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Smart and fast reinforcement design for anti-dip bedding rock slopes

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第11期15卷 2943-2953页

作者： Yun Zheng Congxin Chen Fei meng xiaodong Fu Wei Yuan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China School of Civil Engineering and Architecture Wuhan University of TechnologyWuhan430070China Key Laboratory of Roads and Railway Engineering Safety Control of Ministry of Education Shijiazhuang Tiedao UniversityShijiazhuang050043China

Rock slopes are usually reinforced by a number of rock bolts due to the high efficiency and low ***,where should the rock bolts be installed is still a troublesome *** anti-dip bedding rock slopes(ABRSs),the installation position of rock bolts is a controlling factor that determines the reinforcement *** this work,a theoretical method is firstly proposed for assessing the stability of ABRSs reinforced by rock bolts using a limit equilibrium model.A comparison of theoretical calculations and numerical results was conducted to test the correctness of the theoretical *** on the stability assessment of ABRSs,we introduce adaptive moment estimation method(Adam)to optimize the installation location of rock *** Adam optimizer,the optimal layout of rock bolts with the maximum factor of safety can be determined,and the factor of safety of the slope increases by about 25%using the same amount of rock bolts but with different installation *** proposed method enables the fast stability analysis and supporting design for reinforced ABRSs,which paves the way to smart supporting design of slopes.

关键词： Rock slopes Toppling failure Rock bolts Stability assessment Smart analysis

敲低钙黏素17(CDH17)抑制那可丁耐药性SW480人结肠癌细胞的增殖并促进其凋亡

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细胞与分子免疫学杂志 2017年第5期33卷 606-610页

作者：韩峥黄晓东刘蒙谭洁朱庆曦王艳芬蔡一珊陈爱方田霞武汉市第三医院消化内科湖北武汉430060

目的探讨钙黏素17(CDH17)对那可丁耐药性人结肠癌细胞增殖和凋亡的作用。方法采用小干扰RNA(siRNA)敲低那可丁耐药性SW480人结肠癌细胞CDH17的水平,采用实时荧光定量PCR和Western blot法分别检测SW480细胞中CDH17 mRNA和蛋白水平。那可... 详细信息

目的探讨钙黏素17(CDH17)对那可丁耐药性人结肠癌细胞增殖和凋亡的作用。方法采用小干扰RNA(siRNA)敲低那可丁耐药性SW480人结肠癌细胞CDH17的水平,采用实时荧光定量PCR和Western blot法分别检测SW480细胞中CDH17 mRNA和蛋白水平。那可丁处理CDH17下调后的SW480细胞,平板克隆形成实验和MTT实验检测细胞的增殖及细胞活性情况;异硫氰酸荧光素标记的膜联素Ⅴ/碘化丙啶(annexinⅤ-FITC/PI)双染色结合流式细胞术检测细胞凋亡,Western blot法检测凋亡蛋白多腺苷二磷酸核糖聚合酶(PARP)、caspase-3的蛋白水平。结果与空载感染的SW480细胞以及对照组相比,CDH17-siRNA感染的SW480细胞中CDH17 mRNA和蛋白水平均下调。与空载感染的SW480细胞及对照组相比,那可丁处理后,CDH17-siRNA感染的SW480细胞克隆形成率下降、细胞存活率下降;细胞凋亡率升高,PARP、caspase-3蛋白切割活性增强。结论下调CDH17水平可抑制SW480细胞增殖,同时促进细胞凋亡,增强耐药株SW480细胞对那可丁的敏感性。

关键词：钙黏素17(CDH17) 那可丁耐药性凋亡增殖

An efficient algorithm for approximate Voronoi diagram construction on triangulated surfaces

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Computational Visual Media 2023年第3期9卷 443-459页

作者： Wenlong meng Pengbo Bo xiaodong Zhang Jixiang Hong Shiqing Xin Changhe Tu School of Computer Science and Technology Harbin Institute of TechnologyWeihai 264209China School of Computer Science and Technology Shandong UniversityQingdao 266237China

Voronoi diagrams on triangulated surfaces based on the geodesic metric play a key role in many applications of computer *** methods of constructing such Voronoi diagrams generally depended on having an exact geodesic ***,exact geodesic computation is time-consuming and has high memory usage,limiting wider application of geodesic Voronoi diagrams(GVDs).In order to overcome this issue,instead of using exact methods,we reformulate a graph method based on Steiner point insertion,as an effective way to obtain geodesic ***,since a bisector comprises hyperbolic and line segments,we utilize Apollonius diagrams to encode complicated structures,enabling Voronoi diagrams to encode a medial-axis surface for a dense set of boundary *** on these strategies,we present an approximation algorithm for efficient Voronoi diagram construction on triangulated *** also suggest a measure for evaluating similarity of our results to the exact *** our GVD results are constructed using approximate geodesic distances,we can get GVD results similar to exact results by inserting Steiner points on triangle *** results on many 3D models indicate the improved speed and memory requirements compared to previous leading methods.

关键词： geodesic Voronoi diagrams(GVDs) triangular surfaces mesh surfaces approximate geodesics Apollonius diagrams

Poly(vinyl alcohol)/Graphene Nanocomposite Hydrogel Scaffolds for Control of Cell Adhesion

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Journal of Renewable Materials 2020年第1期8卷 89-99页

作者： xiaodong Wang meng Su Chuntai Liu Changyu Shen Xianhu Liu Department of Materials Science and Engineering Tongji Zhejiang CollegeJiaxing314051China National Engineering Research Center for Advanced Polymer Processing Technology Zhengzhou UniversityZhengzhou450002China

Poly(vinyl alcohol)(PVA)/reduced graphene oxide(rGO)nanocomposites is prepared by the immersion of PVA/graphene oxide(GO)nanocomposites in the reducing agent aqueous *** PVA/graphene nanocomposites can be used as scaffold after treatment by chemical crosslinking *** surface hydrophilicity of the nanocomposite scaffolds decreased with the addition of GO or rGO by measuring the contact angles of *** electrical conductivity of PVA/rGO nanocomposite scaffold increased with rGO content *** highest conductivity of PVA/rGO nanocomposite scaffolds with 10 wt%rGO could reach to 12.16×10^(−3)S/*** NIH-3T3 fibroblasts attach and grow well on the surface of PVA/rGO nanocomposite scaffolds with increasing the content of *** number of cells obviously increases on the PVA/rGO nanocomposite scaffolds,especially,at 5 wt%and 10 wt%***,a good level of conductivity and a variation in the surface property of the PVA/rGO nanocomposite scaffolds have affected NIH-3T3 fibroblasts grow.

关键词： Graphene nanocomposites hydrogels scaffolds

Cold hardiness estimation of Pinus densiflora var. zhangwuensis based on changes in ionic leakage, chlorophyll fluorescence and other physiological activities under cold stress

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Journal of Forestry Research 2015年第3期26卷 641-649页

作者： Peng meng Xuefeng Bai Hongdan Li xiaodong Song Xueli Zhang Liaoning Province Sand-Fixation and Afforestation Research Institute

Pinus densiflora var. zhangwuensis grows fast, and its drought and salinity resistance are better than Pinus sylvestris var. mongolica. We compared cold hardiness and mechanisms of cold hardiness between the two species, to provide a theoretical basis for promoting and applying P. densiflora var. zhangwuensis in cold regions. A cold stress experiment was carried out on 3-year-old plantlets of P. densiflora var. zhangwuensis and P. sylvestris var. mon- golica after hardening at five temperature regimes, 5, -10, -20, -40, and -60 ℃, respectively. Some indices of needle samples for both species were measured, such as relative conductivity （REL）, maximum photochemical efficiency （Fv/Fm）, malondialdehyde （MDA）, catalase （CAT）, proline （Pro）, soluble sugar （SS）, and stomata density. REL and MDA values of both species after hard- ening had the same trend of increasing, but the trend was opposite in Fv/Fm value with increasing cold stress. Com- pared with P. sylvestris var. mongolica, the P. densiflora var. zhangwuensis had smaller increases in REL and MDA, and a smaller decline in Fv/Fm during cold stress. Com- pared to the control, REL growth of P. densiflora var. zhangwuensis and P. sylvestris var. mongolica at -60 ℃were 0.41 and 0.60, and MDA growth was 29.94 mol g-1 FW and 47.80 mol g-1 FW, and Fv/Fm declines were 0.08 and 0.27. Half-lethal temperatures （LT50） calculated by logistic equation for P. densiflora var. zhangwuensis and P. sylvestris var. mongolica were -58.23 and -50.34 ℃, respectively. These data suggest that cold resistance of P. densiflora var. zhangwuensis is stronger than that of P. sylvestris var. mongolica. Cold-resistance mechanisms of the two species differed. In response to cold stress, P. sylvestris var. mongolica had strong osmotic adjustment ability because of higher Pro and SS content, while P. densiflora var. zhangwuensis had strong antioxidant ability due to stronger CAT activity. Stomata density and diameter of P. densiflora var. zhangwuens

关键词： Antioxidant ability Maximumphotochemical efficiency Osmotic adjustment Pinusdensiflora vat. zhangwuensis P. sylvestris var. mongolicaRelative conductivity

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多级扩展医疗方舱环境保障系统的设计

中国医疗设备 2018年第4期33卷 5-9页

作者：李明孟晓东郑静晨谢钦王伟徐冬武警总医院北京100039 合肥天鹅制冷科技有限公司安徽合肥230051 南阳二机车辆制造有限公司河南南阳473006

目的对扩展医疗方舱环境保障系统的设计进行研究。方法通过对多级扩展医疗方舱结构特点、任务需求以及工作环境进行分析,得出环境保障系统必须具备的功能与性能,并对功能实现的方法进行了介绍。结果环境保障系统需具备良好的环境适应性... 详细信息

目的对扩展医疗方舱环境保障系统的设计进行研究。方法通过对多级扩展医疗方舱结构特点、任务需求以及工作环境进行分析,得出环境保障系统必须具备的功能与性能,并对功能实现的方法进行了介绍。结果环境保障系统需具备良好的环境适应性,可根据任务需求进行多功能组合,覆盖了扩展医疗方舱的工作环境需求。结论环境保障系统是多级扩展医疗方舱的重要组成部分,可作为一种技术手段来保障多级扩展医疗方舱完成各种环境下的工作任务。

关键词：医疗方舱环境保障系统环境适应性电加热

Development of allogeneic hematopoietic stem cell transplantation in 2022:Regenerating“Groot”to heal the world

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The Innovation 2023年第1期4卷 34-35页

作者： meng Lv mengzhu Shen xiaodong Mo Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical SciencesBeijing 100044China Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical Sciences2019RU029Beijing 100044China

Allogeneic hematopoietic stem cell transplantation(allo-HSCT),the pioneer and mainstream form of cellular therapy,represents the only curative or preferred treatment for various malignant and nonmalignant disorders or facilitates organ transplantation by reconstituting the new blood and immune system of a patient with donor’s regenerative HSCs,similar to the comics character“Groot,”who has an incredible regeneration *** annual cases of allo-HSCT in China's Mainland increased from 10042 in 2020 to 12744 in 2021,suggesting that the negative impact of the severe acute respiratory syndrome coronavirus 2 pandemic might be eliminated,while Europe and North American registries reported 18796 and 8326 cases in 2020,respectively.1 In addition,cutting-edge progress in other cellular therapies,including chimeric antigen receptor T(CAR-T)cells,mesenchymal stromal cells,and specific cytotoxic T lymphocyte(CTL)cells,promotes the combination of allo-HSCT with these therapies to compose the new chapter“Strong Together,Guardians of Life”to save more patients worldwide.

关键词： hematopoietic generating mainland

The Hong Kong–Zhuhai–Macao Bridge

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Engineering 2019年第1期5卷 10-14页

作者： Yongling Zhu Ming Lin Fanchao meng xiaodong Liu Wei Lin Hong Kong–Zhuhai–Macao Bridge Authority Zhuhai 519000 China China Communications Construction Co. Ltd. Beijing 100088 China CCCC Highway Consultant Co. Ltd. Beijing 100088 China

The Hong Kong–Zhuhai–Macao Bridge (HZMB) is located at the Pearl River Estuary on the southeast coast of China;it is the longest as-build marine crossings made of island, tunnel, and bridge. It links Hong Kong in the east with Zhuhai–Macao in the west with a total length of 55 km. The link was built according to the highway standard of six lanes with three lanes going each way;it has a design speed of 100 km·h^-1 and a design life of 120 years. The HZMB has improved traffic conditions on the east and west sides of the coast of the Pearl River Estuary and strengthened the communication, transportation, and economic integration of the three regions, thus accelerating the formation of the Guangdong–Hong Kong–Macao Greater Bay Area. This paper introduces the design and construction of the HZMB, with a focus on the new technologies involved in building the artificial islands and immersed tunnel.

关键词： Bridge marine tunnel east has was is it

An industrial solution to light-induced degradation of crystalline silicon solar cells

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Frontiers in Energy 2017年第1期11卷 67-71页

作者： meng XIE Changrui REN Liming FU xiaodong QIU Xuegong YU Deren YANG State Key Lab of Silicon Materials and School of Materials Science andEngineering Zhejiang University Hangzhou 310027 China Changzhou Shichuang Energy Technology Co. Ltd Liyang 213300 China

Boron-oxygen defects can cause serious lightinduced degradation （LID） of commercial solar cells based on the boron-doped crystalline silicon （c-Si）, which are formed under the injection of excess carriers induced either by illumination or applying forward bias. In this contribution, we have demonstrated that the passivation process of boron-oxygen defects can be induced by applying forward bias for a large quantity of solar cells, which is much more economic than light illumination. We have used this strategy to trigger the passivation process of batches of aluminum back surface field （A1-BSF） solar cells and passivated emitter and rear contact （PERC） solar cells. Both kinds of the treated solar cells show high stability in efficiency and suffer from very little LID under further illumination at room temperature. This technology is of significance for the suppression of LID of c-Si solar cells for the industrial manufacture.

关键词： Boron-oxygen defects c-Si solar cells lightinduced degradation passivation forward bias