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High-resolution tsunami hazard assessment for the Guangdong-Hong Kong-Macao Greater Bay Area based on a non-hydrostatic tsunami model

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Science China Earth Sciences 2024年第7期67卷 2326-2351页

作者： Yifan ZHU Chao AN Houyun YU Wei ZHANG xiaofei chen Key Laboratory of Hydrodynamics(Ministry of Education) School of Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Earth and Space Sciences Southern University of Science and Technology Shenzhen 518055China

The Guangdong-Hong Kong-Macao Greater Bay Area(GBA)is threatened by potential tsunami hazards from the Littoral Fault Zone(LFZ)and the Manila subduction zone(MSZ),and may suffer huge damage because of its dense population,concentrated infrastructure,and low-lying coasts.Previous tsunami studies for the GBA made simple assumptions on the mechanisms of LFZ earthquakes,and used coarse bathymetry data in tsunami simulation,which limited the prediction of detailed tsunami hazard characteristics.In this paper,we develop a parallel dispersive tsunami model PCOMCOT to efficiently simulate dispersive,nonlinear,and breaking tsunami waves.We also construct large-scale and high-resolution bathymetry models for the GBA by correcting and integrating various data sources.Dynamic rupture simulation is performed for the LFZ to obtain a more reliable earthquake source model.We propose several representative earthquake scenarios for the LFZ and MSZ,and use PCOMCOT to calculate the resulting tsunami waves,currents,and inundation in the GBA.Our results indicate that if an M_(w)7.5 oblique-slip earthquake occurs in the LFZ off the Pearl River Estuary(PRE),the subsequent tsunami will primarily impact Hong Kong,causing maximum positive and negative waves of around 1 m and -2 m,respectively,along with slightly destructive currents(≥1.5 m/s).An M_(w)9.0 MSZ megathrust earthquake can lead to widespread inundation with>1 m depth on the outlying islands of Macao and in the urban areas of Hong Kong around the Victoria Harbour.Besides,it will also cause catastrophic tsunami currents along the narrow waterways in Hong Kong and Macao,and the spatial distribution of strong currents(≥3 m/s)shows a considerable discrepancy from the areas of serious inundation.Thus,more attention should be paid to the potential impacts of tsunami currents on the GBA.

关键词： Tsunami hazards Inundation Tsunami currents Non-hydrostatic model Guangdong-Hong Kong-Macao Greater Bay Area

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Influence of self-similar stresses on scenario earthquake construction:An example along the Tanlu Fault

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Science China Earth Sciences 2024年第5期67卷 1687-1697页

作者： Feng HU Huajian YAO Houyun YU Zeyu LU Jieyi HOU Song LUO Zhigang SHAO xiaofei chen School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Mengcheng Geophysical National Field Scientific Observatory Hefei 230026China Department of Earth and Space Science Southern University of Science and TechnologyShenzhen 518055China Institute of Earthquake Prediction China Earthquake AdministrationBeijing 100036China

As a famous deep and large fault in eastern China,the Tanlu Fault passes through Anhui,Jiangsu,and Shandong and into northeastern China.It is important to improve the understanding of seismic hazard assessments in areas near faults.We start a scenario earthquake simulation in the M7.5 earthquake potential area of the Xinyi-Sihong segment of the Tanlu Fault.The fault rupture length and width are constrained according to the scaling law of large intraplate earthquakes,the background normal stress is depth dependent,and the initial shear stresses are determined using trial and error by matching the earthquake magnitude.Considering the 120 km rupture length of the M7.5 earthquake,we compare the horizontal uniform stress model and self-similar stress perturbation model.Our findings reveal that the seismic source time function of the horizontal uniform stress model is similar to that of the Haskell model and that of the self-similar stress perturbation model is more similar to that of a real earthquake case.We compare the dynamic rupture simulation and ground motion results under four different stress conditions and find that the shorter the characteristic length of the self-similar function is,the rougher the initial stress.For the M7.5earthquake with an epicenter in the vicinity of Suqian,the Xinyi-Tancheng segment,which is located in the IX-intensity zone north of the epicenter,vibrates more strongly on the northern side than on the southern side due to the influence of the lowvelocity zone and the peak slip rate.The response spectra analysis at stations in the study area is useful for improving the earthquake resistance capability.

关键词： Scenario earthquakes Self-similar stress Tanlu Fault Dynamic rupture Ground motion

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Application of artificial hibernation technology in acute brain injury

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Neural Regeneration Research 2024年第9期19卷 1940-1946页

作者： Xiaoni Wang Shulian chen Xiaoyu Wang Zhen Song Ziqi Wang xiaofei Niu Xiaochu chen Xuyi chen Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina

Controlling intracranial pressure,nerve cell regeneration,and microenvironment regulation are the key issues in reducing mortality and disability in acute brain injury.There is currently a lack of effective treatment methods.Hibernation has the characteristics of low temperature,low metabolism,and hibernation rhythm,as well as protective effects on the nervous,cardiovascular,and motor systems.Artificial hibernation technology is a new technology that can effectively treat acute brain injury by altering the body’s metabolism,lowering the body’s core temperature,and allowing the body to enter a state similar to hibernation.This review introduces artificial hibernation technology,including mild hypothermia treatment technology,central nervous system regulation technology,and artificial hibernation-inducer technology.Upon summarizing the relevant research on artificial hibernation technology in acute brain injury,the research results show that artificial hibernation technology has neuroprotective,anti-inflammatory,and oxidative stress-resistance effects,indicating that it has therapeutic significance in acute brain injury.Furthermore,artificial hibernation technology can alleviate the damage of ischemic stroke,traumatic brain injury,cerebral hemorrhage,cerebral infarction,and other diseases,providing new strategies for treating acute brain injury.However,artificial hibernation technology is currently in its infancy and has some complications,such as electrolyte imbalance and coagulation disorders,which limit its use.Further research is needed for its clinical application.

关键词： cute brain injury artificial hibernation hypothermia low metabolism mild hypothermia

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Efficacy and safety of Y- 2 sublingual tablet for patients with acute ischaemic stroke: protocol of a phase III randomised double- blind placebo- controlled multicentre trial

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Stroke & Vascular Neurology 2024年第1期9卷 90-95页

作者： Yu Fu Renhong Tang Rong chen Anxin Wang Jinsheng Ren Shunwei Zhu xiaofei Feng Dongsheng Fan Deparment of Neurology Peking University Third HospitalBeijingChina State Key Laboratory of Neurology and Oncology Drug Development NanjingJiangsuChina Simcere Pharmaceutical Group Limited NanjingJiangsuChina Neurodawn Pharmaceutical Co. LtdNanjingJiangsuChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose Clinical studies have demonstrated that edaravone dexborneol can improve the functional outcomes in patients with acute ischaemic stroke(AIS).The present clinical trial aimed at testing the efficacy and safety of Y-2 sublingual tablet on 90-day functional outcome in patients with AIS.Methods and design This is a randomised,double-blind,placebo-controlled,multicentre,parallel-group trial of Y-2 sublingual tablet on patients with AIS.An estimated 914 patients at age of 18–80 years with AIS within 48 hours after symptom onset from 40 hospitals will be randomly assigned to receive Y-2 sublingual tablet or placebo for 14 days.Patients are at score 6–20 points on National Institutes of Health Stroke Scale(NIHSS)and had a modified Rankin Scale(mRS)≤1 before this stroke,except mechanical thrombectomy and neuroprotective agents treatment.Study outcomes The primary outcome is the proportion of patients with mRS≤1 on day 90 after randomisation.Secondary efficacy outcomes include mRS score on day 90,the proportion of patients with mRS≤2 on day 90;the change of NIHSS score from baseline to day 14 and the proportion of patients with NIHSS score≤1 at the days 14,30 and 90.Discussion This trial will provide valuable evidence for the efficacy and safety of Y-2 sublingual table for improving 90 days the functional outcomes in patients with AIS.Trial registration number NCT04950920.

关键词： patients protective centre

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Aqueous-phase formation of N-containing secondary organic compounds affected by the ionic strength

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Journal of Environmental Sciences 2024年第4期138卷 88-101页

作者： Yuqi Gan Xiaohui Lu Shaodong chen Xinghua Jiang Shanye Yang Xiewen Ma Mei Li Fan Yang Yewen Shi xiaofei Wang Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Guangdong Provincial Observation and Research Station for Coastal Atmosphere and Climate of the Great Bay Area Southern University of Science and TechnologyShenzhen 518055China Institute of Mass Spectrometry and Atmospheric Environment Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air PollutionJinan UniversityGuangzhouChina Environmental Monitoring Station of Pudong New District Shanghai 201200China Shanghai Municipal Center for Disease Control&Prevention Shanghai 200336China

The reaction of carbonyl-to-imine/hemiaminal conversion in the atmospheric aqueous phase is a critical pathway to produce the light-absorbing N-containing secondary organic compounds(SOC).The formation mechanism of these compounds has been wildly investigated in bulk solutions with a low ionic strength.However,the ionic strength in the aqueous phase of the polluted atmosphere may be higher.It is still unclear whether and to what extent the inorganic ions can affect the SOC formation.Here we prepared the bulk solution with certain ionic strength,in which glyoxal and ammonium were mixed to mimic the aqueous-phase reaction.Molecular characterization by High-resolution Mass Spectrometry was performed to identify the N-containing products,and the light absorption of the mixtures was measured by ultraviolet-visible spectroscopy.Thirty-nine N-containing compounds were identified and divided into four categories(N-heterocyclic chromophores,high-molecular-weight compounds with N-heterocycle,aliphatic imines/hemiaminals,and the unclassified).It was observed that the longer reaction time and higher ionic strength led to the formation of more N-heterocyclic chromophores and the increasing of the lightabsorbance of the mixture.The added inorganic ions were proposed to make the aqueous phase somewhat viscous so that the molecules were prone to undergo consecutive and intramolecular reactions to form the heterocycles.In general,this study revealed that the enhanced ionic strength and prolonged reaction time had the promotion effect on the lightabsorbing SOC formation.It implies that the aldehyde-derived aqueous-phase SOC would contribute more light-absorbing particulate matter in the industrial or populated area where inorganic ions are abundant.

关键词： Ionic strength Carbonyl-to-imine/hemiaminal Heterocyclic Brown carbon Mass spectrometry Aqueous-phase reaction

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iTRAQ-based Quantitative Proteomic Profiling of the Regulatory Mechanisms on Immune Functions and Blood Lipids in Aged Mice Fed with Lentinula edodes-Derived Polysaccharides

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Food Science and Human Wellness 2024年

作者： xiaofei Xu xiaofei Liu Jin chen Jingjing Guan Donghui Luo College of Food Science and Engineering Guangdong Ocean University

The mechanisms of mushroom polysaccharides on immune functions and lipid metabolism of aged mammals have not been fully elucidated. In the present study， after assessing the impacts of one type of Lentinula edodes-derived polysaccharides， named L2， on immune functions and blood lipid profiles， isobaric tags for relative and absolute quantification (iTRAQ)-based proteomic profiling of the small intestinal tissues from aged mice treated with L2 was performed. L2 reversed immune function declines and modulated the lipid metabolism of aged mice evidenced by increased levels of serum TC， HDL-C， and LDL-C， and reduced levels of serum TG. Moreover， a total of 95 differentially regulated proteins (DRPs) were identified， of which 75 were up-regulated and 20 were down-regulated. Most of the DRPs were involved in intracellular and extracellular structure organization， and cellular and metabolic regulation. Particularly， approximately 16 and 9 DRPs participated in the regulation of immune functions and lipid metabolism， respectively. Furthermore， protein-protein interaction analysis highlighted that cadherin 1， plectin， cadherin-17， Ras GTPase-activating-like protein IQGAP2， and ezrin might be key proteins in response to L2 treatment. These findings provide new insights into the biological mechanisms of mushroom polysaccharides in anti-aging from a proteomic perspective.

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Built defects of homogeneous junction to enhance the lithium storage capacity of niobium pentoxide materials

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Journal of Energy Chemistry 2024年第5期92卷 730-737页

作者： Huibin Ding Yang Luo Zihan Song Cong chen Kai Feng xiaofei Yang Hongzhang Zhang Xianfeng Li Division of Energy Storage National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China College of Chemistry&Engineering Yantai UniversityYantai 264005ShandongChina

Niobium pentoxide(Nb_(2)O_(5))is deemed one of the promising anode materials for lithium-ion batteries(LIBs)for its outstanding intrinsic fast Li-(de)intercalation kinetics.The specific capacity,however,is still limited,because the(de)intercalation of excessive Li-ions brings the undesired stress to damage Nb_(2)O_(5) crystals.To increase the capacity of Nb_(2)O_(5) and alleviate the lattice distortion caused by stress,numerous homogeneous H-and M-phases junction interfaces were proposed to produce coercive stress within theNb_(2)O_(5)crystals.Such interfaces bring about rich oxygen vacancies with structural shrinkage tendency,which pre-generate coercive stress to resist the expansion stress caused by excessive Li-ions intercalation.Therefore,the synthesized Nb_(2)O_(5) achieves the highest lithium storage capacity of 315 mA h g−1 to date,and exhibits high-rate performance(118 mA h g^(-1) at 20 C)as well as excellent cycling stability(138 mA h g^(-1) at 10 C after 600 cycles).

关键词： Niobiumpent oxide Homojunction polycrystalline Defects Oxygen vacancy

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Topological pseudospin switcher:Mechanism and acoustic realization

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 46-53页

作者： Jia-He chen Yiyin chen Yaoqieyu Song Yongxu Xu Xinrong Li Jingsong Wang Jiawei He Jiaxu Qu Zheng Li xiaofei Li Wenqiang Lin Jiannan chen Caixing Fu Zhi Hong Hang School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China Institute for Advanced Study Soochow UniversitySuzhou 215006China Provincial Key Lab of Thin Films Soochow UniversitySuzhou 215006China

The control of the pseudospin of sound wave has attracted increasing attention in recent years.Utilizing the finite-size effect of topological acoustics,we successfully construct an H-shaped acoustic topological pseudospin switcher that sound wave energy can be easily switched through different passages.The interesting phenomenon of pseudospin flipping is numerically and experimentally demonstrated.A quantitative interference theory is proposed that the constructive and destructive interference of pseudospin states leads to pseudospin flipping and preserving in multiple frequencies.We verify the key parameters of the design,including the length of the passage and its interface state dispersion,and the theory can be extended to other topology acoustics and photonics systems.Moreover,the tunable topological sonic crystal we use provides adjustable convenience to pseudospin switcher design.The pseudospin switching behavior offers an efficient method to control the acoustic topological edge state transport,which has great potential in versatile applications,such as integrated acoustics,acoustic security,and information processing.

关键词： topological acoustics realization

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A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys

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Neuroscience Bulletin 2024年第1期40卷 90-102页

作者： Yefei chen Jingyi Wang Jing Liu Jianbang Lin Yunping Lin Jinyao Nie Qi Yue Chunshan Deng xiaofei Qi Yuantao Li Ji Dai Zhonghua Lu Department of Anesthesiology Shenzhen Maternity and Child Healthcare HospitalThe First School of Clinical MedicineSouthern Medical UniversityShenzhen 518027China Shenzhen Technological Research Center for Primate Translational Medicine Shenzhen Key Laboratory for Molecular Biology of Neural DevelopmentShenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Biomedical Research Institute Hubei University of MedicineShiyan 442000China Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Retrograde adeno-associated viruses(AAVs)are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural networks.However,few retro-grade AAV capsids have been shown to offer access to cor-tical projection neurons across different species and enable the manipulation of neural function in non-human primates(NHPs).Here,we report the development of a novel retro-grade AAV capsid,AAV-DJ8R,which efficiently labeled cortical projection neurons after local administration into the striatum of mice and macaques.In addition,intrastriatally injected AAV-DJ8R mediated opsin expression in the mouse motor cortex and induced robust behavioral alterations.Moreover,AAV-DJ8R markedly increased motor cortical neuron firing upon optogenetic light stimulation after viral delivery into the macaque putamen.These data demonstrate the usefulness of AAV-DJ8R as an efficient retrograde tracer for cortical projection neurons in rodents and NHPs and indicate its suitability for use in conducting functional interrogations.

关键词： Retrograde AAV Capsid variant Cortical projection neuron Optogenetics Monkey

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Seismic prompt gravity strain signals in a layered spherical Earth

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Earthquake Science 2023年第5期36卷 341-355页

作者： Shenjian Zhang Rongjiang Wang xiaofei chen Department of Earth and Space Sciences Southern University of Science and TechnologyShenzhen 518055China Helmholtz Center Potsdam GFZ German Research Center for GeosciencesD-14473 PotsdamGermany Guangdong Provincial Key Laboratory of Geophysical High-resolution Imaging Technology Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of Deep Offshore Oil and Gas Exploration Technology Southern University of Science and TechnologyShenzhen 518055China

Seismic waves generated by an earthquake can produce dynamic perturbations in the Earth’s gravity field before the direct arrival of P-waves.Observations of these so-called prompt elasto-gravity signals by ground-based gravimeters and broadband seismometers have been reported for some large events,such as the 2011 M_(W)9.1 Tohoku earthquake.Recent studies have introduced prompt gravity strain signals(PGSSs)as a new type of observable seismic gravity perturbation that can be used to measure the spatial gradient of the perturbed gravity field.Theoretically,these types of signals can be recorded by indevelopment instruments termed gravity strainmeters,although no successful detection has been reported as yet.Herein,we propose an efficient approach for PGSSs based on a multilayered spherical Earth model.We compared the simulated waveforms with analytical solutions obtained from a homogeneous half-space model,which has been used in earlier studies.This comparison indicates that the effect of the Earth’s structural stratification is significant.With the help of the new simulation approach,we also demonstrated how the PGSSs depend on the magnitude of the seismic source.We further conducted synthetic tests estimating earthquake magnitude using gravity strain signals to demonstrate the potential application of this type of signal in earthquake early warning systems.These results provide essential information for future studies on the synthesis and application of earthquake-induced gravity strain signals.

关键词： gravity strain synthetic seismogram earthquake early warning system

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