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An overview of functional biolubricants

Friction 2023年第1期11卷 23-47页

作者： Lumin YANG xiaoduo zhao Zhengfeng MA Shuanhong MA Feng ZHOU State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Center of Materials Science and Optoelectronics Enginering University of Chinese Academy of SciencesBeijing 100049China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264006China Shandong Laboratory of Yantai Advanced Materials and Green Manufacture Yantai 264006China

At present,more and more diseases are associated with the lubrication dysfunction,which requires a systematic study of the complex lubrication behavior of tissues and organs in human body.Natural biomacromolecular lubricants are essential for maintaining ultra-low coefficients of friction between sliding biological interfaces.However,when the surface lubrication performance of tissues or organs destroys heavily,it will bring friction/shear damage for sliding contact interfaces.Therefore,the application of exogenous biological lubricating materials to improve the lubrication situation of damaged tissue or organ interfaces has attracted extensive attention of researchers.In this review,based on a simple summary of lubrication mechanism at sliding biological interface,we systematically introduce the research progress of several kinds of representatively biolubrication materials,including eye drops,tissue anti-adhesion agents,joint lubricants,and medical device lubricants.Meanwhile,the lubrication mechanism and individual advantage and shortcoming for each of these synthetic exogenous lubricated materials are clarified.Correspondingly,the important lubrication application functionality of these biolubricant materials in typically medical surgery scenes,such as dry eye syndrome,tissue adhesion,arthritis,and interventional medical devices,is discussed.Finally,we look forward to the future development direction of artificial biolubricant materials.

关键词： biolubricants eye drops tissue anti-adhesion arthritis treatment medical devices

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Constructing a biomimetic robust bi-layered hydrophilic lubrication coating on surface of silicone elastomer

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Friction 2022年第7期10卷 1046-1060页

作者： Luyao GAO xiaoduo zhao Shuanhong MA Zhengfeng MA Meirong CAI Yong-Min LIANG Feng ZHOU School of Chemistry and Chemical Engineering Lanzhou UniversityLanzhou 730000China Lanzhou Institute of Chemical Physics Chinese Academy of SciencesLanzhou 730000China

Silicone elastomers-based materials have been extensively involved in the field of biomedical devices,while their use is extremely restricted due to the poor surface lubricity and inherent hydrophobicity.This paper describes a novel strategy for generating a robust layered soft matter lubrication coating on the surface of the polydimethylsiloxane(PDMS)silicone elastomer,by entangling thick polyzwitterionic polyelectrolyte brush of poly(sulfobetaine methacrylate)(PSBMA)into the sub-surface of the initiator-embedded stiff hydrogel coating layer of P(AAm-co-AA-co-HEMA-Br)/Fe,to achieve a unified low friction and high load-bearing properties.Meanwhile,the stiff hydrogel layer with controllable thickness is covalently anchored on the surface of PDMS by adding iron powder to provide catalytic sites through surface catalytically initiated radical polymerization(SCIRP)method and provides high load-bearing capacity,while the topmost brush/hydrogel composite layer is highly effective for aqueous lubrication.Their synergy effects are capable of attaining low friction coefficient(COFs)under wide range of loaded condition in water environment with steel ball as sliding pair.Furthermore,the influence of mechanical modulus of the stiff hydrogel layer on the lubrication performance of layered coating is investigated,for which the COF is the lowest only when the modulus of the stiff hydrogel layer well matches the PDMS substrate.Surprisingly,the COF of the modified PDMS could remain low friction(COF<0.05)stably after encountering 50,000 sliding cycles under 10 N load.Finally,the surface wear characterizations prove the robustness of the layered lubricating coating.This work provides a new route for engineering lubricious silicon elastomer with low friction,high load-bearing capacity,and considerable durability.

关键词： surface modification silicone elastomer layered lubrication coating hydrogels polyzwitterionic brush

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Effects of Surface Oxidation Treatment of Carbon Fibers on Biotribological Properties of CF/PEEK Materials

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Journal of Bionic Engineering 2017年第4期14卷 640-647页

作者： xiaoduo zhao Dangsheng Xiong Xinxin Wu School of Materials Science and Engineering Nanjing University of Science and Technology Nanjing 210094 China

Carbon Fiber （CF） reinforced polyetheretherketone （PEEK） composite is one of the most promising implant biomaterials used in orthopedics. In this article, unfilled PEEK and CF/PEEK specimens were prepared by vacuum hot pressing method, and their tribological properties were evaluated by sliding against a cobalt-chromium-molybdenum （Co-Cr-Mo） alloy block. The influences of mass fraction of carbon fibers in CF/PEEK and the surface oxidation treatment of carbon fibers were explored. The results showed that the water contact angles on the surfaces of CF/PEEK specimens decreased, indicating that their surface wettability was improved. The hardness value of CF/PEEK was significantly improved, the friction coefficients of CF/PEEK were effectively reduced and its wear resistance was enhanced compared with unfilled PEEK. The leading effect on CF/PEEK tribological properties was the mass fraction of CF, followed by surface oxidation of CF, and the calf serum solution had better lubricity than that of saline and deionized water.

关键词： CF/PEEK biocomposites surface oxidation treatment lubrication wear mechanism

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Recent progress of bioinspired cartilage hydrogel lubrication materials

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Biosurface and Biotribology 2022年第3期8卷 225-243页

作者： xiaoduo zhao Weiyi zhao Yunlei Zhang Xiaoqing Zhang Zhengfeng Ma Rui Wang Qiangbing Wei Shuanhong Ma Feng Zhou State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouChina Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering YantaiChina Baiyin Zhongke Innovation Research Institute of Green Materials BaiyinChina College of Chemistry and Chemical Engineering Northwest Normal UniversityLanzhouChina

Hydrogels have been considered as potential candidates for cartilage replacement due to their high‐water content,extreme network hydration,excellent biocompatibility and tunable mechanical properties.Currently,the development of high‐performance cartilageinspired hydrogel lubrication materials has become a hot topic in the field of biomedical materials.This review focusses on the recent development of cartilage‐inspired highstrength hydrogels from the viewpoints of bionic surface/interface and biotribology.Specifically,the composition structure and extraordinary lubrication mechanism of the natural articular cartilage are overviewed first.Subsequently,some of the novel biomimetic design strategies for preparing high strength cartilage hydrogels with various network structures are summarised in detail,while systematic evaluation of lubrication properties and mechanisms are discussed.Furthermore,new surface modification means for improving the lubrication feature of high strength cartilage hydrogel materials are presented.In addition,in order to demonstrate the application potential of cartilage hydrogels in clinical,several bonding methods to decorate hydrogels onto surfaces of natural bone tissues or artificial joint materials are introduced.Finally,current challenges and future research directions are discussed for cartilage‐inspired hydrogel lubrication materials.

关键词： materials. properties. hydrogel

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细粒棘球绦虫抗原Fis1T细胞表位肽缓解过敏性哮喘小鼠气道炎症的免疫学作用研究

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中国病原生物学杂志 2024年第1期19卷 47-51,55页

作者：辛云卓宋东谢笑多杨雪金海容赵嘉庆宁夏医科大学基础医学院宁夏银川750004 宁夏医科大学科学技术研究中心宁夏常见传染病重点实验室宁夏医科大学总医院耳鼻咽喉头颈外科宁夏医科大学临床医学院

目的探讨细粒棘球绦虫Fis1蛋白的T细胞表位肽(Eg.Fis183-102)对过敏性哮喘小鼠气道炎症的缓解作用及免疫学作用机制。方法1)体内试验:将24只6~8周雌性BALB/C小鼠随机分为3组(每组8只),其中B组为对照组,C组为过敏性哮喘组(OVA),T组为干预... 详细信息

目的探讨细粒棘球绦虫Fis1蛋白的T细胞表位肽(Eg.Fis183-102)对过敏性哮喘小鼠气道炎症的缓解作用及免疫学作用机制。方法1)体内试验:将24只6~8周雌性BALB/C小鼠随机分为3组(每组8只),其中B组为对照组,C组为过敏性哮喘组(OVA),T组为干预组(OVA+Eg.Fis183-102)。采用ELISA法检测小鼠血清OVA特异性IgE水平;采用HE,PAS,MASSON组织染色检查小鼠肺组织病理变化;采用流式细胞术分析肺脏和脾脏组织中嗜酸性粒细胞比例、Th1和Th2的分群及比例。2)体外试验:采用裂红法分离小鼠脾脏单个核细胞,每孔以1×106个细胞铺板,分为3组(每组3个复孔),其中B组为对照组,C组为刀豆蛋白刺激组(ConA),T组为干预组(ConA+Eg.Fis183-102),培养3 d后收集上清,采用ELISA法检测IFN-γ和IL-4水平。结果1)体内试验:与C组相比,T组小鼠肺组织的炎细胞浸润、胶原沉积等病理损伤有所改善,血清OVA特异性IgE水平、肺组织嗜酸性粒细胞比例、肺脏和脾脏Th2细胞比例均显著下降(均P<0.05),肺和脾Th1细胞比例显著上升(均P<0.05)。2)体外试验:与B组相比,C组小鼠脾脏单个核细胞培养上清中IFN-γ和IL-4水平均显著上升(均P<0.05);与C组相比,T组脾脏单个核细胞培养上清中IFN-γ水平显著上升,IL-4水平显著下降(均P<0.01),与体内试验结果一致。结论Eg.Fis183-102可缓解过敏性哮喘小鼠肺组织炎症损伤,降低IgE的分泌,并可能通过纠正Th1/Th2免疫应答失衡抑制OVA诱导的过敏性哮喘小鼠的气道炎症。

关键词：过敏性哮喘细粒棘球绦虫 Fis1蛋白T细胞表位肽

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VAMP726 from maize and Arabidopsis confers pollen resistance to heat and UV radiation by influencing lignin content of sporopollenin

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Plant Communications 2023年第6期4卷 163-178页

作者： Wenqi Yang Dongdong Yao Haiyang Duan Junli Zhang Yaling Cai Chen Lan Bing zhao Yong Mei Yan Zheng Erbing Yang xiaoduo Lu Xuehai Zhang Jihua Tang Ke Yu Xuebin Zhang State Key Laboratory of Crop Stress Adaptation and Improvement Henan Joint International Laboratory for Crop Multi-Omics ResearchSchool of Life SciencesHenan UniversityKaifeng 475004China National Key Laboratory of Wheat and Maize Crop Science College of AgronomyHenan Agricultural UniversityZhengzhou 450002China The Shennong Laboratory Zhengzhou 450002China College of Chemistry Zhengzhou UniversityZhengzhou 450001China National Engineering Laboratory of Crop Stress Resistance School of Life ScienceAnhui Agricultural UniversityHefei 230036China

Sporopollenin in the pollen cell wall protects male gametophytes from stresses.Phenylpropanoid derivatives,including guaiacyl(G)lignin units,are known to be structural components of sporopollenin,but the exact composition of sporopollenin remains to be fully resolved.We analyzed the phenylpropanoid derivatives in sporopollenin from maize and Arabidopsis by thioacidolysis coupled with nuclear magnetic resonance(NMR)and gas chromatography–mass spectrometry(GC–MS).The NMR and GC–MS results confirmed the presence of p-hydroxyphenyl(H),G,and syringyl(S)lignin units in sporopollenin from maize and Arabidopsis.Strikingly,H units account for the majority of lignin monomers in sporopollenin from these species.We next performed a genome-wide association study to explore the genetic basis of maize sporopollenin composition and identified a vesicle-associated membrane protein(ZmVAMP726)that is strongly associated with lignin monomer composition of maize sporopollenin.Genetic manipulation of VAMP726 affected not only lignin monomer composition in sporopollenin but also pollen resistance to heat and UV radiation in maize and Arabidopsis,indicating that VAMP726 is functionally conserved in monocot and dicot plants.Our work provides new insight into the lignin monomers that serve as structural components of sporopollenin and characterizes VAMP726,which affects sporopollenin composition and stress resistance in pollen.

关键词： pollen cell wall sporopollenin lignin monomers heat stress UV radiation

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Heterogeneous sea-level rises along coastal zones and small islands

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Science Bulletin 2019年第11期64卷 748-755页

作者： Guoshuai Li Xin Li Tandong Yao Tao Che Hong Yang Mingguo Ma Haipeng zhao xiaoduo Pan Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing 100101China Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000China Dapartment of Geography and Environmental Science University of ReadingWhiteknightsReading RC6 6ABUK Research Base of Karst Eco-environments at Nanchuan in Chongqing Ministry of Natural ResourcesSchool of Geographical SciencesSouthwest UniversityChongqing 400715China Department of Earth and Environmental Systems Indiana State UniversityTerre HauteIN 47809USA

Coastal zones and many small islands are highly susceptible to sea-level rise(SLR). Coastal zones have a large exposed population and integrated high-value assets, and islands provide diverse ecosystem services to millions of people worldwide. The coastal zones and small islands affected by SLR are likely to suffer from submergence, flooding and erosion in the future. However, very few studies have addressed the heterogeneity in SLR changes and the potential risk to coastal zones and small islands. Here we used the mean sea level(MSL) derived from satellite altimetry data to analyse the trends and accelerations of SLRs along global coastal zones and small islands. We found that except for the Antarctic coastal zone, the annual MSL within 50 km of the coasts presented an increasing trend of 3.09 ± 0.13 mm a^-1 but a decreasing acceleration of -0.02 ± 0.02 mm a^-2 from 1993 to 2017. The highest coastal MSL trend of3.85 ± 0.60 mm a^-1 appeared in Oceania, and the lowest trend of 2.32 ± 0.37 mm a^-1 occured in North America. Africa, North America and South America showed acceleration trends, and Eurasia, Australia and Oceania had deceleration trends. Further, MSLs around global small islands reflected an increasing trend with a rate of 3.01 ± 0.16 mm a^-1 but a negative acceleration of -0.02 ± 0.02 mm a^-2. Regional heterogeneity in the trends and accelerations of MSLs along the coasts and small islands suggests that stakeholders should take discriminating precautions to cope with future disadvantageous impacts of the SLR.

关键词： Sea-level rise Coastal zones Small islands Heterogeneity

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Evaluation with low-dose dual-phase helical computed tomography of patients with thyroid lesions

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Chinese Medical Journal 2014年第22期127卷 3937-3943页

作者： Li Lin Wang Yong zhao Yanfeng Zou Shuangmei Lin Meng Yu xiaoduo Tang Wei Zhou Chunwu Luo Dehong Department of Imaging Diagnosis Cancer Hospital & Institute Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100021China Department of Pathology Cancer Hospital & Institute Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100021China

Background The incidence of thyroid cancer has been increasing.Our aim was to evaluate the efficacy of low-dose dualphase helical computed tomography （CT） in the characterization of thyroid lesions,and to discuss the relationship between image characteristics and their pathology.Methods One hundred and six patients with thyroid lesions underwent low-dose dual-phase helical CT after the injection of contrast material.CT scans were obtained at arterial and venous phase with delays of 25 and 65 seconds,and tube current of 60 and 120 mA,respectively.The attenuation change in the lesion between the arterial and venous phase was analyzed and categorized as ＂increased,＂＂decreased,＂＂mixed＂ or ＂no change.＂ Results Histopathologic diagnosis was obtained by surgery in 106 patients （115 lesions）.Of the 106 patients,45 had nodular goiter,5 thyroid adenoma,6 thyroiditis,and 50 papillary thyroid carcinoma （PTC）（59 lesions）.The attenuation value showed a significant difference （P ＜0.05） between the arterial and venous phase for the high attenuation area.There was statistical significant difference in terms of attenuation value in high attenuation areas at both phases and in low attenuation areas on arterial phase between nodular goiter and PTC （P ＜0.05）.However,there was no significant difference in attenuation value between adenoma and PTC.Twenty-nine cases （76.3％） of goiter manifested mixed type,3 cases （3/5） of adenoma showed decreased type,6 cases （6/6） of thyroiditis showed increased type,and 55 cases （93.2％） of PTC showed decreased type attenuation.The sensitivity,specificity for thyroid carcinoma by dual-phase CT were 94.9％ and 80.4％ respectively.The overall diagnostic accuracy for thyroid lesions by dual-phase CT was 87.8％.Conclusions The performance of dual-phase helical CT is related to the pathological structure of the lesions.The analysis of enhancement patterns by using dual-phase helical CT will be helpful in the differential diagnosis of thyroid lesions.

关键词： thyroid lesions low-dose dual-phase computed tomography

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Gene-lndexed Mutations in Maize

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Molecular Plant 2018年第3期11卷 496-504页

作者： xiaoduo Lu Jisheng Liu Wen Ren Qun Yang Zhenguang Chai Rumei Chen Lei Wang Jun zhao Zhihong Lang Haiyang Wang Yunliu Fan Jiuran zhao Chunyi Zhang Institute of Molecular Breeding for Maize Qilu Normal University Jinan 250200 China Biotechnology Research Institute Chinese Academy of Agricultural Sciences Beijing 100081 China Maize Research Center Beijing Academy of Agriculture & Forestry Sciences Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding Beijing100097 China These authors contributed equally to this article.

The availability of the B73 inbred reference genome sets the stage for high-throughput functional charac- terization of maize genes on a whole-genome scale. Among the 39 324 protein-coding genes predicted, the vast majority are untapped due to the lack of suitable high-throughput reverse genetic resources. We have generated a gene-indexed maize mutant collection through ethyl methanesulfonate mutagenesis and de- tected the mutations by combining exome capture and next-generation sequencing. A total of 1086 mutated MI plants were sequenced, and 195 268 CG〉TA-type point mutations, including stop gain/loss, missplice, start gain/loss, and various non-synonymous protein mutations as well as 4610 InDel mutations, were identified. These mutations were distributed on 32 069 genes, representing 82% of the predicted protein-coding genes in the maize genome. We detected an average of 180 mutations per mutant line and 6.1 mutations per gene. As many as 27 214 mutations of start codons, stop codons, or missplice sites were identified in 14 101 genes, among which 6232 individual genes harbored more than two such muta- tions. Application of this mutant collection is exemplified by the identification of the ent-kaurene synthase gene, which encodes a key enzyme in the gibberellin biosynthesis pathway. This gene-indexed genome- wide mutation collection provides an important resource for functional analysis of maize genes and may bring desirable allelic variants for genetic breeding in maize.

关键词： maize ethyl methanesulfonate mutation exome capture next-generation sequencing functional genomics

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安全稳定控制装置标准化测试系统研究与开发

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电测与仪表 2022年第11期59卷 147-154,175页

作者：金吉良彭书涛朱云峰白申义李小腾赵晓铎国网陕西省电力有限公司电力科学研究院西安710100 许继电气股份有限公司河南许昌461000

安全稳定控制系统作为保证电力系统安全稳定运行的第二道防线,稳控装置现场标准化测试是保证电网安全稳定运行的重要手段。为解决目前稳控系统调试手段单一、检测设备功能不足、现有开环测试方法无法模拟复杂故障时序和自动化程度低等... 详细信息

安全稳定控制系统作为保证电力系统安全稳定运行的第二道防线,稳控装置现场标准化测试是保证电网安全稳定运行的重要手段。为解决目前稳控系统调试手段单一、检测设备功能不足、现有开环测试方法无法模拟复杂故障时序和自动化程度低等问题。提出了稳控系统现场标准化检测方案,研究了稳控系统现场测试体系中信息交互、标准化接口及平台实现技术等关键技术,开发了稳控系统标准化测试系统,研制了多协议智能检测终端。以实际工程为基础,基于RTDS实时仿真系统搭建了验证平台,通过试验验证了文中方法的有效性,方便快捷地实现了安全稳定控制的全面标准化检测。

关键词：安全稳定控制标准化测试标准化接口多协议智能检测终端

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