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游戏化激励机制在健康管理产品设计中的应用

鞋类工艺与设计 2024年第16期4卷 147-149页

作者：吴倩莉裘晓菲刘佩燕江汉大学湖北武汉430056

本研究旨在探讨并构建一套适用于健康管理产品的游戏化激励机制设计思路与策略框架。本文采用文献研究法,系统梳理并分析了游戏化激励机制的多种实现方式及其理论基础。深入了解了健康管理过程中用户健康行为介入的不同阶段及其特点。... 详细信息

本研究旨在探讨并构建一套适用于健康管理产品的游戏化激励机制设计思路与策略框架。本文采用文献研究法,系统梳理并分析了游戏化激励机制的多种实现方式及其理论基础。深入了解了健康管理过程中用户健康行为介入的不同阶段及其特点。基于上述分析,构建了一个以用户健康行为介入阶段为核心的游戏化激励机制设计模型。以游戏化激励机制作为创新手段,在健康管理中展现出巨大潜力。

关键词：游戏化激励机制健康管理产品设计

桐柏南缘镁铁质岩席的年代学及地球化学特征:对扬子北缘早奥陶世拉张事件的启示

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地质论评 2024年第S1期70卷 189-190页

作者：江拓赵信文吴琪邱啸飞卢山松邓新赵幸悦子中国地质调查局武汉地质调查中心(中南地质科技创新中心) 武汉430205 自然资源部信息中心北京100812

南秦岭地区古生代岩浆岩以早志留世基性—碱性岩浆岩为主,而缺乏奥陶纪及以前的古生代岩浆记录(Dong Yunpeng et al.,2021),这严重制约了对南秦岭早古生代早期构造演化的理解,尤其是对勉略洋开启时间的认识。镁铁质岩席通常被认为是大... 详细信息

南秦岭地区古生代岩浆岩以早志留世基性—碱性岩浆岩为主,而缺乏奥陶纪及以前的古生代岩浆记录(Dong Yunpeng et al.,2021),这严重制约了对南秦岭早古生代早期构造演化的理解,尤其是对勉略洋开启时间的认识。镁铁质岩席通常被认为是大陆岩石圈伸展条件下岩浆作用的产物,是研究区域构造—岩浆事件性质和意义的重要对象(Zhao Junhong et al.,2010)。

关键词：桐柏造山带早奥陶世镁铁质岩席

First Discovery of Hadean Xenocrystal Zircons from Granitic Gneisses in the Northern Dabie Orogen

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Acta Geologica Sinica(English Edition) 2021年第5期95卷 1775-1776页

作者： qiu xiaofei DENG Xin JIANG Tuo XU Qiong YANG Wenwu Isotope Geochemistry Laboratory Wuhan Center of China Geological SurveyWuhan 430205China Research Center of Petrogenesis and Mineralization of Granitoid Rock China Geological SurveyWuhan 430205China Hubei Key Laboratory of Paleontology and Geological Environment Evolution Wuhan Center of China Geological SurveyWuhan 430205China

Objective Geological records of Earth history in the Hadean(>4.0 Ga)are critical for understanding the earliest evolution of the planet’s continental ***,investigation of such proto-continental crust,including its formation mechanism and evolution,has been extremely limited due to the scarcity of Hadean terranes,because most ancient crustal records have been destroyed during subsequent geological processes.

关键词： continental evolution crustal

NMDA Receptor Antagonist MK801 Protects Against 1-Bromopropane-Induced Cognitive Dysfunction

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Neuroscience Bulletin 2019年第2期35卷 347-361页

作者： Lin Xu xiaofei qiu Shuo Wang Qingshan Wang Xiu-Lan Zhao School of Public Health Shandong University School of Pharmacy Liaocheng University School of Public Health Dalian Medical University

Occupational exposure to 1-bromopropane(1-BP) induces learning and memory deficits. However, no therapeutic strategies are currently available. Accumulating evidence has suggested that N-methyl-D-aspartate receptors(NMDARs) and neuroinflammation are involved in the cognitive impairments in neurodegenerative diseases. In this study we aimed to investigate whether the noncompetitive NMDAR antagonist MK801 protects against 1-BPinduced cognitive dysfunction. Male Wistar rats were administered with MK801(0.1 mg/kg) prior to 1-BP intoxication(800 mg/kg). Their cognitive performance was evaluated by the Morris water maze test. The brains of rats were dissected for biochemical, neuropathological,and immunological analyses. We found that the spatial learning and memory were significantly impaired in the1-BP group, and this was associated with neurodegeneration in both the hippocampus(especially CA1 and CA3)and cortex. Besides, the protein levels of phosphorylated NMDARs were increased after 1-BP exposure. MK801 ameliorated the 1-BP-induced cognitive impairments and degeneration of neurons in the hippocampus and ***, MK801 abrogated the 1-BP-induced disruption of excitatory and inhibitory amino-acid balance and NMDAR abnormalities. Subsequently, MK801 inhibited the microglial activation and release of pro-inflammatory cytokines in 1-BP-treated rats. Our findings, for the first time, revealed that MK801 protected against 1-BP-induced cognitive dysfunction by ameliorating NMDAR function and blocking microglial activation, which might provide a potential target for the treatment of 1-BP poisoning.

关键词： 1-Bromopropane Cognitive dysfunction MK801 N-methyl-D-aspartate receptors Microglia NLRP3 inflammasome

扬子克拉通北部前泥盆纪地壳演化:来自碎屑锆石U-Pb和Hf同位素证据

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地质学报 2022年第11期96卷 3784-3798页

作者：邱啸飞中国地质调查局武汉地质调查中心湖北武汉430205 中南地质科技创新中心湖北武汉430205 中国地质大学(武汉)地质调查研究院湖北武汉430074

扬子克拉通前泥盆纪地壳演化过程一直是地学界研究的热点。本文报道了扬子克拉通北部武汉地区玉笋山剖面的志留系坟头组和泥盆系云台观组碎屑沉积岩中锆石U-Pb年龄和Hf同位素组成。结果表明,武汉地区坟头组和云台观组样品中最年轻的碎... 详细信息

扬子克拉通前泥盆纪地壳演化过程一直是地学界研究的热点。本文报道了扬子克拉通北部武汉地区玉笋山剖面的志留系坟头组和泥盆系云台观组碎屑沉积岩中锆石U-Pb年龄和Hf同位素组成。结果表明,武汉地区坟头组和云台观组样品中最年轻的碎屑锆石年龄分别为430±5 Ma和415±5 Ma,将该地区坟头组和云台观组的沉积时代各限定在中志留世和晚泥盆世。碎屑锆石Hf同位素特点表明,沉积物源区在中太古代、新太古代以及新元古代形成了少量初生地壳,而古老地壳的再造主要发生在新太古代、新元古代和古生代,区域上最显著的初生地壳生长时期则是古元古代。综合对比扬子克拉通北部东、西两侧具有明显不同的锆石U-Pb年龄、微量元素和Hf同位素组成,暗示扬子克拉通可能由多个相对独立地壳演化过程的部分构成,而不具有统一的早前寒武纪基底。

关键词：扬子克拉通北部前泥盆纪武汉地区碎屑锆石地壳演化

2.2Ga Subduction-Related Mafic Magmatic Rocks in the Kongling Complex:Evidence for the Assembly of the Columbia Supercontinent

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Acta Geologica Sinica(English Edition) 2017年第5期91卷 1926-1927页

作者： LU Shansong qiu xiaofei JIANG Tuo PENG Lianhong ZHAO Xiaoming WEI Yunxu DUAN Ruichun WU Nianwen Isotope Geochemistry Laboratory Wuhan Center of Geological Survey Research Center of Petrogenesis and Mineralization of Granitoid Rock China Geological Survey

Objective Petrogenesis of the Paleoproterozoic mafic dikes and their tectonic implications are of great significance to the tectonic evolution of the Yangtze craton as well as the paleoposition of the Yangtze craton r... 详细信息

关键词： Subduction-Related Mafic Magmatic Rocks in the Kongling Complex:Evidence for the Assembly of the Columbia Supercontinent Pb Ga

Decoupled Ce-Nd Isotopic Systematics of the Neoproterozoic Huangling Intrusive Complex and Its Geological Significance, Eastern Three Gorges, South China

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Journal of Earth Science 2016年第5期27卷 864-873页

作者： Yongjuan Gao Wenli Ling xiaofei qiu Ziwan Chen Shansong Lu Xiao Bai Xiujuan Bai Junbo Zhang Hongmei Yang Ruichun Duan Chengdu Institute of Geology and Mineral Resource Chengdu 610081 China State Key Laboratory of Geological Progresses and Mineral Resources China University of Geosciences Wuhan 430074 China School of Earth Sciences China University of Geosciences Wuhan 430074 China Wuhan Center of Geological Survey Wuhan 430205 China

Cerium is one of multivalent rear earth elements, which can transfer from trivalence to tretavalence at oxidizing environment. This process may cause variable degrees of fractionation of Ce from other trivalent rear earth elements, and thus may provide specific insight into the geological processes associated with marked redoxomorphism. Multiple geochemical tracing of Sr-Nd-Ce isotopes are performed on the felsic and mafic intrusives of the Neoproterozoic（~800 Ma） Huangling complex located at the eastern Three Gorges, South China. The intrusive rocks exclusively show various extents of negative Ce anomalies. On the εCe-εNd plot, most samples from the mafic intrusions scatter within the second quadrant, whereas those from the felsic intrusions within the fourth Quadrant. Both of the two groups exhibit relatively large range of ？Ce（t） variation but limited ？Nd（t） range, which cause a deviation from the ＂crustal array＂ and reveal a decoupled Nd-Ce isotope correlation. The intermediate-felsic suite have varied Ce/Ce＊ ratios but broadly proximate εCe（t） values, indicating that their negative Ce anomalies were generated during the magmatism; on the contrary, a positive correlation between εCe（t） and Ce/Ce＊ is observed for the intermediate-mafic suite, an indication of an origin of post-magmatic alteration or metamorphism for their Ce anomalies. Calculation of model age, the occurrence age of negative Ce anomalies（TCe） for the intermediate-mafic samples infers that the alteration events took place 〉350 Ma. Data showed that negative Ce anomalies of the felsic intrusions may reflect an increase of oxygen fugacity during magma ascending, rather than an inheritance from their source rocks. This explanation implies that the Neoproterozoic magmatism occurred at the continental nucleus of the Yangtze block were developing at a geodynamic context of rapidly regional uplifting.

关键词： negative Ce anomalies Ce-Nd isotopic decoupling alteration oxidation environment.

Mesoproterozoic to Paleozoic Nd isotope stratigraphy of the South China continental nucleus and its geological significance

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Science China Earth Sciences 2011年第11期54卷 1665-1674页

作者： BAI Xiao LING WenLi DUAN RuiChun qiu xiaofei LIU ChengXin KUANG Hua GAO YongJuan ZHOU Lian CHEN ZiWan LU Shah-Song State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Wuhan 430074 China Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China Yichang Institute of Geology and Mineral Resources Yichang 443003 China Geological Survey of Hubei Province Wuhan 430030 China

The Yangtze continental nucleus in South China is situated in the Huangling-Shennongjia area in western Hubei *** comprises the early Precambrian crystalline basement and generally successive Proterozoic to Phanerozoic sedimentary *** paper reports a comprehensive Nd isotope study of fine-grained sedimentary rocks from the regional Mesoproterozoic to early Paleozoic *** Nd model ages display a V-shaped variation from ～2.5-2.8 Ga during the late Mesoproterozoic through ～1.5-1.7 Ga during the Neoproterozoic Nanhua Period to ～1.8-2.1 Ga during the Paleozoic Ordovician,with corresponding Nd (t) ranges of 11 to 14,1.1 to 5.3,and 7.9 to 9.9,*** evolutionary trend broadly resembles those documented in the sedimentary strata along the southeastern margin of the Yangtze Craton and within the Jiangnan orogenic belt,indicating that the whole South China block underwent a mantle-input related tectono-magmatic event at ～0.8 Ga or ***,the Huangling-Shennongjia area is discriminated from the other two regions by highly variable model ages (～1.5-2.7 Ga) and Nd (t) values (1.38-12.0) of the early Mesoproterozoic *** with the Archean model ages of the late Mesoproterozoic strata,it is suggested that the Mesoproterozoic sedimentary provenance of the Yangtze continental nucleus was distinct from that of the southeastern Yangtze Craton,likely indicative of an intervening aulacogen (or rift zone) or oceanic *** addition,the high comparability in Neoproterozoic to Paleozoic Nd isotope stratigraphy between the Yangtze Craton and the Jiangnan orogenic belt infers that the whole South China block had shared the same sedimentary basin and provenance since the Yangtze-Cathaysia welding at ～0.9 ***,it is proposed that the Yangtze Craton had comprised a collage of micro-continents during the pre-Neoproterozoic until the Rodinia assemblage when the primitive South China block was formed.

关键词： Yangtze continental nucleus fine-grained sedimentary strata Nd isotope model age micro-continents assemblage

Ore-Forming Material Sources of the Shizishan Pb-Zn Deposit in Western Hunan Province,China

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Acta Geologica Sinica(English Edition) 2016年第5期90卷 1929-1930页

作者： WANG Yunfeng YANG Hongmei qiu xiaofei LU Shansong CAI Yingxiong China University of Geosciences Beijing 100083 China China Academy of Geological Sciences Beijing 10003 7 China Isotope Geochemistry Lab Wuhan Center of Geological Survey China Geological Survey Wuhan 430205 Hubei China Research Center of Petrogenesis and Mineralization of Granitoid Rock China Geological Survey Wuhan 430205 Hubei China

Objective The Shizishan Pb-Zn deposit is located in the southeastern margin of the Yangtze Block,and its Pb-Zn orebodies are mainly hosted in the Lower Cambrian Qingxudong Formation *** researches have investigated th... 详细信息

关键词： Pb Ore-Forming Material Sources of the Shizishan Pb-Zn Deposit in Western Hunan Province,China Zn