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多学科国际化医学研究生培养模式的探索与实践

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中华医学教育杂志 2015年第5期35卷 756-758,778页

作者：谭晖尤小芳钱序史慧静汪玲复旦大学公共卫生学院妇幼与儿少卫生学教研室上海200032 复旦大学上海医学院上海200032

本文分析了培养医学研究生具有多学科知识和国际化视野的必要性,并结合复旦大学儿少卫生与妇幼保健学学科团队多年的探索和实践,提出了多学科国际化医学研究生培养模式的具体路径,即通过优化研究生培养方案,设置多学科特色课程,构建国... 详细信息

本文分析了培养医学研究生具有多学科知识和国际化视野的必要性,并结合复旦大学儿少卫生与妇幼保健学学科团队多年的探索和实践,提出了多学科国际化医学研究生培养模式的具体路径,即通过优化研究生培养方案,设置多学科特色课程,构建国际化交流平台等方式,使医学研究生在知识结构、学术视野和综合素质等方面得以提升,从而培养出更加符合多学科交叉化和公共卫生全球化要求的新时期复合型医学人才.

关键词：多学科国际化研究生培养探索实践

膨润土对溶液中阴离子态Cr(Ⅵ)的吸附特性及机理研究

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中国矿业 2018年第8期27卷 131-138页

作者：王倩王亚萍由晓芳王志明李琳邱俊吕宪俊曹晓强山东科技大学化学与环境工程学院山东青岛266590 山东大学环境科学与工程学院山东济南251000 南开大学环境科学与工程学院天津300350

本文研究了阴离子态Cr(Ⅵ)在膨润土中的吸附行为,并对吸附机理进行了分析。结果表明,pH=2~12,膨润土表面ζ电位均为负值,随着溶液pH值提高,膨润土对Cr(Ⅵ)的吸附效率明显下降。膨润土对Cr(Ⅵ)的吸附符合准2级动力学模型,吸附传质速率主... 详细信息

本文研究了阴离子态Cr(Ⅵ)在膨润土中的吸附行为,并对吸附机理进行了分析。结果表明,pH=2~12,膨润土表面ζ电位均为负值,随着溶液pH值提高,膨润土对Cr(Ⅵ)的吸附效率明显下降。膨润土对Cr(Ⅵ)的吸附符合准2级动力学模型,吸附传质速率主要受膜扩散过程影响。Freundlich方程能够更精确的描述膨润土对Cr(Ⅵ)的吸附行为。热力学分析结果说明膨润土吸附Cr(Ⅵ)是一个自发的吸热反应,低pH值条件下少量Cr(Ⅵ)会发生还原反应从而生成Cr^(3+),导致部分Cr(Ⅵ)以Cr^(3+)的形式被去除。综合分析认为Cr(Ⅵ)的初始浓度较低时,内界表面配合是主要去除机制;初始浓度较高时,同时存在物理吸附以及内界表面配合作用。

关键词：膨润土铬吸附表面配合

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu you Lin Niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

Inter-Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding, Sensing and Thermal Management

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Li, Xufeng Chen, Chunyan Li, Zhenyang Yi, Peng Zou, Haihan Deng, Gao Fang, Ming He, Junzhe Sun, Xin Yu, Ronghai Shui, Jianglan Pan, Caofeng Liu, xiaofang Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Beihang Univ Inst Atom Mfg Beijing 100191 Peoples R China Tianmushan Lab Xixi Octagon City Hangzhou 310023 Peoples R China Beijing Inst Environm Features Sci & Technol Electromagnet Scattering Lab Beijing 100854 Peoples R China

Unique inter-skeleton conductive films are constructed in polymer *** resistance change of the foam can reach four orders of magnitude under *** foam exhibits strain-adaptive electromagnetic interference shielding performance, anti-interference pressure sensor with high sensitivity over a wide pressure range and compression-regulated Joule heating function. Conductive polymer foam (CPF) with excellent compressibility and variable resistance has promising applications in electromagnetic interference (EMI) shielding and other integrated functions for wearable electronics. However, its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation. Here, an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression. Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton (denoted as AMLM-PM foam). Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films. Therefore, the resistance change of AMLM-PM reaches four orders of magnitude under compression. Moreover, the inter-skeleton conductive films can improve the mechanical strength of foam, prevent the leakage of liquid metal and increase the scattering area of EM wave. AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness, solving the problem of traditional CPFs upon compression. The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

Single photon response of superconducting nanowire single photon detector

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Chinese Science Bulletin 2010年第4期55卷 441-445页

作者： you LiXing SHEN xiaofang YANG XiaoYan State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology (SIMIT) Chinese Academy of Sciences Shanghai 200050 China

Single photon detection is one of the key technologies for quantum key distribution in quantum communication. As a novel single photon detection technology, superconducting nanowire single photon detector (SNSPD) surpasses conventional semiconducting single photon detectors with high count rate and low dark count rate. In this article, we introduce SNSPD fabricated from NbN ultrathin superconducting film and lab-based SNSPD system. The characteristics of single photon response pulse of SNSPD are analyzed in detail. Also discussed is the relationship between waveform of single photon response and system bandwidth. Circuit model is made to analyze the performance of SNSPD. The simulation result agrees well with the experimental data. Those results are valuable for understanding the mechanism of SNSPD and building future SNSPD system for quantum communication.

关键词：单光子探测器超导薄膜纳米线反应量子通信高计数率 PD系统密钥分配

健康中国建设背景下公共卫生硕士研究生教育的理念与实践

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中华医学教育杂志 2019年第11期39卷 807-811页

作者：尤小芳包江波谢静波何更生汪玲复旦大学医学教育研究所上海200032

公共卫生高层次人才是贯彻实施卫生与健康工作方针的关键人力资源.健康中国建设既需要具有国际视野和创新能力的高水平研究人员,也需要实践技能过硬的应用型人才.以高层次人才为培养目标的公共卫生硕士研究生教育,应当根据健康中国建设... 详细信息

公共卫生高层次人才是贯彻实施卫生与健康工作方针的关键人力资源.健康中国建设既需要具有国际视野和创新能力的高水平研究人员,也需要实践技能过硬的应用型人才.以高层次人才为培养目标的公共卫生硕士研究生教育,应当根据健康中国建设对公共卫生的新要求分类培养,学术学位研究生的培养应当注重学科之间的交叉融合、国际化视野的拓展和原始创新能力的提升;专业学位研究生的培养应当聚焦岗位胜任力、注重实践环节和突出应用能力.

关键词：健康中国建设公共卫生研究生教育

“新工科”背景下矿山环境研究生导师团队建设机制研究

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中国冶金教育 2024年第1期 23-24页

作者：李琳王凌云由晓芳郭琳王俊祥山东科技大学化学与生物工程学院山东青岛266590 山东科技大学研究生院山东青岛266590

结合研究生导师团队建设现状,分析研究生导师团队建设机制的意义,针对“新工科”背景下矿山环境研究生导师团队建立、成员考核与激励办法及“多层次-分阶段”研究生梯级培养模式构建提出了建设方案。

关键词：新工科矿山环境研究生导师团队建设

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矿物加工工程专业绿色智能化方向建设

中国冶金教育 2023年第1期 19-21页

作者：李琳由晓芳王凌云郭琳王俊祥山东科技大学化学与生物工程学院山东青岛266590 山东科技大学研究生院山东青岛266590

结合矿物加工工程专业绿色智能化方向发展现状,概括了国内相关高校的改革举措,对矿物加工工程专业绿色智能化方向建设提出建议。

关键词：矿物加工矿山环境绿色智能方向建设

美金刚调控Limk抑制MCAO大鼠Cofilin Rod生成从而减轻脑缺血损伤

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中风与神经疾病杂志 2019年第10期36卷 890-895页

作者：陈斌高兆鹤游小芳林晗莹王晶林万庆福建中医药大学附属人民医院康复科

目的探讨美金刚(Memantine)对缺血性脑卒中的神经保护作用与潜在分子机制。方法将36只雄性SD大鼠随机分为假手术组(Sham)、生理盐水组(Saline)及美金刚(MEM)组,采用Zea Longa法制备大鼠局灶性脑缺血模型,通过神经功能缺损得分和脑梗死... 详细信息

目的探讨美金刚(Memantine)对缺血性脑卒中的神经保护作用与潜在分子机制。方法将36只雄性SD大鼠随机分为假手术组(Sham)、生理盐水组(Saline)及美金刚(MEM)组,采用Zea Longa法制备大鼠局灶性脑缺血模型,通过神经功能缺损得分和脑梗死体积明确Memantine对脑缺血大鼠的神经保护作用,使用Cofilin免疫荧光染色法观察Memantine对皮质梗死区Rod生成的影响,应用Western blot检测缺血侧皮质中p-Limk/Limk、pp38/p38蛋白表达情况。结果 Memantine干预可明显改善脑缺血大鼠的神经缺损症状和脑梗死体积;抑制皮质梗死区Rod的形成;促进皮质梗死区p-Limk的表达水平;降低p-p38的活性。结论 Memantine可通过调控脑缺血皮质区p-Limk的表达,抑制Cofilin Rod的形成,降低p-p38的表达,从而改善脑缺血大鼠的神经功能缺损症状和脑梗死体积。

关键词：美金刚脑缺血丝切蛋白