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Neural Regeneration Research 2011年第2期6卷 150-154页

作者： xiaofan you Wei Qin Jing Ye Yonggang Hao Wenhui Zhao Wenli Hu Department of Neurology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China

Uric acid is reduced in demyelinating diseases, including multiple sclerosis and neuromyelitis optica （NMO）. Longitudinally extensive transverse myelitis （LETM） is often an early manifestation of NMO. Whether uric acid levels are reduced at presentation of LETM remains unknown. The present study investigated serum uric acid levels by evaluating 35 patients with LETM, 64 with NMO, 62 with multiple sclerosis, 63 with other neurological diseases and 65 healthy controls. In addition, we tested the correlation between serum uric acid and the clinical characteristics of LETM. All patients were in the acute phase, defined as less than 1 month from onset or relapse. The results revealed that serum uric acid levels in LETM were significantly lower than in multiple sclerosis, other neurological diseases and healthy controls, but no difference was found between LETM and NMO. A negative correlation between uric acid levels and Expanded Disability Status Scale scores was found in LETM patients （r = -0.545, P 〈 0.05）. The results suggest that uric acid levels are reduced in patients with LETM, raising the possibility that lower uric acid levels are an indicator of disease disability. Moreover, reduced uric acid levels may be a risk factor in NMO.

关键词： uric acid longitudinally extensive transverse myelitis neuromyelitis optica neuromyelitis optica-lgG auto-antibody

表现为最后区综合征的视神经脊髓炎谱系疾病临床分析

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中华医学杂志 2018年第9期98卷 668-672页

作者：尤小凡胡洪涛叶静北京积水潭医院神经内科 100096 首都医科大学宣武医院神经内科

目的研究表现为最后区综合征的视神经脊髓炎谱系疾病（NMOSD）临床特点、影像学特征、实验室检查和预后。方法回顾性分析2006--2016年在北京积水潭医院神经内科和首都医科大学宜武医院神经内科就诊的120例NMOSD患者，对其中表现为最后... 详细信息

目的研究表现为最后区综合征的视神经脊髓炎谱系疾病（NMOSD）临床特点、影像学特征、实验室检查和预后。方法回顾性分析2006--2016年在北京积水潭医院神经内科和首都医科大学宜武医院神经内科就诊的120例NMOSD患者，对其中表现为最后区综合征的18例患者分析其临床特点，影像学特征以及与水通道蛋白4（AQP4）抗体的关系。结果最后区损害组18例（15％，18／120）。最后区症状可作为疾病的首发症状（14／18），问隔3d至7个月（中位数40d）出现视神经或脊髓受累。视神经炎后出现最后区症状1例。最后区和视神经或脊髓症状同时出现3例（3／18）。最后区症状表现为难治性恶心、呕吐、呃逆。最后区损害组（18例）与无最后区损害组（102例）相比，病程较短，视神经受累较少，两组差异有统计学意义（P〈0．05）。两组性别、起病年龄、单一病程与复发病程比例、EDSS评分差异无统计学意义。脊髓MRI显示延髓病灶呈片状或线样损害，12例患者颈髓延髓交界区受累（12／18），11例伴有超过3个节段的长节段脊髓损害。最后区组AQP4抗体阳性率（14／18），无最后区损害组AQP4抗体阳性率73．5％（75／102），两组差异无统计学意义。激素治疗后最后区症状好转。结论NMOSD可表现为最后区综合征，呃逆、呕吐可作为首发症状，延髓颈髓延续病灶是较为特异的影像学表现，早期识别有助于诊断和治疗。

关键词：视神经脊髓炎谱系疾病最后区水通道蛋白质4 磁共振成像

Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang Xiangyu Gao xiaofan Jiang Kangyi Yue Peng Luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

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低温低浊度地表水源水处理设计的新思路

水处理技术 2009年第11期35卷 104-107页

作者：游晓凡张远柱宋琦文张文婷武汉加利水处理工程有限公司湖北武汉430015 东风汽车公司热电厂湖北十堰442002

介绍了以地表水为水源的水处理系统设计中,不设计澄清池与无阀滤池的另类系统。该系统极其简单,少占用土地,不加凝聚药剂,能充分利用老水处理系统的设备,投资少,见效快,出水质量高。解决了低温、低浊度、地表水源地区澄清池出力低,运行... 详细信息

介绍了以地表水为水源的水处理系统设计中,不设计澄清池与无阀滤池的另类系统。该系统极其简单,少占用土地,不加凝聚药剂,能充分利用老水处理系统的设备,投资少,见效快,出水质量高。解决了低温、低浊度、地表水源地区澄清池出力低,运行稳定性差的难题。

关键词：澄清池无阀滤池低温低浊度地表水

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120例视神经脊髓炎谱系疾病临床特点分析

中风与神经疾病杂志 2018年第4期35卷 333-337页

作者：尤小凡胡洪涛叶静北京积水潭医院神经内科北京100096 首都医科大学宣武医院神经内科北京100096

目的基于2015年诊断标准分析视神经脊髓炎谱系疾病(NMOSD)患者的临床特点和影像学特征。方法回顾性分析120例NMOSD患者的临床特点、影像学特征、以及对比水通道蛋白4(AQP4)抗体阳性和阴性患者的临床异同点。结果女性∶男性=2.75∶1,平... 详细信息

目的基于2015年诊断标准分析视神经脊髓炎谱系疾病(NMOSD)患者的临床特点和影像学特征。方法回顾性分析120例NMOSD患者的临床特点、影像学特征、以及对比水通道蛋白4(AQP4)抗体阳性和阴性患者的临床异同点。结果女性∶男性=2.75∶1,平均发病年龄37.1岁,平均病程21个月,80%患者为复发病程。起病症状视神经炎和脊髓炎分别占41.7%和40%。15.8%患者伴有自身免疫病;5.8%患者伴有内分泌疾病。78.1%的患者AQP4抗体阳性,抗体阳性组疾病严重程度评分显著高于抗体阴性组(P=0.026)。长节段横贯性脊髓炎占83.7%。头部MRI异常见于36.7%(44/120)患者。28.3%(34/120)患者脑脊液白细胞升高(>5×10~6/L),脑脊液蛋白49.5 mg/dl(正常值:15~45 mg/dl);30.8%(37/120)患者寡克隆区带阳性;52.2%(24/46)患者髓鞘碱性蛋白阳性;40%(48/120)患者脑脊液免疫球蛋白G升高。结论 2015年诊断标准有助于NMOSD诊断,NMOSD长节段脊髓炎多见,短节段脊髓炎不能排除NMOSD,AQP4抗体阳性患者病情更重,应重视早期诊断。

关键词：视神经脊髓炎谱系疾病临床特点水通道蛋白4抗体核磁影像

Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第01期 146-156页

作者： Mingxing Li Xiaoge Wang xiaofan Cao Zhiqun He Chunjun Liang Mingxing Chen Jing Ju Fangtian you Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

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Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： you Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

何以必然何以可能:中国式现代化是走和平发展道路的现代化

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海南大学学报（人文社会科学版） 2025年第1期43卷 43-50页

作者：李冉郭小凡复旦大学马克思主义学院上海200433

审视中国式现代化走和平发展道路的必然性和可能性,既是诠释中国式现代化内在意蕴的应有之义,也能为回答人类未来何去何从的“世界之问”提供重要参考。这条和平发展道路是在传承中华优秀传统文化中开辟的,蕴含了爱好和平的民族精神;是... 详细信息

审视中国式现代化走和平发展道路的必然性和可能性,既是诠释中国式现代化内在意蕴的应有之义,也能为回答人类未来何去何从的“世界之问”提供重要参考。这条和平发展道路是在传承中华优秀传统文化中开辟的,蕴含了爱好和平的民族精神;是在以西方现代化道路为镜鉴中开辟的,蕴含了自立自强的奋斗精神;是在以马克思主义为价值引领中开辟的,蕴含了不负使命的担当精神;是在进行伟大斗争中开辟的,蕴含了捍卫国家和人类安全的天下情怀。面对“百年未有之大变局”中的新问题与新挑战,这条和平发展道路必将展现出更为深刻的价值。

关键词：走和平发展道路中国式现代化百年未有之大变局

Visualizing traumatic brain injury:ocular clues for diagnosis and assessment

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Neural Regeneration Research 2025年第5期20卷 1399-1400页

作者： Morteza Abyadeh Vivek Gupta Yuyi you Joao A.Paulo Mehdi Mirzaei ProGene Technologies Pty Ltd SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA

Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the *** is considered a silent public health epidemic causing significant death and disability *** were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.

关键词： diagnosis ocular injury

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu you Lin Niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry