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The role of high mobility group box 1(HMGB1)in the pathogenesis of kidney diseases

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Acta Pharmaceutica Sinica B 2016年第3期6卷 183-188页

作者： Qingjie Chen xiaofeng guan Xiaocong Zuo Jianglin Wang Wenjun Yin Clinical Pharmacy and Pharmacology Research Institute The Third Xiangya Hospital of Central South University School of Pharmaceutical Sciences Central South University

High mobility group box 1 (HMGB1) is a nuclear protein that can bind to DNA and act as a co-factor for gene transcription. When released into extracellular fluid, it plays a proinflammatory role by acting as a damage-associated molecular pattern molecule (DAMP) (also known as an alarmin) to initiate innate immune responses by activating multiple cell surface receptors such as the receptor for advanced glycation end-products (RAGE) and toll-like receptors (TLRs), TLR2, TLR4 or TLR9. This proinflammatory role is now considered to be important in the pathogenesis of a wide range of kidney diseases whether they result from hemodynamic changes, renal tubular epithelial cell apoptosis, kidney tissue fibrosis or inflammation. This review summarizes our current understanding of the role of HMGB1 in kidney diseases and how the HMGB1-mediated signaling pathway may constitute a new strategy for the treatment of kidney diseases. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

关键词： High mobility group box 1 Inflammation Acute kidney injury Chronic kidney disease Diabetic nephropthy Antineutrophil cytoplasmic autoantibody-associated vasculitis Clear cell renal cell carcinoma Nephritis

Influence of Co, W and Ti on the Stress-rupture Lives of a Single Crystal Nickel-base Superalloy

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Journal of Materials Science & Technology 2006年第2期22卷 169-172页

作者： Dayun YANG Tao JIN Nairen ZHAO Zhihui WANG xiaofeng SUN Hengrong guan Zhuangqi HU Department of Superalloy Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

The influence of Co, W and Ti on stress-rupture lives of a Ni-Cr-AI-Mo-Ta-Co-W-Ti single crystal nickel-base superalloy has been investigated using a L9 （34） orthogonal array design （OAD） by statistical analysis. At a selected composition range, Ti content was the most important factor to the effect of the stress-rupture lives and then followed by Co content. W content had the minimum effect on stress-rupture lives. The optimal alloy should contain 10 wt pct Co, 8 wt pct W and zero Ti. The optimized alloy also had good microstructural stability during thermal exposure at 870℃ for 500 h.

关键词： Nickel-base single crystal superalloy Orthogonal array design Stress-rupture

Creep Rupture Behavior of K40S Alloy at Elevated Temperatures

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Journal of Materials Science & Technology 2004年第2期20卷 175-179页

作者： Fumin YANG, xiaofeng SUN, Hengrong guan and Zhuangqi HUInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

Creep testing was conducted on K40S alloy. The detailed creep deformation and fracture mechanisms under constant load were studied. The results show that the stress exponent ranges between 7 and 14.4 at elevated temperature 973~1173 K, and that the activation energy is approximately 449.1 kJ/mol. During creep, the grain boundary sliding cut off primary carbides at the boundary, generating the 'O' model cracks. The creep failure mode of K40S alloy is transgranular ductile and cracks originate at the primary carbides. A long carbide and matrix interface is often a preferential path for crack propagation. The creep mechanism is discussed in light of the creep microstructure, the stress exponent and the activation energy.

关键词： K40S alloy Creep Fracture Crack propagation

Crack growth behavior of SRR99 single crystal superalloy under thermal fatigue

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Rare Metals 2008年第5期27卷 526-530页

作者： LIU Yuan YU Jinjiang XU Yan SUN xiaofeng guan Hengrong HU Zhuangqi Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

The thermal fatigue behavior of a single crystal superalloy SRR99 was investigated. Specimens with V-type notch were tested at the peak temperatures of 900, 1000, and 1100℃. The crack growth curves as a function of the number of cycles were plotted. With the increase of peak temperature, the crack initiation life was shortened dramatically. Through optical microscopy （OM） and scanning electron microscopy （SEM） observation, it was found that multiple small cracks nucleated at the notch tip region but only one or two of them continued to develop in the following thermal cycles. The primary cracks generally propagated along a preferential direction. Microstructure changes after thermal fatigue were also discussed on the basis of SEM observation.

关键词： single crystal superalloy thermal fatigue crack growth behavior dendrite orientation

Effect of Phosphorus on Microstructure and High Temperature Properties of a Cast Ni-base Superalloy

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Journal of Materials Science & Technology 2002年第6期18卷 555-557页

作者： Chao YUAN, Fengshi YIN, xiaofeng SUN, Hengrong guan and Zhuangqi HUInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

Effect of phosphorus on the microstructure and high temperature properties of a cast Ni-base superalloy M963 has been investigated. SEM observation and EDS analysis showed that P was mostly enriched in the interdendritic region, and the P-rich phase was formed in the front position of finally solidified eutectics in high P doped alloys. It was found that the P-rich phase, as preferred initiation and propagation site of cracks, could aggravate the fracture process at high temperature in high P doped alloys. Consequently, high P addition would reduce remarkably the ductility and creep life of M963 superalloy at high temperature.

关键词： Phosphorus Cast superalloy Microstructure Mechanical properties

Self-Q-switched and wavelength-tunable tungsten disulfide-based passively Q-switched Er:Y2O3 ceramic lasers

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Photonics Research 2018年第9期6卷 830-836页

作者： xiaofeng guan JIAWEI WANG YUZHAO ZHANG BIN XU ZHENGQIAN LUO HUIYING XU ZHIPING CAI XIAODONG XU JIAN ZHANG JUN XU Department of Electronic Engineering Xiamen UniversityXiamen 361005China Jiangsu Key Laboratory of Advanced Laser Materials and Devices School of Physics and Electronic EngineeringJiangsu Normal UniversityXuzhou 221116China Key Laboratory of Transparent Opto-functional Inorganic Materials Chinese Academy of SciencesShanghai 201899China School of Physics Science and Engineering Institute for Advanced StudyTongji UniversityShanghai 200092China

We report on diode-pumped Er:Y_2O_3 ceramic lasers at about 2.7 μm in the tunable continuous-wave, selfQ-switching and tungsten disulfide(WS2)-based passively Q-switching regimes. For stable self-Q-switched operation, the maximum output power reaches 106.6 m W under an absorbed power of 2.71 W. The shortest pulse width is measured to be about 1.39 μs at a repetition rate of 26.7 kHz at maximum output. Using a spin-coated WS2 as a saturable absorber, a passively Q-switched Er:Y_2O_3 ceramic laser is also realized with a maximum average output power of 233.5 m W(for the first time, to the best of our knowledge). The shortest pulse width decreases to 0.72 μs at a corresponding repetition rate of 29.4 kHz, which leads to a pulse energy of 7.92 μJ and a peak power of 11.0 W. By inserting an undoped YAG thin plate as a Fabry–Perot etalon, for the passive Q switching, wavelength tunings are also demonstrated at around 2710, 2717, 2727, and 2740 nm.

关键词：陶瓷激光器二极管通讯技术发展现状

Oxidation Behavior of Pd-Modified Aluminide Coating at High Temperature

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Journal of Materials Science & Technology 2003年第3期19卷 213-217页

作者： Mengjin LI, xiaofeng SUN, Hengrong guan, Xiaoxia JIANG Zhuangqi HUState Key Laboratory for Corrosion and Protection, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Lab. for Corrosion and Protection Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

(Ni,Pd)AI coating, prepared by low pressure pack cementation on the Ni-base superalloy M38 where Pd-20 wt pct Ni alloy was predeposited, consists of a single β-(Ni,Pd)AI phase. The initial isothermal oxidation behavior of (Ni,Pd)AI coating was investigated by TGA, XRD, SEM/EDS at 800-1100℃. Results show that oxidation kinetics accord preferably with parabolic law at 800, 900 and 1100℃, but not at 1000℃. θ-AI203 was observed at 800-1100℃. It is found that Pd plays an important role in accelerating the diffusion of Ti from the substrate to the coating surface in the aluminide coating.

关键词： (Ni,Pd)Al coating High temperature oxidation Oxidation kinetics θ-Al_2O_3

Dual-wavelength Bi2Se3-based passively Q-switching Nd3+-doped glass all-fiber laser

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Chinese Optics Letters 2018年第2期16卷 103-107页

作者： xiaofeng Rong Saiyu Luo Wensong Li Shuisen Jiang Xigun Yah xiaofeng guan Zhiyong Zhou Bin Xu Nan Chen Degui Wang Huiying Xu Zhiping Cai Department of Electronic Engineering School of Information Science and EngineeringXiamen UniversityXiamen 361005China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China

We demonstrate a dual-wavelength passively Q-switched Nd^（3＋）-doped glass fiber laser using a few-layer topological insulator Bi2Se3 as a saturable absorber（SA） for the first time, to the best of our knowledge. The laser resonator is a simple and compact linear cavity using two fiber end-facet mirrors. The SA is fabricated by Bi2Se3/polyvinyl alcohol composite film. By inserting the SA into the laser cavity, a stable Q-switching operation is achieved with the shortest pulse width and maximum pulse repetition rate of 601 ns and 205.2 kHz,respectively. The maximum average output power and maximum pulse energy obtained are about 6.6 mW and 38.8 nJ, respectively.

关键词： length doped glass all-fiber laser Dual-wavelength Bi2Se3-based passively Q-switching Nd SA Bi

Desulphurization during VIM Refining Ni-base Superalloy using CaO Crucible

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Journal of Materials Science & Technology 2003年第1期19卷 69-72页

作者： Jianping NIU, Kenu YANG, Tao JIN, xiaofeng SUN, Hengrong guan and Zhuangqi HUInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Chinese Acad Sci Inst Met Res Shenyang 110016 Peoples R China

The variation of S content during VIM refining Ni-base superalloy using CaO crucible was studied. It was foundthat the desulphurization process could not be carried out by only using CaO crucible. The role of Al additionto desulphurization was also studied. Combining with the results of XRD and composition analysis of the CaOcrucible, the mechanism of desulphurization was proposed. Thermodynamical calculation about the reaction betweenthe interface of CaO crucible and liquid metal has been discussed. This work indicated that under proper refiningtechnology the S content in the liquid Ni-base alloy could be reduced from 3×10-5 to 2×10-6~4×10-6.

关键词： Ni-base superalloy CaO crucible VIM Desulphurization