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Strain effect on intersubband transitions in rolled-up quantum well infrared photodetectors

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Journal of Semiconductors 2017年第5期38卷 73-77页

作者： Han Wang Shilong Li Honglou Zhen xiaofei nie Gaoshan Huang Yongfeng Mei Wei Lu National Laboratory for Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai 200083 China University of Chinese Academy of Sciences Beijing 100049 China Department of Materials Science Fudan University Shanghai 200433 China

Pre-strained nanomembranes with four embedded quantum wells（QWs） are rolled up into threedimensional（3D） tubular QW infrared photodetectors（QWIPs）,which are based on the QW intersubband transition（ISBT）.A redshift of ～0.42 meV in photocurrent response spectra is observed and attributed to two strain contributions due to the rolling of the pre-strained nanomembranes.One is the overall strain that mainly leads to a redshift of ～0.5 meV,and the other is the strain gradient which results in a very tiny variation.The blue shift of the photocurrent response spectra with the external bias are also observed as quantum-confined Stark effect（QCSE）in the ISBT.

关键词： quantum well infrared photodetector rolled-up microtube strain Stark effect

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产妇产后创伤后成长质性研究的Meta整合

军事护理 2024年第6期41卷 94-97,102页

作者：文铭浚王睿程利聂小菲彭忠帆陈功张桃桃湖北医药学院护理学院湖北十堰442000

目的系统评价和整合产妇产后创伤后成长体验的质性研究,为产科护理实践提供参考。方法计算机检索建库至2023年2月发表于PubMed、Cochrane Library、Web of science、Embase、中国知网、维普、万方、SinoMed中有关产妇产后创伤后成长... 详细信息

目的系统评价和整合产妇产后创伤后成长体验的质性研究,为产科护理实践提供参考。方法计算机检索建库至2023年2月发表于PubMed、Cochrane Library、Web of science、Embase、中国知网、维普、万方、SinoMed中有关产妇产后创伤后成长的质性研究,并采用Meta整合方法对结果进行整合。结果纳入11项研究,共提取44个研究结果,归纳为13个类别,得到4个整合结果,即影响因素、自我反思、采取行动、多元发展。结论医护人员应正确理解创伤后成长内涵,挖掘产妇产后积极心理体验,采取措施帮助其应对分娩创伤。

关键词：创伤后成长产妇质性研究 Meta整合

疼痛评估知识和信心自我感知量表在安宁疗护医护人员中的应用研究

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中国社会医学杂志 2024年第2期41卷 200-204页

作者：吕翻翻李龙倜贾佳聂小菲十堰市太和医院·湖北医药学院附属医院服务质量办公室湖北十堰442000 十堰市太和医院·湖北医药学院附属医院护理部湖北十堰442000 湖北医药学院护理学院湖北十堰442000

目的汉化疼痛评估知识和信心自我感知量表,并在安宁疗护医护人员群体中检验其信效度。方法先翻译原量表,再回译和跨文化调试,形成中文版疼痛评估知识和信心自我感知量表。于2022年1月便利抽取湖北省某市三甲医院的临床安宁疗护医护人员... 详细信息

目的汉化疼痛评估知识和信心自我感知量表,并在安宁疗护医护人员群体中检验其信效度。方法先翻译原量表,再回译和跨文化调试,形成中文版疼痛评估知识和信心自我感知量表。于2022年1月便利抽取湖北省某市三甲医院的临床安宁疗护医护人员303人作为研究对象,在该人群中检验汉化量表的信效度。结果中文版疼痛评估知识和信心自我感知量表包括17个条目,Cronbach'sα系数为0.935,重测信度系数为0.930;总量表的内容效度指数为0.920,各条目内容效度指数在0.830~1.000之间;该量表是三因素量表,累计方差贡献率为73.329%,各拟合系数均接近于0.900。结论中文版疼痛评估知识和信心自我感知量表具有较好的信效度,可作为我国安宁疗护医护人员对临终患者疼痛评估能力自我评价的可靠性工具。

关键词：安宁疗护疼痛评估医护人员信度效度

Variations of Farming Systems and Their Impacts on Surface Water Environment in Past 60 Years in Intensive Agricultural Area of Taihu Region, China

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Journal of Water Resource and Protection 2015年第8期7卷 647-658页

作者： Xinyan Li Hengpeng Li Guishan Yang Nkotagu Hudson Huan Zhang xiaofei nie Key Laboratory of Lake and Environment Key Laboratory of Basin Geology Chinese Academy of Sciences Nanjing Institute of Geography and Limnology Nanjing China Department of Geology University of Dar es Salaam Dar es Salaam Tanzania School of Geographic and Oceanographic Sciences Nanjing University Nanjing China

Based on agricultural nitrogen (N) balance model and field experiments, the impacts of farming system changes of Taihu Region of China on surface water environment were studied. During past 60 years, farming systems changed greatly in Taihu Region. The traditional method of manure collection and application was replaced by chemical fertilizer utilization gradually. Chemical N fertilization intensity decreased greatly due to the abolition of “3 crops per year” and reduction of cropland area in 1990-2010. Crops depleting soil fertility increased, while those improving soil fertility decreased, leading to an excessive dependence on chemical fertilizer application, which increased the risks of soil N loss to surface water environment in Taihu region. However, field experiments showed that the agricultural N loss with runoff only accounted for 2% of fertilizer N application rate. The majority of N was exported by crop harvesting. Our findings showed that the agricultural N loss might not be the main source of N pollution in Lake Tai after 2000. To control N pollution of Lake Tai, more attention should be paid to industrial and domestic wastewater from urban and rural areas, wastes from livestock and poultry breeding, bait input for aquaculture, etc in the Taihu Region, China.

关键词： Farming Systems Agricultural Nitrogen Balance Fertilization Environmental Pollution Taihu

双胎妊娠合并StanfordA型主动脉夹层患者行剖宫产及孙氏手术的围手术期护理

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中华急危重症护理杂志 2024年第4期5卷 338-340页

作者：陈功张桃桃聂小菲程利罗湘玉郭菁菁文铭浚湖北医药学院护理学院十堰市442000

总结1例双胎妊娠合并StanfordA型主动脉夹层患者行剖宫产及孙氏手术的围手术期护理体会。针对患者夹层撕裂范围广、双胎且处于孕晚期、护理难度大的特点,术前合理搬运、控制好心率及血压、保护胎儿,平稳过渡至手术;术中预防压力性损伤,... 详细信息

总结1例双胎妊娠合并StanfordA型主动脉夹层患者行剖宫产及孙氏手术的围手术期护理体会。针对患者夹层撕裂范围广、双胎且处于孕晚期、护理难度大的特点,术前合理搬运、控制好心率及血压、保护胎儿,平稳过渡至手术;术中预防压力性损伤,加强体温管理;术后对循环及容量精细化管控、连续性肾脏替代治疗清除体内水分和毒素、预防并发症,同时加强营养支持、落实产科护理、实施个性化心理支持。经过43d精心治疗和护理,患者顺利出院,母婴结局良好。

关键词：妊娠,双胎动脉瘤,夹层剖宫产术围手术期护理

Low-dose fractionated radiation reverses cisplatin resistance in ovarian cancer cells via PI3K/AKT/GSK-3β signaling

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Oncology and Translational Medicine 2017年第5期3卷 203-209页

作者： Xiangmin Jia Jie Ming xiaofei nie Donghai Liang Tao Jiang Shihai Liu Hongsheng Yu Department of Oncology The Affiliated Hospital of Qingdao University Department of Ultrasound The Central Hospital of Linyi

Objective To investigate whether low-dose fractionated radiation(LDFRT) could enhance cisplatin sensitivity in drug-resistant human ovarian cancer cells SKOV3/DDP, and to further explore the underlying mechanism.Methods SKOV3/DDP ovarian cancer cells were divided into three groups as follows: control, LDFRT, and conventional-dose radiation groups. Cells from all three groups were treated with different concentrations of cisplatin(0, 1.25, 2.5, 5, 10, and 20 μg/m L) for 48 h. The proliferation inhibition rate was investigated using the cell counting kit 8(CCK8). The rate of apoptosis was determined by flow cytometry(FCM). Protein levels of AKT, P-AKT, GSK-3β, P-GSK-3β, P21, cyclin D1, and P27 were examined by Western blotting. Results As expected, LDFRT significantly reduced the half-maximal inhibitory concentration(IC50) of cisplatin and promoted apoptosis in SKOV3/DDP cells. Moreover, in the LDFRT group, protein levels of P-AKT, P-GSK-3β, and cyclin D1 were markedly decreased, those of P21 and P27 were greatly increased, and total AKT and GSK-3β levels showed no significant difference compared to those in both the control and conventional-dose radiation groups.Conclusion LDFRT sensitizes resistant SKOV3/DDP ovarian cancer cells to cisplatin through inactivation of PI3 K/AKT/GSK-3β signaling.

关键词： low-dose fractionated radiation (LDFRT) cisplatin-resistance ovarian cancer PI3K/AKT/GSK-3β pathway

营养风险筛查与评估工具在脑卒中病人中的应用研究进展

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循证护理 2024年第9期10卷 1577-1582页

作者：饶真真杨宝义李亚玲聂小菲袁杰湖北医药学院护理学院湖北442000 十堰市太和医院

综述国内外营养风险筛查与评估工具的主要内容、特点及其在脑卒中病人中的应用情况与局限性。建议根据现有普适性工具特点,结合脑卒中病人专科疾病特点,开发适合脑卒中病人的营养风险筛查与评估工具,为脑卒中病人营养风险精细化管理提... 详细信息

综述国内外营养风险筛查与评估工具的主要内容、特点及其在脑卒中病人中的应用情况与局限性。建议根据现有普适性工具特点,结合脑卒中病人专科疾病特点,开发适合脑卒中病人的营养风险筛查与评估工具,为脑卒中病人营养风险精细化管理提供参考依据。

关键词：脑卒中营养不良营养风险筛查评估工具综述

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A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys

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Neuroscience Bulletin 2024年第1期40卷 90-102页

作者： Yefei Chen Jingyi Wang Jing Liu Jianbang Lin Yunping Lin Jinyao nie Qi Yue Chunshan Deng xiaofei Qi Yuantao Li Ji Dai Zhonghua Lu Department of Anesthesiology Shenzhen Maternity and Child Healthcare HospitalThe First School of Clinical MedicineSouthern Medical UniversityShenzhen 518027China Shenzhen Technological Research Center for Primate Translational Medicine Shenzhen Key Laboratory for Molecular Biology of Neural DevelopmentShenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Biomedical Research Institute Hubei University of MedicineShiyan 442000China Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Retrograde adeno-associated viruses(AAVs)are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural networks.However,few retro-grade AAV capsids have been shown to offer access to cor-tical projection neurons across different species and enable the manipulation of neural function in non-human primates(NHPs).Here,we report the development of a novel retro-grade AAV capsid,AAV-DJ8R,which efficiently labeled cortical projection neurons after local administration into the striatum of mice and macaques.In addition,intrastriatally injected AAV-DJ8R mediated opsin expression in the mouse motor cortex and induced robust behavioral alterations.Moreover,AAV-DJ8R markedly increased motor cortical neuron firing upon optogenetic light stimulation after viral delivery into the macaque putamen.These data demonstrate the usefulness of AAV-DJ8R as an efficient retrograde tracer for cortical projection neurons in rodents and NHPs and indicate its suitability for use in conducting functional interrogations.

关键词： Retrograde AAV Capsid variant Cortical projection neuron Optogenetics Monkey

Enhanced identification and localization of metabolites in Scutellariae Radix using ion mobility enabled MALDI-Q-TOF/MS imaging

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Journal of Pharmaceutical Analysis 2024年第2期14卷 284-286页

作者： Lixing nie Lieyan Huang xiaofei Jia Shuai Kang Lingwen Yao Yanpei Wu Hao Yuan Yongli Liu Feng Wei Hongyu Jin Xiang Li Shuangcheng Ma National Institutes for Food and Drug Control Beijing102629China Chinese Academy of Medical Science and Peking Union Medical College Beijing100006China Waters Corporation Beijing102600China Hebei Institute for Drug and Medical Device Control Shijiazhuang050227China Department of Pharmacy Medical Supplies Center of the PLA General HospitalBeijing100853China

Unraveling the distribution of metabolites in traditional Chinese medicine(TCM)provides direct indications for understanding their regulatory and functional basis,which is of paramount significance for better utilization and quality control of medicinal plants[1].Recently,imaging techniques such as near-infrared spectroscopy,Raman spectroscopy,and mass spectrometry(MS)were explored to reveal the spatial context of component accumulation and localization[2,3].

关键词： medicine(TCM) Radix Scutellaria