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Chaiqin Chengqi decoction inhibits inflammatory mediators and attenuates acute pancreatitis through deactivation of janus kinase/signal transducer and activator of transcription signaling pathway

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Journal of Traditional Chinese Medicine 2019年第2期39卷 166-173页

作者： Dong Jianxia Chen Xiaoshuang Song Yi fei xiaofan Department of Clinical Pharmacy West China Hospital of Sichuan University

OBJECTIVE: To investigate the effect of Chaiqin Chengqi decoction(CQCQD) on acute pancreatitis(AP) by janus kinase/signal transducer and activator of transcription(JAK/STAT) signaling pathway in vitro and in ***: AP was induced by caerulein both in AR42J cells and in mice. AR42J cells were divided into five groups: the control group, the AP group, the CQCQD group, JAK/STAT signaling pathway inhibitor AG490 group, and the CQCQD and AG490 *** induction, cellular supernatant of five groups were collected for measuring the concentrations of inflammatory cytokine amylase, interleukin 6(IL-6),tumor necrosis factor α(TNF-α), interleukin 1β(IL-1β), nuclear factor κB(NF-κB) by enzyme-linked immunosorbent assay and the expression of JAK-2,STAT-3 signaling transduction proteins by Western blot, respectively. Experiments in mice were performed similar to that of in AR42J ***: Treatment of AR42J cells with CQCQD reduced the pancreatic injury and negatively regulated the activities of amylase, as well as inhibited expression of several inflammatory cytokines such as IL-6, TNF-α, IL-1β, NF-κB. Administration of CQCQD significantly inhibited JAK-2 activation and down-regulated phosphorylation of downstream substrate STAT-3 the same as AG490, resulting in inhibition of inflammatory mediators and amelioration of ***: The results suggested that CQCQD exerted anti-inflammatory effects on AP via reducing expression and phosphorylation of JAK and STAT.

关键词： Pancreatic diseases Anti-inflammatory agents Janus kinase 2 STAT transcription factors Chaiqin Chengqi decoction

Can nanoparticles and nano-protein interactions bring a bright future for insulin delivery?

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Acta Pharmaceutica Sinica B 2021年第3期11卷 651-667页

作者： Ting Zhang James Zhenggui Tang xiaofan fei Yanping Li Yi Song Zhiyong Qian Qiang Peng Department of Pharmacy West China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China Research Institute in Healthcare Science Faculty of Science and EngineeringSchool of PharmacyUniversity of WolverhamptonWVI ILYUK Laboratory of Clinical Pharmacy and Adverse Drug Reaction West China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China

Insulin therapy plays an essential role in the treatment of diabetes ***,frequent injections required to effectively control the glycemic levels lead to substantial inconvenience and low patient *** order to improve insulin delivery,many efforts have been made,such as developing the nanoparticles (NPs)-based release systems and oral *** some improvements have been achieved,the ultimate results are still unsatisfying and none of insulin-loaded NPs systems have been approved for clinical use so ***,nano?protein interactions and protein corona formation have drawn much attention due to their negative influence on the in vivo fate of NPs *** the other side of a coin,such interactions can also be used for constructing advanced drug delivery ***,we aim to provide an insight into the advance and flaws of various NPs-based insulin delivery ***,an interesting discussion on nano?protein interactions and its potentials for developing novel insulin delivery systems is initiated.

关键词： Insulin Diabetic Nanomaterials Absorption Controlled release Protein adsorption

Antioxidant and immunomodulatory activities of a polysaccharide from Flammulina velutipes

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Journal of Traditional Chinese Medicine 2014年第6期34卷 733-740页

作者： Ming Wu Xia Luo Xiaoyan Xu Wei Wei Mengyao Yu Nan Jiang Liming Ye Zhirong Yang xiaofan fei College of Life Sciences Sichuan University Laboratory of Cellular and Molecular Biology Sichuan Academy of Chinese Medicine Science West China Hospital Sichuan University

OBJECTIVE: To evaluate the antioxidant and immunomodulatory activities of a unique polysaccharide from the medicinal fungus Flammulina velutipes in ***: Using water extraction and alcohol precipitation, crude polysaccharides were obtained. After purification by DEAE-cellulose 52 ion exchange chromatography and Sephacryl S-300 HR gel filtration chromatography, High performance liquid chromatography equipped with evaporative light-scattering detector, Infrared radiation and Nuclear magnetic resonance were used to evaluate the structure of the polysaccharide. Its immunomodulatory activity was measured by examining the production of nitric oxide(NO) and cytokine secretion, and via lymphocyte proliferation experiments. Its effects on the scavenging activities of hydroxyl radical, superoxide anion and reducing power were also ***: A water-soluble polysaccharide, Flammulina velutipes polysaccharide I-A(FVP I-A), was obtained with a molecular mass of 8.14×104Da determined by high performance gel permeation chromatography. An in vitro antioxidant assay indicated that FVP I-A could scavenge hydroxyl radical, superoxide anion and possessed reducing power and could largely promote NO production and augment the interleukin-1β, interleukin-6, and tumor necrosis factor-α secretion by RAW264.7 macrophages(P<0.05). Moreover, FVP I-A could promote lymphocyte proliferation(P<0.05), and synergistically enhance the augmentation of the proliferation of mouse lymphocytes by concanavalin A and lipopolysaccharides(P<0.01, P<0.05).CONCLUSION: The FVP I-A obtained from Flammulina velutipes possessed antioxidant activity and could enhance non-specific and specific immune responses in vitro.

关键词： Flammulina Isolation & purification Polysaccharides Antioxidants Immunomodulation Cytokines

Constraints on the primordial curvature power spectrum by pulsar timing array data:a polynomial parameterization approach

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Communications in Theoretical Physics 2024年第1期76卷 96-104页

作者： Qin fei School of Mathematics and Physics Hubei Polytechnic UniversityHuangshi 435003China

The recent stochastic signal observed jointly by NANOGrav,parkes pulsar timing array,European pulsar timing array,and Chinese pulsar timing array can be accounted for by scalarinduced gravitational waves(SIGWs).The source of the SIGWs is from the primordial curvature perturbations,and the main contribution to the SIGWs is from the peak of the primordial curvature power *** effectively model this peak,we apply the Taylor expansion to parameterize *** the Taylor expansion parameterization,we apply Bayesian methods to constrain the primordial curvature power spectrum based on the NANOGrav 15 year data *** constraint on the primordial curvature power spectrum possesses a degree of generality,as the Taylor expansion can effectively approximate a wide range of function profiles.

关键词： pulsar timing array scalar-induced gravitational waves inflation

Surface Polarization Effects on Collapse Transition of Polyelectrolyte Brushes

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Chinese Journal of Polymer Science 2024年第9期42卷 1313-1320,I0006页

作者： Xiao-fei Xu State Key Laboratory of Chemical Engineering and School of Chemical Engineering East China University of Science and TechnologyShanghai200237China

Polyelectrolyte brushes(PEBs)are commonly used to modify surface that have attracted great research *** dielectric permittivity of the grafted surface is typically significantly different from that of solution,which results in surface polarization(SP)effect with a jump of electric *** is thus important to study how SP alters the PEB’s structure and *** this work,the SP effects on PEB structure was studied using a statistical thermodynamic *** free energy functional to describe SP effect was constructed by using the image-charge ***,the electrostatic potential was solved from a modified Poisson-Boltzmann equation taking the ion solvation effect into *** the absence of SP,the thickness of PEB exhibited a continuous collapse transition when decreasing the solvent *** the presence of SP,the collapse became a jump-like *** energy analysis showed that the long-range Coulombic interaction dominated the transition because of the enhanced counterion condensation in the presence of *** theory provides an effective tool to study SP effect on PEBs,and the results explain the underlying physics in PEB collapse transition.

关键词： Surface polarization Polyelectrolyte brush Image charge Ion solvation Polyelectrolyte collapse transition

Self-assembly of perovskite nanocrystals:From driving forces to applications

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Journal of Energy Chemistry 2024年第1期88卷 561-578,I0013页

作者： Yi Li fei Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Self-assembly of metal halide perovskite nanocrystals(NCs)into superlattices can exhibit unique collective properties,which have significant application values in the display,detector,and solar cell *** review discusses the driving forces behind the self-assembly process of perovskite NCs,and the commonly used self-assembly methods and different self-assembly structures are ***,we summarize the collective optoelectronic properties and application areas of perovskite superlattice ***,we conclude with an outlook on the potential issues and future challenges in developing perovskite NCs.

关键词： Self-assembly Metal halide perovskite Nanocrystals Driving forces

THE TRUNCATED EM METHOD FOR JUMP-DIFFUSION SDDES WITH SUPER-LINEARLY GROWING DIFFUSION AND JUMP COEFFICIENTS

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Journal of Computational Mathematics 2024年第1期42卷 178-216页

作者： Shounian Deng Chen fei Weiyin fei Xuerong Mao Key Laboratory of Advanced Perception and Intelligent Control of High-end Equipment Ministry of Educationand School of Mathematics-Physics and FinanceAnhui Polytechnic UniversityWuhu 241000China Business School University of Shanghai for Science and TechnologyShanghai 200093China Department of Mathematics and Statistics University of StrathclydeGlasgow G11XHUK

This work is concerned with the convergence and stability of the truncated EulerMaruyama(EM)method for super-linear stochastic differential delay equations(SDDEs)with time-variable delay and Poisson *** constructing appropriate truncated functions to control the super-linear growth of the original coefficients,we present two types of the truncated EM method for such jump-diffusion SDDEs with time-variable delay,which is proposed to be approximated by the value taken at the nearest grid points on the left of the delayed *** first type is proved to have a strong convergence order which is arbitrarily close to 1/2 in mean-square sense,under the Khasminskii-type,global monotonicity with U function and polynomial growth *** second type is convergent in q-th(q<2)moment under the local Lipschitz plus generalized Khasminskii-type *** addition,we show that the partially truncated EM method preserves the mean-square and H∞stabilities of the true ***,we carry out some numerical experiments to support the theoretical results.

关键词： SDDEs Truncated EM method Time-variable delay Poisson jumps

Exploring a Promising Region and Enhancing Decision Space Diversity for Multimodal Multi-Objective Optimization

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Tsinghua Science and Technology 2024年第2期29卷 325-342页

作者： fei Ming Wenyin Gong School of Computer Science China University of GeosciencesWuhan 430074China

During the past decade,research efforts have been gradually directed to the widely existing yet less noticed multimodal multi-objective optimization problems(MMOPs)in the multi-objective optimization ***,researchers have begun to investigate enhancing the decision space diversity and preserving valuable dominated solutions to overcome the shortage caused by a preference for objective space ***,many existing methods still have limitations,such as giving unduly high priorities to convergence and insufficient ability to enhance decision space *** overcome these shortcomings,this article aims to explore a promising region(PR)and enhance the decision space diversity for handling *** traditional methods,we propose the use of non-dominated solutions to determine a limited region in the PR in the decision space,where the Pareto sets(PSs)are included,and explore this region to assist in solving ***,we develop a novel neighbor distance measure that is more suitable for the complex geometry of PSs in the decision space than the crowding *** on the above methods,we propose a novel dual-population-based coevolutionary *** studies on three benchmark test suites demonstrates that our proposed methods can achieve promising performance and versatility on different *** effectiveness of the proposed neighbor distance has also been justified through comparisons with crowding distance methods.

关键词： multimodal multi-objective optimization evolutionary algorithms promising region neighbor distance decision space coevolution

Homer1a reduces inflammatory response after retinal ischemia/reperfusion injury

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Neural Regeneration Research 2024年第7期19卷 1608-1617页

作者： Yanan Dou Xiaowei fei Xin He Yu Huan Jialiang Wei Xiuquan Wu Weihao Lyu Zhou fei Xia Li fei fei Department of Neurosurgery Xijing HospitalAir Force Military Medical UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology Xijing HospitalAir Force Military Medical UniversityXi’anShaanxi ProvinceChina

Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual *** is repo rted to play a protective role in neuroinflammation in the ***,the effects of Homerla on NLRP3inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain *** our study,animal models we re constructed using C57BL/6J and Homer1^(flox/-)/Homerla^(+/-)/Nestin-Cre^(+/-)mice with elevated IOP-induced retinal ischemia/repe rfusion *** in vitro expe riments,the oxygen-glucose deprivation/repe rfusion injury model was constructed with M uller *** found that Homerla ove rexpression amelio rated the decreases in retinal thickness and Muller cell viability after ischemia/reperfusion ***,Homerla knockdown promoted NF-κB P65^(Ser536)activation via caspase-8,NF-κB P65 nuclear translocation,NLRP3 inflammasome formation,and the production and processing of interleukin-1βand inte *** opposite results we re observed with Homerla ove ***,the combined administration of Homerla protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1^(flox/-)Homer1a^(+/-)/Nestin-Cre^(+/-)mice and apoptosis in M uller cells after ischemia/reperfusion *** together,these studies demonstrate that Homer1a exerts protective effects on retinal tissue and M uller cells via the caspase-8/NF-KB P65/NLRP3 pathway after I/R injury.

关键词： caspase-8 Homer1a interleukin-18 interleukin-1β intraocular pressure ischemia/reperfusion injury JSH-23 Müller cells NLRP3 nuclear factor-kB p65 retina