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On the laws of the iterated logarithm with mean-uncertainty under sublinear expectations

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Probability, Uncertainty and Quantitative Risk 2022年第1期7卷 1-12页

作者： xiaofan guo Shan Li Xinpeng Li Research Center for Mathematics and Interdisciplinary Sciences Shandong UniversityQingdao 266237ShandongChina Frontiers Science Center for Nonlinear Expectations(Ministry of Education) Shandong UniversityQingdao 266237ShandongChina School of Mathematics Shandong UniversityJinan 250100ShandongChina

A new Hartman-Wintner-type law of the iterated logarithm for independent random variables with mean-uncertainty under sublinear expectations is established by the martingale analogue of the Kolmogorov law of the itera... 详细信息

关键词： Law of the iterated logarithm Mean-uncertainty Upper and lower variances Sublinear expectation

RAVL1 Activates IDD3 to Negatively Regulate Rice Resistance to Sheath Blight Disease

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Rice science 2021年第2期28卷 146-155页

作者： SUN Qian YANG Shuo guo xiaofan WANG Siting JIA Xintong LI Shuang XUAN Yuanhu College of Plant Protection Shenyang Agricultural UniversityShenyang 110866China School of Life Science and Technology Hubei Engineering UniversityXiaogan 432000China Shaanxi Key Laboratory of Chinese Jujube/College of Life Yan’an UniversityYan’an 716000China

Sheath blight disease (ShB) has a severe impact on the production of rice. ABI3/VP1-like 1(RAVL1) negatively regulated the rice defense mechanism against ShB, however, this regulatorymechanism is not clearly understood. In this study, we identified that indeterminate domain 3 (IDD3) waspositively regulated by RAVL1. Further, chromatin immunoprecipitation (ChIP) assay, yeast one-hybridassay and transient expression assay indicated a direct binding between RAVL1 and the IDD3 promoterregion. IDD3 was ubiquitously expressed in different tissues and at different stages, and its expressionwas significantly enhanced by Rhizoctonia solani infection. IDD3 exhibited transcription activation activityin yeast and IDD3-GFP was found to be localized in the nucleus. IDD3 mutants exhibited no significantdifferences in response to ShB, while IDD3 overexpressors were more susceptible to ShB compared withwild type (WT) plants. Furthermore, IDD3 repressors were less susceptible to R. solani than WT ***, the expression of brassinosteroid-related genes (D2, D11 and BRI1) was lower in IDD3repressors and higher in IDD3 overexpressors compared with WT. However, the ChIP assay revealedthat IDD3 did not directly bind to the D2 and D11 promoters. Overexpression of IDD3 in BRI1 mutantd61-1 inhibited the activity of IDD3, reducing its susceptibility to ShB compared with IDD3 overexpressorand WT plants, indicating that IDD3 negatively regulated the rice defense mechanism against ShB by activatingthe BR signaling pathway. Thus, our analyses provided information to enhance the understanding of therice defense mechanism against ShB.

关键词： sheath blight disease AB13/VP1-like 1 indeterminate domain 3 rice promoter

Clinical outcomes of second-line chemotherapy in patients with advanced pancreatic adenocarcinoma:a real-world study

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Cancer Biology & Medicine 2024年第9期21卷 799-812页

作者： Yuxiao Liu xiaofan guo Peijun Xu Yuning Song Jing Huang Xingyun Chen Wenbo Zhu Jihui Hao Song Gao Department of Pancreatic Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China

Objective:Little progress has been made in recent years using first-line chemotherapy,including gemcitabine combined with nab-paclitaxel,FOLFIRINOX,and NALIRIFOX,for advanced pancreatic adenocarcinoma(APC).In addition,the optimal second-line chemotherapy regimen has not been *** study aimed to compare the effectiveness of different types of second-line chemotherapy for ***:Patients with APC who received first-line treatment from January 2008 to January 2021 were considered eligible for this retrospective *** primary and secondary endpoints were overall survival(OS)and progression-free survival(PFS),***:Four hundred and thirty-seven and 617 patients were treated with 5-fluorouracil-and gemcitabine-based chemotherapy as first-line treatment,*** and clinical features,except age and liver metastasis,were comparable between the two groups(P<0.05).The median OS was 8.8 and 7.8 months in patients who received a 5-fluorouracil-and gemcitabine-based combined regimen for first-line therapy,respectively(HR=1.244,95%CI=1.090–1.419;P<0.001).The median OS was 5.6 and 1.9 months in patients who received second-line chemotherapy and supportive care,respectively(HR=0.766,95%CI=0.677–0.867;P<0.001).The median PFS was not significantly differently between gemcitabine or 5-fluorouracil monotherapy and combination ***:A 5-fluorouracil-or gemcitabine-based combined regimen was shown to be as effective as a single 5-fluorouracil or gemcitabine regimen as second-line therapy for patients with APC.

关键词： Second-line chemotherapy advanced pancreatic adenocarcinoma 5-fluorouracil gemcitabine real-world study

Inequalities in lifestyle behaviors, dietary habits and familial factors among normal weight, overweight or obese Chinese children and adolescents

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Inequalities in lifestyle behaviors, dietary habits and fami...

中华医学会第十五次全国心血管病学大会

作者： xiaofan guo Yingxian Sun Department of Cardiology The First Affiliated Hospital of China Medical University

Background Pediatric obesity has become a global public health problem. Data on the lifestyle behaviors, dietary habits and familial factors of overweight and obese children and adolescents are limited. The present study aimed to compare the health related factors among normal weight, overweight and obese Chinese children and adolescents.

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Blood pressure/height ratio: a new method for diagnosing pediatric hypertension

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Blood pressure/height ratio: a new method for diagnosing ped...

中华医学会第十五次全国心血管病学大会

作者： xiaofan guo Yingxian Sun Department of Cardiology First Affiliated Hospital China Medical University

Aim A new method using systolic blood pressure-to-height ratio (SBPHR) and diastolic blood pressure-to-height ratio (DBPHR) for diagnosing hypertension has been raised recently. We aimed to further confirm and examine whether it is applicable in children. Methods We conducted a cross-sectional study consisted of 6837 children and adolescents aged 5-18 years.

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Epidemiological evidence for the links between sleep duration and high blood pressure: a systematic review and meta-analysis

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Epidemiological evidence for the links between sleep duratio...

中华医学会第十五次全国心血管病学大会

作者： xiaofan guo Yingxian Sun Department of Cardiology The First Affiliated Hospital of China Medical University

Background Recent evidence-based studies suggest a U-shaped relationship between sleep duration and diabetes, cardiovascular diseases and all-cause mortality. The association between habitual sleep duration and hypertension is under discussion. Objectives To assess whether the relationship between short or long sleep duration and hypertension is present from epidemiologic evidence, and investigate the relationship quantitatively.

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Anti-PD-L1/TGF-BR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer

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Cancer Communications 2022年第1期42卷 17-36页

作者： Bo Cheng Kaikai Ding Pengxiang Chen Jianxiong Ji Tao Luo xiaofan guo Wei Qiu Chunhong Ma Xue Meng Jian Wang Jinming Yu Yuan Liu Department of Radiation Oncology Shandong Cancer Hospital and InstituteCheeloo College of MedicineShandong UniversityJinanShandong 250012P.R.China Department of Radiation Oncology Qilu Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinanShandong 250012P.R.China Department of Neurosurgery Qilu Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinanShandong 250012P.R.China Department of Neurology Loma Linda University HealthLoma LindaCA 92354USA Shandong Key Laboratory of Brain Functional Remodeling JinanShandong 250012P.R.China Department of Biomedicine University of BergenBergen 5009Norway Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology Shandong University School of MedicineJinanShandong 250012P.R.China Department of Neurosurgery the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310000P.R.China

Background:Second-generation programmed cell death-protein 1/pro-grammed death-ligand 1(PD-1/PD-L1)inhibitors,such as bintrafusp alfa(M7824),SHR-1701,and YM101,have been developed to simultaneously block PD-1/PD-L1 and transforming growth factor-beta/transforming growth factor-beta receptor(TGF-P/TGF-βR).Consequently,it is necessary to identify predictive factors of lung cancer patients who are not only resistant to PD-1/PD-LI inhibitors but also sensitive to bifunctional *** purpose of this study was to search for such ***:Multivariable Cox regression was used to study the association between the clinical outcome of treatment with PD-1/PD-L1 inhibitors and lym-phocyte recovery after lymphopenia in lung cancer *** CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic *** imag-ing,flow cytometry,and immunohistochemistry were employed to detrmine response to immunotherapy and function of tumor-infiltrating immune ***:For lung cancer patients treated with anti-PD-1/PD-LI antibodies,poor lymphocyte recovery was associated with a shorter progression-free survival(PFS;P<0.001),an accumulation of regulatory T cells(Tregs),and an elimi-nation of CD8+T cells in the peripheral *** of CD8+T cells and Treg cells were also imbalanced in the tumors and peripheral immune organs of mice with poor lymphocyte recovery after ***,these mice failed to respond to anti-PD-1 antibodies but remained sensitive to the anti-PD-LI/TGF-βR fusion protein(SHR-1701).Consistently,SHR-1701 but not anti-PD-1 antibod-ies,markedly enhanced IFN-γproduction and Ki-67 expression in peripheral CD8+T cells from patients with impaired lymphocyte ***:Lung cancer patients with poor lymphocyte recovery and suffer-ing from persistent lymphopenia after previous chemotherapy are resistant to anti-PD-1/PD-L1 antibodies but might be sen

关键词： SHR impaired markedly

The role of biomarker in pancreatic neuroendocrine tumor:a narrative review

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Journal of Pancreatology 2021年第3期4卷 122-129页

作者： xiaofan guo Song Gao Zekun Li Jihui Hao Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinChina

Pancreatic neuroendocrine tumors(pNET)are heterogenous tumors originated from the diffuse neuroendocrine cells of pancreas,which show the function of synthesis,storage and secretion of peptide hormones and biomimetic *** play a crucial role in the diagnosing,evaluating prognosis and predicting treatment response for pNET *** NET markers such as chromogranin A and Neuron Specific Enolase,as a diagnostic biomarker,have relatively low sensitivity and specificity in pNET *** emergence of new types of biomarkers provides more reliable indicators for diagnosis and prognosis *** them,NETest score is a promising biomarker with the highest diagnostic sensitivity(80%)and specificity(94%).In addition,this molecule can be also used as a prognostic biomarker,which can predict disease progression and shorter overall *** related to therapeutic targets,such as vascular endothelial growth factor,vascular endothelial growth factor receptor,and key molecules of mTOR signaling pathway,have capability to predict response of *** the development of nextgeneration sequencing,chip array,and digital droplet PCR,novel biomarkers such as circulating tumor cells,tumor-derived exosomes,and circulating tumor DNA and mRNA are expected to provide more accurate diagnosis,prognostic information,and prospective therapeutic *** this paper,biomarkers of pancreatic neuroendocrine tumor and their role in diagnosis,prognosis,diagnosis,treatment and monitoring are systematically *** conclusions can provide new basis for clinicians in the diagnosis and treatment process.

关键词： Biomarker Diagnosis Pancreatic neuroendocrine tumor Prognosis

Underestimated self- and parental perceptions of overweight and obesity among school children and adolescents in Northern China

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Underestimated self- and parental perceptions of overweight ...

中华医学会第十五次全国心血管病学大会

作者： Shasha Yu xiaofan guo Liqiang Zheng Yingxian Sun Department of Cardiology The First Affiliated Hospital of China Medical University Department of clinical epidemiology Library Shengjing Hospital of China Medical University

Background Few studies investigated self-and parental perceptions of child’s weigh status in Northern Chinese Schools. This study intended to examine the prevalence and the associated factors of underestimated self-and parental perceptions of child’s weight status. Methods A cross-sectional sample of children and adolescents aged 5-18 years (n=5934) and their parents

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