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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg xiaofei li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

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SDN中DDoS攻击检测与混合防御技术

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现代电子技术 2025年第2期48卷 85-89页

作者：李小菲陈义河北大学信息技术中心河北保定071002 河北大学计算机教学部河北保定071001

DDoS攻击是软件定义网络(SDN)安全领域的一大威胁,严重威胁网络控制器及交换机等设备的正常运行,因此提出一种SDN中DDoS攻击检测与混合防御技术。在DDoS攻击检测方面,利用卡方检验值对SDN中控制器收到的Packet_In数据流内数据帧数量进... 详细信息

DDoS攻击是软件定义网络(SDN)安全领域的一大威胁,严重威胁网络控制器及交换机等设备的正常运行,因此提出一种SDN中DDoS攻击检测与混合防御技术。在DDoS攻击检测方面,利用卡方检验值对SDN中控制器收到的Packet_In数据流内数据帧数量进行统计分析,将高于数据流卡方阈值的数据流初步判断为可疑流;继续计算数据流与可疑流的相对Sibson距离,区分可疑流是DDoS攻击流还是正常突发流;最后通过计算数据流之间的Sibson距离,根据DDoS攻击流的特征,确定攻击流是否为DDoS攻击流。在DDoS攻击防御方面,采用共享流表空间支持和Packet_In报文过滤方法混合防御,被DDoS攻击的交换机流表空间过载,将过载流表引流到其他交换机,从而完成数据层的防御;溯源得到DDoS攻击MAC地址并进行Packet_In数据流过滤,完成控制层的防御。实验结果表明,所提方法可有效检测软件定义网络交换机和控制器内的DDoS攻击流,能够防御不同的DDoS攻击。

关键词：软件定义网络 DDoS攻击流攻击检测混合防御卡方检验值 Sibson距离流表空间共享

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Doppler spectral analysis for time-evolving sea surfaces using second-order small slope approximation

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Journal of Systems Engineering and Electronics 2011年第5期22卷 754-759页

作者： xiaofei li Xiaojian Xu School of Electronics and Information Engineering Beihang University Beijing 100191 P. R. China

The second-order small slope approximation （SSA2） method is introduced to study the Doppler characteristics from time-evolving sea surfaces. Simulation results show better agreement between the SSA2 model and the numerical method for both vertical and horizontal polarizations, meaning that SSA2 gives a satisfactory prediction of the spectral difference between two po- larizations; while such discrepancy cannot be captured using the lowest-order SSA （SSA1） model. In particular, the Doppler shifts and spectral widths for different incident angles, wind directions and polarizations are analyzed, demonstrating correct variations with respect to such parameters. Those observations prove that the SSA2 provides an efficient and relatively fast tool for sea surface Doppler spectral analysis.

关键词： rough sea surface electromagnetic scattering sma slope approximation Doppler spectra.

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Projections of temperature extremes based on preferred CMIP5 models:a case study in the Kaidu-Kongqi River basin in Northwest China

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Journal of Arid Land 2021年第6期13卷 568-580页

作者： CHEN li XU Changchun li xiaofei MOE Key Laboratory of Oasis Ecology College of Resource and Environment SciencesXinjiang UniversityUrumqi 830000China School of Civil Engineering and Environmental Science University of OklahomaNorman OK 73072USA

The extreme temperature has more outstanding impact on ecology and water resources in arid regions than the average *** the downscaled daily temperature data from 21 Coupled Model Inter-comparison Project(CMIP)models of NASA Earth Exchange Global Daily Downscaled Projections(NEX-GDDP)and the observation data,this paper analyzed the changes in temporal and spatiotemporal variation of temperature extremes,i.e.,the maximum temperature(Tmax)and minimum temperature(Tmin),in the Kaidu-Kongqi River basin in Northwest China over the period 2020–2050 based on the evaluation of preferred Multi-Model Ensemble(MME).Results showed that the Partial Least Square ensemble mean participated by Preferred Models(PM-PLS)was better representing the temporal change and spatial distribution of temperature extremes during 1961–2005 and was chosen to project the future *** 2020–2050,the increasing rate of Tmax(Tmin)under RCP(Representative Concentration Pathway)8.5 will be 2.0(1.6)times that under RCP4.5,and that of Tmin will be larger than that of Tmax under each corresponding *** will keep contributing more to global warming than *** spatial distribution characteristics of Tmax and Tmin under the two RCPs will overall the same;but compared to the baseline period(1986–2005),the increments of Tmax and Tmin in plain area will be larger than those in mountainous *** the emission concentration increased,however,the response of Tmax in mountainous area will be more sensitive than that in plain area,and that of Tmin will be equivalently sensitive in mountainous area and plain *** impacts induced by Tmin will be universal and *** of spatiotemporal variation of temperature extremes indicate that large increases in the magnitude of warming in the basin may occur in the *** projections can provide the scientific basis for water and land plan management and disaster prevention and mitigation in the inland river basin.

关键词： temperature extremes multi-model ensemble RCP projection Kaidu-Kongqi River basin

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Bending Deformation of Multilayered One-Dimensional Quasicrystal Nanoplates Based on the Modified Couple Stress Theory

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Acta Mechanica Solida Sinica 2019年第6期32卷 785-802页

作者： xiaofei li Junhong Guo Tuoya Sun Department of Mechanics Inner Mongolia University of TechnologyHohhot 010051China

The modified couple stress theory has been applied in many nanomaterials except for *** this paper,the modified couple stress theory is firstly adopted to analyze the static bending deformation of multilayered one-dimensional(ID)hexagonal quasicrystal(QC)nanoplates under surface *** general solutions for the extended displacement and traction vectors in a simply supported and homogeneous QC nanoplate are derived by solving an eigenvalue problem reduced from the governing *** the propagator matrix method,the analytical solutions of multilayered ID QC nanoplates are then obtained by assuming that the layer interfaces are *** examples for some kinds of nanoplates made up of QC and crystal(BaTiOa)are provided to illustrate the effects of the material length parameter,the number of layers and the stacking sequence of nanoplates on the phonon and phason fields,which is helpful for the application of QCs to surface coating and solar energy selective absorber.

关键词： Quasicrystals(QCs) Nanoplate Layered structure Modified couple stress Analytical solution

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GROWTH AND DISTORTION THEOREMS FOR ALMOST STARliKE MAPPINGS OF COMPLEX ORDER λ

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Acta Mathematica Scientia 2018年第3期38卷 769-777页

作者： xiaofei ZHANG Jin LU xiaofei li School of Mathematics and Statistics Pingdingshan Universit Department of Mathematics Huzhou Universit

In this article, the sharp growth theorem for almost starlike mappings of complex order λ is given firstly. Secondly, distortion theorem along a unit direction is also established as the application of the growth the... 详细信息

关键词： Distortion theorem convex mapping Schwarz lemma at the boundary

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Vision‐audio fusion SLAM in dynamic environments

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CAAI Transactions on Intelligence Technology 2023年第4期8卷 1364-1373页

作者： Tianwei Zhang Huayan Zhang xiaofei li Shenzhen Institute of Artificial Intelligence and Robotics for Society ShenzhenChina Department of Robotics Ritsumeikan UniversityShigaJapan Westlake University and Westlake Institute for Advanced Study HangzhouChina

Moving humans,agents,and subjects bring many challenges to robot self‐localisation and environment *** adapt to dynamic environments,SLAM researchers typically apply several deep learning image segmentation models to eliminate these moving ***,these moving obstacle segmentation methods cost too much computation resource for the onboard processing of mobile *** the current industrial environment,mobile robot collaboration scenario,the noise of mobile robots could be easily found by on‐board audio‐sensing processors and the direction of sound sources can be effectively acquired by sound source estimation algorithms,but the distance estimation of sound sources is ***,in the field of visual perception,the 3D structure information of the scene is relatively easy to obtain,but the recognition and segmentation of moving objects is more *** address these problems,a novel vision‐audio fusion method that combines sound source localisation methods with a visual SLAM scheme is proposed,thereby eliminating the effect of dynamic obstacles on multi‐agent *** heterogeneous robots experiments in different dynamic scenes indicate very stable self‐localisation and environment reconstruction performance of our method.

关键词： dynamic environment intelligent robots sensor fusion

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Expectation-maximisation for speech source separation using convolutive transfer function

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CAAI Transactions on Intelligence Technology 2019年第1期4卷 47-53页

作者： xiaofei li Laurent Girin Radu Horaud INRIA Grenoble Rhoe-Alpes Montbonnot Saint-MartinFrance GIPSA-lab Saint-Martin d’HèresFrance UniversitéGrenoble Alpes Saint-Martin d’HèresFrance

This study addresses the problem of under-determined speech source separation from multichannel microphone signals,*** convolutive mixtures of multiple *** time-domain signals are first transformed to the short-time Fourier transform(STFT)*** represent the room filters in the STFT domain,instead of the widely used narrowband assumption,the authors propose to use a more accurate model,*** convolutive transfer function(CTF).At each frequency band,the CTF coefficients of the mixing filters and the STFT coefficients of the sources are jointly estimated by maximising the likelihood of the microphone signals,which is resolved by an expectation-maximisation *** show that the proposed method provides very satisfactory performance under highly reverberant environments.

关键词： STFT CTF

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The Role of Initial Cloud Condensation Nuclei Concentration in Hail Using the WRF NSSL 2-moment Microphysics Scheme

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Advances in Atmospheric Sciences 2017年第9期34卷 1106-1120页

作者： xiaofei li Qinghong ZHANG Huiwen XUE Department of Atmospheric and Oceanic Sciences School of PhysicsPeking University

The effects of the initial cloud condensation nuclei （CCN） concentrations （100-3000 mg-1） on hail properties were investigated in an idealized non-severe hail storm experiment using the Weather Research and Forecasting （WRF） model, with the National Severe Storms Laboratory 2-moment microphysics scheme. The initial CCN concentration （CCNC） had obvious non-monotonic effects on the mixing ratio, number concentrations, and radius of hail, both in clouds and at the surface, with a CCNC threshold between 300 and 500 mg-1. An increasing CCNC is conducive （suppressive） to the amount of surface hail precipitation below （above） the CCNC threshold. The non-monotonic effects were due to both the thermodynamics and microphysics. Below the CCNC threshold, the mixing ratios with the increasing CCNC, resulting in more latent heat released of cloud droplets and ice crystals increased dramatically from condensation and frozen between 4 and 8 km and intensified updraft volume. The extent of the riming process, which is the primary process for hail production, increased dramatically. Above the CCNC threshold, the mixing ratio of cloud droplets and ice crystals increased continuously, but the maximum updraft volume was weakened because of reduced frozen latent heating at low level. The smaller ice crystals reduced the formation of hail and smaller clouds, with decreased rain water reducing riming efficiency so that graupel and hail also decreased with increasing CCNC, which is unfavorable for hail growth.

关键词： CCN hail microphysics thermodynamics threshold

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基于Unity3d的电气实验教学平台的设计与实现

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天津理工大学学报 2025年第1期41卷 104-111页

作者：康军张鹏李晓飞天津理工大学电气工程与自动化学院

针对传统电气实验教学中长期存在且尚未得到有效解决的问题，以电气专业知识为基础，以VR眼镜为设备载体，以Unity3d为开发平台，通过电气技术和虚拟现实技术的有效结合设计开发出一种基于Unity3d的电气实验教学平台。该平台使用Maya建... 详细信息

针对传统电气实验教学中长期存在且尚未得到有效解决的问题，以电气专业知识为基础，以VR眼镜为设备载体，以Unity3d为开发平台，通过电气技术和虚拟现实技术的有效结合设计开发出一种基于Unity3d的电气实验教学平台。该平台使用Maya建模软件进行三维建模，利用Unity3d中功能强大的系统和灵活的C#脚本语言编程实现人机交互效果，在此平台上开发的电动机运行实验，使学生不仅可以完成电动机接线、运行、过载等基础实验，还可以在保障用电安全的前提下进行任意操作，模拟电路短路、电机损坏等事故的发生，情景化感受事故后果。该电气实验教学平台的优势主要体现在低实验成本运行、高安全系数操作、创新教学模式和提升教学效率上，在学生提升相应工程技能的同时，不断创新电气实验教学模式，实现高质量教学产出。

关键词：虚拟现实 Unity3d 实验教学电气专业

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