

Nanozymes are nanomaterials-based enzyme mimics which have received increasing research interests owing to their distinctive merits over natural enzymes,such as low costs, facile preparation,and high stability (Wei and Wang,2013;Gao and Yan,2016).By now,a plenty of nanomaterials,like metal oxide nanoparticles,noble metal nanoparticles,nanocarbon materials and transition metal dichalcogenides have been reported to exhibit several enzyme-like catalytic activities (Sun et al.,2018)(Figure 1).Over the past decade, nanozymes have been widely investigated in biomedical applications including immunoassays,biosensors,cancer therapy,and anti-bacteria.

关键词： Nanozymes nanomaterials-based enzyme metal dichalcogenides

Enzyme-directed pH-responsive exfoliation and dispersion of graphene and its decoration by gold nanoparticles for use as a hybrid catalyst

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Nano Research 2013年第9期6卷 693-702页

作者： Konggang qu Li Wu Jinsong Ren xiaogang qu Laboratory of Chemical Biology Division of Biological Inorganic Chemistry State Key Laboratory of Rare Earth Resource UtilizationChangchun Institute of Applied Chemistry Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences ChangchunJilin 130022 China

A non-destructive, safe and practical strategy to produce high quality graphene in high yield is urgently required, since this would pave the way for a wide range of applications of graphene in the future. Here we present a pH-responsive water-dispersible method for the exfoliation and functionalization of graphene by using lysozyme. The pH-responsive dispersion of graphene may be useful for the reversible assembly of multicomponent/multifunctional nanohybrid materials and nanoscale electronic devices. More importantly, composites can be easily constructed through the interactions between disulphide groups in lysozyme and gold nanoparticles （AuNPs）. The resulting graphene-AuNPs composites show excellent catalytic activity towards reduction of o-nitroaniline by NaBH4. Since lysozyme is low cost and has antibacterial properties, and has been widely used in food preservation, medicine and the pharmaceutical industry, our approach may open a new scalable route for the manufacture of high-quality, nondestructive graphene for practical applications.

关键词： grapheme exfoliation lysozyme pH-responsive catalysis protein

Intelligent Optimization Methods for the Design of an Overhead Travelling Crane

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Chinese Journal of Mechanical Engineering 2015年第1期28卷 187-196页

作者： qu xiaogang XU Gening FAN Xiaoning BI Xiaoheng School of Mechanical & Electronical Engineering Lanzhou University of Technology School of Mechanical Engineering Taiyuan University of Science and Technology

In design optimization of crane metal structures, present approaches are based on simple models and mixed variables, which are difficult to use in practice and usually lead to failure of optimized results for rounding variables. Crane metal structure optimal design（CMSOD） belongs to a constrained nonlinear optimization problem with discrete variables. A novel algorithm combining ant colony algorithm with a mutation-based local search（ACAM） is developed and used for a real CMSOD for the first time. In the algorithm model, the encoded mode of continuous array elements is introduced. This not only avoids the need to round optimization design variables during mixed variable optimization, but also facilitates the construction of heuristic information, and the storage and update of the ant colony pheromone. Together with the proposed ACAM, a genetic algorithm（GA） and particle swarm optimization（PSO） are used to optimize the metal structure of a crane. The optimization results show that the convergence speed of ACAM is approximately 20% of that of the GA and around 11% of that of the PSO. The objective function value given by ACAM is 22.23% less than the practical design value, a reduction of 16.42% over the GA and 3.27% over the PSO. The developed ACAM is an effective intelligent method for CMSOD and superior to other methods.

关键词： crane metal structure design optimization continuous array element encoded model ant colony optimization particle swarm optimization genetic algorithm

Multicolor Luminescent Carbon Nanoparticles： Synthesis, Supramolecular Assembly with Porphyrin, Intrinsic Peroxidase-Like Catalytic Activity and Applications

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Nano Research 2011年第9期4卷 908-920页

作者： Xiaohui Wang Konggang qu Bailu Xu Jinsong Ren xiaogang qu Division of Biological Inorganic Chemistry State Key Laboratory of Rare Earth Resource Utilization Laboratory of Chemical Biology Changchun Institute Of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 China Graduate School of the Chinese Academy of Sciences Changchun Jilin 130022 China

Luminescent carbon nanoparticles （CNPs） are newcomers to the world of nanomaterials and have shown great impact in health and environmental applications as well as being promising building blocks for future nanodevices because of their fascinating photoluminescence and potential to serve as nontoxic replacements for traditional heavy-metals-based quantum dots. Herein, fluorescent CNPs have been prepared from candle soot by re fluxing with HNO3 and subsequently separated by a single centrifugation. The CNPs can be represented by the empirical formula C1Ho.677Oo.586No.o15Nao.069, and have a size of 20-100 nm, height of 3.0 nm, lifetime of 7.31 ns ＋ 0.06 ns and quantum yield of -1.7%. Further studies demonstrate that：（1）the as-prepared CNPs exhibit excellent stability in biological media and their luminescence intensity does not change with ionic strength or pH in the physiological and pathological range of pH 4.5-8.8; （2） CNPs can act as electron donors and transporters and porphyrin can assemble onto CNPs through electrostatic and ^-stacking interactions to form porphyrin-CNPs supramolecular composites; （3）CNPs have strong intrinsic peroxidase-like activity. Based on this intrinsic peroxidase activity, a simple, cheap, and highly selective and sensitive colorimetric and quantitative assay has been developed for the detection of glucose levels. This assay has been used to analyze real samples, such as diluted blood and fruit juice.

关键词： Carbon nanoparticles luminescence supramolecular assembly peroxidase biosensing

Enhancing multifunctional photocatalysis with acetate-assisted cesium doping and unlocking the potential of Z-scheme solar water splitting

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Carbon Energy 2024年第3期6卷 178-195页

作者： Mengmeng Ma Jingzhen Li xiaogang Zhu Kong Liu Kaige Huang Guodong Yuan Shizhong Yue Zhijie Wang Shengchun qu Key Laboratory of Semiconductor Materials Science Beijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesInstitute of SemiconductorsChinese Academy of SciencesBeijingChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina Department of Physics College of Physical Science and TechnologyXiamen UniversityXiamenChina State Key Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijingChina

Graphitic carbon nitride(g-C_(3)N_(4))has been extensively doped with alkali metals to enlarge photocatalytic output,in which cesium(Cs)doping is predicted to be the most ***,the sluggish diffusion and doping kinetics of precursors with high melting points,along with imprecise regulation,have raised the debate on whether Cs doping could make *** this matter,we attempt to confirm the positive effects of Cs doping on multifunctional photocatalysis by first using cesium acetate with the character of easy *** optimized Csdoped g-C_(3)N_(4)(CCN)shows a 41.6-fold increase in visible-light-driven hydrogen evolution reaction(HER)compared to pure g-C_(3)N_(4) and impressive degradation capability,especially with 77%refractory tetracycline and almost 100%rhodamine B degradedwithin an *** penetration ofCs+is demonstrated to be a mode of interlayer doping,and Cs–N bonds(especially with sp^(2) pyridine N in C═N–C),along with robust chemical interaction and electron exchange,are *** atomic configuration triggers the broadened spectral response,the improved charge migration,and the activated photocatalytic ***,we evaluate the CCN/cadmium sulfide hybrid as a Z-scheme configuration,promoting the visible HER yield to 9.02 mmol g^(−1) h^(−1),which is the highest ever reported among all CCN *** work adds to the rapidly expanding field of manipulation strategies and supports further development of mediating served for photocatalysis.

关键词： acetate-assisted cesium doping multifunctional photocatalysis Z-scheme